Novel objects in a holeboard probe the role of the locus coeruleus in curiosity: support for two modes of attention in the rat.


:Idazoxan, an alpha 2 adrenoceptor antagonist (2 mg/kg), enhanced novel object investigation in a holeboard in rats as previously reported (V. Devauges & S. J. Sara, 1990). Two weeks of 10 min/day in 37 degrees C water increased dopamine-beta-hydroxylase staining density in the locus coeruleus but did not enhance novel object investigation. In contrast to idazoxan, however, the warm water treatment increased rearing, center entries, and activity, a pattern previously described during tonic infusion of norepinephrine into the hippocampus. Correlations among dopamine-beta-hydroxylase measures and behavior reinforced these tonic norepinephrine/behavior associations. The behavioral effects across the idazoxan and warm water experiments support G. Aston-Jones et al.'s (1999) 2 modes of attention hypothesis for locus coeruleus function: Phasic locus coeruleus activity promotes focused attention; tonic locus coeruleus activity promotes scanning attention.


Behav Neurosci


Behavioral neuroscience


Mansour AA,Babstock DM,Penney JH,Martin GM,McLean JH,Harley CW




Has Abstract


2003-06-01 00:00:00












  • Phantom auditory sensation in rats: an animal model for tinnitus.

    abstract::In order to measure tinnitus induced by sodium salicylate injections, 84 pigmented rats, distributed among 14 groups in five experiments, were used in a conditioned suppression paradigm. In Experiment 1, all groups were trained with a conditioned stimulus (CS) consisting of the offset of a continuous background noise....

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Jastreboff PJ,Brennan JF,Coleman JK,Sasaki CT

    更新日期:1988-12-01 00:00:00

  • Behavior of rat fetuses following chemical or tactile stimulation.

    abstract::The behavior of fetal rats was examined on Day 19 of gestation with procedures that enabled chemical stimulation and direct observation of fetuses. Rat fetuses are sensitive to both tactile stroking and intraoral infusion of chemical solutions, but the pattern and amount of activity depend upon the modality of stimula...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Smotherman WP,Robinson SR

    更新日期:1988-02-01 00:00:00

  • Effects of nicotine exposure and anxiety on motivation for reward and gambling-like cues under reward uncertainty.

    abstract::Reward uncertainty is a common characteristic of gambling and may powerfully enhance attraction to gambling-related cues, thus promoting maladaptive gambling behaviors in susceptible individuals. The co-occurrence of gambling disorder with tobacco use disorder (60.4%) suggests a common mechanism for their pathology, a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Russell TI,Robinson MJF

    更新日期:2019-08-01 00:00:00

  • Selective effects of triazolam on memory for emotional, relative to neutral, stimuli: differential effects on gist versus detail.

    abstract::Benzodiazepines are known to reduce learning and memory performance, presumably through their facilitation of GABAergic neurotransmission, but the effects of these drugs specifically on memory for emotional material has not been addressed in humans. The effects of a benzodiazepine (triazolam, 0.25 mg) on nonincidental...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Buchanan TW,Karafin MS,Adolphs R

    更新日期:2003-06-01 00:00:00

  • Delayed spontaneous alternation in intact and cerebellectomized control and lurcher mutant mice: differential role of cerebellar cortex and deep cerebellar nuclei.

    abstract::Lurcher mutant (+/Lc) mice exhibit a massive loss of neurons in the cerebellar cortex and in the inferior olivary nucleus while deep cerebellar nuclei are essentially intact. To discriminate the respective participation of the cerebellar cortex and deep structures in learning and memory, the authors subjected 3- to 6-...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Caston J,Vasseur F,Delhaye-Bouchaud N,Mariani J

    更新日期:1997-02-01 00:00:00

  • Corticotropin-releasing factor antagonist attenuates defensive-withdrawal behavior elicited by odors of stressed conspecifics.

    abstract::This study examined the hypothesis that defensive responsiveness induced by threatening stimuli of biological origin is mediated by the action of endogenous corticotropin-releasing factor (CRF). Rats were exposed for 15 min to a large open field containing a small chamber. Twenty-four hours later, rats received intrac...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Takahashi LK,Kalin NH,Baker EW

    更新日期:1990-04-01 00:00:00

  • Modulation of memory consolidation for olfactory learning by reversible inactivation of the basolateral amygdala.

    abstract::The role of the basolateral amygdala (BLA) in the consolidation of an association between an olfactory stimulus and footshock was investigated with a reversible lesion technique of post-training intra-BLA infusions of tetrodotoxin. Rats receiving tetrodotoxin infusions following paired odor-shock presentations spent m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Kilpatrick L,Cahill L

    更新日期:2003-02-01 00:00:00

  • Sustained attention in the mouse: a study of the relationship with the cerebellum.

    abstract::To explore the role of the cerebellum in sustained attention, the authors tested lurcher, wildtype, and lurcher chimeric mice with zero, normal, and variable numbers of Purkinje cells, respectively, in a previously validated task of sustained attention. Results indicate that lurcher mice had a deficit in performance l...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Martin LA,Goldowitz D,Mittleman G

    更新日期:2006-04-01 00:00:00

  • Developmental exposure to methimazole increases anxiety behavior in zebrafish.

    abstract::The role of thyroid hormones in vertebrate development has been well documented for several decades. As hypothyroidism during critical periods of development can cause defects to the development of every major organ system, including brain, eye, and general morphology, we hypothesized that hypothyroidism would affect ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Reider M,Connaughton VP

    更新日期:2015-10-01 00:00:00

  • Central administration of cocaine produces age-dependent effects on behavior in the fetal rat.

    abstract::Rat fetuses were exposed to cocaine, lidocaine, or saline on Gestational Day 20 or 21 to provide information about cocaine effects on behavior during prenatal development. Cocaine was administered into the cisterna magna of individual fetal subjects to restrict effects to the CNS. Behavioral effects of cocaine were co...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Simonik DK,Robinson SR,Smotherman WP

    更新日期:1994-12-01 00:00:00

  • The "proactive" model of learning: Integrative framework for model-free and model-based reinforcement learning utilizing the associative learning-based proactive brain concept.

    abstract::Reinforcement learning (RL) is a powerful concept underlying forms of associative learning governed by the use of a scalar reward signal, with learning taking place if expectations are violated. RL may be assessed using model-based and model-free approaches. Model-based reinforcement learning involves the amygdala, th...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Zsuga J,Biro K,Papp C,Tajti G,Gesztelyi R

    更新日期:2016-02-01 00:00:00

  • Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors.

    abstract::These experiments tested whether nucleus accumbens muscarinic or nicotinic acetylcholine receptor activation is required for rats to learn to lever press for sucrose. Muscarinic blockade with scopolamine (1.0 microg/side or 10.0 microg/side), but not nicotinic antagonism with mecamylamine (10.0 microg/side), inhibited...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Pratt WE,Kelley AE

    更新日期:2004-08-01 00:00:00

  • Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olfactory processing in schizophrenia.

    abstract::The catechol-O-methyltransferase (COMT) val158met polymorphism has received attention in schizophrenia due to its role in prefrontal dopamine catabolism. Given the rich dopaminergic innervations of the olfactory bulb and the influence of dopamine on the transmission of olfactory signals, the authors examined the influ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Kamath V,Moberg PJ,Gur RE,Doty RL,Turetsky BI

    更新日期:2012-02-01 00:00:00

  • Impairing forgetting by preventing new learning and memory.

    abstract::Two causes of forgetting have been promulgated: memory trace decay and retroactive interference. The authors show that forgetting is an active process requiring both new learning and memory. In the present (1)Lymnaea model system, prevention of new learning of a conflicting association, inhibition of memory consolidat...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Sangha S,Scheibenstock A,Martens K,Varshney N,Cooke R,Lukowiak K

    更新日期:2005-06-01 00:00:00

  • Re-examination of amphetamine-induced conditioned suppression of tastant intake in rats: the task-dependent drug effects hypothesis.

    abstract::This study reexamined Grigson's reward comparison hypothesis (1997), which claimed to have resolved the paradox of addictive, rewarding drugs manifesting an aversive effect in the conditioned taste aversion (CTA) paradigm. Here, the authors compared the conditioned suppression effects of lithium chloride (LiCl) and am...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Huang AC,Hsiao S

    更新日期:2008-12-01 00:00:00

  • What does a pigeon (Columba livia) brain look like during homing? selective examination of ZENK expression.

    abstract::Lesion studies have shown that the avian hippocampus plays a crucial role in homing pigeon (Columba livia) navigation. Using the expression of the immediate early gene protein ZENK in intact pigeons, the authors found regional variation in hippocampal activation as a consequence of homing and, necessarily, the behavio...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Shimizu T,Bowers AN,Budzynski CA,Kahn MC,Bingman VP

    更新日期:2004-08-01 00:00:00

  • Conditioned brain-stimulation reward attenuates the acoustic startle reflex in rats.

    abstract::The acoustic startle reflex (ASR) in rats is attenuated by a light paired with food or, in humans, by "pleasant" pictures. Rats were trained to barpress for lateral hypothalamus (LH) stimulation. ASR amplitudes were then measured at 4 intensities, with or without a light. Control rats that did not receive brain-stimul...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Steidl S,Li L,Yeomans JS

    更新日期:2001-06-01 00:00:00

  • Identification of quantitative trait loci involved in contextual and auditory-cued fear conditioning in BXD recombinant inbred strains.

    abstract::Fear conditioning shows associations formed between contextual or auditory stimuli with an unconditioned stimulus. Inbred mouse strains differ in their ability to demonstrate fear conditioning, suggesting at least a partial genetic influence. The present study identified the possible chromosomal loci regulating fear c...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Owen EH,Christensen SC,Paylor R,Wehner JM

    更新日期:1997-04-01 00:00:00

  • Memory of social defeat is facilitated by cAMP response element-binding protein overexpression in the amygdala.

    abstract::The cAMP-responsive element binding protein (CREB) is a transcription factor that regulates synaptic plasticity and memory formation. Studies that have used conditioned fear models have established that CREB is important for the acquisition and consolidation of fear learning. The authors demonstrate that overexpressio...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Jasnow AM,Shi C,Israel JE,Davis M,Huhman KL

    更新日期:2005-08-01 00:00:00

  • Amygdala central nucleus lesions attenuate acoustic startle stimulus-evoked heart rate changes in rats.

    abstract::Amygdala central nucleus (CNA) lesions were used to test the hypothesis that stimulus-evoked heart rate changes can reflect the development of fear during acoustic startle testing. A 120-dB white noise startle stimulus produced freezing as well as phasic heart rate accelerations and decelerations, and an abrupt decrea...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Young BJ,Leaton RN

    更新日期:1996-04-01 00:00:00

  • Maternity: neural mechanisms, motivational processes, and physiological adaptations.

    abstract::This review focuses on research on both the neural substrate of maternal responsiveness and on the physiological, behavioral, and motivational adaptations to the maternal state. The female's response to her young is presented as a model motivational system and the mechanisms and neural circuitry through which the medi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,评审


    authors: Numan M,Woodside B

    更新日期:2010-12-01 00:00:00

  • Peptide effects on social behavior: effects of vasotocin and isotocin on social approach behavior in male goldfish (Carassius auratus).

    abstract::The authors measured the effects of centrally infused peptides on social approach behaviors in goldfish (Carassius auratus), a social teleost. Vasotocin (VT) inhibited approach responses toward the visual stimuli of conspecifics in the absence of aggressive or sexual olfactory contextual cues in males, and a V1 recept...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Thompson RR,Walton JC

    更新日期:2004-06-01 00:00:00

  • Sex differences in the relationship between activity and weight loss in the rat.

    abstract::Access to a running wheel combined with restricted feeding produced body weight loss at an equivalent rate in male and female litter-mate rats (Experiment 1). Thus, despite weighing less and running more, females were not more vulnerable to this procedure. When factors influencing weight loss were varied, no sex diffe...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Boakes RA,Mills KJ,Single JP

    更新日期:1999-10-01 00:00:00

  • Differential sensitivity to the wake-promoting actions of norepinephrine within the medial preoptic area and the substantia innominata.

    abstract::Mapping studies were conducted to delineate the site(s) of action for the arousal-enhancing actions of norepinephrine (NE) within the basal forebrain region encompassing the medial preoptic area (MPOA) and the substantia innominata (SI). Varying doses of NE, the beta-agonist, isoproterenol, or the alpha1-agonist, phen...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Berridge CW,O'Neill J

    更新日期:2001-02-01 00:00:00

  • Two nonassociative components of the proboscis extension reflex in the blow fly, Phormia regina, which may affect measures of conditioning and of the central excitatory state.

    abstract::With the use of controls not included in previous studies, evidence is presented for the existence of water-induced central excitatory state (w-CES) from analyses of pure-breeding high- and low-CES lines in the blow fly, Phormia regina. The CES lines differed in base-level responsiveness to distilled water (and to sal...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Tully T,Hirsch J

    更新日期:1983-02-01 00:00:00

  • Dissociable properties of memory systems: differences in the flexibility of declarative and nondeclarative knowledge.

    abstract::Amnesic patients (n = 8), who have severely impaired declarative memory, learned a probabilistic classification task at the same rate as normal subjects (n = 16) but subsequently were impaired on transfer tests that required flexible use of their task knowledge. A second group of controls (n = 20) rated the questions ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Reber PJ,Knowlton BJ,Squire LR

    更新日期:1996-10-01 00:00:00

  • Sensory gating impairments in heavy cannabis users are associated with altered neural oscillations.

    abstract::Central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in can...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Edwards CR,Skosnik PD,Steinmetz AB,O'Donnell BF,Hetrick WP

    更新日期:2009-08-01 00:00:00

  • Cynomolgus monkeys do not develop tolerance to opioids.

    abstract::In order to examine the development of tolerance to opioids, eight cynomolgus and two rhesus monkeys were trained to press a lever for food reinforcement and then were catheterized so that drugs could be infused. Three doses of hydromorphone and six different interdose intervals were studied. Hydromorphone infusions i...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Ternes JW,Ehrman R,O'Brien CP

    更新日期:1983-04-01 00:00:00

  • Behavioral spectral sensitivities of different retinal areas in pigeons.

    abstract::The spectral sensitivity of the red and the yellow retinal fields of head-fixed pigeons was separately measured for wavelengths between 340 and 640 nm by a behavioral perimetric technique. Within this spectral range the mean spectral sensitivity of both fields was found to be maximal at 584 nm and minimal at the lower...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Remy M,Emmerton J

    更新日期:1989-02-01 00:00:00

  • Does shape matter? Theoretical comment on Jones, Pearce, Davies, Good, and McGregor (2007).

    abstract::An influential view in the field of spatial cognition is that an obligatory geometric module constrains spatial learning and memory. In this issue, P. M. Jones, J. M. Pearce, V. J. Davies, M. A. Good, and A. McGregor (2007) showed that learning based on the geometry, or shape, of the environment requires the hippocamp...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章


    authors: Dudchenko PA

    更新日期:2007-12-01 00:00:00