Functional consequences of embryonic neocortex transplanted to rats with prefrontal cortex lesions.

abstract：:Galanin is a 29-amino-acid neuropeptide that is overexpressed in Alzheimer's disease (AD) and impairs performance on rodent learning and memory tasks. M40, a peptidergic galanin receptor ligand, blocks galanin-induced impairments on delayed non-matching-to-position (DNMTP). The present experiments used the 192IgG-sapo...

journal_title：Behavioral neuroscience

authors： McDonald MP,Wenk GL,Crawley JN

更新日期：1997-06-01 00:00:00

abstract：:Rats implanted with cannula tips placed above the nucleus of the solitary tract (NTS) were trained to obtain food pellets placed in 2 arms of a Y maze and then given a footshock in 1 arm of the maze. The rats then received bilateral injections of lidocaine or buffer into the NTS and peripheral injections of saline or ...

journal_title：Behavioral neuroscience

authors： Williams CL,McGaugh JL

更新日期：1993-12-01 00:00:00

abstract：:Four experiments studied the opioid receptor subtype and signal transduction mechanisms mediating fear extinction in the ventrolateral quadrant of the midbrain periaqueductal gray (vlPAG). Microinjection of a mu- but not a delta- or kappa-opioid receptor antagonist into the vlPAG retarded extinction. Extinction was al...

journal_title：Behavioral neuroscience

authors： McNally GP,Lee BW,Chiem JY,Choi EA

更新日期：2005-08-01 00:00:00

abstract：:Based on work done in animal models showing that autism-like symptoms are ameliorated following exposure to an enriched sensorimotor environment, we attempted to develop a comparable therapy for children with autism. In an initial randomized controlled trial, children with autism who received sensorimotor enrichment a...

journal_title：Behavioral neuroscience

authors： Woo CC,Donnelly JH,Steinberg-Epstein R,Leon M

更新日期：2015-08-01 00:00:00

abstract：:The present study was designed to evaluate the impact of neonatal injury on adult spinal plasticity in rats. Subjects were randomly assigned to 1 of 4 experimental conditions: (a) hind-paw injury at Postnatal Day (PD) 2, (b) hind-paw injury at PD 5, (c) anesthesia exposure only on PD 2, or (d) anesthesia exposure only...

journal_title：Behavioral neuroscience

authors： Young EE,Baumbauer KM,Elliot A,Joynes RL

更新日期：2007-10-01 00:00:00

abstract：:Studies have shown that ovarian hormones protect against some of the cognitive deficits associated with aging. Although much of the literature in rodents has focused on hippocampal dependent tasks, studies suggest that tasks dependent on the prefrontal cortex are also influenced by ovarian hormones. The present study ...

journal_title：Behavioral neuroscience

authors： Chisholm NC,Juraska JM

更新日期：2012-02-01 00:00:00

abstract：:Cognitive functions, such as working memory, are disrupted in most psychiatric disorders. Many of these processes are believed to depend on the medial prefrontal cortex (mPFC). Traditionally, maze-based behavioral tasks, which have a strong exploratory component, have been used to study the role of the mPFC in working...

journal_title：Behavioral neuroscience

authors： Benoit LJ,Holt ES,Teboul E,Taliaferro JP,Kellendonk C,Canetta S

更新日期：2020-06-01 00:00:00

abstract：:The present series of three experiments was concerned with the effects of morphine and the morphine antagonist naloxone on the development of a classical aversive heart rate (HR) conditioned response (CR) to a tone conditioned stimulus (CS) paired with an electric shock unconditioned stimulus (US). In the first study,...

journal_title：Behavioral neuroscience

authors： Mahalik T,Fitzgerald RD

更新日期：1988-04-01 00:00:00

abstract：:These experiments examined the sufficiency of pairing an odor with either intrabulbar activation of noradrenergic beta-receptors or pharmacological stimulation of the locus coeruleus to support learned odor preferences in Postnatal Day 6-7 rat pups. The results showed that pups exposed to odor paired with beta-recepto...

journal_title：Behavioral neuroscience

authors： Sullivan RM,Stackenwalt G,Nasr F,Lemon C,Wilson DA

更新日期：2000-10-01 00:00:00

abstract：:Substantial evidence suggests that pharmacological manipulations of neural serotonin pathways influence ingestive behaviors. Despite the known role of the nucleus accumbens in directing appetitive and consummatory behavior, there has been little examination of the influences that serotonin receptors may play in modula...

journal_title：Behavioral neuroscience

authors： Pratt WE,Blackstone K,Connolly ME,Skelly MJ

更新日期：2009-10-01 00:00:00

abstract：:The acoustic startle reflex (ASR) in rats is attenuated by a light paired with food or, in humans, by "pleasant" pictures. Rats were trained to barpress for lateral hypothalamus (LH) stimulation. ASR amplitudes were then measured at 4 intensities, with or without a light. Control rats that did not receive brain-stimul...

journal_title：Behavioral neuroscience

authors： Steidl S,Li L,Yeomans JS

更新日期：2001-06-01 00:00:00

abstract：:Fluoxetine is the only selective serotonin reuptake inhibitor registered for the treatment of major depressive disorder in pediatric populations, despite reports that it is disproportionately associated with an array of adverse side effects that include agitation, hostility, and overt acts of pathological aggression a...

journal_title：Behavioral neuroscience

authors： Ricci LA,Melloni RH Jr

更新日期：2012-10-01 00:00:00

abstract：:The effects of postingestive feedback on the value of intraoral sucrose and lateral hypothalamic (LH) stimulation were compared. Rats chose between a fixed LH stimulation train or a compound reward composed of the same stimulation train and an oral infusion of 1 M sucrose. The rats preferred the compound reward when p...

journal_title：Behavioral neuroscience

authors： Conover KL,Shizgal P

更新日期：1994-06-01 00:00:00

abstract：:The hippocampus is important for the acquisition of new memories. It is also one of the few regions in the adult mammalian brain that can generate new nerve cells. The authors tested the hypothesis that voluntary exercise increases neurogenesis and enhances spatial learning in mice selectively bred for high levels of ...

journal_title：Behavioral neuroscience

authors： Rhodes JS,van Praag H,Jeffrey S,Girard I,Mitchell GS,Garland T Jr,Gage FH

更新日期：2003-10-01 00:00:00

abstract：:The present study examined the effect of lesions of the caudate nucleus or fimbria-fornix on the acquisition of two water maze tasks. In both tasks, two rubber balls with different visual patterns were used as platforms (i.e., cues). The "correct" cue was attached to a submerged rectangular platform and could be mount...

journal_title：Behavioral neuroscience

authors： Packard MG,McGaugh JL

更新日期：1992-06-01 00:00:00

abstract：:The intermediate and medial hyperstriatum ventrale (IMHV) of the chick forebrain is a site of recognition memory for the learning process of imprinting. The results reported here demonstrate that neural cell adhesion molecules (NCAMs) play a time-dependent role in this recognition memory. Dark-reared chicks were train...

journal_title：Behavioral neuroscience

authors： Solomonia RO,McCabe BJ,Horn G

更新日期：1998-06-01 00:00:00

abstract：:This study examined the hypothesis that defensive responsiveness induced by threatening stimuli of biological origin is mediated by the action of endogenous corticotropin-releasing factor (CRF). Rats were exposed for 15 min to a large open field containing a small chamber. Twenty-four hours later, rats received intrac...

journal_title：Behavioral neuroscience

authors： Takahashi LK,Kalin NH,Baker EW

更新日期：1990-04-01 00:00:00

abstract：:The role of the hippocampus in associative learning was investigated in 3 experiments with rats as subjects. Hippocampal rats were impaired in the acquisition of conditioned responding both when food was signaled by the insertion of a lever (Experiment 1) and when the presentation of auditory or visual events served a...

journal_title：Behavioral neuroscience

authors： Good M,Honey RC

更新日期：1991-08-01 00:00:00

abstract：:Two experiments examined whether the pudendal and pelvic autonomic nerves are important for pacing behavior shown by the female rat during mating. Ovariectomized female rats received bilateral transection of the pudendal (Pux), pelvic (Pex), or pudendal and pelvic (Pu + Pex) nerves or were sham-operated (Shx). Lordoti...

journal_title：Behavioral neuroscience

authors： Erskine MS

更新日期：1992-08-01 00:00:00

abstract：:The defensive withdrawal reflex of the mantle organs (gill, siphon, and mantle shelf) of the marine mollusc Aplysia californica has been the subject of numerous studies investigating the cellular and molecular mechanisms of learning. In behavioral experiments, the reflex has been monitored by means of two different re...

journal_title：Behavioral neuroscience

authors： Stopfer M,Carew TJ

更新日期：1987-04-01 00:00:00

abstract：:Biological markers for acquisition and extinction of fear conditioning were studied in 40 individuals selected for displaying either good or poor acquisition of fear conditioning. as estimated by the skin conductance response. Participants with a short serotonin transporter (5-HTT) promoter allele or low monoamine oxi...

journal_title：Behavioral neuroscience

authors： Garpenstrand H,Annas P,Ekblom J,Oreland L,Fredrikson M

更新日期：2001-04-01 00:00:00

abstract：:Mapping studies were conducted to delineate the site(s) of action for the arousal-enhancing actions of norepinephrine (NE) within the basal forebrain region encompassing the medial preoptic area (MPOA) and the substantia innominata (SI). Varying doses of NE, the beta-agonist, isoproterenol, or the alpha1-agonist, phen...

journal_title：Behavioral neuroscience

authors： Berridge CW,O'Neill J

更新日期：2001-02-01 00:00:00

abstract：:The role of cholecystokinin (CCK) in food intake was investigated in rats by using BIM-18216, a novel CCK receptor antagonist. In rats fed 6 hr/day, BIM-18216 antagonized the reduction of food intake induced by exogenous CCK octapeptide (CCK-8; 4 micrograms/kg) in a dose-dependent manner and had a maximum effect at 1 ...

journal_title：Behavioral neuroscience

authors： Laferrere B,Nguyen M,Bonhomme G,Legall A,Basdevant A,Guy-Grand B

更新日期：1991-10-01 00:00:00

abstract：:Morphological changes in the anterior cingulate cortex are found in subjects with schizophrenia, attention deficit hyperactivity disorder, and obsessive-compulsive disorder. These changes are hypothesized to underlie the impairments these individuals show on tasks that require cognitive control. The anterior cingulate...

journal_title：Behavioral neuroscience

authors： Newman LA,McGaughy J

更新日期：2011-06-01 00:00:00

abstract：:It has been proposed that the cognitive dysfunction observed in patients with schizophrenia reflects a failure in cognitive control, in particular an inability to use task-relevant information to guide behavior. Using a prefrontal-dependent task designed to reflect aspects of cue and response conflict seen in human co...

journal_title：Behavioral neuroscience

authors： Haddon JE,Killcross S

更新日期：2011-06-01 00:00:00

abstract：:In humans, congenital deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) results in a disorder known as the Lesch-Nyhan syndrome. Patients with this disorder exhibit a prominent neurobehavioral phenotype that results in part from dysfunction of catecholaminergic systems in the striatum. HPR...

journal_title：Behavioral neuroscience

authors： Jinnah HA,Gage FH,Friedmann T

更新日期：1991-12-01 00:00:00

abstract：:Microstructural analysis of licking behavior in the rat was conducted (a) to describe in detail the characteristics of benzodiazepine-induced changes in ingestion and (b) to determine if the changes are consistent with an alteration in palatability. The effects of the benzodiazepine receptor (BZR) agonist midazolam (0...

journal_title：Behavioral neuroscience

authors： Higgs S,Cooper SJ

更新日期：1998-04-01 00:00:00

abstract：:Only the function relating the required pulse frequency to the interburst interval discriminates between the priming effect and the rewarding effect: Separating two short bursts of pulses has no effect on their combined rewarding effect, but it enhances their priming effect. There are significant nonscalar differences...

journal_title：Behavioral neuroscience

authors： Sax L,Gallistel CR

更新日期：1991-12-01 00:00:00

abstract：:Spatial learning and memory were studied in dogs of varying ages and sources. Compared to young dogs, a significantly higher proportion of aged dogs could not acquire a spatial delayed nonmatching-to-sample task. A regression analysis revealed a significant age effect during acquisition. Spatial memory was studied by ...

journal_title：Behavioral neuroscience

authors： Head E,Mehta R,Hartley J,Kameka M,Cummings BJ,Cotman CW,Ruehl WW,Milgram NW

更新日期：1995-10-01 00:00:00

abstract：:Three experiments are reported whose purpose was to examine the effect of the cholinergic antagonist atropine on the acquisition of different learning tasks known to be sensitive or insensitive to impairment by hippocampal lesions; on the retention of performance acquired in the absence of the drug; and on memory cons...

journal_title：Behavioral neuroscience

authors： Hagan JJ,Tweedie F,Morris RG

更新日期：1986-08-01 00:00:00