Dissociations between appetitive and consummatory responses by pharmacological manipulations of reward-relevant brain regions.


:Appetitive behaviors of rats were monitored in a runway situation following central infusions of neuroactive substances into brain areas implicated in electrical self-stimulation. Microinjections of the dopamine antagonist cis-flupentixol or the cholinergic antagonist atropine into the nucleus accumbens (Acb) severely reduced the approach speed and anticipatory shuttlebox activity while leaving the consumption of the 20% sucrose reward intact. Microinjections of GABA into the ventral tegmental area (VTA), pedunculopontine tegmental nucleus (PPTg), and oral pontine reticular nucleus (PnO) also severely disrupted approach without decreasing consumption. The highest doses of atropine into the VTA, PPTg, and PnO disrupted both consummatory and approach responses equally. The results indicate that modulation of various neurochemistries along the trajectory of the self-stimulation system has stronger effects on appetitive approach than consummatory motivation. The implications for understanding appetitive-approach motivation in the brain are discussed.


Behav Neurosci


Behavioral neuroscience


Ikemoto S,Panksepp J




Has Abstract


1996-04-01 00:00:00












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    abstract::Feeding-related gustatory, olfactory, and visual activation of the orbitofrontal cortex (OFC) decreases following satiety. Previous neurophysiological studies have concentrated on the caudolateral OFC (clOFC). We describe satiety-induced modulation of 23 gustatory, 5 water, and 15 control neurons in the medial OFC (mO...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Pritchard TC,Nedderman EN,Edwards EM,Petticoffer AC,Schwartz GJ,Scott TR

    更新日期:2008-02-01 00:00:00

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    abstract::In Pavlovian eyeblink conditioning, the conditioned response (CR) is highly lateralized to the eye to which the unconditioned stimulus (US) has been directed. However, the initial conditioning of one eye can facilitate subsequent conditioning of the other eye, a phenomenon known as the intereye transfer (IET) effect. ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Lee T,Kim JJ,Wagner AR

    更新日期:2008-12-01 00:00:00

  • Circadian modulation of the rat acoustic startle response.

    abstract::The acoustic startle response (ASR) of male rats was measured during several sessions over a 24-hr period in both a light-dark cycle and a constant-dark condition. Each session consisted of 10 trials each at 80, 90, 100, 110, and 120 dB white noise. The results indicate robust daily and circadian modulation of ASR amp...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Chabot CC,Taylor DH

    更新日期:1992-10-01 00:00:00

  • Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.

    abstract::The neurexins are a family of presynaptic cell adhesion molecules. Human genetic studies have found heterozygous deletions affecting NRXN1 and NRXN2, encoding α-neurexin I (Nrxn1α) and α-neurexin II (Nrxn2α), in individuals with autism spectrum disorders and schizophrenia. However, the link between α-neurexin deficien...

    journal_title:Behavioral neuroscience

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    authors: Dachtler J,Ivorra JL,Rowland TE,Lever C,Rodgers RJ,Clapcote SJ

    更新日期:2015-12-01 00:00:00

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    abstract::Although the retrosplenial cortex (RSC) is necessary for the retrieval of remotely acquired fear to a discrete auditory cue, it is not necessary for the retrieval of recently acquired cued-fear memories. Thus, the RSC's role in memory retrieval for discrete cues is time-dependent. The purpose of the current experiment...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Todd TP,Jiang MY,DeAngeli NE,Bucci DJ

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    abstract::Activation of memory retrieval after weak learning (WL), during either the short- or intermediate-term stages of memory in day-old chickens, resulted in the strengthening of the memory to levels normally associated with strong learning. Administration of the calcium channel antagonist lanthanum chloride, the glutamate...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Summers MJ,Crowe SF,Ng KT

    更新日期:2000-08-01 00:00:00

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Minor TR,Winslow JL,Chang WC

    更新日期:1994-04-01 00:00:00

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Wolgin DL,Munoz JR

    更新日期:2006-04-01 00:00:00

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: McGaughy J,Sarter M

    更新日期:1999-12-01 00:00:00

  • Distinct roles for striatal subregions in mediating response processing revealed by focal excitotoxic lesions.

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Brasted PJ,Robbins TW,Dunnett SB

    更新日期:1999-04-01 00:00:00

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Jinnah HA,Gage FH,Friedmann T

    更新日期:1991-12-01 00:00:00

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    journal_title:Behavioral neuroscience

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Agmo A,Gómez M

    更新日期:1993-10-01 00:00:00

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    abstract::Mice with genetically associated variations in the number and density of granule cells in the dentate gyrus were tested for open-field activity, spatial maze learning, and two-way avoidance conditioning. The number of granule cells was not associated with any behavior measured. Only avoidance conditioning was related ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Wimer C,Wimer RE,Wimer JS

    更新日期:1983-12-01 00:00:00

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    journal_title:Behavioral neuroscience

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    authors: Blass EM,Jackson AM,Smotherman WP

    更新日期:1991-10-01 00:00:00

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    journal_title:Behavioral neuroscience

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    authors: Matzel LD,Collin C,Alkon DL

    更新日期:1992-12-01 00:00:00

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Raslear TG,Pierrel-Sorrentino R,Rudnick F

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    authors: Kumari V,ffytche DH,Das M,Wilson GD,Goswami S,Sharma T

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    journal_title:Behavioral neuroscience

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    authors: Chow SY,Sakai RR,Witcher JA,Adler NT,Epstein AN

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    abstract::These studies were designed to determine the dose-response autonomic and behavioral thermoregulatory effects and the motor effects of dopamine (DA) and prostaglandin E1 (PGE1) injected into the lateral cerebral ventricles of rats. These studies were made possible with a computer-controlled thermocline that permits fre...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Marques PR,Spencer RL,Burks TF,McDougal JN

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    authors: Gritton HJ,Sutton BC,Martinez V,Sarter M,Lee TM

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    abstract::This study examined the role of the amygdala in mediating the effects of glucocorticoids on spatial memory in rats. Adrenalectomy (ADX) induced 4-5 days prior to training impaired memory in a water-maze spatial task. This effect was reversed by a posttraining injection of dexamethasone (0.3 mg/kg sc) but not by cortic...

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    authors: Roozendaal B,Portillo-Marquez G,McGaugh JL

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    authors: Flynn FW,Evey LA,Steele TL,Mitchell JC

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    journal_title:Behavioral neuroscience

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    authors: Zaehringer J,Schmahl C,Ende G,Paret C

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    pub_type: 杂志文章


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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Reeves TM,Smith DC

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    pub_type: 杂志文章


    authors: Meaney MJ,Aitken DH,Bodnoff SR,Iny LJ,Tatarewicz JE,Sapolsky RM

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    pub_type: 杂志文章


    authors: Berridge CW,O'Neill J

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    pub_type: 杂志文章


    authors: Pitman DL,Natelson BH,Ottenweller JE,McCarty R,Pritzel T,Tapp WN

    更新日期:1995-08-01 00:00:00