Abstract:
:Two experiments examined the effects of the competitive N-methyl-D-aspartate (NMDA) antagonist D-APV (D-2-amino-5-phosphonovalerate) on rats' ability to acquire potentiated aversions to the odor element of a taste-odor compound. In Experiment 1, pretreatment with D-APV (2.5 micrograms/side icv) caused stereospecific deficits in potentiated odor aversion learning but left simple taste and odor aversion learning intact. In Experiment 2, pretreatment with D-APV had no effect on rats' acquisition of an illness-based odor discrimination task. These results parallel those previously obtained using a noncompetitive NMDA antagonist (Robinson, Crooks, Shinkman, & Gallagher, 1989) and show that interference with NMDA receptors can selectively impair potentiated odor aversion learning. These results suggest that NMDA receptors play a critical role in some, but not all, forms of learning and memory.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Willner J,Gallagher M,Graham PW,Crooks GB Jrdoi
10.1037//0735-7044.106.2.315subject
Has Abstractpub_date
1992-04-01 00:00:00pages
315-23issue
2eissn
0735-7044issn
1939-0084journal_volume
106pub_type
杂志文章abstract::Quipazine is a 5-HT2A-receptor agonist that has been used to induce motor activity and promote recovery of function after spinal cord injury in neonatal and adult rodents. Sensory stimulation also activates sensory and motor circuits and promotes recovery after spinal cord injury. In rats, tail pinching is an effectiv...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000176
更新日期:2017-02-01 00:00:00
abstract::The role of the pedunculopontine tegmental nucleus (PPTg) in stimulus-reward learning was assessed by testing the effects of PPTg lesions on performance in visual autoshaping and conditioned reinforcement (CRf) paradigms. Rats with PPTg lesions were unable to learn an association between a conditioned stimulus (CS) an...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.114.2.285
更新日期:2000-04-01 00:00:00
abstract::Cutaneous desensitization of the upper, rostral snout by bilateral section of the infraorbital nerves in lactating Norway rat dams markedly, but transiently, disrupted retrieval and licking of pups, nursing behavior, and fighting with a strange male intruder. Removal of the mystacial vibrissae, which provide major inp...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.105.6.984
更新日期:1991-12-01 00:00:00
abstract::To examine the role of the medial zona incerta (mZI) in female sexual behavior, ovariectomized estrogen- and progesterone-treated female rats were tested for sexual receptivity after bilateral injections of the selective neurotoxin ibotenic acid (3 micrograms/0.3 microliter) directly into the mZI. These injections pro...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.105.1.210
更新日期:1991-02-01 00:00:00
abstract::Two experiments were conducted in which adrenalectomized male Sprague-Dawley rats were maintained ad lib on distilled water, 3% saline, and sodium-free food. In Experiment 1, 45 rats were given 100, 200, 400, 800, and 1,000 micrograms/kg/day desoxycorticosterone acetate (DOCA) im for 5 days to determine the dose of DO...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.100.4.597
更新日期:1986-08-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0017128
更新日期:2009-10-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1986-06-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.117.2.236
更新日期:2003-04-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.108.3.559
更新日期:1994-06-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.99.3.436
更新日期:1985-06-01 00:00:00
abstract::Bilateral peripeduncular (PPN) lesions made on the seventh postpartum day (L7) with either radiofrequency (RF) current or N-methyl-d,l-aspartic acid (NMDA)/phosphate buffered saline (PBS) reduced maternal aggression (MA) and partially inhibited lactation without producing significant deficits in other items of materna...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.107.1.166
更新日期:1993-02-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1037//0735-7044.113.3.420
更新日期:1999-06-01 00:00:00
abstract::Based on work done in animal models showing that autism-like symptoms are ameliorated following exposure to an enriched sensorimotor environment, we attempted to develop a comparable therapy for children with autism. In an initial randomized controlled trial, children with autism who received sensorimotor enrichment a...
journal_title:Behavioral neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1037/bne0000068
更新日期:2015-08-01 00:00:00
abstract::Nondemented Parkinson's disease (PD) patients report problems on nonmotor tasks that depend on visual or visuospatial abilities. In PD, foveal vision is impaired. Experimental studies in humans and monkeys established that foveal processing and visuospatial attention may be linked through saccadic eye movements. Sacca...
journal_title:Behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.1037/a0031225
更新日期:2013-04-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.119.6.1459
更新日期:2005-12-01 00:00:00
abstract::Rhesus monkeys were trained to learn a large series of visuomotor conditional associations, each involving the arbitrary coupling of a visual stimulus with 1 of 3 potentially correct forelimb movements. The monkeys then received bilateral aspiration lesions of either the amygdala plus subjacent cortex or the hippocamp...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.6.1261
更新日期:1996-12-01 00:00:00
abstract::The ontogeny of associative learning in delay (750-ms conditional stimulus [CS], 650-ms interstimulus interval [ISI]), long-delay (1,350-ms CS, 1,250-ms ISI), and trace (750-ms CS, 500-ms trace interval, 1,250-ms ISI) eyeblink conditioning was examined in 5-month-old human infants and adults. Infants and adults showed...
journal_title:Behavioral neuroscience
pub_type: 临床试验,杂志文章
doi:10.1037/0735-7044.117.6.1196
更新日期:2003-12-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.102.6.811
更新日期:1988-12-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.5.1139
更新日期:1989-10-01 00:00:00
abstract::Infusing conscious unrestrained rats with either 0.5 M NaCl-CSF or 0.7 M sucrose-CSF into the lateral cerebral ventricle (IVT) at 38 microliters/hr for 4 hr induced drinking. Although the infusates were nearly equiosmotic, water drinking during the 0.5 M NaCl-CSF was greater than during 0.7 M sucrose-CSF. However, IVT...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.101.3.371
更新日期:1987-06-01 00:00:00
abstract::It has been proposed that the cognitive dysfunction observed in patients with schizophrenia reflects a failure in cognitive control, in particular an inability to use task-relevant information to guide behavior. Using a prefrontal-dependent task designed to reflect aspects of cue and response conflict seen in human co...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0023572
更新日期:2011-06-01 00:00:00
abstract::Several experiments were conducted to examine the effects of intracranial injection of opioid peptides and antagonists on learning and memory in the chick. Pretraining injection of [leu5]enkephalin and the selective delta receptor agonist [D-Pen2,L-Pen5]enkephalin (DPLPE) into the intermediate medial hyperstriatum ven...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.2.429
更新日期:1989-04-01 00:00:00
abstract::Dopamine in the medial preoptic area (MPOA) facilitates copulation in male rats, and nitric oxide (NO) regulates basal and female-stimulated MPOA dopamine release. Microinjection of L-nitro-arginine methyl ester (L-NAME, an NO synthesis inhibitor) into the MPOA blocked copulation in naive rats and impaired copulation ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.118.6.1317
更新日期:2004-12-01 00:00:00
abstract::Rats had repeated treatments with cocaine associated with a specific context (paired group). Evidence for classical conditioning of cocaine's motor-activity effects and context-specific behavioral sensitization to cocaine was obtained, relative to vehicle-treated (control) and pseudoconditioned (unpaired) groups. Only...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.6.1388
更新日期:1996-12-01 00:00:00
abstract::Regulation of energy intake depends in part on both memory for prior food intake and internal signals of hunger and satiety. These functions are both mediated by the hippocampus, a brain structure that animal studies have shown to be impaired after maintenance on high fat and refined sugar (HFS) diets. Study 1, using ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0025998
更新日期:2011-12-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.106.1.81
更新日期:1992-02-01 00:00:00
abstract::While under deep barbiturate anesthesia, rats received a series of 10 classical conditioning trials in which white noise was paired with intramuscular shock. The anesthetized animals received either saline or epinephrine injections prior to the training trials. Independent sets of animals were tested for retention per...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.99.5.1019
更新日期:1985-10-01 00:00:00
abstract::The present study examined the effects of lesions of the central nucleus of the amygdala (CeA) on the acquisition of a new response with conditioned reinforcement (CR) and its potentiation by intra-accumbens infusions of d-amphetamine (1, 3, 10, and 20 microg/microl). Rats were trained to associate a light-plus-noise ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.5.981
更新日期:1996-10-01 00:00:00