Facilitation of fear extinction by midbrain periaqueductal gray infusions of RB101(S), an inhibitor of enkephalin-degrading enzymes.

Abstract:

:Mu-opioid receptors in the ventrolateral quadrant midbrain periaqueductal gray (vIPAG) contribute to extinction of conditioned fear. The present experiment studied whether fear extinction could be facilitated by infusions of a peptidase inhibitor that reduces catabolism of vIPAG enkephalins. Rats were trained to fear an auditory conditioned stimulus. Fear was then extinguished. Extinction training was preceded by infusions of vehicle or RB101(S), an inhibitor of enkephalin catabolising enzymes. RB101(S) dose dependently facilitated extinction as indexed by performance during extinction and on a drug-free test. This facilitation was not observed when RB101(S) was infused outside the vIPAG. These results confirm that vIPAG endogenous opioids contribute to fear extinction and show that extinction can be facilitated by manipulations that increase vIPAG opioid neuromodulation.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

McNally GP

doi

10.1037/0735-7044.119.6.1672

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1672-7

issue

6

eissn

0735-7044

issn

1939-0084

pii

2006-00645-024

journal_volume

119

pub_type

杂志文章
  • Behavioral sensitization to cocaine, but not cocaine-conditioned behavior, is associated with increased dopamine occupation of its receptors in the nucleus accumbens.

    abstract::Rats had repeated treatments with cocaine associated with a specific context (paired group). Evidence for classical conditioning of cocaine's motor-activity effects and context-specific behavioral sensitization to cocaine was obtained, relative to vehicle-treated (control) and pseudoconditioned (unpaired) groups. Only...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.6.1388

    authors: Burechailo L,Martin-Iverson MT

    更新日期:1996-12-01 00:00:00

  • Circadian modulation of the rat acoustic startle response.

    abstract::The acoustic startle response (ASR) of male rats was measured during several sessions over a 24-hr period in both a light-dark cycle and a constant-dark condition. Each session consisted of 10 trials each at 80, 90, 100, 110, and 120 dB white noise. The results indicate robust daily and circadian modulation of ASR amp...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.5.846

    authors: Chabot CC,Taylor DH

    更新日期:1992-10-01 00:00:00

  • Anticipatory errors after unilateral lesions of the subthalamic nucleus in the rat: evidence for a failure of response inhibition.

    abstract::The nature of anticipatory responding in rats with unilateral subthalamic nucleus lesions was examined. Rats were trained to respond toward visual targets that were preceded by 1 of 4 different cues. For normal rats, a cue invokes an involuntary attentional orienting that enhances processing of the target at the locat...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.114.1.150

    authors: Phillips JM,Brown VJ

    更新日期:2000-02-01 00:00:00

  • Conditioned cyclosporine effects but not conditioned taste aversion in immunized rats.

    abstract::In 2 experiments, the development of adjuvant arthritis (an experimental autoimmune disease) was inhibited by exposing rats to a flavored solution that had previously been paired with injections of cyclosporine (an immunodepressive drug) compared with rats with the same history but exposed to a flavored solution that ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.104.5.716

    authors: Klosterhalfen S,Klosterhalfen W

    更新日期:1990-10-01 00:00:00

  • Thyroxine treatment reduces the anorectic effect of estradiol in rats.

    abstract::In order to examine a possible interaction between thyroxine and estradiol in the control of feeding, 14 ovariectomized adult female rats were given daily injections of 9.8 micrograms/100 g of body weight of 1-thyroxine (T). Another 14 rats received 0.15 ml of saline (S) subcutaneously each day, and food intake was me...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.2.284

    authors: Young JK

    更新日期:1986-04-01 00:00:00

  • A history of bingeing on fat enhances cocaine seeking and taking.

    abstract::Binge eating and substance dependence are disorders characterized by a loss of control over consummatory behaviors. Given the common characteristics of these two types of disorders, it is not surprising that the comorbidity between eating disorders and substance abuse disorders is high (20-40%; Conason et al., 2006). ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0025759

    authors: Puhl MD,Cason AM,Wojnicki FH,Corwin RL,Grigson PS

    更新日期:2011-12-01 00:00:00

  • Treadmill performance of mice with cerebellar lesions: 1. Purkinje cell degeneration mutant mice.

    abstract::The purpose of this study was to evaluate the sensorimotor skills of a spontaneous mouse mutant, Purkinje cell degeneration (PCD), marked by selective cerebellar cortical atrophy on a treadmill activated at 1 of 2 speeds and at 1 of 3 slopes, requiring forward movements to avoid footshocks. There was no difference in ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.1.225

    authors: Le Marec N,Lalonde R

    更新日期:1998-02-01 00:00:00

  • Stressor-provoked behavioral changes in six strains of mice.

    abstract::Behavioral changes induced by inescapable shock were examined in six strains of mice. Exposure to shock provoked time-dependent disturbances of shuttle escape performance. In some strains the shock treatment did not affect escape performance, whereas in others profound performance deficits were evident. The inescapabl...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.102.6.894

    authors: Shanks N,Anisman H

    更新日期:1988-12-01 00:00:00

  • Is sexual motivational state linked to dopamine release in the medial preoptic area?

    abstract::The medial preoptic area (mPOA) is a key site for the dopaminergic enhancement of male sexual behavior. Dopamine release increases in the rat mPOA with mating, supporting the critical stimulatory role played by preoptic dopamine on male sexual behavior. However, it has been questioned whether dopamine is specifically ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0018767

    authors: Kleitz-Nelson HK,Dominguez JM,Cornil CA,Ball GF

    更新日期:2010-04-01 00:00:00

  • Loudness scaling and masking in rats.

    abstract::Two groups of rats were trained on operant discriminations in which the discriminanda were two different sound pressure levels of a 4-kHz tone. The discriminanda were chosen so that the loudness difference between stimuli was equivalent for each group when calculated from a power function with an exponent of .35. Half...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.3.392

    authors: Raslear TG,Pierrel-Sorrentino R,Rudnick F

    更新日期:1983-06-01 00:00:00

  • Mediodorsal thalamic lesions and Pavlovian conditioning of heart rate and eyeblink responses in the rabbit.

    abstract::Rabbits received ibotenic acid lesions of the mediodorsal nucleus of the thalamus (MD) or sham lesions. These animals were compared on 4 sessions of Pavlovian eyeblink and heart rate conditioning, in which a tone was the conditioned stimulus and a paraorbital electrical shock was the unconditioned stimulus. Lesions of...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.104.6.912

    authors: Buchanan SL,Thompson RH

    更新日期:1990-12-01 00:00:00

  • Brain regional neuropeptide changes resulting from social defeat.

    abstract::Past work has demonstrated robust brain changes in cholecystokinin (CCK-8) following social defeat. Here the authors analyzed brain regional, CCK-8, substance P, corticotropin releasing factor (CRF), and neuropeptide Y levels in adult male Long-Evans rats defeated in a resident-intruder social aggression paradigm, as ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.121.6.1364

    authors: Panksepp J,Burgdorf J,Beinfeld MC,Kroes RA,Moskal JR

    更新日期:2007-12-01 00:00:00

  • Sodium depletion increases rats' preferences for salted food.

    abstract::In contrast to humans, sodium-replete rats prefer dilute saline to water and do not prefer salted food to plain food. Sodium depletion is known to enhance the intake of and preference for salt provided in water. Here, we examined whether the context of the delivery vehicle for salt could influence salt intake and pref...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.102.4.565

    authors: Bertino M,Tordoff MG

    更新日期:1988-08-01 00:00:00

  • Different neural responses to stranger and personally familiar faces in shy and bold adults.

    abstract::The shy-bold continuum is a fundamental behavioral trait conserved across human and nonhuman animals. Individual differences along the shy-bold continuum are presumed to arise from, and are maintained by, differences in the excitability of forebrain limbic areas involved in the evaluation of stimulus saliency. To test...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.3.704

    authors: Beaton EA,Schmidt LA,Schulkin J,Antony MM,Swinson RP,Hall GB

    更新日期:2008-06-01 00:00:00

  • Anterior rhinal cortex and amygdala: dissociation of their contributions to memory and food preference in rhesus monkeys.

    abstract::Rhesus monkeys were trained on 2 versions of delayed nonmatching-to-sample, one with multiple pairs of objects and the other with a single pair, to evaluate their ability to remember objects. They then received either bilateral aspiration lesions of the anterior rhinal cortex or bilateral excitotoxic lesions of the am...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Murray EA,Gaffan EA,Flint RW Jr

    更新日期:1996-02-01 00:00:00

  • Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors.

    abstract::These experiments tested whether nucleus accumbens muscarinic or nicotinic acetylcholine receptor activation is required for rats to learn to lever press for sucrose. Muscarinic blockade with scopolamine (1.0 microg/side or 10.0 microg/side), but not nicotinic antagonism with mecamylamine (10.0 microg/side), inhibited...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.4.730

    authors: Pratt WE,Kelley AE

    更新日期:2004-08-01 00:00:00

  • Bright light suppresses hyperactivity induced by excitotoxic dorsal hippocampus lesions in the rat.

    abstract::The hippocampus has been implicated in anxiety, novelty detection, spatial- contextual processing, and hyperactivity. Accordingly, the authors contrasted the role of the dorsal hippocampus (DH) and the basolateral amygdala complex (BLA) in an open field task that presents the onset and termination of a bright light gr...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.5.1339

    authors: Godsil BP,Stefanacci L,Fanselow MS

    更新日期:2005-10-01 00:00:00

  • Rat prefrontal dopamine and cognitive control: impaired and enhanced conflict performance.

    abstract::It has been proposed that the cognitive dysfunction observed in patients with schizophrenia reflects a failure in cognitive control, in particular an inability to use task-relevant information to guide behavior. Using a prefrontal-dependent task designed to reflect aspects of cue and response conflict seen in human co...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0023572

    authors: Haddon JE,Killcross S

    更新日期:2011-06-01 00:00:00

  • Enhanced appetitive learning and reversal learning in a mouse model for Prader-Willi syndrome.

    abstract::Prader-Willi syndrome (PWS) is caused by lack of paternally derived gene expression from the imprinted gene cluster on human chromosome 15q11-q13. PWS is characterized by severe hypotonia, a failure to thrive in infancy and, on emerging from infancy, evidence of learning disabilities and overeating behavior due to an ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0028155

    authors: Relkovic D,Humby T,Hagan JJ,Wilkinson LS,Isles AR

    更新日期:2012-06-01 00:00:00

  • Light-dark differences in behavioral sensitivity to oxytocin.

    abstract::Ovariectomized female rats treated with estradiol benzoate (EB) and progesterone (P) were infused intracerebroventricularly with a low (200 ng) or high (1 microgram) dose of oxytocin (OT). The low dose of OT facilitated lordosis behavior only during the dark phase of the light-dark cycle in females that were pretreate...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.105.3.487

    authors: Schumacher M,Coirini H,Pfaff DW,McEwen BS

    更新日期:1991-06-01 00:00:00

  • Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associate memory task.

    abstract::Experimental data and computational models suggest that blockade of muscarinic cholinergic receptors impairs paired-associate learning and increases proactive interference (E. DeRosa & M. E. Hasselmo, 2000; M. E. Hasselmo & J. M. Bower, 1993). The results presented here provide evidence in humans supporting these hypo...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.1.223

    authors: Atri A,Sherman S,Norman KA,Kirchhoff BA,Nicolas MM,Greicius MD,Cramer SC,Breiter HC,Hasselmo ME,Stern CE

    更新日期:2004-02-01 00:00:00

  • Repeated fluoxetine administration during adolescence stimulates aggressive behavior and alters serotonin and vasopressin neural development in hamsters.

    abstract::Fluoxetine is the only selective serotonin reuptake inhibitor registered for the treatment of major depressive disorder in pediatric populations, despite reports that it is disproportionately associated with an array of adverse side effects that include agitation, hostility, and overt acts of pathological aggression a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0029761

    authors: Ricci LA,Melloni RH Jr

    更新日期:2012-10-01 00:00:00

  • Effect of dopamine-depleting brain lesions in rat pups: role of striatal serotonergic neurons in behavior.

    abstract::Previous results from our laboratory have demonstrated that 3-day-old rats given dopamine (DA)-depleting brain lesions are spared the severe behavioral dysfunctions seen after comparable brain damage in adults. This behavioral sparing is accompanied by a sprouting of serotonin (5-HT)-containing neurons in the striatum...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.6.806

    authors: Bruno JP,Jackson D,Zigmond MJ,Stricker EM

    更新日期:1987-12-01 00:00:00

  • Long-term replacement of estrogen in combination with medroxyprogesterone acetate improves acquisition of an alternation task in middle-aged female rats.

    abstract::Studies have shown that ovarian hormones protect against some of the cognitive deficits associated with aging. Although much of the literature in rodents has focused on hippocampal dependent tasks, studies suggest that tasks dependent on the prefrontal cortex are also influenced by ovarian hormones. The present study ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0026461

    authors: Chisholm NC,Juraska JM

    更新日期:2012-02-01 00:00:00

  • Anteromedial temporal lobe damage blocks startle modulation by fear and disgust.

    abstract::The acoustic startle reflex (ASR) is potentiated during negative emotion, but attenuated during positive emotional experience. The modulation of the ASR by fear depends critically on the amygdala. The authors investigated ASR modulation to fearful, disgusting, pleasant, and neutral stimuli in 12 patients with unilater...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.2.429

    authors: Buchanan TW,Tranel D,Adolphs R

    更新日期:2004-04-01 00:00:00

  • Biophysical and behavioral correlates of memory storage, degradation, and reactivation.

    abstract::Neural correlates of associative memory and "forgetting" were observed 1, 6, and 14 days after acquisition of a conditioned response (CR) in the marine snail Hermissenda. Behavioral expression of a light-rotation association, as indexed by contraction of the animal's foot in response to light, dissipated throughout th...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.6.954

    authors: Matzel LD,Collin C,Alkon DL

    更新日期:1992-12-01 00:00:00

  • Delayed spontaneous alternation in intact and cerebellectomized control and lurcher mutant mice: differential role of cerebellar cortex and deep cerebellar nuclei.

    abstract::Lurcher mutant (+/Lc) mice exhibit a massive loss of neurons in the cerebellar cortex and in the inferior olivary nucleus while deep cerebellar nuclei are essentially intact. To discriminate the respective participation of the cerebellar cortex and deep structures in learning and memory, the authors subjected 3- to 6-...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.111.1.214

    authors: Caston J,Vasseur F,Delhaye-Bouchaud N,Mariani J

    更新日期:1997-02-01 00:00:00

  • Long-term effects of leucine-enkephalin on active avoidance responding in mice.

    abstract::The effects of peripherally administered leucine-enkephalin on the acquisition and retention of active avoidance behavior was studied in mice. Mice received 4 training trials on Day 1, 24 test trials on Day 2, and 10 test trials on Day 5. Leucine-enkephalin impaired the aquisition of avoidance behavior when administer...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.2.185

    authors: Dana RC,Martinez JL Jr

    更新日期:1986-04-01 00:00:00

  • Strain differences in patterns of drug-intake during prolonged access to cocaine self-administration.

    abstract::The current study examined possible interactions between genetic factors and prolonged drug access by testing the Fischer (F344), Lewis (LEW), and Wistar rat strains in a prolonged access cocaine self-administration (SA) procedure. Before prolonged access, the strains did not differ in breakpoints for food or cocaine ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0013727

    authors: Freeman KB,Kearns DN,Kohut SJ,Riley AL

    更新日期:2009-02-01 00:00:00

  • Once is too much: conditioned aversion develops immediately and predicts future cocaine self-administration behavior in rats.

    abstract::Rats emit aversive taste reactivity (TR) behavior (i.e., gapes) following intraoral delivery of a cocaine-paired taste cue and greater conditioned aversive TR at the end of training predicts greater drug-seeking and taking. Here, we examined the development of this conditioned aversive TR behavior on a trial-by-trial ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0036264

    authors: Colechio EM,Imperio CG,Grigson PS

    更新日期:2014-04-01 00:00:00