Double dissociation of fornix and caudate nucleus lesions on acquisition of two water maze tasks: further evidence for multiple memory systems.

Abstract:

:The present study examined the effect of lesions of the caudate nucleus or fimbria-fornix on the acquisition of two water maze tasks. In both tasks, two rubber balls with different visual patterns were used as platforms (i.e., cues). The "correct" cue was attached to a submerged rectangular platform and could be mounted by an animal to escape the water. The "incorrect" cue was attached to a thin round pedestal and could not be mounted. In a spatial version of the task, the correct cue was located in the same quadrant of the maze on all trials, whereas the visual pattern on the cue was varied from trial to trial. Lesions of the fornix, but not the caudate nucleus, impaired acquisition of this spatial task in relation to control animals. In a simultaneous visual discrimination version of the task, the correct cue on all trials was one with a specific visual pattern, and the spatial location of the correct cue was varied from trial to trial. Lesions of the caudate nucleus, but not the fornix, impaired acquisition of this visual discrimination task in relation to control animals. The double dissociation observed supports the hypothesis that the hippocampus and caudate nucleus are parts of systems that differ in the type of memory they mediate.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Packard MG,McGaugh JL

doi

10.1037//0735-7044.106.3.439

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

439-46

issue

3

eissn

0735-7044

issn

1939-0084

journal_volume

106

pub_type

杂志文章
  • Place navigation in rats with unilateral tetrodotoxin inactivation of the dorsal hippocampus: place but not procedural learning can be lateralized to one hippocampus.

    abstract::Lateralization of the Morris water maze task was examined by injecting 5 ng of tetrodotoxin (TTX) into one dorsal hippocampus (HPC) of chronically cannulated rats (n = 20). The task, acquired (A) during unilateral HPC block, was retrieved (R) during TTX blockade of the ipsi- (I) or contralateral (C) HPC. Escape latenc...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.107.4.552

    authors: Fenton AA,Bures J

    更新日期:1993-08-01 00:00:00

  • Involvement of nitric oxide in sexual learning via action in the medial preoptic area: theoretical comment on Lagoda et al. (2004).

    abstract::Repeated exposure to female-related stimuli causes functional alterations in the neural circuitry mediating male rat sexual behavior. In a study published in the current issue of this journal, G. M. Lagoda, J. W. Muschamp, A. Vigdorchik, and E. M. Hull (2004) provide interesting new evidence as to the mechanisms respo...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章

    doi:10.1037/0735-7044.118.6.1473

    authors: Coolen LM

    更新日期:2004-12-01 00:00:00

  • The impact of napping on memory for future-relevant stimuli: Prioritization among multiple salience cues.

    abstract::Prior research has demonstrated that sleep enhances memory for future-relevant information, including memory for information that is salient due to emotion, reward, or knowledge of a later memory test. Although sleep has been shown to prioritize information with any of these characteristics, the present study investig...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000142

    authors: Bennion KA,Payne JD,Kensinger EA

    更新日期:2016-06-01 00:00:00

  • Behavioral thermoregulation, core temperature, and motor activity: simultaneous quantitative assessment in rats after dopamine and prostaglandin E1.

    abstract::These studies were designed to determine the dose-response autonomic and behavioral thermoregulatory effects and the motor effects of dopamine (DA) and prostaglandin E1 (PGE1) injected into the lateral cerebral ventricles of rats. These studies were made possible with a computer-controlled thermocline that permits fre...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.5.858

    authors: Marques PR,Spencer RL,Burks TF,McDougal JN

    更新日期:1984-10-01 00:00:00

  • Sexual experience modulates partner preference and mPOA nitric oxide synthase in female rats.

    abstract::Sexually experienced female rats return to the male more quickly after intromissions, exhibit shorter interintromission intervals, and spend more time with the male rat during a test of paced mating behavior in comparison to naïve rats. The present study tested whether these changes reflect heightened sexual motivatio...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000163

    authors: Meerts SH,Park JH,Sekhawat R

    更新日期:2016-10-01 00:00:00

  • Long-term memory facilitation in rats by posttraining epinephrine.

    abstract::Effects of posttraining epinephrine (EPI) on retention of a massed (1 session, 30 trials) 2-way active avoidance task in rats were studied. The rats received an injection (ip) of 0.05 mg/kg EPI, 0.01 mg/kg EPI, or distilled water immediately after the training session. EPI did not improve retention 24 hr after the tra...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.3.469

    authors: Costa-Miserachs D,Portell-Cortés I,Aldavert-Vera L,Torras-García M,Morgado-Bernal I

    更新日期:1994-06-01 00:00:00

  • Dopamine-stimulated sexual behavior is testosterone dependent in mice.

    abstract::Mice unable to synthesize dopamine (DA) in dopaminergic neurons were generated by gene-targeting techniques (Q.-Y. Zhou & R. D. Palmiter, 1995). These dopamine-deficient (DA-/-) mice required daily administration of 3,4-dihydroxyphenylalanine (L-DOPA) for survival beyond 2 to 3 weeks of age. This treatment stimulated ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.5.1229

    authors: Szczypka MS,Zhou QY,Palmiter RD

    更新日期:1998-10-01 00:00:00

  • Spatial judgment in Parkinson's disease: Contributions of attentional and executive dysfunction.

    abstract::Spatial judgment is impaired in Parkinson's disease (PD), with previous research suggesting that disruptions in attention and executive function are likely contributors. If judgment of center places demands on frontal systems, performance on tests of attention/executive function may correlate with extent of bias in PD...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000329

    authors: Salazar RD,Moon KLM,Neargarder S,Cronin-Golomb A

    更新日期:2019-08-01 00:00:00

  • A history of bingeing on fat enhances cocaine seeking and taking.

    abstract::Binge eating and substance dependence are disorders characterized by a loss of control over consummatory behaviors. Given the common characteristics of these two types of disorders, it is not surprising that the comorbidity between eating disorders and substance abuse disorders is high (20-40%; Conason et al., 2006). ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0025759

    authors: Puhl MD,Cason AM,Wojnicki FH,Corwin RL,Grigson PS

    更新日期:2011-12-01 00:00:00

  • Functional disconnection of a prefrontal cortical-dorsal striatal system disrupts choice reaction time performance: implications for attentional function.

    abstract::This series of experiments investigated the role of a prefrontal cortical-dorsal striatal circuit in attention, using a continuous performance task of sustained and spatially divided visual attention. A unilateral excitotoxic lesion of the medial prefrontal cortex and a contralateral lesion of the medial caudate-putam...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.115.4.812

    authors: Christakou A,Robbins TW,Everitt BJ

    更新日期:2001-08-01 00:00:00

  • Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors.

    abstract::These experiments tested whether nucleus accumbens muscarinic or nicotinic acetylcholine receptor activation is required for rats to learn to lever press for sucrose. Muscarinic blockade with scopolamine (1.0 microg/side or 10.0 microg/side), but not nicotinic antagonism with mecamylamine (10.0 microg/side), inhibited...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.4.730

    authors: Pratt WE,Kelley AE

    更新日期:2004-08-01 00:00:00

  • Anterograde amnesia induced by hyperthermia in rats.

    abstract::Anterograde amnesia (AA), forgetting of events that occur following a traumatic episode, has recently been demonstrated by using a mild decrease in temperature (hypothermia) as the amnestic agent. However, no data currently exist to indicate if an increase in body temperature (hyperthermia) might affect memory process...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.3.333

    authors: Ahlers ST,Riccio DC

    更新日期:1987-06-01 00:00:00

  • Receptor contributions to configural and elemental odor mixture perception.

    abstract::Odor mixture perception can be configural (the mixture is qualitatively different from the components) or elemental (the components are recognizable). Some have argued that configural properties are dependent on chemical similarity and possible overlap at the receptor level. The authors show that a binary mixture in w...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.117.5.1108

    authors: Kay LM,Lowry CA,Jacobs HA

    更新日期:2003-10-01 00:00:00

  • Enkephalin hydrolysis in plasma is highly correlated with escape performance in the rat.

    abstract::A very high correlation was found in rats between latency to escape on the first trial of an active avoidance task and the rate at which [leu]enkephalin is hydrolyzed in plasma. In addition, the rate of [leu]enkephalin hydrolysis is significantly altered following the first training trial. The results suggest that a r...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.102.3.404

    authors: Martinez JL Jr,Weinberger SB

    更新日期:1988-06-01 00:00:00

  • Local dopamine production in the dorsal striatum restores goal-directed behavior in dopamine-deficient mice.

    abstract::To determine whether dopamine signaling in the dorsal striatum is sufficient for performance of goal-directed behaviors, local dopamine production was restored in the dorsal striatum of dopamine-deficient (DD) mice through viral-mediated gene therapy. Virally rescued DD (vrDD) mice were tested for learning of an appet...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.1.000

    authors: Robinson S,Sotak BN,During MJ,Palmiter RD

    更新日期:2006-02-01 00:00:00

  • Modification of a weak learning experience by memory retrieval in the day-old chick.

    abstract::Activation of memory retrieval after weak learning (WL), during either the short- or intermediate-term stages of memory in day-old chickens, resulted in the strengthening of the memory to levels normally associated with strong learning. Administration of the calcium channel antagonist lanthanum chloride, the glutamate...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.114.4.713

    authors: Summers MJ,Crowe SF,Ng KT

    更新日期:2000-08-01 00:00:00

  • Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans.

    abstract::The effects of various doses (40 microg/kg/hr, 300 microg/kg/hr, 600 microg/kg/hr or placebo) of hydrocortisone on tasks assessing working and declarative memory function were measured in 4 groups of 10 young men. During the infusion, participants were given an item-recognition working memory task, a paired-associate ...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//0735-7044.113.3.420

    authors: Lupien SJ,Gillin CJ,Hauger RL

    更新日期:1999-06-01 00:00:00

  • Developmental exposure to methimazole increases anxiety behavior in zebrafish.

    abstract::The role of thyroid hormones in vertebrate development has been well documented for several decades. As hypothyroidism during critical periods of development can cause defects to the development of every major organ system, including brain, eye, and general morphology, we hypothesized that hypothyroidism would affect ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000087

    authors: Reider M,Connaughton VP

    更新日期:2015-10-01 00:00:00

  • Inhibitory effects of estrogen on stimulated salt appetite in rats.

    abstract::Adult male rats consumed 50-150% more 0.5 M NaCl solution than females did during a 7-hr drinking test when robust salt appetite was elicited by dietary sodium deprivation for 8 days, daily injections of deoxycorticosterone, or adrenalectomy followed by 2 days of sodium deprivation. In contrast, male rats drank much l...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Scheidler MG,Verbalis JG,Stricker EM

    更新日期:1994-02-01 00:00:00

  • Lack of task specificity and absence of posttraining effects of atropine on learning.

    abstract::Three experiments are reported whose purpose was to examine the effect of the cholinergic antagonist atropine on the acquisition of different learning tasks known to be sensitive or insensitive to impairment by hippocampal lesions; on the retention of performance acquired in the absence of the drug; and on memory cons...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.4.483

    authors: Hagan JJ,Tweedie F,Morris RG

    更新日期:1986-08-01 00:00:00

  • Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats.

    abstract::The striatum is implicated in response selection and performance, the dorsal striatum in sensorimotor control and habit learning, and the ventral striatum in motivation and rewarded behaviors. Ventral striatal lesions produce performance changes on food-reinforced, progressive-ratio (PR) schedules, but the effects of ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.113.4.718

    authors: Eagle DM,Humby T,Dunnett SB,Robbins TW

    更新日期:1999-08-01 00:00:00

  • Lesions of basolateral and central amygdala differentiate conditioned cue preference learning with and without unreinforced preexposure.

    abstract::In the separated arms conditioned cue preference (CCP) task rats are trained by confining them in one arm of an eight-arm radial maze with food and in another arm on the opposite side of the maze with no food on alternate days. After two such trials, rats prefer the food-paired arm when allowed to move freely between ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0021976

    authors: Naeem M,White NM

    更新日期:2011-02-01 00:00:00

  • Loudness scaling and masking in rats.

    abstract::Two groups of rats were trained on operant discriminations in which the discriminanda were two different sound pressure levels of a 4-kHz tone. The discriminanda were chosen so that the loudness difference between stimuli was equivalent for each group when calculated from a power function with an exponent of .35. Half...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.3.392

    authors: Raslear TG,Pierrel-Sorrentino R,Rudnick F

    更新日期:1983-06-01 00:00:00

  • Either main or accessory olfactory system signaling can mediate the rewarding effects of estrous female chemosignals in sexually naive male mice.

    abstract::A long-held view has been that interest of male mice in female body odors reflects an activation of reward circuits in the male brain following their detection by the vomeronasal organ (VNO) and processing via the accessory olfactory system. We found that adult, sexually naive male mice acquired a conditioned place pr...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0033945

    authors: Korzan WJ,Freamat M,Johnson AG,Cherry JA,Baum MJ

    更新日期:2013-10-01 00:00:00

  • Amygdala inactivation blocks expression of conditioned memory modulation and the promotion of avoidance and freezing.

    abstract::Rats were exposed to shock-paired cues immediately after training on an appetitive preference task. Elevated levels of freezing in and active avoidance of the shock-paired compartment were observed, and memory for the appetitive task was improved when tested 24 hr later. Intra-amygdala muscimol injected before the pos...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.1.24

    authors: Holahan MR,White NM

    更新日期:2004-02-01 00:00:00

  • Interactions between cognition and circadian rhythms: attentional demands modify circadian entrainment.

    abstract::Animals and humans are able to predict and synchronize their daily activity to signals present in their environments. Environmental cues are most often associated with signaling the beginning or the end of a daily activity cycle, but they can also be used to time the presentation or availability of scarce resources. I...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0017128

    authors: Gritton HJ,Sutton BC,Martinez V,Sarter M,Lee TM

    更新日期:2009-10-01 00:00:00

  • Neuron production, neuron number, and structure size are seasonally stable in the hippocampus of the food-storing black-capped chickadee (Poecile atricapillus).

    abstract::Neuronal recruitment in the black-capped chickadee (Poecile atricapillus) hippocampus occurs at a higher rate in the fall than at other times of the year. As a means of determining whether this increase in recruitment results from greater neuron production, chickadees were caught in the wild between October and March ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.2.345

    authors: Hoshooley JS,Sherry DF

    更新日期:2004-04-01 00:00:00

  • Central nervous system regulation of finicky feeding by the blowfly.

    abstract::Finicky feeding refers to an animal's tendency to become more particular in accepting and choosing food as satiation is approached. We tested the hypothesis that finickiness in the blowfly is related to the balance between internal inhibition, generated by a full crop, and external sensory information, generated by or...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.4.541

    authors: Moss CF,Dethier VG

    更新日期:1983-08-01 00:00:00

  • Fovea and foveation in Parkinson's disease.

    abstract::Nondemented Parkinson's disease (PD) patients report problems on nonmotor tasks that depend on visual or visuospatial abilities. In PD, foveal vision is impaired. Experimental studies in humans and monkeys established that foveal processing and visuospatial attention may be linked through saccadic eye movements. Sacca...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.1037/a0031225

    authors: Bodis-Wollner I,Glazman S,Yerram S

    更新日期:2013-04-01 00:00:00

  • Thyroxine treatment reduces the anorectic effect of estradiol in rats.

    abstract::In order to examine a possible interaction between thyroxine and estradiol in the control of feeding, 14 ovariectomized adult female rats were given daily injections of 9.8 micrograms/100 g of body weight of 1-thyroxine (T). Another 14 rats received 0.15 ml of saline (S) subcutaneously each day, and food intake was me...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.2.284

    authors: Young JK

    更新日期:1986-04-01 00:00:00