Abstract：
:Norway rat pups were either handled (H) or undisturbed (nonhandled, NH) in the period between birth and weaning on Day 21. Following weaning, half of the animals in each group were housed socially (Soc), and half were housed in isolation (Isol). At 120-150 days of age, all animals were sacrificed, and the following regions were dissected and frozen at -70 degrees C until the time of assay: frontal cortex, hippocampus, hypothalamus, amygdala, septum, and pituitary. [3H]Dexamethasone (3H Dex) binding in each region was examined by an in vitro, cytosol, receptor assay. 3H Dex binding was significantly higher in the hippocampus of both H-Soc and H-Isol than in NH groups. In the frontal cortex, 3H Dex binding was higher in the H-Soc animals than in the H-Isol and NH-Isol animals. There were no significant handling or housing effects found in the amygdala, hypothalamus, septum, or pituitary. Thus, early postnatal handling appears to influence the development of the glucocorticoid receptor system in the hippocampus and frontal cortex. These results are discussed as providing a possible mechanism for some of the previously reported effects of early handling on the development of the pituitary-adrenal response to stress.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Meaney MJ,Aitken DH,Bodnoff SR,Iny LJ,Tatarewicz JE,Sapolsky RMdoi
10.1037//0735-7044.99.4.765subject
Has Abstractpub_date
1985-08-01 00:00:00pages
765-70issue
4eissn
0735-7044issn
1939-0084journal_volume
99pub_type
杂志文章abstract：:In 2 experiments, the development of adjuvant arthritis (an experimental autoimmune disease) was inhibited by exposing rats to a flavored solution that had previously been paired with injections of cyclosporine (an immunodepressive drug) compared with rats with the same history but exposed to a flavored solution that ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.104.5.716
更新日期：1990-10-01 00:00:00
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doi：10.1037/bne0000191
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更新日期：1988-02-01 00:00:00
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更新日期：1986-04-01 00:00:00
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doi：10.1037//0735-7044.109.1.150
更新日期：1995-02-01 00:00:00
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journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.100.5.777
更新日期：1986-10-01 00:00:00
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更新日期：1989-06-01 00:00:00
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更新日期：2011-06-01 00:00:00
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journal_title：Behavioral neuroscience
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doi：
更新日期：2002-10-01 00:00:00
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journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.109.3.502
更新日期：1995-06-01 00:00:00
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journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.108.3.469
更新日期：1994-06-01 00:00:00
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pub_type： 杂志文章
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journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.103.4.755
更新日期：1989-08-01 00:00:00
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journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：2001-10-01 00:00:00
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更新日期：2009-04-01 00:00:00
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doi：10.1037//0735-7044.103.6.1176
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更新日期：2005-08-01 00:00:00
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更新日期：2011-12-01 00:00:00
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更新日期：2006-04-01 00:00:00
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更新日期：2010-04-01 00:00:00
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journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.105.1.210
更新日期：1991-02-01 00:00:00
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