Abstract:
:Rats emit aversive taste reactivity (TR) behavior (i.e., gapes) following intraoral delivery of a cocaine-paired taste cue and greater conditioned aversive TR at the end of training predicts greater drug-seeking and taking. Here, we examined the development of this conditioned aversive TR behavior on a trial-by-trial basis in an effort to determine when the change in behavior occurs and whether early changes in this behavior can be used to predict later drug taking. The results show that conditioned aversive TR to a cocaine-paired cue occurs very early in training (i.e., following as few as 1-2 taste-drug pairings) and, importantly, that it can be used to predict later drug seeking and drug taking in rats.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Colechio EM,Imperio CG,Grigson PSdoi
10.1037/a0036264subject
Has Abstractpub_date
2014-04-01 00:00:00pages
207-16issue
2eissn
0735-7044issn
1939-0084pii
2014-14502-010journal_volume
128pub_type
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