Once is too much: conditioned aversion develops immediately and predicts future cocaine self-administration behavior in rats.

Abstract:

:Rats emit aversive taste reactivity (TR) behavior (i.e., gapes) following intraoral delivery of a cocaine-paired taste cue and greater conditioned aversive TR at the end of training predicts greater drug-seeking and taking. Here, we examined the development of this conditioned aversive TR behavior on a trial-by-trial basis in an effort to determine when the change in behavior occurs and whether early changes in this behavior can be used to predict later drug taking. The results show that conditioned aversive TR to a cocaine-paired cue occurs very early in training (i.e., following as few as 1-2 taste-drug pairings) and, importantly, that it can be used to predict later drug seeking and drug taking in rats.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Colechio EM,Imperio CG,Grigson PS

doi

10.1037/a0036264

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

207-16

issue

2

eissn

0735-7044

issn

1939-0084

pii

2014-14502-010

journal_volume

128

pub_type

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