Long-term study of chronic oral aluminum exposure and spatial working memory in rats.

Abstract:

:The authors report an effort to advance animal models that mimic the cognitive decline of Alzheimer's disease. Rats were trained and repeatedly tested in a spatial delayed matching-to-position paradigm in the water maze, with the location of the submerged platform changing between, but not within, days. After Trial 1 (random search) and intertrial intervals of 30 s or 1 hr, memory was tested in Trial 2. Young rats quickly acquired this task and were repeatedly tested after different intervals over 7 months, with a slight increase in performance toward the end of testing, but no difference in latencies between delays. Oral long-term treatment of 1 group with 0.1% aluminum caused no delay-dependent working memory deficit. This testing protocol may enable between- and within-subject long-term assessment of spatial working memory before and after drug treatment and may prove useful in animal models of progressive cognitive decline.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

von Linstow Roloff E,Platt B,Riedel G

doi

10.1037//0735-7044.116.2.351

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

351-6

issue

2

eissn

0735-7044

issn

1939-0084

journal_volume

116

pub_type

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