Effect of BIM-18216, a novel cholecystokinin receptor antagonist, on food intake reduction induced by cholecystokinin.

Abstract:

:The role of cholecystokinin (CCK) in food intake was investigated in rats by using BIM-18216, a novel CCK receptor antagonist. In rats fed 6 hr/day, BIM-18216 antagonized the reduction of food intake induced by exogenous CCK octapeptide (CCK-8; 4 micrograms/kg) in a dose-dependent manner and had a maximum effect at 1 mg/kg. BIM-18216 did not antagonize the effect of bombesin on food intake and showed some degree of specificity. BIM-18216 was not able to prevent the effect of endogenous CCK at the beginning of the feeding period. These data demonstrate that BIM-18216 is a potent CCK-specific antagonist. These results also suggest that endogenous and exogenous CCK could act by different regulating pathways.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Laferrere B,Nguyen M,Bonhomme G,Legall A,Basdevant A,Guy-Grand B

doi

10.1037//0735-7044.105.5.707

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

707-11

issue

5

eissn

0735-7044

issn

1939-0084

journal_volume

105

pub_type

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