Novel objects in a holeboard probe the role of the locus coeruleus in curiosity: support for two modes of attention in the rat.

Abstract:

:Idazoxan, an alpha 2 adrenoceptor antagonist (2 mg/kg), enhanced novel object investigation in a holeboard in rats as previously reported (V. Devauges & S. J. Sara, 1990). Two weeks of 10 min/day in 37 degrees C water increased dopamine-beta-hydroxylase staining density in the locus coeruleus but did not enhance novel object investigation. In contrast to idazoxan, however, the warm water treatment increased rearing, center entries, and activity, a pattern previously described during tonic infusion of norepinephrine into the hippocampus. Correlations among dopamine-beta-hydroxylase measures and behavior reinforced these tonic norepinephrine/behavior associations. The behavioral effects across the idazoxan and warm water experiments support G. Aston-Jones et al.'s (1999) 2 modes of attention hypothesis for locus coeruleus function: Phasic locus coeruleus activity promotes focused attention; tonic locus coeruleus activity promotes scanning attention.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Mansour AA,Babstock DM,Penney JH,Martin GM,McLean JH,Harley CW

doi

10.1037/0735-7044.117.3.621

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

621-31

issue

3

eissn

0735-7044

issn

1939-0084

journal_volume

117

pub_type

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