Hippocampal theta-band activity and trace eyeblink conditioning in rabbits.

Abstract:

:The authors examined the relationship between hippocampal theta activity and trace eyeblink conditioning. Hippocampal electrophysiological local field potentials were recorded before, during, and after conditioning or explicitly unpaired training sessions in adult male New Zealand White rabbits. As expected, a high relative power of theta activity (theta ratio) in the hippocampus predicted faster acquisition of the conditioned response during trace conditioning but, contrary to previous results obtained using the delay paradigm, only in the initial stage of learning. The presentation of the conditioned stimulus overall elicited an increase in the hippocampal theta ratio. The theta ratio decreased in the unpaired group as a function of training, remained high throughout conditioning in the fast learners, and rapidly increased in the slow learners initially showing a low theta ratio. Our results indicate a reciprocal connection between the hippocampal oscillatory activity and associative learning. The hippocampal theta ratio seems to reflect changes and differences in the subjects' alertness and responsiveness to external stimuli, which affect the rate of learning and are, in turn, affected by both conditioning and unpaired training.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Nokia MS,Penttonen M,Korhonen T,Wikgren J

doi

10.1037/a0015334

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

631-40

issue

3

eissn

0735-7044

issn

1939-0084

pii

2009-07961-018

journal_volume

123

pub_type

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