Effects of excitotoxic lesions of the central amygdaloid nucleus on the potentiation of reward-related stimuli by intra-accumbens amphetamine.

Abstract:

:The present study examined the effects of lesions of the central nucleus of the amygdala (CeA) on the acquisition of a new response with conditioned reinforcement (CR) and its potentiation by intra-accumbens infusions of d-amphetamine (1, 3, 10, and 20 microg/microl). Rats were trained to associate a light-plus-noise compound stimulus with the availability of a sucrose solution before receiving both bilateral ibotenic acid lesions of the CeA and cannulas implanted above the nucleus accumbens. Lesions of the central nucleus did not impair the performance of positively reinforced discriminated approach, nor did they impair the acquisition of a new response with conditioned reinforcement. However, the potentiation of responding with CR following intra-accumbens amphetamine was blocked in lesioned animals. These results are discussed in terms of the possible interactions between associative mechanisms in the amygdala and the mesolimbic dopamine projection.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Robledo P,Robbins TW,Everitt BJ

doi

10.1037//0735-7044.110.5.981

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

981-90

issue

5

eissn

0735-7044

issn

1939-0084

journal_volume

110

pub_type

杂志文章
  • Perinatal stress effects on later anxiety and hormone secretion in male mandarin voles.

    abstract::The estradiol (E2), estrogen receptor-α (ERα), testosterone (T), and androgen receptor (AR) can contribute to anxiety, but whether they are associated with the reversion of prenatal adverse outcomes remains unclear. Here, we tested the interactive effects of prenatal maternal restraint stress and early postnatal short...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000094

    authors: He FQ,Fang G,Wang B,Guo XJ,Guo CL

    更新日期:2015-12-01 00:00:00

  • Cardiac startle and orienting responses in the great apes.

    abstract::Cardiac patterns of startle and orienting in response to auditory and vibrotactile stimuli were investigated in the infant chimpanzee and gorilla. Results revealed a notable cardiac acceleration in response to the initial presentations of stimuli of either modality. This acceleratory response appeared to reflect the c...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.5.914

    authors: Berntson GG,Boysen ST

    更新日期:1984-10-01 00:00:00

  • Delayed development of place navigation compared to directional responding in young rats.

    abstract::Recent work from our laboratory demonstrates that both young and adult rats show a preference for directional responding over place navigation in the Morris water task. Based on these findings, previous studies on the postnatal development of spatial learning have most likely assessed the ontogeny of directional respo...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0014594

    authors: Akers KG,Candelaria-Cook FT,Rice JP,Johnson TE,Hamilton DA

    更新日期:2009-04-01 00:00:00

  • Cognitive gender differences in very young children parallel biologically based cognitive gender differences in monkeys.

    abstract::Infant humans were trained on 2 cognitive tests that have previously revealed, in infant monkeys, a double dissociation that was reversible by perinatal manipulations of androgens and ablations of specific brain sites. Children showed the same sex-linked behavior found with infant monkeys: young boys were superior on ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.4.673

    authors: Overman WH,Bachevalier J,Schuhmann E,Ryan P

    更新日期:1996-08-01 00:00:00

  • Estradiol benzoate facilitates lordosis and ear wiggling of 4- to 6-day-old rats.

    abstract::The effects of exogenous and endogenous steroids on components of female sexual behavior of neonatal male and female rats were investigated. In Experiment 1, 4-day-old rats were treated with 0, 0.1, 1.0, 10, or 100 micrograms/10 g body weight estradiol benzoate (EB) and were tested 44 hr later. In Experiment 2, male r...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.5.718

    authors: Williams CL

    更新日期:1987-10-01 00:00:00

  • Opioids and attachment in rhesus macaque (Macaca mulatta) abusive mothers.

    abstract::This study investigated the role of the endogenous opioid system in maternal and affiliative behavior of group-living rhesus macaque (Macaca mulatta) mothers with a history of abusive parenting. Eighteen mothers received an injection of the opioid antagonist naltrexone or saline for 5 days per week for the first 4 wee...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.116.3.489

    authors: Graves FC,Wallen K,Maestripieri D

    更新日期:2002-06-01 00:00:00

  • Pairings of a drug or place conditioned stimulus with lithium chloride produce conditioned sickness, not antisickness.

    abstract::In different experiments, pairings of a drug (pentobarbital or morphine) or place as the conditioned stimulus (CS) with lithium-induced sickness as the unconditioned stimulus (US) were given to rats to produce Pavlovian conditioning. Control rats received unpaired exposures. In the test, each rat was exposed to the CS...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.1.106

    authors: Lett BT

    更新日期:1992-02-01 00:00:00

  • Bilateral lesions of the interpositus nucleus completely prevent eyeblink conditioning in Purkinje cell-degeneration mutant mice.

    abstract::The authors have previously demonstrated that Purkinje cell-degeneration (pcd) mutant mice are impaired in eyeblink conditioning (L. Chen et al., 1996a). The present study addresses the following 3 questions: (a) whether pcd mice perceive the conditioned and unconditioned stimuli as well as the wild-type mice, (b) whe...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.113.1.204

    authors: Chen L,Bao S,Thompson RF

    更新日期:1999-02-01 00:00:00

  • Conditioned cyclosporine effects but not conditioned taste aversion in immunized rats.

    abstract::In 2 experiments, the development of adjuvant arthritis (an experimental autoimmune disease) was inhibited by exposing rats to a flavored solution that had previously been paired with injections of cyclosporine (an immunodepressive drug) compared with rats with the same history but exposed to a flavored solution that ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.104.5.716

    authors: Klosterhalfen S,Klosterhalfen W

    更新日期:1990-10-01 00:00:00

  • The development of a conditioned place preference to morphine: effects of lesions of various CNS sites.

    abstract::This study examined the neural substrates underlying the development of a conditioned place preference (CPP) to morphine (2 mg/kg x 3 pairings) by testing whether lesions of 7 different neural sites block a morphine-induced CPP. Lesions of the pedunculopontine tegmental nucleus (PPTg), the periaqueductal gray (PAG), o...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.111.6.1313

    authors: Olmstead MC,Franklin KB

    更新日期:1997-12-01 00:00:00

  • Aggression upon adolescent cocaine exposure linked to serotonin anomalies: theoretical comment on Ricci et al. (2004).

    abstract::Aggressive tendencies may be linked to the psychopharmacology of cocaine, yet few experimental approaches have been brought to bear on understanding the neurobiological implications of cocaine exposure during the developmentally sensitive period of adolescence. In this issue, Melloni and coauthors (L. A. Ricci, J. M. ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.1037/0735-7044.118.5.1143

    authors: Cunningham KA

    更新日期:2004-10-01 00:00:00

  • Dissociations among the anxiolytic effects of septal, hippocampal, and amygdaloid lesions.

    abstract::Fear reactions of rats given bilateral lesions to the septum, hippocampus, or amygdala were compared with those of rats given sham lesions, in 2 animal models of anxiety: the shock-probe burying test and the elevated plus-maze test. Septal lesions produced anxiolytic effects in both tests (i.e., an increase in open-ar...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.111.3.653

    authors: Treit D,Menard J

    更新日期:1997-06-01 00:00:00

  • Temporal coding of sensation: mimicking taste quality with electrical stimulation of the brain.

    abstract::Two experiments suggested that the temporal pattern of a taste response in the brain can convey meaningful information. In Experiment 1, rats avoided lick-contingent electrical stimulation of the nucleus of the solitary tract (NTS; the first synaptic relay for taste) when the temporal pattern of pulses mimicked the el...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.117.6.1423

    authors: Di Lorenzo PM,Hallock RM,Kennedy DP

    更新日期:2003-12-01 00:00:00

  • Rapid effects of 17β-estradiol on male copulatory behaviors are not elicited by the novel membrane active estrogenic compound STX.

    abstract::Estrogens have been shown to rapidly promote male copulatory behaviors with a time-course that suggests rapid signaling events are involved. The present study tested the hypothesis that estrogen acts through a novel Gq protein-coupled membrane estrogen receptor (ER). Thus, either estradiol (E2), STX (a diphenylacrylam...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0032950

    authors: Kaufman KR,Kelly MJ,Roselli CE

    更新日期:2013-08-01 00:00:00

  • Anterograde amnesia induced by hyperthermia in rats.

    abstract::Anterograde amnesia (AA), forgetting of events that occur following a traumatic episode, has recently been demonstrated by using a mild decrease in temperature (hypothermia) as the amnestic agent. However, no data currently exist to indicate if an increase in body temperature (hyperthermia) might affect memory process...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.3.333

    authors: Ahlers ST,Riccio DC

    更新日期:1987-06-01 00:00:00

  • Selective effects of triazolam on memory for emotional, relative to neutral, stimuli: differential effects on gist versus detail.

    abstract::Benzodiazepines are known to reduce learning and memory performance, presumably through their facilitation of GABAergic neurotransmission, but the effects of these drugs specifically on memory for emotional material has not been addressed in humans. The effects of a benzodiazepine (triazolam, 0.25 mg) on nonincidental...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037/0735-7044.117.3.517

    authors: Buchanan TW,Karafin MS,Adolphs R

    更新日期:2003-06-01 00:00:00

  • Memory stages and brain asymmetry in chick learning.

    abstract::Stages of formation of memory and the roles of different forebrain structures in memory formation were investigated by injecting various agents into the brains of chicks close to the time of peck-avoidance training. With L-glutamate injected bilaterally into the hyperstriatum 5 min pretraining, retention was good 1 mi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.6.856

    authors: Patterson TA,Alvarado MC,Warner IT,Bennett EL,Rosenzweig MR

    更新日期:1986-12-01 00:00:00

  • Dopamine modulates novelty seeking behavior during decision making.

    abstract::Novelty seeking refers to the tendency of humans and animals to explore novel and unfamiliar stimuli and environments. The idea that dopamine modulates novelty seeking is supported by evidence that novel stimuli excite dopamine neurons and activate brain regions receiving dopaminergic input. In addition, dopamine is s...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0037128

    authors: Costa VD,Tran VL,Turchi J,Averbeck BB

    更新日期:2014-10-01 00:00:00

  • Cortico-basal ganglia and cortico-cerebellar circuits in Parkinson's disease: pathophysiology or compensation?

    abstract::The basal ganglia and the cerebellum are anatomically and functionally linked to the cerebral cortex through a series of well-established circuits. The disruption of dopaminergic projections in Parkinson's disease (PD) leads to an imbalance within these circuits, leading to motor and cognitive symptoms. The cortico-ce...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.1037/a0031226

    authors: Martinu K,Monchi O

    更新日期:2013-04-01 00:00:00

  • Sexual reinforcement is blocked by infusion of naloxone into the medial preoptic area.

    abstract::The present experiment was designed to determine whether infusions of naloxone into specific brain sites can block sexual reinforcement as evaluated with the conditioned place preference procedure. Methylnaloxonium (5 micrograms/cannula) was infused bilaterally either into the medial preoptic area (MPOA) or into the n...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.107.5.812

    authors: Agmo A,Gómez M

    更新日期:1993-10-01 00:00:00

  • Identification of quantitative trait loci involved in contextual and auditory-cued fear conditioning in BXD recombinant inbred strains.

    abstract::Fear conditioning shows associations formed between contextual or auditory stimuli with an unconditioned stimulus. Inbred mouse strains differ in their ability to demonstrate fear conditioning, suggesting at least a partial genetic influence. The present study identified the possible chromosomal loci regulating fear c...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.111.2.292

    authors: Owen EH,Christensen SC,Paylor R,Wehner JM

    更新日期:1997-04-01 00:00:00

  • Parametric investigation of social place preference in adolescent mice.

    abstract::Social interaction promotes survival by helping animals to form stable and supportive groups. Additionally, maladaptive social behavior is a hallmark of disorders such as autism and schizophrenia. In many different animal species, including humans, social interaction can be inherently rewarding. Lately there has been ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000406

    authors: Cann C,Venniro M,Hope BT,Ramsey LA

    更新日期:2020-10-01 00:00:00

  • Perirhinal cortex contributions to performance in the Morris water maze.

    abstract::Rats with bilateral, electrolytic lesions of perirhinal cortex (PRC), lateral entorhinal cortex (LEC), or combined lesions (PRLE) were impaired relative to controls (sham) during initial acquisition in the Morris water maze, although all groups were eventually able to learn to locate the platform. A further deficit in...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.2.304

    authors: Liu P,Bilkey DK

    更新日期:1998-04-01 00:00:00

  • Amiloride sensitivity in the neonatal rat.

    abstract::Amiloride-sensitive sodium channels in taste buds appear to play a key role in the response to NaCl stimulation, at least in adult rats. The researchers examined whether neonatal rats, which display an exaggerated preference for hypertonic NaCl solutions, lack functional amiloride-sensitive sodium channels. NaCl intak...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.5.981

    authors: Sollars SI,Bernstein IL

    更新日期:1994-10-01 00:00:00

  • The relation of feeding and activity following septal lesions in rats.

    abstract::The patterns of intake of liquid diet and water were recorded in diet-deprived rats with septal lesions and neurologically intact controls during the first hour of diet access. The occurrences of grooming, resting/sleeping, and exploring were also recorded. Both groups of rats consumed similar amounts of diet in one m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.3.416

    authors: Flynn FW,Evey LA,Steele TL,Mitchell JC

    更新日期:1986-06-01 00:00:00

  • Environmental rearing effects on impulsivity and reward sensitivity.

    abstract::Previous research has indicated that rearing in an enriched environment may promote self-control in an impulsive choice task. To further assess the effects of rearing environment on impulsivity, 2 experiments examined locomotor activity, impulsive action, impulsive choice, and different aspects of reward sensitivity a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0034124

    authors: Kirkpatrick K,Marshall AT,Clarke J,Cain ME

    更新日期:2013-10-01 00:00:00

  • Sustained attention in the mouse: a study of the relationship with the cerebellum.

    abstract::To explore the role of the cerebellum in sustained attention, the authors tested lurcher, wildtype, and lurcher chimeric mice with zero, normal, and variable numbers of Purkinje cells, respectively, in a previously validated task of sustained attention. Results indicate that lurcher mice had a deficit in performance l...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.2.477

    authors: Martin LA,Goldowitz D,Mittleman G

    更新日期:2006-04-01 00:00:00

  • Spatial judgment in Parkinson's disease: Contributions of attentional and executive dysfunction.

    abstract::Spatial judgment is impaired in Parkinson's disease (PD), with previous research suggesting that disruptions in attention and executive function are likely contributors. If judgment of center places demands on frontal systems, performance on tests of attention/executive function may correlate with extent of bias in PD...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000329

    authors: Salazar RD,Moon KLM,Neargarder S,Cronin-Golomb A

    更新日期:2019-08-01 00:00:00

  • Altered spatial learning and memory in mice lacking the mGluR4 subtype of metabotropic glutamate receptor.

    abstract::The glutamate analog, L-2-amino-4-phosphonobutyric acid (L-AP4) is a selective agonist for several members of the metabotropic glutamate receptor (mGluR) family. Activation of presynaptic mGluRs by L-AP4 causes a suppression of synaptic transmission in the central nervous system. In this study, the role of 1 subtype o...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.3.525

    authors: Gerlai R,Roder JC,Hampson DR

    更新日期:1998-06-01 00:00:00

  • Time-based prospective memory impairment in patients with thalamic stroke.

    abstract::The role of the thalamus in memory is potentially very complex. However, most studies on the memory impairments of thalamic lesions have focused on retrospective memory, rarely on prospective memory. To explore the effect of thalamic lesions on event-based prospective memory (EBPM) and time-based prospective memory (T...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0018306

    authors: Cheng H,Tian Y,Hu P,Wang J,Wang K

    更新日期:2010-02-01 00:00:00