N-methyl-D-aspartate antagonist D-APV selectively disrupts taste-potentiated odor aversion learning.

Abstract:

:Two experiments examined the effects of the competitive N-methyl-D-aspartate (NMDA) antagonist D-APV (D-2-amino-5-phosphonovalerate) on rats' ability to acquire potentiated aversions to the odor element of a taste-odor compound. In Experiment 1, pretreatment with D-APV (2.5 micrograms/side icv) caused stereospecific deficits in potentiated odor aversion learning but left simple taste and odor aversion learning intact. In Experiment 2, pretreatment with D-APV had no effect on rats' acquisition of an illness-based odor discrimination task. These results parallel those previously obtained using a noncompetitive NMDA antagonist (Robinson, Crooks, Shinkman, & Gallagher, 1989) and show that interference with NMDA receptors can selectively impair potentiated odor aversion learning. These results suggest that NMDA receptors play a critical role in some, but not all, forms of learning and memory.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Willner J,Gallagher M,Graham PW,Crooks GB Jr

doi

10.1037//0735-7044.106.2.315

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

315-23

issue

2

eissn

0735-7044

issn

1939-0084

journal_volume

106

pub_type

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