Dopamine modulates novelty seeking behavior during decision making.

Abstract:

:Novelty seeking refers to the tendency of humans and animals to explore novel and unfamiliar stimuli and environments. The idea that dopamine modulates novelty seeking is supported by evidence that novel stimuli excite dopamine neurons and activate brain regions receiving dopaminergic input. In addition, dopamine is shown to drive exploratory behavior in novel environments. It is not clear whether dopamine promotes novelty seeking when it is framed as the decision to explore novel options versus the exploitation of familiar options. To test this hypothesis, we administered systemic injections of saline or GBR-12909, a selective dopamine transporter (DAT) inhibitor, to monkeys and assessed their novelty seeking behavior during a probabilistic decision making task. The task involved pseudorandom introductions of novel choice options. This allowed monkeys the opportunity to explore novel options or to exploit familiar options that they had already sampled. We found that DAT blockade increased the monkeys' preference for novel options. A reinforcement learning (RL) model fit to the monkeys' choice data showed that increased novelty seeking after DAT blockade was driven by an increase in the initial value the monkeys assigned to novel options. However, blocking DAT did not modulate the rate at which the monkeys learned which cues were most predictive of reward or their tendency to exploit that knowledge. These data demonstrate that dopamine enhances novelty-driven value and imply that excessive novelty seeking-characteristic of impulsivity and behavioral addictions-might be caused by increases in dopamine, stemming from less reuptake.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Costa VD,Tran VL,Turchi J,Averbeck BB

doi

10.1037/a0037128

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

556-66

issue

5

eissn

0735-7044

issn

1939-0084

pii

2014-23803-001

journal_volume

128

pub_type

杂志文章
  • Attentional effects of lesions to the anterior cingulate cortex: how prior reinforcement influences distractibility.

    abstract::Morphological changes in the anterior cingulate cortex are found in subjects with schizophrenia, attention deficit hyperactivity disorder, and obsessive-compulsive disorder. These changes are hypothesized to underlie the impairments these individuals show on tasks that require cognitive control. The anterior cingulate...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0023250

    authors: Newman LA,McGaughy J

    更新日期:2011-06-01 00:00:00

  • Auditory streaming by phase relations between components of harmonic complexes: a comparative study of human subjects and bird forebrain neurons.

    abstract::Auditory streaming describes a percept in which a sequential series of sounds either is segregated into different streams or is integrated into one stream based on differences in their spectral or temporal characteristics. This phenomenon has been analyzed in human subjects (psychophysics) and European starlings (neur...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0030249

    authors: Dolležal LV,Itatani N,Günther S,Klump GM

    更新日期:2012-12-01 00:00:00

  • Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice.

    abstract::Neuropsin (kallikrein-related peptidase 8) is concentrated in the hippocampus, amygdala, olfactory bulb, and prefrontal cortex. Earlier studies showed that protease deficiency causes a significant impairment of early-phase long-term potentiation in the Schaffer collateral pathway and hippocampus-dependent memory in th...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.3.498

    authors: Horii Y,Yamasaki N,Miyakawa T,Shiosaka S

    更新日期:2008-06-01 00:00:00

  • Involvement of D1- and D2-like dopamine receptors within the rat nucleus accumbens in the maintenance of morphine rewarding properties in the rats.

    abstract::Previous studies on drug abuse have shown that response to drug-associated cues exist during prolonged abstinence. In succession to previous investigations in our laboratory on morphine dependence and our research on acquisition and expression phases of morphine-conditioned place preference (CPP), in this study we att...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000336

    authors: Namvar P,Zarrabian S,Nazari-Serenjeh F,Sadeghzadeh F,Haghparast A

    更新日期:2019-12-01 00:00:00

  • Therapeutic effects of exercise: wheel running reverses stress-induced interference with shuttle box escape.

    abstract::Exercise can reduce symptoms of depression and anxiety in humans, but therapeutic effects of exercise in an animal model of stress-related mood disorders have yet to be demonstrated. In the current study, the authors investigated the ability of wheel running to reverse a long-lasting interference with shuttle box esca...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.121.5.992

    authors: Greenwood BN,Strong PV,Dorey AA,Fleshner M

    更新日期:2007-10-01 00:00:00

  • The role of ventral and orbital prefrontal cortex in conditional visuomotor learning and strategy use in rhesus monkeys (Macaca mulatta).

    abstract::Four rhesus monkeys (Macaca mulatta) were trained to learn novel sets of visuomotor associations in 50 trials or less, within single test sessions. After bilateral ablation of the orbital and ventral prefrontal cortex, the monkeys lost the ability to learn these associations within a session, although they could learn...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.115.5.971

    authors: Bussey TJ,Wise SP,Murray EA

    更新日期:2001-10-01 00:00:00

  • Taste-potentiated odor conditioning: impairment produced by infusion of an N-methyl-D-aspartate antagonist into basolateral amygdala.

    abstract::Two experiments examined the effects of infusing an N-methyl-D-aspartate (NMDA) receptor antagonist, d-2-amino-5-phosphonovalerate(d-APV), on taste-potentiated odor conditioning: a form of learning that is dependent on information processing in 2 sensory modalities. In Experiment 1, rats infused with d-APV were impair...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.4.663

    authors: Hatfield T,Gallagher M

    更新日期:1995-08-01 00:00:00

  • Selective serotonin receptor stimulation of the medial nucleus accumbens causes differential effects on food intake and locomotion.

    abstract::Substantial evidence suggests that pharmacological manipulations of neural serotonin pathways influence ingestive behaviors. Despite the known role of the nucleus accumbens in directing appetitive and consummatory behavior, there has been little examination of the influences that serotonin receptors may play in modula...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0016882

    authors: Pratt WE,Blackstone K,Connolly ME,Skelly MJ

    更新日期:2009-10-01 00:00:00

  • Mediodorsal thalamic lesions and Pavlovian conditioning of heart rate and eyeblink responses in the rabbit.

    abstract::Rabbits received ibotenic acid lesions of the mediodorsal nucleus of the thalamus (MD) or sham lesions. These animals were compared on 4 sessions of Pavlovian eyeblink and heart rate conditioning, in which a tone was the conditioned stimulus and a paraorbital electrical shock was the unconditioned stimulus. Lesions of...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.104.6.912

    authors: Buchanan SL,Thompson RH

    更新日期:1990-12-01 00:00:00

  • The NO/sGC/PKG signaling pathway in the NAc shell is necessary for the acquisition of morphine-induced place preference.

    abstract::There is evidence that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP-dependent protein kinase (PKG) signaling pathway in the basal lateral amygdala and hippocampus plays a key role in memory processing, but it is not known if this NO signaling pathway in the nucleus accumbens (Gomes et al., 2006), a known ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0036964

    authors: Shen F,Wang N,Qi C,Li YJ,Cui CL

    更新日期:2014-08-01 00:00:00

  • Strain differences in patterns of drug-intake during prolonged access to cocaine self-administration.

    abstract::The current study examined possible interactions between genetic factors and prolonged drug access by testing the Fischer (F344), Lewis (LEW), and Wistar rat strains in a prolonged access cocaine self-administration (SA) procedure. Before prolonged access, the strains did not differ in breakpoints for food or cocaine ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0013727

    authors: Freeman KB,Kearns DN,Kohut SJ,Riley AL

    更新日期:2009-02-01 00:00:00

  • Anterior rhinal cortex and amygdala: dissociation of their contributions to memory and food preference in rhesus monkeys.

    abstract::Rhesus monkeys were trained on 2 versions of delayed nonmatching-to-sample, one with multiple pairs of objects and the other with a single pair, to evaluate their ability to remember objects. They then received either bilateral aspiration lesions of the anterior rhinal cortex or bilateral excitotoxic lesions of the am...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Murray EA,Gaffan EA,Flint RW Jr

    更新日期:1996-02-01 00:00:00

  • Memory of rats with amygdala lesions induced 30 days after footshock-motivated escape training reflects degree of original training.

    abstract::This experiment was conducted to determine whether the amount of preoperative training influences the effects, on retention, of amygdala lesions induced 30 days after escape training. Rats received 1 or 10 footshock-motivated escape training trials; 30 days later, sham or neurotoxic amygdala lesions were induced. Resu...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.6.1080

    authors: Parent MB,West M,McGaugh JL

    更新日期:1994-12-01 00:00:00

  • Maternity: neural mechanisms, motivational processes, and physiological adaptations.

    abstract::This review focuses on research on both the neural substrate of maternal responsiveness and on the physiological, behavioral, and motivational adaptations to the maternal state. The female's response to her young is presented as a model motivational system and the mechanisms and neural circuitry through which the medi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.1037/a0021548

    authors: Numan M,Woodside B

    更新日期:2010-12-01 00:00:00

  • Effects of exposure to stressors of varying predictability on adrenal function in rats.

    abstract::For 5 days, rats were exposed to shocks that were signalled by a light 0, 33, 66, or 100% of the time. Basal hormone levels and responses to a light-shock pair were measured daily. Greater predictability was associated with higher basal plasma corticosterone and norepinephrine levels indicative of chronic stress. Habi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.4.767

    authors: Pitman DL,Natelson BH,Ottenweller JE,McCarty R,Pritzel T,Tapp WN

    更新日期:1995-08-01 00:00:00

  • Effects of hydrocortisone on false memory recognition in healthy men and women.

    abstract::Most of the studies focusing on the effect of stress on false memories by using psychosocial and physiological stressors yielded diverse results. In the present study, we systematically tested the effect of exogenous hydrocortisone using a false memory paradigm. In this placebo-controlled study, 37 healthy men and 38 ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000170

    authors: Duesenberg M,Weber J,Schaeuffele C,Fleischer J,Hellmann-Regen J,Roepke S,Moritz S,Otte C,Wingenfeld K

    更新日期:2016-12-01 00:00:00

  • Functional consequences of embryonic neocortex transplanted to rats with prefrontal cortex lesions.

    abstract::In four experiments we reexamined the recent report by Labbe, Firl, Mufson, and Stein (1983) that fetal cortical tissue transplanted to an aspirative prefrontal cortical cavity in rats can ameliorate the learning impairments induced by the aspirative lesions. Healthy surviving grafts from young (E16) embryonic donors ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.4.489

    authors: Dunnett SB,Ryan CN,Levin PD,Reynolds M,Bunch ST

    更新日期:1987-08-01 00:00:00

  • Cortical responses in rats predict perceptual sensitivities to complex sounds.

    abstract::The common assumption that perceptual sensitivities are related to neural representations of sensory stimuli has seldom been directly demonstrated. The authors analyzed the similarity of spike trains evoked by complex sounds in the rat auditory cortex and related cortical responses to performance in an auditory task. ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.1.256

    authors: Orduña I,Mercado E 3rd,Gluck MA,Merzenich MM

    更新日期:2005-02-01 00:00:00

  • Bilateral lesions of the interpositus nucleus completely prevent eyeblink conditioning in Purkinje cell-degeneration mutant mice.

    abstract::The authors have previously demonstrated that Purkinje cell-degeneration (pcd) mutant mice are impaired in eyeblink conditioning (L. Chen et al., 1996a). The present study addresses the following 3 questions: (a) whether pcd mice perceive the conditioned and unconditioned stimuli as well as the wild-type mice, (b) whe...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.113.1.204

    authors: Chen L,Bao S,Thompson RF

    更新日期:1999-02-01 00:00:00

  • Sustained potential shifts in the toad tectum reflect prey-catching and avoidance behavior.

    abstract::Sustained potential shifts (SPS) were recorded for 10 s from the surface of the optic tectum of toads presented with live prey and moving artificial prey stimuli. On the anterior tectal surface, a negative SPS was followed by a positive wave; the converse was true for the posterior tectum. Some animals were immobilize...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.1.150

    authors: Laming PR,Ocherashvili IV,Nicol AU,Roughan JV,Laming BA

    更新日期:1995-02-01 00:00:00

  • Effect of dopamine-depleting brain lesions in rat pups: role of striatal serotonergic neurons in behavior.

    abstract::Previous results from our laboratory have demonstrated that 3-day-old rats given dopamine (DA)-depleting brain lesions are spared the severe behavioral dysfunctions seen after comparable brain damage in adults. This behavioral sparing is accompanied by a sprouting of serotonin (5-HT)-containing neurons in the striatum...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.6.806

    authors: Bruno JP,Jackson D,Zigmond MJ,Stricker EM

    更新日期:1987-12-01 00:00:00

  • Exploration, anxiety, and spatial memory in transgenic anophthalmic mice.

    abstract::Contradictory results are found in the literature concerning the role of vision in the perception of space or in spatial navigation, in part because of the lack of murine models of total blindness used so far. The authors evaluated the spatial abilities of anophthalmic transgenic mice. These mice did not differ qualit...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Buhot MC,Dubayle D,Malleret G,Javerzat S,Segu L

    更新日期:2001-04-01 00:00:00

  • Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olfactory processing in schizophrenia.

    abstract::The catechol-O-methyltransferase (COMT) val158met polymorphism has received attention in schizophrenia due to its role in prefrontal dopamine catabolism. Given the rich dopaminergic innervations of the olfactory bulb and the influence of dopamine on the transmission of olfactory signals, the authors examined the influ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0026466

    authors: Kamath V,Moberg PJ,Gur RE,Doty RL,Turetsky BI

    更新日期:2012-02-01 00:00:00

  • Strychnine increases acoustic startle amplitude but does not alter short-term or long-term habituation.

    abstract::Theories of habituation have included an increase in postsynaptic inhibition as one possible mechanism underlying response decrement following repetitive stimulus presentation. In this study, the glycine antagonist strychnine (1.0 mg/kg, ip, 10 min pretreatment) was used to investigate the involvement of glycinergic n...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.6.955

    authors: Kehne JH,Davis M

    更新日期:1984-12-01 00:00:00

  • Sex versus sweet: opposite effects of opioid drugs on the reward of sucrose and sexual pheromones.

    abstract::Endogenous opioids mediate some reward processes involving both natural (food, sweet taste) and artificial (morphine, heroin) rewards. In contrast, sexual behavior (which is also reinforcing) is generally inhibited by opioids. To establish the role of endogenous opioids for a newly described natural reinforcer, namely...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.2.416

    authors: Agustín-Pavón C,Martínez-Ricós J,Martínez-García F,Lanuza E

    更新日期:2008-04-01 00:00:00

  • A small amount of wheel running facilitates eating in nondeprived rats.

    abstract::A high level of dopaminergic activation such as that produced by a high dose of amphetamine suppresses eating, whereas a low level such as that produced by a low dose can have the opposite effect. Like a high dose of amphetamine, a high level of wheel running also suppresses eating. It was hypothesized that this suppr...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.6.1492

    authors: Lett BT,Grant VL,Gaborko LL

    更新日期:1996-12-01 00:00:00

  • Interactive contributions of intracellular calcium and protein phosphatases to massed-trials learning deficits in Hermissenda.

    abstract::Using Hermissenda as subjects, massed-trials training deficits were examined. Associative pairings of light and rotation induced a progressively greater conditioned foot contraction in response to light as the intertrial interval (ITI) was extended (up to 8 min). In contrast, a short ITI (30 s) produced no evidence of...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.113.1.103

    authors: Muzzio IA,Ramirez RR,Talk AC,Matzel LD

    更新日期:1999-02-01 00:00:00

  • Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses.

    abstract::New Zealand male rabbits (Oryctolagus cuniculus) were trained on a trace eyeblink conditioning paradigm using a 250-ms tone conditioned stimulus, a 100-ms airpuff unconditioned stimulus, and a 500-ms trace interval. Rabbits received bilateral hippocampal aspirations either 1 day or 1 month after learning. Controls con...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.2.195

    authors: Kim JJ,Clark RE,Thompson RF

    更新日期:1995-04-01 00:00:00

  • Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.

    abstract::The neurexins are a family of presynaptic cell adhesion molecules. Human genetic studies have found heterozygous deletions affecting NRXN1 and NRXN2, encoding α-neurexin I (Nrxn1α) and α-neurexin II (Nrxn2α), in individuals with autism spectrum disorders and schizophrenia. However, the link between α-neurexin deficien...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000108

    authors: Dachtler J,Ivorra JL,Rowland TE,Lever C,Rodgers RJ,Clapcote SJ

    更新日期:2015-12-01 00:00:00

  • Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster).

    abstract::Male prairie voles (Microtus ochrogaster) form a pair bond with a female partner after mating, and this behavior is regulated by the neuropeptide vasopressin (AVP). The authors report that AVP in the lateral septum is important for pair bond formation. Administration of an AVP V1a receptor antagonist in the lateral se...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.115.4.910

    authors: Liu Y,Curtis JT,Wang Z

    更新日期:2001-08-01 00:00:00