Abstract:
:Previous results from our laboratory have demonstrated that 3-day-old rats given dopamine (DA)-depleting brain lesions are spared the severe behavioral dysfunctions seen after comparable brain damage in adults. This behavioral sparing is accompanied by a sprouting of serotonin (5-HT)-containing neurons in the striatum. The present results extend these observations by demonstrating that rats given the brain lesions as 15- or 27-day-olds continue to suckle, wean, and grow into adulthood without exhibiting any obvious behavioral dysfunctions, yet striatal 5-HT levels do not increase. Moreover, combined destruction of DA- and 5-HT-containing neurons in 3-day-old rat pups also produced no obvious behavioral dysfunctions. These and other results indicate that increases in striatal 5-HT are not necessary for the behavioral sparing observed after DA-depleting brain lesions in neonatal rats.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Bruno JP,Jackson D,Zigmond MJ,Stricker EMdoi
10.1037//0735-7044.101.6.806subject
Has Abstractpub_date
1987-12-01 00:00:00pages
806-11issue
6eissn
0735-7044issn
1939-0084journal_volume
101pub_type
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