L-DOPA and quipazine elicit air-stepping in neonatal rats with spinal cord transections.

Abstract:

:Acute mid-thoracic spinal cord transection eliminates hindlimb air-stepping in neonatal rats suspended in harnesses and administered L-DOPA. Because spinal cord transection eliminates all descending inputs to the hindlimb locomotor circuits, this experiment determined if coadministration of L-DOPA and quipazine (serotonin receptor agonist) would induce hindlimb air-stepping in rat pups 24 hr after transection. Hindlimb steps of spinally transected pups that received L-DOPA or quipazine alone were infrequent and slow; hindlimb steps induced by L-DOPA + quipazine occurred more frequently and were faster than those elicited by either drug alone. These findings suggest that catecholaminergic and serotonergic systems both contribute to hindlimb stepping.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

McEwen ML,Van Hartesveldt C,Stehouwer DJ

doi

10.1037//0735-7044.111.4.825

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

825-33

issue

4

eissn

0735-7044

issn

1939-0084

journal_volume

111

pub_type

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