Abstract:
:Two different strains of mice, C57BL/6J and BALB/c, with hippocampal, cortical, or sham lesions, underwent contextual fear conditioning. In both strains, contextual fear, as measured by the freezing response, was significantly impaired in hippocampus-lesioned animals compared with sham control animals. Fear conditioning was not affected in the cortical-lesioned group. Moreover, there was a strain difference in fear conditioning: The C57BL/6J mice exhibited freezing more frequently than the BALB/c mice. Consistent with previous hippocampal lesion studies in rats, these results indicate that contextual fear conditioning in mice also requires the intact hippocampus. This study provides a basis for evaluating hippocampal synaptic mechanisms in relation to contextual fear conditioning in widely available gene knockout or transgenic mice.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Chen C,Kim JJ,Thompson RF,Tonegawa Sdoi
10.1037//0735-7044.110.5.1177subject
Has Abstractpub_date
1996-10-01 00:00:00pages
1177-80issue
5eissn
0735-7044issn
1939-0084journal_volume
110pub_type
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journal_title:Behavioral neuroscience
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journal_title:Behavioral neuroscience
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pub_type: 杂志文章
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journal_title:Behavioral neuroscience
pub_type: 杂志文章,评审
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更新日期:1985-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-10-01 00:00:00
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更新日期:2006-04-01 00:00:00
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更新日期:1998-12-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-08-01 00:00:00
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1987-06-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.117.6.1318
更新日期:2003-12-01 00:00:00
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doi:
更新日期:2000-02-01 00:00:00
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更新日期:1991-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-06-01 00:00:00
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journal_title:Behavioral neuroscience
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更新日期:2012-08-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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更新日期:1994-10-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章
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