Dissociations between appetitive and consummatory responses by pharmacological manipulations of reward-relevant brain regions.

Abstract:

:Appetitive behaviors of rats were monitored in a runway situation following central infusions of neuroactive substances into brain areas implicated in electrical self-stimulation. Microinjections of the dopamine antagonist cis-flupentixol or the cholinergic antagonist atropine into the nucleus accumbens (Acb) severely reduced the approach speed and anticipatory shuttlebox activity while leaving the consumption of the 20% sucrose reward intact. Microinjections of GABA into the ventral tegmental area (VTA), pedunculopontine tegmental nucleus (PPTg), and oral pontine reticular nucleus (PnO) also severely disrupted approach without decreasing consumption. The highest doses of atropine into the VTA, PPTg, and PnO disrupted both consummatory and approach responses equally. The results indicate that modulation of various neurochemistries along the trajectory of the self-stimulation system has stronger effects on appetitive approach than consummatory motivation. The implications for understanding appetitive-approach motivation in the brain are discussed.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Ikemoto S,Panksepp J

doi

10.1037//0735-7044.110.2.331

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

331-45

issue

2

eissn

0735-7044

issn

1939-0084

journal_volume

110

pub_type

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