Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore.

Abstract:

:This study uses an operant, behavioral model to assess the daily changes in the decay rate of short-term memory, motivation, and motor ability in rats exposed to chronic restraint. Restraint decreased reward-related motivation by 50% without altering memory decay rate or motor ability. Moreover, chronic restraint impaired hippocampal-dependent spatial memory on the Y maze (4-hr delay) and produced CA3 dendritic retraction without altering hippocampal-independent maze navigation (1-min delay) or locomotion. Thus, mechanisms underlying motivation for food reward differ from those underlying Y maze exploration, and neurobiological substrates of spatial memory, such as the hippocampus, differ from those that underlie short-term memory. Chronic restraint produces functional, neuromorphological, and physiological alterations that parallel symptoms of depression in humans.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Kleen JK,Sitomer MT,Killeen PR,Conrad CD

doi

10.1037/0735-7044.120.4.842

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

842-51

issue

4

eissn

0735-7044

issn

1939-0084

pii

2006-09890-008

journal_volume

120

pub_type

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