Light-dark differences in behavioral sensitivity to oxytocin.

Abstract:

:Ovariectomized female rats treated with estradiol benzoate (EB) and progesterone (P) were infused intracerebroventricularly with a low (200 ng) or high (1 microgram) dose of oxytocin (OT). The low dose of OT facilitated lordosis behavior only during the dark phase of the light-dark cycle in females that were pretreated with low doses of EB (2 micrograms) and P (250 micrograms). In contrast, the high dose of OT facilitated lordosis behavior during both the light and the dark phases but only in long-term ovariectomized females that were primed with large amounts of EB (2 x 10 micrograms) and P (500 micrograms). In females that were primed with lower amounts of ovarian steroids, the high dose of OT failed to increase levels of lordosis responding in either the dark or light phase. Thus, when female rats are treated with physiological amounts of ovarian hormones and OT, they are more sensitive to the facilitative effects of the OT on lordosis behavior during the dark phase.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Schumacher M,Coirini H,Pfaff DW,McEwen BS

doi

10.1037//0735-7044.105.3.487

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

487-92

issue

3

eissn

0735-7044

issn

1939-0084

journal_volume

105

pub_type

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