Abstract:
:Mu-opioid receptors in the ventrolateral quadrant midbrain periaqueductal gray (vIPAG) contribute to extinction of conditioned fear. The present experiment studied whether fear extinction could be facilitated by infusions of a peptidase inhibitor that reduces catabolism of vIPAG enkephalins. Rats were trained to fear an auditory conditioned stimulus. Fear was then extinguished. Extinction training was preceded by infusions of vehicle or RB101(S), an inhibitor of enkephalin catabolising enzymes. RB101(S) dose dependently facilitated extinction as indexed by performance during extinction and on a drug-free test. This facilitation was not observed when RB101(S) was infused outside the vIPAG. These results confirm that vIPAG endogenous opioids contribute to fear extinction and show that extinction can be facilitated by manipulations that increase vIPAG opioid neuromodulation.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
McNally GPdoi
10.1037/0735-7044.119.6.1672subject
Has Abstractpub_date
2005-12-01 00:00:00pages
1672-7issue
6eissn
0735-7044issn
1939-0084pii
2006-00645-024journal_volume
119pub_type
杂志文章abstract::Rats had repeated treatments with cocaine associated with a specific context (paired group). Evidence for classical conditioning of cocaine's motor-activity effects and context-specific behavioral sensitization to cocaine was obtained, relative to vehicle-treated (control) and pseudoconditioned (unpaired) groups. Only...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.6.1388
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pub_type: 杂志文章
doi:10.1037//0735-7044.106.5.846
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.114.1.150
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.104.5.716
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pub_type: 杂志文章
doi:10.1037//0735-7044.100.2.284
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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journal_title:Behavioral neuroscience
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.102.6.894
更新日期:1988-12-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0018767
更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-06-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.104.6.912
更新日期:1990-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1037/0735-7044.121.6.1364
更新日期:2007-12-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.102.4.565
更新日期:1988-08-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.122.3.704
更新日期:2008-06-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.118.4.730
更新日期:2004-08-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.119.5.1339
更新日期:2005-10-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0023572
更新日期:2011-06-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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更新日期:1987-12-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0026461
更新日期:2012-02-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.118.2.429
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.106.6.954
更新日期:1992-12-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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journal_title:Behavioral neuroscience
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00