Abstract:
:Mice unable to synthesize dopamine (DA) in dopaminergic neurons were generated by gene-targeting techniques (Q.-Y. Zhou & R. D. Palmiter, 1995). These dopamine-deficient (DA-/-) mice required daily administration of 3,4-dihydroxyphenylalanine (L-DOPA) for survival beyond 2 to 3 weeks of age. This treatment stimulated mounting and aggressive behavior of adult DA-/- males toward both male and female mice. Both a nonspecific DA agonist (apomorphine) and a specific D1 agonist (SKF81297) stimulated aggression and mounting behavior; however, a D2 agonist (quinpirole) was less effective. Castration of male DA-/- mice demonstrated that these L-DOPA-stimulated behaviors depend on testosterone. In addition, replacement of testosterone to castrated males showed that the testosterone-responsive pathways of DA-/- males were more sensitive to testosterone than wild-type mice.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Szczypka MS,Zhou QY,Palmiter RDdoi
10.1037//0735-7044.112.5.1229subject
Has Abstractpub_date
1998-10-01 00:00:00pages
1229-35issue
5eissn
0735-7044issn
1939-0084journal_volume
112pub_type
杂志文章abstract::In humans and some nonhuman vertebrates, a sound containing brief silent gaps can be rendered perceptually continuous by inserting noise into the gaps. This so-called "continuity illusion" arises from a phenomenon known as "auditory induction" and results in the perception of complete auditory objects despite fragment...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000115
更新日期:2016-02-01 00:00:00
abstract::Chronic exposure to light at night (LAN) is a circadian disruptor and may be linked to various health risks, including mood disorders. We recently demonstrated that chronic exposure to dim (5 lux) LAN provokes depressive-like behaviors and reduced hippocampal CA1 dendritic spine density in female hamsters. Whether thi...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0029699
更新日期:2012-10-01 00:00:00
abstract::Pinealectomized lizards (Podarcis sicula) whose locomotor rhythms were recorded in constant temperature (29 degrees C) and darkness were subdivided into 2 groups of hosts: Each belonging to the 1st group (experimentals) received from a donor a pineal gland, and each belonging to the 2nd one (controls) received a piece...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.111.5.1123
更新日期:1997-10-01 00:00:00
abstract::Several experiments were conducted to examine the effects of intracranial injection of opioid peptides and antagonists on learning and memory in the chick. Pretraining injection of [leu5]enkephalin and the selective delta receptor agonist [D-Pen2,L-Pen5]enkephalin (DPLPE) into the intermediate medial hyperstriatum ven...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.2.429
更新日期:1989-04-01 00:00:00
abstract::Highly developed odor learning was shown in the terrestrial slug Limax maximus. In addition, several key cellular elements of the neural network that controls ingestive feeding have been identified. The results of 3 experiments demonstrate an interaction between odor input and ingestive feeding in that olfactory stimu...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.106.3.563
更新日期:1992-06-01 00:00:00
abstract::The effects of peripherally administered leucine-enkephalin on the acquisition and retention of active avoidance behavior was studied in mice. Mice received 4 training trials on Day 1, 24 test trials on Day 2, and 10 test trials on Day 5. Leucine-enkephalin impaired the aquisition of avoidance behavior when administer...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.100.2.185
更新日期:1986-04-01 00:00:00
abstract::Rats had repeated treatments with cocaine associated with a specific context (paired group). Evidence for classical conditioning of cocaine's motor-activity effects and context-specific behavioral sensitization to cocaine was obtained, relative to vehicle-treated (control) and pseudoconditioned (unpaired) groups. Only...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.6.1388
更新日期:1996-12-01 00:00:00
abstract::Rhesus monkeys were trained to learn a large series of visuomotor conditional associations, each involving the arbitrary coupling of a visual stimulus with 1 of 3 potentially correct forelimb movements. The monkeys then received bilateral aspiration lesions of either the amygdala plus subjacent cortex or the hippocamp...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.6.1261
更新日期:1996-12-01 00:00:00
abstract::Amphetamine and stress can sensitize mesolimbic dopamine-related systems. In Pavlovian autoshaping, repeated exposure to uncertainty of reward prediction can enhance motivated sign-tracking or attraction to a discrete reward-predicting cue (lever-conditioned stimulus; CS+), as well as produce cross-sensitization to am...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000064
更新日期:2015-08-01 00:00:00
abstract::A high level of dopaminergic activation such as that produced by a high dose of amphetamine suppresses eating, whereas a low level such as that produced by a low dose can have the opposite effect. Like a high dose of amphetamine, a high level of wheel running also suppresses eating. It was hypothesized that this suppr...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.6.1492
更新日期:1996-12-01 00:00:00
abstract::This study was prompted by reports of functionally normal humans with micrencephaly or cortical hypoplasia. Methylazoxymethanol acetate (MAM) treatment, which induces micrencephaly in rats, was administered by injection (20 mg/kg) on gestational day 14. Prior to weaning and into adulthood, offspring were assessed on m...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.107.6.1067
更新日期:1993-12-01 00:00:00
abstract::An influential view in the field of spatial cognition is that an obligatory geometric module constrains spatial learning and memory. In this issue, P. M. Jones, J. M. Pearce, V. J. Davies, M. A. Good, and A. McGregor (2007) showed that learning based on the geometry, or shape, of the environment requires the hippocamp...
journal_title:Behavioral neuroscience
pub_type: 评论,杂志文章
doi:10.1037/0735-7044.121.6.1442
更新日期:2007-12-01 00:00:00
abstract::In 2 experiments, the development of adjuvant arthritis (an experimental autoimmune disease) was inhibited by exposing rats to a flavored solution that had previously been paired with injections of cyclosporine (an immunodepressive drug) compared with rats with the same history but exposed to a flavored solution that ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.104.5.716
更新日期:1990-10-01 00:00:00
abstract::Two different strains of mice, C57BL/6J and BALB/c, with hippocampal, cortical, or sham lesions, underwent contextual fear conditioning. In both strains, contextual fear, as measured by the freezing response, was significantly impaired in hippocampus-lesioned animals compared with sham control animals. Fear conditioni...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.5.1177
更新日期:1996-10-01 00:00:00
abstract::Six females rats were trained to lever press under a free operant shock-postponement schedule. Each subject had a yoked control which received shock whenever the subject did. The shock-postponement interval (R-S) was varied from 5, 10, 20, 40, to 80 s over blocks of sessions. Corticosteroid levels were taken prior to ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.98.6.1094
更新日期:1984-12-01 00:00:00
abstract::Amnesic patients (n = 8), who have severely impaired declarative memory, learned a probabilistic classification task at the same rate as normal subjects (n = 16) but subsequently were impaired on transfer tests that required flexible use of their task knowledge. A second group of controls (n = 20) rated the questions ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.5.861
更新日期:1996-10-01 00:00:00
abstract::Cutaneous desensitization of the upper, rostral snout by bilateral section of the infraorbital nerves in lactating Norway rat dams markedly, but transiently, disrupted retrieval and licking of pups, nursing behavior, and fighting with a strange male intruder. Removal of the mystacial vibrissae, which provide major inp...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.105.6.984
更新日期:1991-12-01 00:00:00
abstract::This study examined the hypothesis that defensive responsiveness induced by threatening stimuli of biological origin is mediated by the action of endogenous corticotropin-releasing factor (CRF). Rats were exposed for 15 min to a large open field containing a small chamber. Twenty-four hours later, rats received intrac...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.104.2.386
更新日期:1990-04-01 00:00:00
abstract::Neural correlates of associative memory and "forgetting" were observed 1, 6, and 14 days after acquisition of a conditioned response (CR) in the marine snail Hermissenda. Behavioral expression of a light-rotation association, as indexed by contraction of the animal's foot in response to light, dissipated throughout th...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.106.6.954
更新日期:1992-12-01 00:00:00
abstract::Conditioned inhibition (CI) of the rat eyeblink response and the neuronal correlates of CI in the cerebellar interpositus nucleus were examined in the present study. In Experiment 1, CI was established with a novel, 3-group design. In Experiment 2, neuronal activity in the anterior interpositus nucleus was recorded du...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract::The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with th...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.121.5.877
更新日期:2007-10-01 00:00:00
abstract::Prader-Willi syndrome (PWS) is caused by lack of paternally derived gene expression from the imprinted gene cluster on human chromosome 15q11-q13. PWS is characterized by severe hypotonia, a failure to thrive in infancy and, on emerging from infancy, evidence of learning disabilities and overeating behavior due to an ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0028155
更新日期:2012-06-01 00:00:00
abstract::The behavior of fetal rats was examined on Day 19 of gestation with procedures that enabled chemical stimulation and direct observation of fetuses. Rat fetuses are sensitive to both tactile stroking and intraoral infusion of chemical solutions, but the pattern and amount of activity depend upon the modality of stimula...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.102.1.24
更新日期:1988-02-01 00:00:00
abstract::In humans, congenital deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) results in a disorder known as the Lesch-Nyhan syndrome. Patients with this disorder exhibit a prominent neurobehavioral phenotype that results in part from dysfunction of catecholaminergic systems in the striatum. HPR...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.105.6.1004
更新日期:1991-12-01 00:00:00
abstract::To determine whether dopamine signaling in the dorsal striatum is sufficient for performance of goal-directed behaviors, local dopamine production was restored in the dorsal striatum of dopamine-deficient (DD) mice through viral-mediated gene therapy. Virally rescued DD (vrDD) mice were tested for learning of an appet...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.120.1.000
更新日期:2006-02-01 00:00:00
abstract::Previous research has indicated that rearing in an enriched environment may promote self-control in an impulsive choice task. To further assess the effects of rearing environment on impulsivity, 2 experiments examined locomotor activity, impulsive action, impulsive choice, and different aspects of reward sensitivity a...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0034124
更新日期:2013-10-01 00:00:00
abstract::The effects of neurotoxic lesions of the amygdala central nucleus (CN) on changes in the associability of a conditioned stimulus (CS) in appetitive Pavlovian conditioning were examined in 2 experiments with rats. In Experiment 1, CN lesions had no effect on the reduction in the associability of a CS produced by preexp...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.107.2.246
更新日期:1993-04-01 00:00:00
abstract::Past work has demonstrated robust brain changes in cholecystokinin (CCK-8) following social defeat. Here the authors analyzed brain regional, CCK-8, substance P, corticotropin releasing factor (CRF), and neuropeptide Y levels in adult male Long-Evans rats defeated in a resident-intruder social aggression paradigm, as ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.121.6.1364
更新日期:2007-12-01 00:00:00
abstract::The sensitivity of several inbred strains of mice was assessed for ethanol's effects on activity, body temperature, ataxia, balance, and the righting reflex. Genotypic correlations among the mean responses for the strains were estimated as indexes of pleiotropic influences of genes on drug responses. Three major group...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.97.2.280
更新日期:1983-04-01 00:00:00
abstract::A modified learned food aversion paradigm simulated the prolonged food and illness exposure likely to characterize nutrient deficiencies or tumor growth. In this paradigm, a continuously available food was associated with a slow, continuous infusion of LiCl provided by osmotic minipump. Significant aversions were acqu...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.97.2.290
更新日期:1983-04-01 00:00:00