Abstract:
:Contradictory results are found in the literature concerning the role of vision in the perception of space or in spatial navigation, in part because of the lack of murine models of total blindness used so far. The authors evaluated the spatial abilities of anophthalmic transgenic mice. These mice did not differ qualitatively from their wild-type littermates in general locomotor activity, spontaneous alternation, object exploration, or anxiety, but their level of exploratory activity was generally lower. In the spatial version of the water maze, they displayed persistent thigmotaxic behavior and showed severe spatial learning impairments. However, their performances improved with training, suggesting that they may have acquired a rough representation of the platform position. These results suggest that modalities other than vision enable some degree of spatial processing in proximal and structured spaces but that vision is critical for accurate spatial navigation.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Buhot MC,Dubayle D,Malleret G,Javerzat S,Segu Lsubject
Has Abstractpub_date
2001-04-01 00:00:00pages
455-67issue
2eissn
0735-7044issn
1939-0084journal_volume
115pub_type
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