Modulation of nicotine but not ethanol preference by the mouse Chrna4 A529T polymorphism.

Abstract:

:Available evidence indicates that common genes influence alcohol and tobacco abuse in humans. The studies reported here used mouse models to evaluate the hypothesis that genetically determined variability in the alpha4beta2* nicotinic receptor modulates genetically determined variability in the intake of both nicotine and alcohol. Data obtained with inbred mouse strains suggested an association between a polymorphism in the mouse alpha4 nAChR subunit gene, Chrna4, and variability in nicotine and ethanol preference. These associations were assessed in F2 animals derived by crossing C57BL/6-super(beta2-/-) mice and A/J mice. The results obtained by the authors indicate that the polymorphism in Chrna4 plays an important role in modulating variability in oral nicotine intake but is linked to a gene that regulates alcohol intake.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Butt CM,King NM,Hutton SR,Collins AC,Stitzel JA

doi

10.1037/0735-7044.119.1.26

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

26-37

issue

1

eissn

0735-7044

issn

1939-0084

pii

2005-01705-004

journal_volume

119

pub_type

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