Abstract:
:Biological markers for acquisition and extinction of fear conditioning were studied in 40 individuals selected for displaying either good or poor acquisition of fear conditioning. as estimated by the skin conductance response. Participants with a short serotonin transporter (5-HTT) promoter allele or low monoamine oxidase activity in platelets (trbc-MAO) displayed better acquisition than those with only long alleles or high trbc-MAO, whereas participants with a long dopamine D4 receptor (D4DR) exon III allele showed delayed extinction compared with those with only short alleles. The findings, that D4DR exon III and 5-HTT promoter genotypes and trbc-MAO activity are related to human fear conditioning, a basic form of associative learning, are consistent with animal studies suggesting a genetic contribution to fear conditioning. The authors suggest that in humans these genetic mechanisms are partly dopaminergic and serotonergic in origin.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Garpenstrand H,Annas P,Ekblom J,Oreland L,Fredrikson Msubject
Has Abstractpub_date
2001-04-01 00:00:00pages
358-64issue
2eissn
0735-7044issn
1939-0084journal_volume
115pub_type
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