Exploration, anxiety, and spatial memory in transgenic anophthalmic mice.

Abstract:

:Contradictory results are found in the literature concerning the role of vision in the perception of space or in spatial navigation, in part because of the lack of murine models of total blindness used so far. The authors evaluated the spatial abilities of anophthalmic transgenic mice. These mice did not differ qualitatively from their wild-type littermates in general locomotor activity, spontaneous alternation, object exploration, or anxiety, but their level of exploratory activity was generally lower. In the spatial version of the water maze, they displayed persistent thigmotaxic behavior and showed severe spatial learning impairments. However, their performances improved with training, suggesting that they may have acquired a rough representation of the platform position. These results suggest that modalities other than vision enable some degree of spatial processing in proximal and structured spaces but that vision is critical for accurate spatial navigation.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Buhot MC,Dubayle D,Malleret G,Javerzat S,Segu L

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

455-67

issue

2

eissn

0735-7044

issn

1939-0084

journal_volume

115

pub_type

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