Sensory gating impairments in heavy cannabis users are associated with altered neural oscillations.

Abstract:

:Central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in cannabis users. Seventeen heavy cannabis users and 16 cannabis naïve controls participated. Analyses included P50 amplitudes, and time-frequency analyses (event-related spectral perturbations, ERSPs; intertrial coherence, ITC). Consistent with prior studies, cannabis users exhibited reduced P50 gating. The ERSP analysis yielded attenuated high frequency activity in the beta range (13-29 Hz) post-S1 and in the gamma range (30-50 Hz) post-S2 in the cannabis group, compared with the control group. Greater levels of cannabis use were positively associated with high P50 ratios and negatively with post-S2 ERSP gamma power. Findings suggest that heavy cannabis use is associated with aberrant beta and gamma activity in the dual-click procedure, which corroborates recent work demonstrating disruption of beta/gamma by cannabinoid receptor (CB1) agonists in a rat analogue of this task and highlights the translational potential of the dual-click procedure [corrected]

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Edwards CR,Skosnik PD,Steinmetz AB,O'Donnell BF,Hetrick WP

doi

10.1037/a0016328

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

894-904

issue

4

eissn

0735-7044

issn

1939-0084

pii

2009-10928-023

journal_volume

123

pub_type

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