Hippocampal lesions impair contextual fear conditioning in two strains of mice.

Abstract:

:Two different strains of mice, C57BL/6J and BALB/c, with hippocampal, cortical, or sham lesions, underwent contextual fear conditioning. In both strains, contextual fear, as measured by the freezing response, was significantly impaired in hippocampus-lesioned animals compared with sham control animals. Fear conditioning was not affected in the cortical-lesioned group. Moreover, there was a strain difference in fear conditioning: The C57BL/6J mice exhibited freezing more frequently than the BALB/c mice. Consistent with previous hippocampal lesion studies in rats, these results indicate that contextual fear conditioning in mice also requires the intact hippocampus. This study provides a basis for evaluating hippocampal synaptic mechanisms in relation to contextual fear conditioning in widely available gene knockout or transgenic mice.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Chen C,Kim JJ,Thompson RF,Tonegawa S

doi

10.1037//0735-7044.110.5.1177

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

1177-80

issue

5

eissn

0735-7044

issn

1939-0084

journal_volume

110

pub_type

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