Abstract:
:This study examined the relative roles of distinct striatal areas in response processing. Rats were trained on a reaction time task that enabled performance on each side of the rat's body to be assessed independently. Rats then received unilateral lesions of the whole dorsal striatum or restricted medial or lateral lesions. Both medial and lateral lesions induced a response bias in contralateral space, but this bias was less severe in rats with medial lesions. Medial striatal lesions led to an increase in premature responses. Lateral striatal lesions produced an increase in late responses. It is suggested that the lateral striatum mediates the selection of responses, and the medial striatum acts to influence inhibitory control over responding. Discrete striatal areas are thus functionally dissociable, but both have a crucial role in the organization of responding in space.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Brasted PJ,Robbins TW,Dunnett SBdoi
10.1037//0735-7044.113.2.253subject
Has Abstractpub_date
1999-04-01 00:00:00pages
253-64issue
2eissn
0735-7044issn
1939-0084journal_volume
113pub_type
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