Abstract:
:This study uses an operant, behavioral model to assess the daily changes in the decay rate of short-term memory, motivation, and motor ability in rats exposed to chronic restraint. Restraint decreased reward-related motivation by 50% without altering memory decay rate or motor ability. Moreover, chronic restraint impaired hippocampal-dependent spatial memory on the Y maze (4-hr delay) and produced CA3 dendritic retraction without altering hippocampal-independent maze navigation (1-min delay) or locomotion. Thus, mechanisms underlying motivation for food reward differ from those underlying Y maze exploration, and neurobiological substrates of spatial memory, such as the hippocampus, differ from those that underlie short-term memory. Chronic restraint produces functional, neuromorphological, and physiological alterations that parallel symptoms of depression in humans.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Kleen JK,Sitomer MT,Killeen PR,Conrad CDdoi
10.1037/0735-7044.120.4.842subject
Has Abstractpub_date
2006-08-01 00:00:00pages
842-51issue
4eissn
0735-7044issn
1939-0084pii
2006-09890-008journal_volume
120pub_type
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