Cognitive impairment in rats fed high-fat diets: a specific effect of saturated fatty-acid intake.

Abstract:

:One-month-old rats were fed 1 of 4 high-fat diets (20% fat) or chow (4.5% fat) for 3 months. Dietary saturated (SFA), monounsaturated (MUFA), or polyunsaturated (PUFA) fatty acids varied such that their independent effects on cognitive performance could be tested. Rats were tested on a variable-interval delayed-alternation task. Impairment in both the ability to learn the basic alternation rule and remembering trial-specific information over time was observed in rats fed the experimental diets relative to those fed chow. The degree of impairment was highly associated with the level of SFAs fed and independent of the MUFAs or PUFAs. Dietary fat altered brain phosphatidylcholine fatty-acid profile, but the membrane changes did not correlate with cognitive impairment. The results demonstrate that cognitive impairment is directly associated with SFA intake but suggest that the mechanism is independent of bulk brain membrane compositional changes.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Greenwood CE,Winocur G

doi

10.1037//0735-7044.110.3.451

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

451-9

issue

3

eissn

0735-7044

issn

1939-0084

journal_volume

110

pub_type

杂志文章
  • Modification of the acoustic startle response in hearing-impaired C57BL/6J mice: prepulse augmentation and prolongation of prepulse inhibition.

    abstract::Modification of acoustic startle amplitude by a 10-ms tone prepulse (S1) was evaluated as a function of the interstimulus interval (ISI) between the onset of S1 and the onset of the startle-evoking stimulus (S2). Subjects were normal-hearing 1-month-old C57BL/6J (C57) mice and CBA/CaJ mice and 5-month-old C57 mice wit...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.3.396

    authors: Willott JF,Carlson S

    更新日期:1995-06-01 00:00:00

  • Differential effects of neurokinin-1 receptor activation in subregions of the periaqueductal gray matter on conditional and unconditional fear behaviors in rats.

    abstract::Central neurokinin-1 (NK-1) receptors are thought to modulate aversion, whereas the periaqueductal gray matter (PAG) is a common pathway for the integration of fear behaviors. The authors determined whether injection of an NK-1 agonist (GR73632) into subregions of the PAG would alter fear-related behaviors. Behavioral...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.5.1125

    authors: Mongeau R,De Oca BM,Fanselow MS,Marsden CA

    更新日期:1998-10-01 00:00:00

  • Involvement of nitric oxide in sexual learning via action in the medial preoptic area: theoretical comment on Lagoda et al. (2004).

    abstract::Repeated exposure to female-related stimuli causes functional alterations in the neural circuitry mediating male rat sexual behavior. In a study published in the current issue of this journal, G. M. Lagoda, J. W. Muschamp, A. Vigdorchik, and E. M. Hull (2004) provide interesting new evidence as to the mechanisms respo...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章

    doi:10.1037/0735-7044.118.6.1473

    authors: Coolen LM

    更新日期:2004-12-01 00:00:00

  • Implications of temporal variation in maternal care for the prediction of neurobiological and behavioral outcomes in offspring.

    abstract::Previous studies in Long-Evans rats demonstrated a significant relationship between variation in pup licking/grooming and arched-back nursing (LG-ABN) and offspring development. However, maternal care is dynamic and exhibits significant temporal variation. In the current study, we assessed temporal variation in LG and...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0031219

    authors: Jensen Peña C,Champagne FA

    更新日期:2013-02-01 00:00:00

  • Morphine influences on classical aversive conditioned heart rate in rats.

    abstract::The present series of three experiments was concerned with the effects of morphine and the morphine antagonist naloxone on the development of a classical aversive heart rate (HR) conditioned response (CR) to a tone conditioned stimulus (CS) paired with an electric shock unconditioned stimulus (US). In the first study,...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.102.2.244

    authors: Mahalik T,Fitzgerald RD

    更新日期:1988-04-01 00:00:00

  • Configurational and nonconfigurational interactions between odorants in binary mixtures.

    abstract::Studies on odor mixture perception suggest that although odor components can often be identified in mixtures, mixtures can also give rise to novel perceptual qualities that are not present in the components. Using an olfactory habituation task, the authors evaluated how the perceptual similarity between components in ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.117.2.236

    authors: Wiltrout C,Dogra S,Linster C

    更新日期:2003-04-01 00:00:00

  • The hippocampal memory indexing theory.

    abstract::The hippocampal formation (comprising the hippocampus proper, the dentate gyrus, and the subiculum) has been repeatedly implicated in information storage models of the mammalian brain. The precise nature of the hippocampal role in the storage of information has, however, remained elusive. Here it is proposed that the ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.2.147

    authors: Teyler TJ,DiScenna P

    更新日期:1986-04-01 00:00:00

  • Response characteristics of neurons in the medial component of the medial geniculate nucleus during Pavlovian differential fear conditioning in rabbits.

    abstract::Recent evidence suggests that the amygdaloid central nucleus (ACE) may contribute significantly to Pavlovian fear-conditioned bradycardic responses during the presentation of conditioned emotional stimuli. Because the medial component of the medial geniculate nucleus (MGm) is a major source of input to the region of t...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.6.1276

    authors: Supple WF Jr,Kapp BS

    更新日期:1989-12-01 00:00:00

  • Transient inactivation of the thalamic nucleus reuniens and rhomboid nucleus produces deficits of a working-memory dependent tactile-visual conditional discrimination task.

    abstract::Working memory depends on communication between the hippocampus and the prefrontal cortex (PFC); however, the neural circuitry that mediates interactions between these brain areas has not been well characterized. Two candidate structures are the thalamic reuniens (RE) and rhomboid (Rh) nuclei, which are reciprocally c...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0034653

    authors: Hallock HL,Wang A,Shaw CL,Griffin AL

    更新日期:2013-12-01 00:00:00

  • Footshock-induced sensitization of electrically elicited startle reflexes.

    abstract::The acoustic startle reflex can be facilitated by the presentation of a train of footshocks presented in rapid succession (footshock sensitization). Acoustic startle is a short-latency reflex mediated by a neural circuit consisting of the ventral cochlear nucleus (VCN), ventral nucleus of the lateral lemniscus (VLL), ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.3.504

    authors: Boulis NM,Davis M

    更新日期:1989-06-01 00:00:00

  • Interpositus lesion abolition of the eyeblink conditioned response is not due to effects on performance.

    abstract::Classical conditioning of the rabbit eyeblink response was used to study the effects of cerebellar lesions on performance in animals trained with low-intensity unconditioned stimuli (US). Animals were trained with 1 of 2 low-intensity corneal-airpuff USs paired with a tone-conditioned stimulus. This study confirms ear...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.107.3.530

    authors: Ivkovich D,Lockard JM,Thompson RF

    更新日期:1993-06-01 00:00:00

  • Sustained attention in the mouse: a study of the relationship with the cerebellum.

    abstract::To explore the role of the cerebellum in sustained attention, the authors tested lurcher, wildtype, and lurcher chimeric mice with zero, normal, and variable numbers of Purkinje cells, respectively, in a previously validated task of sustained attention. Results indicate that lurcher mice had a deficit in performance l...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.2.477

    authors: Martin LA,Goldowitz D,Mittleman G

    更新日期:2006-04-01 00:00:00

  • Pattern of [14C]2-deoxyglucose concentration associated with potentiation of reproductive behavior by prostaglandin E2.

    abstract::One indication of receptive behavior of the female leopard frog, Rana pipiens, is absence of a release call during tactile stimulation of the trunk. Prostaglandin E2 (PGE2) inhibits this call. This experiment demonstrates a different pattern of [14C]2-deoxyglucose concentration in brains of 5 receptive females silence...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.5.1028

    authors: Diakow C,Woicyk W,McEachron DL,Adler NT

    更新日期:1989-10-01 00:00:00

  • Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.

    abstract::The neurexins are a family of presynaptic cell adhesion molecules. Human genetic studies have found heterozygous deletions affecting NRXN1 and NRXN2, encoding α-neurexin I (Nrxn1α) and α-neurexin II (Nrxn2α), in individuals with autism spectrum disorders and schizophrenia. However, the link between α-neurexin deficien...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000108

    authors: Dachtler J,Ivorra JL,Rowland TE,Lever C,Rodgers RJ,Clapcote SJ

    更新日期:2015-12-01 00:00:00

  • Species differences in the vasopressin-immunoreactive pathways in the bed nucleus of the stria terminalis and medial amygdaloid nucleus in prairie voles (Microtus ochrogaster) and meadow voles (Microtus pennsylvanicus).

    abstract::Vasopressin-immunoreactive (AVP-ir) cells in the bed nucleus of the stria terminalis (BST) and medial amygdaloid nucleus (MA) and their AVP-ir projections to the lateral septum were studied in monogamous prairie voles (Microtus ochrogaster) and promiscuous meadow voles (M. pennsylvanicus). A sexually dimorphic AVP-ir ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.2.305

    authors: Wang Z

    更新日期:1995-04-01 00:00:00

  • Estrogen and the neural mediation of female-male mounting in the rat.

    abstract::Sexually receptive females mount sexually sluggish males to entice them to copulate, and estrogen and male olfactory cues mediate this female-male mounting (FMM) in the rat. This study examined whether brain regions that concentrate steroid hormones and receive olfactory projections were important for the mediation of...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0014121

    authors: Afonso VM,Lehmann H,Tse M,Woehrling A,Pfaus JG

    更新日期:2009-04-01 00:00:00

  • Long-term replacement of estrogen in combination with medroxyprogesterone acetate improves acquisition of an alternation task in middle-aged female rats.

    abstract::Studies have shown that ovarian hormones protect against some of the cognitive deficits associated with aging. Although much of the literature in rodents has focused on hippocampal dependent tasks, studies suggest that tasks dependent on the prefrontal cortex are also influenced by ovarian hormones. The present study ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0026461

    authors: Chisholm NC,Juraska JM

    更新日期:2012-02-01 00:00:00

  • Lack of task specificity and absence of posttraining effects of atropine on learning.

    abstract::Three experiments are reported whose purpose was to examine the effect of the cholinergic antagonist atropine on the acquisition of different learning tasks known to be sensitive or insensitive to impairment by hippocampal lesions; on the retention of performance acquired in the absence of the drug; and on memory cons...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.4.483

    authors: Hagan JJ,Tweedie F,Morris RG

    更新日期:1986-08-01 00:00:00

  • Contingency learning and causal detection in Hermissenda: I. Behavior.

    abstract::The addition of extra light-alone or rotation-alone presentations to sequences of light-rotation pairings reduced the associative suppression of phototaxic behavior for the nudibranch Hermissenda. Training-induced changes in Type B photoreceptor light responses were found to parallel the training-induced behavioral ch...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.1.13

    authors: Farley J

    更新日期:1987-02-01 00:00:00

  • Amiloride sensitivity in the neonatal rat.

    abstract::Amiloride-sensitive sodium channels in taste buds appear to play a key role in the response to NaCl stimulation, at least in adult rats. The researchers examined whether neonatal rats, which display an exaggerated preference for hypertonic NaCl solutions, lack functional amiloride-sensitive sodium channels. NaCl intak...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.5.981

    authors: Sollars SI,Bernstein IL

    更新日期:1994-10-01 00:00:00

  • Impairing forgetting by preventing new learning and memory.

    abstract::Two causes of forgetting have been promulgated: memory trace decay and retroactive interference. The authors show that forgetting is an active process requiring both new learning and memory. In the present (1)Lymnaea model system, prevention of new learning of a conflicting association, inhibition of memory consolidat...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.3.787

    authors: Sangha S,Scheibenstock A,Martens K,Varshney N,Cooke R,Lukowiak K

    更新日期:2005-06-01 00:00:00

  • Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors.

    abstract::These experiments tested whether nucleus accumbens muscarinic or nicotinic acetylcholine receptor activation is required for rats to learn to lever press for sucrose. Muscarinic blockade with scopolamine (1.0 microg/side or 10.0 microg/side), but not nicotinic antagonism with mecamylamine (10.0 microg/side), inhibited...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.4.730

    authors: Pratt WE,Kelley AE

    更新日期:2004-08-01 00:00:00

  • Central administration of cocaine produces age-dependent effects on behavior in the fetal rat.

    abstract::Rat fetuses were exposed to cocaine, lidocaine, or saline on Gestational Day 20 or 21 to provide information about cocaine effects on behavior during prenatal development. Cocaine was administered into the cisterna magna of individual fetal subjects to restrict effects to the CNS. Behavioral effects of cocaine were co...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.6.1179

    authors: Simonik DK,Robinson SR,Smotherman WP

    更新日期:1994-12-01 00:00:00

  • 17beta-estradiol modifies stress-induced and age-related changes in hippocampal synaptic plasticity.

    abstract::The female steroid hormone 17beta-estradiol enhances synaptic transmission and the magnitude of longterm potentiation (LTP) in adult rodent hippocampal slices. Long-term depression (LTD), another form of synaptic plasticity, occurs more prominently in hippocampal slices from aged rodents. A decrease in LTP has been re...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.2.301

    authors: Foy MR,Baudry M,Foy JG,Thompson RF

    更新日期:2008-04-01 00:00:00

  • What does a pigeon (Columba livia) brain look like during homing? selective examination of ZENK expression.

    abstract::Lesion studies have shown that the avian hippocampus plays a crucial role in homing pigeon (Columba livia) navigation. Using the expression of the immediate early gene protein ZENK in intact pigeons, the authors found regional variation in hippocampal activation as a consequence of homing and, necessarily, the behavio...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.4.845

    authors: Shimizu T,Bowers AN,Budzynski CA,Kahn MC,Bingman VP

    更新日期:2004-08-01 00:00:00

  • Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice.

    abstract::Neuropsin (kallikrein-related peptidase 8) is concentrated in the hippocampus, amygdala, olfactory bulb, and prefrontal cortex. Earlier studies showed that protease deficiency causes a significant impairment of early-phase long-term potentiation in the Schaffer collateral pathway and hippocampus-dependent memory in th...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.3.498

    authors: Horii Y,Yamasaki N,Miyakawa T,Shiosaka S

    更新日期:2008-06-01 00:00:00

  • Naloxone, preshock, and defensive burying.

    abstract::Rats were injected with naloxone hydrochloride (3 mg/kg) or saline and subjected to preshock or no preshock prior to receiving a test shock that elicited defensive burying. Preshock was administered in a context different from, or the same as, that in which the test shock was delivered. The combination of naloxone and...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.99.3.436

    authors: Whiteside DA,Devenport LD

    更新日期:1985-06-01 00:00:00

  • Developmental exposure to methimazole increases anxiety behavior in zebrafish.

    abstract::The role of thyroid hormones in vertebrate development has been well documented for several decades. As hypothyroidism during critical periods of development can cause defects to the development of every major organ system, including brain, eye, and general morphology, we hypothesized that hypothyroidism would affect ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000087

    authors: Reider M,Connaughton VP

    更新日期:2015-10-01 00:00:00

  • Re-examination of amphetamine-induced conditioned suppression of tastant intake in rats: the task-dependent drug effects hypothesis.

    abstract::This study reexamined Grigson's reward comparison hypothesis (1997), which claimed to have resolved the paradox of addictive, rewarding drugs manifesting an aversive effect in the conditioned taste aversion (CTA) paradigm. Here, the authors compared the conditioned suppression effects of lithium chloride (LiCl) and am...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0013511

    authors: Huang AC,Hsiao S

    更新日期:2008-12-01 00:00:00

  • A nitric oxide synthesis inhibitor in the medial preoptic area inhibits copulation and stimulus sensitization in male rats.

    abstract::Dopamine in the medial preoptic area (MPOA) facilitates copulation in male rats, and nitric oxide (NO) regulates basal and female-stimulated MPOA dopamine release. Microinjection of L-nitro-arginine methyl ester (L-NAME, an NO synthesis inhibitor) into the MPOA blocked copulation in naive rats and impaired copulation ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.6.1317

    authors: Lagoda G,Muschamp JW,Vigdorchik A,Hull EM

    更新日期:2004-12-01 00:00:00