Dopamine-stimulated sexual behavior is testosterone dependent in mice.

Abstract:

:Mice unable to synthesize dopamine (DA) in dopaminergic neurons were generated by gene-targeting techniques (Q.-Y. Zhou & R. D. Palmiter, 1995). These dopamine-deficient (DA-/-) mice required daily administration of 3,4-dihydroxyphenylalanine (L-DOPA) for survival beyond 2 to 3 weeks of age. This treatment stimulated mounting and aggressive behavior of adult DA-/- males toward both male and female mice. Both a nonspecific DA agonist (apomorphine) and a specific D1 agonist (SKF81297) stimulated aggression and mounting behavior; however, a D2 agonist (quinpirole) was less effective. Castration of male DA-/- mice demonstrated that these L-DOPA-stimulated behaviors depend on testosterone. In addition, replacement of testosterone to castrated males showed that the testosterone-responsive pathways of DA-/- males were more sensitive to testosterone than wild-type mice.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Szczypka MS,Zhou QY,Palmiter RD

doi

10.1037//0735-7044.112.5.1229

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

1229-35

issue

5

eissn

0735-7044

issn

1939-0084

journal_volume

112

pub_type

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