Abstract:
:Withdrawal from an escalating-dose, bingelike regimen of cocaine administration in rats produced significantly depressed levels of locomotor activity during the nocturnal portion of the day-night cycle. This effect was observed during the first 48 hr of testing. Extracellular single-unit recordings of ventral tegmental area (VTA) dopamine (DA) neurons revealed no differences between saline- and cocaine-treated rats with respect to basal firing rates. However, significantly fewer spontaneously active VTA DA neurons were encountered in rats withdrawn from binge cocaine. As with the nocturnal hypoactivity, this effect was observed only during the first 48 hr of withdrawal. These findings suggest that short-term DA neuron dysfunction during cocaine withdrawal temporally corresponds to behavioral disruptions that are similar to those described in human addicts.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Koeltzow TE,White FJdoi
10.1037/0735-7044.117.4.860subject
Has Abstractpub_date
2003-08-01 00:00:00pages
860-5issue
4eissn
0735-7044issn
1939-0084journal_volume
117pub_type
杂志文章abstract::Mother rabbits nurse once daily with circadian periodicity. The authors investigated brain structures involved in regulating this activity by quantifying c-FOS-immunoreactive (IR) cells in the forebrain of: (1) mothers killed on postpartum Day 1 (PPD 1) after nursing (Group 1) or not given pups (Group 2); (2) mothers ...
journal_title:Behavioral neuroscience
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更新日期:2004-02-01 00:00:00
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pub_type: 评论,杂志文章
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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更新日期:2020-10-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.116.2.351
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更新日期:1995-06-01 00:00:00
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更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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更新日期:2012-02-01 00:00:00
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journal_title:Behavioral neuroscience
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