Two functional serotonin polymorphisms moderate the effect of food reinforcement on BMI.

Abstract:

:Food reinforcement, or the motivation to eat, has been associated with increased energy intake, greater body weight, and prospective weight gain. Much of the previous research on the reinforcing value of food has focused on the role of dopamine, but it may be worthwhile to examine genetic polymorphisms in the serotonin and opioid systems as these neurotransmitters have been shown to be related to reinforcement processes and to influence energy intake. We examined the relationship among 44 candidate genetic polymorphisms in the dopamine, serotonin, and opioid systems, as well as food reinforcement and body mass index (BMI) in a sample of 245 individuals. Polymorphisms in the monoamine oxidase A (MAOA-LPR) and serotonin receptor 2A genes (rs6314) moderated the effect of food reinforcement on BMI, accounting for an additional 5-10% variance and revealed a potential role of the single nucleotide polymorphism, rs6314, in the serotonin 2A receptor as a differential susceptibility factor for obesity. Differential susceptibility describes a factor that can confer either risk or protection depending on a second variable, such that rs6314 is predictive of both high and low BMI based on the level of food reinforcement, while the diathesis stress or dual-gain model only influences one end of the outcome measure. The interaction with MAOA-LPR better fits the diathesis stress model, with the 3.5R/4R allele conferring protection for individuals low in food reinforcement. These results provide new insight into genes theoretically involved in obesity, and support the hypothesis that genetics moderate the association between food reinforcement and BMI.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Carr KA,Lin H,Fletcher KD,Sucheston L,Singh PK,Salis RJ,Erbe RW,Faith MS,Allison DB,Stice E,Epstein LH

doi

10.1037/a0032026

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

387-99

issue

3

eissn

0735-7044

issn

1939-0084

pii

2013-10618-001

journal_volume

127

pub_type

杂志文章
  • Sex differences in brain and personality correlates of the ability to identify popular word associations.

    abstract::The ability of men to identify popular word associations had earlier been shown to be affected by left-sided thalamic surgery for movement disorders; now, over a year later, the impairment has been observed with operations on both sides. In addition, upon testing at approximately the same time interval, men who had un...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.4.893

    authors: Lansdell H

    更新日期:1989-08-01 00:00:00

  • Tonic and phasic activation and arousal effects as a function of feedback in repetitive-choice reaction time tasks.

    abstract::This study examines the effects of positive and negative feedback on performance during choice reaction time tasks to assess whether they differentially affect phasic arousal and tonic activation. Participants (N = 96) received either no feedback or signals of reward, punishment, or both during a semantic and a visuos...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.116.3.397

    authors: De Brabander B,Declerck CH,Boone C

    更新日期:2002-06-01 00:00:00

  • Motor cortex lesions do not affect learning or performance of the eyeblink response in rabbits.

    abstract::The possible modulatory role of motor cortex in classical conditioning of the eyeblink response was examined by ablating anterior neocortex in rabbits and training them with an auditory conditioned stimulus (CS) and an airpuff unconditioned stimulus (US) in either a delay (Experiment 1) or a trace (Experiment 2) condi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.111.4.727

    authors: Ivkovich D,Thompson RF

    更新日期:1997-08-01 00:00:00

  • Ibotenic acid-induced lesions of the medial zona incerta decrease lordosis behavior in the female rat.

    abstract::To examine the role of the medial zona incerta (mZI) in female sexual behavior, ovariectomized estrogen- and progesterone-treated female rats were tested for sexual receptivity after bilateral injections of the selective neurotoxin ibotenic acid (3 micrograms/0.3 microliter) directly into the mZI. These injections pro...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.105.1.210

    authors: Dornan WA,Peterson M,Matuszewich L,Malen P

    更新日期:1991-02-01 00:00:00

  • Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals.

    abstract::Regulation of energy intake depends in part on both memory for prior food intake and internal signals of hunger and satiety. These functions are both mediated by the hippocampus, a brain structure that animal studies have shown to be impaired after maintenance on high fat and refined sugar (HFS) diets. Study 1, using ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0025998

    authors: Francis HM,Stevenson RJ

    更新日期:2011-12-01 00:00:00

  • Role of the anterior hypothalamus-preoptic area in the regulation of courtship behavior in the male Canadian red-sided garter snake (Thamnophis sirtalis parietalis): lesion experiments.

    abstract::Lesions of the medial preoptic area and/or the ventromedial hypothalamus resulted in an abrupt and immediate decline in courtship behavior in adult male Canadian red-sided garter snakes (Thamnophis sirtalis parietalis). Lesions of the more anterior portions of the preoptic area resulted in a more gradual, delayed decl...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.99.5.942

    authors: Friedman D,Crews D

    更新日期:1985-10-01 00:00:00

  • Adrenal responses to reinforcement and extinction: role of expectancy versus instrumental responding.

    abstract::Plasma corticosterone levels were evaluated during operant conditioning in order to determine the effect of reinforced and nonreinforced responding (extinction) on adrenal activation. The influence of instrumental responding was assessed by comparing trained rats with yoked subjects that received a matched reward sche...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.4.654

    authors: Coe CL,Stanton ME,Levine S

    更新日期:1983-08-01 00:00:00

  • Sensitivity to ethanol in inbred mice: genotypic correlations among several behavioral responses.

    abstract::The sensitivity of several inbred strains of mice was assessed for ethanol's effects on activity, body temperature, ataxia, balance, and the righting reflex. Genotypic correlations among the mean responses for the strains were estimated as indexes of pleiotropic influences of genes on drug responses. Three major group...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.2.280

    authors: Crabbe JC

    更新日期:1983-04-01 00:00:00

  • Amygdalo-striatal interaction in the enhancement of stimulus salience in associative learning.

    abstract::Function of the central nucleus of the amygdala (CeA) is critical to 2 aspects of attention in associative learning: the conditioning of orienting responses (ORs) to cues paired with food, and the enhancement of cue salience by the surprising omission of expected events. Such salience enhancements have been found to d...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000041

    authors: Esber GR,Torres-Tristani K,Holland PC

    更新日期:2015-04-01 00:00:00

  • Central nervous system regulation of finicky feeding by the blowfly.

    abstract::Finicky feeding refers to an animal's tendency to become more particular in accepting and choosing food as satiation is approached. We tested the hypothesis that finickiness in the blowfly is related to the balance between internal inhibition, generated by a full crop, and external sensory information, generated by or...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.4.541

    authors: Moss CF,Dethier VG

    更新日期:1983-08-01 00:00:00

  • Functional recovery of taste sensitivity to sodium chloride depends on regeneration of the chorda tympani nerve after transection in the rat.

    abstract::Chorda tympani nerve (CT) transection (CTX) raises sodium chloride (NaCl) taste detection threshold, but the effect of CT regeneration on NaCl threshold is unknown. This experiment examined whether CT regeneration supports normal NaCl threshold in the rat. Thresholds were measured with a 2-lever operant procedure. Thr...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Kopka SL,Spector AC

    更新日期:2001-10-01 00:00:00

  • Behavioral spectral sensitivities of different retinal areas in pigeons.

    abstract::The spectral sensitivity of the red and the yellow retinal fields of head-fixed pigeons was separately measured for wavelengths between 340 and 640 nm by a behavioral perimetric technique. Within this spectral range the mean spectral sensitivity of both fields was found to be maximal at 584 nm and minimal at the lower...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.1.170

    authors: Remy M,Emmerton J

    更新日期:1989-02-01 00:00:00

  • Dopaminergic activity modulation via aggression, status, and a visual social signal.

    abstract::Social interaction may elicit aggression, establish social rank, and be influenced by changes in central dopaminergic activity. In the lizard Anolis carolinensis, a sign stimulus (darkening of postorbital skin or eyespots) inhibits aggressive response from opponents, in part because it forms more rapidly in dominant m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.1.93

    authors: Korzan WJ,Forster GL,Watt MJ,Summers CH

    更新日期:2006-02-01 00:00:00

  • Amygdala central nucleus lesions disrupt increments, but not decrements, in conditioned stimulus processing.

    abstract::The effects of neurotoxic lesions of the amygdala central nucleus (CN) on changes in the associability of a conditioned stimulus (CS) in appetitive Pavlovian conditioning were examined in 2 experiments with rats. In Experiment 1, CN lesions had no effect on the reduction in the associability of a CS produced by preexp...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.107.2.246

    authors: Holland PC,Gallagher M

    更新日期:1993-04-01 00:00:00

  • Memory impairment on a delayed non-matching-to-position task after lesions of the perirhinal cortex in the rat.

    abstract::Previous research conducted in monkeys and rats has established that the perirhinal cortex is critically involved in object- or stimulus-recognition memory, whereas other research suggests this region may contribute to memory for object discriminations. These findings do not rule out the possibility that the perirhina...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.4.827

    authors: Wiig KA,Burwell RD

    更新日期:1998-08-01 00:00:00

  • Examining changes in rodent temperament following repetitive mild traumatic brain injury in adolescence.

    abstract::Mild traumatic brain injuries are known to cause a host of symptoms, including headaches, nausea, and depression, that when persistent, are known as postconcussive syndrome. In addition to these overt symptomologies, individuals may experience changes in day-to-day behavior or temperament, which although not meeting c...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000413

    authors: Hazari A,Salberg S,Griep Y,Yamakawa GR,Mychasiuk R

    更新日期:2020-10-01 00:00:00

  • Configurational and nonconfigurational interactions between odorants in binary mixtures.

    abstract::Studies on odor mixture perception suggest that although odor components can often be identified in mixtures, mixtures can also give rise to novel perceptual qualities that are not present in the components. Using an olfactory habituation task, the authors evaluated how the perceptual similarity between components in ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.117.2.236

    authors: Wiltrout C,Dogra S,Linster C

    更新日期:2003-04-01 00:00:00

  • Sex differences in the relationship between activity and weight loss in the rat.

    abstract::Access to a running wheel combined with restricted feeding produced body weight loss at an equivalent rate in male and female litter-mate rats (Experiment 1). Thus, despite weighing less and running more, females were not more vulnerable to this procedure. When factors influencing weight loss were varied, no sex diffe...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Boakes RA,Mills KJ,Single JP

    更新日期:1999-10-01 00:00:00

  • Exploration, anxiety, and spatial memory in transgenic anophthalmic mice.

    abstract::Contradictory results are found in the literature concerning the role of vision in the perception of space or in spatial navigation, in part because of the lack of murine models of total blindness used so far. The authors evaluated the spatial abilities of anophthalmic transgenic mice. These mice did not differ qualit...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Buhot MC,Dubayle D,Malleret G,Javerzat S,Segu L

    更新日期:2001-04-01 00:00:00

  • Effects of D-cycloserine on extinction of conditioned freezing.

    abstract::The present study tested the prediction that D-cycloserine (DCS), a partial N-methyl-D-aspartate agonist, would facilitate extinction of conditioned freezing in male Sprague-Dawley rats. Rats received 5 light-shock pairings (conditioning). The following day, rats received 6 light-alone presentations (extinction traini...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.117.2.341

    authors: Ledgerwood L,Richardson R,Cranney J

    更新日期:2003-04-01 00:00:00

  • An accessory sex gland aggression-promoting chemosignal in male mice.

    abstract::The present study investigated male murine accessory sex glands as potential sources of a urinary aggression-promoting chemosignal. Experiments 1-4 were designed to determine whether the removal of the following glands would eliminate voided urine chemosignal activity: vesicular and coagulating glands, Cowper's gland,...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.5.777

    authors: Ingersoll DW,Morley KT,Benvenga M,Hands C

    更新日期:1986-10-01 00:00:00

  • Peptide effects on social behavior: effects of vasotocin and isotocin on social approach behavior in male goldfish (Carassius auratus).

    abstract::The authors measured the effects of centrally infused peptides on social approach behaviors in goldfish (Carassius auratus), a social teleost. Vasotocin (VT) inhibited approach responses toward the visual stimuli of conspecifics in the absence of aggressive or sexual olfactory contextual cues in males, and a V1 recept...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.3.620

    authors: Thompson RR,Walton JC

    更新日期:2004-06-01 00:00:00

  • Modulation of memory consolidation for olfactory learning by reversible inactivation of the basolateral amygdala.

    abstract::The role of the basolateral amygdala (BLA) in the consolidation of an association between an olfactory stimulus and footshock was investigated with a reversible lesion technique of post-training intra-BLA infusions of tetrodotoxin. Rats receiving tetrodotoxin infusions following paired odor-shock presentations spent m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.117.1.184

    authors: Kilpatrick L,Cahill L

    更新日期:2003-02-01 00:00:00

  • Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans.

    abstract::The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with th...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.121.5.877

    authors: Epstein LH,Temple JL,Neaderhiser BJ,Salis RJ,Erbe RW,Leddy JJ

    更新日期:2007-10-01 00:00:00

  • Chronic lithium chloride infusions: conditioned suppression of food intake and preference.

    abstract::A modified learned food aversion paradigm simulated the prolonged food and illness exposure likely to characterize nutrient deficiencies or tumor growth. In this paradigm, a continuously available food was associated with a slow, continuous infusion of LiCl provided by osmotic minipump. Significant aversions were acqu...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.2.290

    authors: Bernstein IL,Goehler LE

    更新日期:1983-04-01 00:00:00

  • Interactions between cognition and circadian rhythms: attentional demands modify circadian entrainment.

    abstract::Animals and humans are able to predict and synchronize their daily activity to signals present in their environments. Environmental cues are most often associated with signaling the beginning or the end of a daily activity cycle, but they can also be used to time the presentation or availability of scarce resources. I...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0017128

    authors: Gritton HJ,Sutton BC,Martinez V,Sarter M,Lee TM

    更新日期:2009-10-01 00:00:00

  • Loudness scaling and masking in rats.

    abstract::Two groups of rats were trained on operant discriminations in which the discriminanda were two different sound pressure levels of a 4-kHz tone. The discriminanda were chosen so that the loudness difference between stimuli was equivalent for each group when calculated from a power function with an exponent of .35. Half...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.3.392

    authors: Raslear TG,Pierrel-Sorrentino R,Rudnick F

    更新日期:1983-06-01 00:00:00

  • Increases in vocalization and motor reflex thresholds are influenced by the site of morphine microinjection: comparisons following administration into the periaqueductal gray, ventral medulla, and spinal subarachnoid space.

    abstract::The relative influence of morphine microinjected into the periaqueductal gray, ventral medulla (nucleus raphé magnus or nucleus reticularis gigantocellularis), or spinal subarachnoid space on the thresholds of responses organized at spinal (spinal motor reflexes, SMRs), medullary (vocalizations elicited during shock, ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.3.502

    authors: Borszcz GS

    更新日期:1995-06-01 00:00:00

  • Effects of exposure to stressors of varying predictability on adrenal function in rats.

    abstract::For 5 days, rats were exposed to shocks that were signalled by a light 0, 33, 66, or 100% of the time. Basal hormone levels and responses to a light-shock pair were measured daily. Greater predictability was associated with higher basal plasma corticosterone and norepinephrine levels indicative of chronic stress. Habi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.4.767

    authors: Pitman DL,Natelson BH,Ottenweller JE,McCarty R,Pritzel T,Tapp WN

    更新日期:1995-08-01 00:00:00

  • Response-reinforcer associations after caudate-putamen lesions in the rat: spatial discrimination and overshadowing-potentiation effects in instrumental learning.

    abstract::Experiment 1 demonstrated that rats with caudate-putamen lesions show an impairment in the acquisition and reversal of a spatial maze task when compared with unoperated control subjects. Experiment 2 examined lever-press responding supported by a variable interval schedule in three groups of subjects: a group with cau...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.99.6.1074

    authors: Mitchell JA,Channell S,Hall G

    更新日期:1985-12-01 00:00:00