Abstract:
:The amygdala is an integrator of affective processing, and a key component of a network regulating social behavior. While decades of lesion studies in nonhuman primates have shown alterations in social interactions after amygdala damage, acute manipulations of the amygdala in primates have been underexplored. We recently reported (Wellman, Forcelli, Aguilar, & Malkova, 2016) that acute pharmacological inhibition of the basolateral complex of the amygdala (BLA) or the central nucleus of the amygdala increased affiliative social interactions in experimental dyads of macaques; this was achieved through microinjection of a GABA-A receptor agonist. Prior studies in rodents have shown similar effects achieved by blocking NMDA receptors or AMPA receptors within the BLA. Here, we sought to determine the role of these receptor systems in the primate BLA in the context of social behavior. In familiar dyads, we microinjected the NMDA receptor antagonist 2-amino-7-phosphonoheptanoic acid (AP7) or the AMPA receptor antagonist 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide (NBQX) and observed behaviors and social interactions in the immediate postinjection period. In striking contrast with our prior report using GABA agonists, and in contrast with prior reports in rodents using glutamate antagonists, we found that neither NMDA nor AMPA blockade increase social interaction. Both treatments, however, were associated with decreases in locomotion and manipulation and increases in passive behavior. These data suggest that local blockade of glutamatergic neurotransmission in BLA is not the functional equivalent of local activation of GABAergic signaling, and raise interesting questions regarding the functional microcircuitry of the nonhuman primate amygdala in the context of social behavior. (PsycINFO Database Record
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Forcelli PA,Wellman LL,Malkova Ldoi
10.1037/bne0000187subject
Has Abstractpub_date
2017-04-01 00:00:00pages
192-200issue
2eissn
0735-7044issn
1939-0084pii
2017-07858-001journal_volume
131pub_type
杂志文章abstract::Classical conditioning of the rabbit eyeblink response was used to study the effects of cerebellar lesions on performance in animals trained with low-intensity unconditioned stimuli (US). Animals were trained with 1 of 2 low-intensity corneal-airpuff USs paired with a tone-conditioned stimulus. This study confirms ear...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.107.3.530
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
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pub_type: 杂志文章
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doi:
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journal_title:Behavioral neuroscience
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