Abstract:
:In 3 experiments, the authors examined the role of adenosine regulation in escape deficits produced by earlier exposure to inescapable shock in rats (learned helplessness). Adenosine analogs injected before escape testing mimicked the effect of earlier inescapable shock, with the magnitude of the deficit varying with dose and drug specificity for A2 adenosine receptors. Agonist-induced and stress-induced escape deficits were eliminated by pretest treatment with the centrally acting adenosine receptor antagonist theophylline but not the peripheral antagonist 8-[p-sulfophenyl]-theophylline. Finally, preexposure to an ineffective number of inescapable shocks interacted in synergy with an ineffective pretest injection of adenosine agonist to maximize deficits in escape performance. These data implicate energy regulation and a central compensatory action by adenosine in the aspects of helplessness related to conservation-withdrawal.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Minor TR,Winslow JL,Chang WCdoi
10.1037//0735-7044.108.2.265subject
Has Abstractpub_date
1994-04-01 00:00:00pages
265-76issue
2eissn
0735-7044issn
1939-0084journal_volume
108pub_type
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