Abstract:
:Adult rats have been phenotyped as high (HRs) or low (LRs) responders to novelty, the former associated with high-risk behaviors. Data indicating that adolescent rodents exhibit increased novelty-seeking relative to adults are equivocal, and phenotypic variations in adolescent novel stimulus reactivity are unknown. To determine whether novelty-seeking differs between adolescent and adult rats, reflecting phenotypic variations within each age, activities in an inescapable novel environment and novel object exploration were measured. Adolescents moved further, faster, and more continuously than adults, and exhibited a greater variability and range of activity in the novel environment. Both adolescent and adult LRs habituated to the environment by the second trial, but HRs maintained increased activity throughout 8 trials. In the free-choice paradigm, adolescents approached the novel object more frequently and spent more time in proximity to the object than adults. Similar results were obtained using arenas and objects of the same size or scaled to animal size. Results confirm that novelty-seeking by adolescents is greater than by adults, a behavior attributed primarily to the response magnitude exhibited by adolescents with the HR phenotype.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Philpot RM,Wecker Ldoi
10.1037/0735-7044.122.4.861subject
Has Abstractpub_date
2008-08-01 00:00:00pages
861-75issue
4eissn
0735-7044issn
1939-0084pii
2008-09788-015journal_volume
122pub_type
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