Abstract:
:Available evidence indicates that common genes influence alcohol and tobacco abuse in humans. The studies reported here used mouse models to evaluate the hypothesis that genetically determined variability in the alpha4beta2* nicotinic receptor modulates genetically determined variability in the intake of both nicotine and alcohol. Data obtained with inbred mouse strains suggested an association between a polymorphism in the mouse alpha4 nAChR subunit gene, Chrna4, and variability in nicotine and ethanol preference. These associations were assessed in F2 animals derived by crossing C57BL/6-super(beta2-/-) mice and A/J mice. The results obtained by the authors indicate that the polymorphism in Chrna4 plays an important role in modulating variability in oral nicotine intake but is linked to a gene that regulates alcohol intake.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Butt CM,King NM,Hutton SR,Collins AC,Stitzel JAdoi
10.1037/0735-7044.119.1.26subject
Has Abstractpub_date
2005-02-01 00:00:00pages
26-37issue
1eissn
0735-7044issn
1939-0084pii
2005-01705-004journal_volume
119pub_type
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journal_title:Behavioral neuroscience
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