Estrogen and cognitive functioning in women: lessons we have learned.

Abstract:

:Extant research findings allow several conclusions regarding the relationship between estrogen and cognitive functioning across the female life span. First, performance on tests of verbal memory fluctuates in concert with physiological changes in ovarian hormone production during the menstrual cycle and during pregnancy and the postpartum period. Estrogen therapy (ET) prevents the decrease in verbal memory when administered immediately following the surgical removal of both ovaries in premenopausal women. Some, but relatively little evidence is available to support the idea that ET, initiated at the time of a natural or a surgical menopause for a few years, may protect against cognitive decline 30 years later and more research in this area is urgently needed. Finally, the evidence to date strongly suggests that the initiation of ET decades after the menopause has occurred does not protect against cognitive decline or dementia. Taken together, these findings support the so-called "window of opportunity" hypothesis which holds that ET will be neuroprotective only when administered closely in time to a natural or surgical menopause.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Sherwin BB

doi

10.1037/a0025539

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

123-7

issue

1

eissn

0735-7044

issn

1939-0084

pii

2011-23880-001

journal_volume

126

pub_type

杂志文章,评审
  • Transient inactivation of the thalamic nucleus reuniens and rhomboid nucleus produces deficits of a working-memory dependent tactile-visual conditional discrimination task.

    abstract::Working memory depends on communication between the hippocampus and the prefrontal cortex (PFC); however, the neural circuitry that mediates interactions between these brain areas has not been well characterized. Two candidate structures are the thalamic reuniens (RE) and rhomboid (Rh) nuclei, which are reciprocally c...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0034653

    authors: Hallock HL,Wang A,Shaw CL,Griffin AL

    更新日期:2013-12-01 00:00:00

  • Neural cell adhesion molecules, learning, and memory in the domestic chick.

    abstract::The intermediate and medial hyperstriatum ventrale (IMHV) of the chick forebrain is a site of recognition memory for the learning process of imprinting. The results reported here demonstrate that neural cell adhesion molecules (NCAMs) play a time-dependent role in this recognition memory. Dark-reared chicks were train...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.3.646

    authors: Solomonia RO,McCabe BJ,Horn G

    更新日期:1998-06-01 00:00:00

  • Response-reinforcer associations after caudate-putamen lesions in the rat: spatial discrimination and overshadowing-potentiation effects in instrumental learning.

    abstract::Experiment 1 demonstrated that rats with caudate-putamen lesions show an impairment in the acquisition and reversal of a spatial maze task when compared with unoperated control subjects. Experiment 2 examined lever-press responding supported by a variable interval schedule in three groups of subjects: a group with cau...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.99.6.1074

    authors: Mitchell JA,Channell S,Hall G

    更新日期:1985-12-01 00:00:00

  • Microinjection of morphine into the nucleus accumbens impairs contextual learning in rats.

    abstract::A unilateral microinjection of morphine into the amygdala impaired fear conditioning to both a conditioned stimulus (CS) paired with shock and the context where shock occurred, whereas a microinjection of morphine into the nucleus accumbens (NA) spared fear conditioning to the CS but impaired, in a dose-dependent and ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.111.5.996

    authors: Westbrook RF,Good AJ,Kiernan MJ

    更新日期:1997-10-01 00:00:00

  • Delta activity from amygdala in squirrel monkeys (Saimiri sciureus): influence of social and environmental context.

    abstract::A previous study reported that power in the delta band of the amygdala is selectively elevated when primates are exposed to affectively ladened stimuli (Kling, Steklis, & Deutsch, 1979). Radiotelemetric recordings suggested that this elevation was greatest when the animal was confronted with conspecific behaviors that...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.105.2.223

    authors: Lloyd RL,Kling AS

    更新日期:1991-04-01 00:00:00

  • Dopamine-stimulated sexual behavior is testosterone dependent in mice.

    abstract::Mice unable to synthesize dopamine (DA) in dopaminergic neurons were generated by gene-targeting techniques (Q.-Y. Zhou & R. D. Palmiter, 1995). These dopamine-deficient (DA-/-) mice required daily administration of 3,4-dihydroxyphenylalanine (L-DOPA) for survival beyond 2 to 3 weeks of age. This treatment stimulated ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.5.1229

    authors: Szczypka MS,Zhou QY,Palmiter RD

    更新日期:1998-10-01 00:00:00

  • Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions.

    abstract::Norway rat pups were either handled (H) or undisturbed (nonhandled, NH) in the period between birth and weaning on Day 21. Following weaning, half of the animals in each group were housed socially (Soc), and half were housed in isolation (Isol). At 120-150 days of age, all animals were sacrificed, and the following re...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.99.4.765

    authors: Meaney MJ,Aitken DH,Bodnoff SR,Iny LJ,Tatarewicz JE,Sapolsky RM

    更新日期:1985-08-01 00:00:00

  • Effects of parturition and maternal experience on noradrenaline and acetylcholine release in the olfactory bulb of sheep.

    abstract::Acetylcholine (ACh) and noradrenaline (NA) release in the olfactory bulb (OB) of ewes was monitored using microdialysis. Both ACh and NA release increased at parturition in multiparous but not in primiparous ewes. However, vaginocervical stimulation performed 6 hr postpartum induced an increase of ACh and NA release i...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.107.4.662

    authors: Lévy F,Guevara-Guzman R,Hinton MR,Kendrick KM,Keverne EB

    更新日期:1993-08-01 00:00:00

  • Functional consequences of embryonic neocortex transplanted to rats with prefrontal cortex lesions.

    abstract::In four experiments we reexamined the recent report by Labbe, Firl, Mufson, and Stein (1983) that fetal cortical tissue transplanted to an aspirative prefrontal cortical cavity in rats can ameliorate the learning impairments induced by the aspirative lesions. Healthy surviving grafts from young (E16) embryonic donors ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.4.489

    authors: Dunnett SB,Ryan CN,Levin PD,Reynolds M,Bunch ST

    更新日期:1987-08-01 00:00:00

  • Prenatal development of intrafetal and maternal-fetal synchrony.

    abstract::Fetal and maternal data were monitored serially at 6 gestational ages from 20 to 38 weeks in 195 Peruvian fetuses. Digitized data included fetal heart rate and motor activity, as well as maternal heart rate and electrodermal conductance. Time series analysis evaluated the development of synchrony in 2 streams of fetal...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.3.687

    authors: DiPietro JA,Caulfield LE,Irizarry RA,Chen P,Merialdi M,Zavaleta N

    更新日期:2006-06-01 00:00:00

  • Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans.

    abstract::The effects of various doses (40 microg/kg/hr, 300 microg/kg/hr, 600 microg/kg/hr or placebo) of hydrocortisone on tasks assessing working and declarative memory function were measured in 4 groups of 10 young men. During the infusion, participants were given an item-recognition working memory task, a paired-associate ...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//0735-7044.113.3.420

    authors: Lupien SJ,Gillin CJ,Hauger RL

    更新日期:1999-06-01 00:00:00

  • Sex versus sweet: opposite effects of opioid drugs on the reward of sucrose and sexual pheromones.

    abstract::Endogenous opioids mediate some reward processes involving both natural (food, sweet taste) and artificial (morphine, heroin) rewards. In contrast, sexual behavior (which is also reinforcing) is generally inhibited by opioids. To establish the role of endogenous opioids for a newly described natural reinforcer, namely...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.2.416

    authors: Agustín-Pavón C,Martínez-Ricós J,Martínez-García F,Lanuza E

    更新日期:2008-04-01 00:00:00

  • Cynomolgus monkeys do not develop tolerance to opioids.

    abstract::In order to examine the development of tolerance to opioids, eight cynomolgus and two rhesus monkeys were trained to press a lever for food reinforcement and then were catheterized so that drugs could be infused. Three doses of hydromorphone and six different interdose intervals were studied. Hydromorphone infusions i...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.2.327

    authors: Ternes JW,Ehrman R,O'Brien CP

    更新日期:1983-04-01 00:00:00

  • Therapeutic effects of exercise: wheel running reverses stress-induced interference with shuttle box escape.

    abstract::Exercise can reduce symptoms of depression and anxiety in humans, but therapeutic effects of exercise in an animal model of stress-related mood disorders have yet to be demonstrated. In the current study, the authors investigated the ability of wheel running to reverse a long-lasting interference with shuttle box esca...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.121.5.992

    authors: Greenwood BN,Strong PV,Dorey AA,Fleshner M

    更新日期:2007-10-01 00:00:00

  • Effect of BIM-18216, a novel cholecystokinin receptor antagonist, on food intake reduction induced by cholecystokinin.

    abstract::The role of cholecystokinin (CCK) in food intake was investigated in rats by using BIM-18216, a novel CCK receptor antagonist. In rats fed 6 hr/day, BIM-18216 antagonized the reduction of food intake induced by exogenous CCK octapeptide (CCK-8; 4 micrograms/kg) in a dose-dependent manner and had a maximum effect at 1 ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.105.5.707

    authors: Laferrere B,Nguyen M,Bonhomme G,Legall A,Basdevant A,Guy-Grand B

    更新日期:1991-10-01 00:00:00

  • Central dopamine turnover in guinea pig pups during separation from their mothers in a novel environment.

    abstract::Guinea pig pups that were separated from their mothers and placed into a novel environment for 90 min showed an increase in dopamine (DA) turnover (ratio of metabolites to DA) in the septum compared with undisturbed baseline controls. Pups placed into the novel environment with their mothers exhibited an intermediate ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.104.4.607

    authors: Tamborski A,Lucot JB,Hennessy MB

    更新日期:1990-08-01 00:00:00

  • A comparison of the short- and long-term effects of corticosterone exposure on extinction in adolescence versus adulthood.

    abstract::Human and nonhuman adolescents have impaired retention of extinction of learned fear, relative to juveniles and adults. It is unknown whether exposure to stress affects extinction differently in adolescents versus adults. These experiments compared the short- and long-term effects of exposure to the stress-related hor...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000022

    authors: Den ML,Altmann SR,Richardson R

    更新日期:2014-12-01 00:00:00

  • Mediodorsal thalamic lesions and Pavlovian conditioning of heart rate and eyeblink responses in the rabbit.

    abstract::Rabbits received ibotenic acid lesions of the mediodorsal nucleus of the thalamus (MD) or sham lesions. These animals were compared on 4 sessions of Pavlovian eyeblink and heart rate conditioning, in which a tone was the conditioned stimulus and a paraorbital electrical shock was the unconditioned stimulus. Lesions of...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.104.6.912

    authors: Buchanan SL,Thompson RH

    更新日期:1990-12-01 00:00:00

  • Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors.

    abstract::These experiments tested whether nucleus accumbens muscarinic or nicotinic acetylcholine receptor activation is required for rats to learn to lever press for sucrose. Muscarinic blockade with scopolamine (1.0 microg/side or 10.0 microg/side), but not nicotinic antagonism with mecamylamine (10.0 microg/side), inhibited...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.4.730

    authors: Pratt WE,Kelley AE

    更新日期:2004-08-01 00:00:00

  • Nonlinear temporal integration of brain stimulation reward.

    abstract::A good deal is known about psychological factors that contribute to reward value, but very little is known about how reward is computed in the brain. Integration in the circuit for brain stimulation reward may provide a simple model system. Parametric studies have favored the idea that the integration is linear, altho...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0026180

    authors: Hawkins RD

    更新日期:2011-12-01 00:00:00

  • Altered spatial learning and memory in mice lacking the mGluR4 subtype of metabotropic glutamate receptor.

    abstract::The glutamate analog, L-2-amino-4-phosphonobutyric acid (L-AP4) is a selective agonist for several members of the metabotropic glutamate receptor (mGluR) family. Activation of presynaptic mGluRs by L-AP4 causes a suppression of synaptic transmission in the central nervous system. In this study, the role of 1 subtype o...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.3.525

    authors: Gerlai R,Roder JC,Hampson DR

    更新日期:1998-06-01 00:00:00

  • Modification of the acoustic startle response in hearing-impaired C57BL/6J mice: prepulse augmentation and prolongation of prepulse inhibition.

    abstract::Modification of acoustic startle amplitude by a 10-ms tone prepulse (S1) was evaluated as a function of the interstimulus interval (ISI) between the onset of S1 and the onset of the startle-evoking stimulus (S2). Subjects were normal-hearing 1-month-old C57BL/6J (C57) mice and CBA/CaJ mice and 5-month-old C57 mice wit...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.3.396

    authors: Willott JF,Carlson S

    更新日期:1995-06-01 00:00:00

  • Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals.

    abstract::Regulation of energy intake depends in part on both memory for prior food intake and internal signals of hunger and satiety. These functions are both mediated by the hippocampus, a brain structure that animal studies have shown to be impaired after maintenance on high fat and refined sugar (HFS) diets. Study 1, using ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0025998

    authors: Francis HM,Stevenson RJ

    更新日期:2011-12-01 00:00:00

  • Memory of rats with amygdala lesions induced 30 days after footshock-motivated escape training reflects degree of original training.

    abstract::This experiment was conducted to determine whether the amount of preoperative training influences the effects, on retention, of amygdala lesions induced 30 days after escape training. Rats received 1 or 10 footshock-motivated escape training trials; 30 days later, sham or neurotoxic amygdala lesions were induced. Resu...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.6.1080

    authors: Parent MB,West M,McGaugh JL

    更新日期:1994-12-01 00:00:00

  • Tonic and phasic activation and arousal effects as a function of feedback in repetitive-choice reaction time tasks.

    abstract::This study examines the effects of positive and negative feedback on performance during choice reaction time tasks to assess whether they differentially affect phasic arousal and tonic activation. Participants (N = 96) received either no feedback or signals of reward, punishment, or both during a semantic and a visuos...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.116.3.397

    authors: De Brabander B,Declerck CH,Boone C

    更新日期:2002-06-01 00:00:00

  • Context-specific habituation of the freezing response in newborn chicks.

    abstract::Previous studies have found that in mature animals habituation is context-specific in some species but not in others. Given the mixed evidence present in the literature, we decided to explore whether habituation is context-specific in newborn chicks. The results showed that 3 days after hatching, chicks were capable o...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000212

    authors: Chiandetti C,Turatto M

    更新日期:2017-10-01 00:00:00

  • Processing of preconsciously acquired information measured by hemispheric asymmetry and selection accuracy.

    abstract::This study was conducted to investigate the effects of instruction types on hemispheric activation and accurate selection of spatial stimuli that had been previously presented at a subliminal level. Right-handed females randomly received either an "analytic" or a "holistic" instruction. Both groups first saw a series ...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//0735-7044.100.3.343

    authors: Barchas PR,Perlaki KM

    更新日期:1986-06-01 00:00:00

  • Cholinergic mechanisms of the context preexposure facilitation effect in adolescent rats.

    abstract::The context preexposure facilitation effect (CPFE) is a variant of contextual fear conditioning in which context learning, context-shock association, and expression of context conditioning occur in 3 separate phases-preexposure, training, and testing. During the preexposure phase, the CPFE is disrupted by hippocampal ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000134

    authors: Robinson-Drummer PA,Dokovna LB,Heroux NA,Stanton ME

    更新日期:2016-04-01 00:00:00

  • Prefrontal cortex and rule abstraction: where and whether? Theoretical comment on Moore et al. (2009).

    abstract::The primate dorsolateral prefrontal cortex is implicated in diverse aspects of behavioral regulation, cognitive control, and memory. However, direct neuropsychological evidence supporting a requirement of this area in functions other than spatial working memory has been scarce. T. L. Moore, S. P. Schettler, R. J. Kill...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章

    doi:10.1037/a0015236

    authors: Baxter MG

    更新日期:2009-04-01 00:00:00

  • Double dissociation of fornix and caudate nucleus lesions on acquisition of two water maze tasks: further evidence for multiple memory systems.

    abstract::The present study examined the effect of lesions of the caudate nucleus or fimbria-fornix on the acquisition of two water maze tasks. In both tasks, two rubber balls with different visual patterns were used as platforms (i.e., cues). The "correct" cue was attached to a submerged rectangular platform and could be mount...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.3.439

    authors: Packard MG,McGaugh JL

    更新日期:1992-06-01 00:00:00