3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro.

abstract：:Hepatitis delta virus (HDV) replicates by RNA-dependent RNA synthesis according to a double rolling circle model. Also synthesized during replication is a 0.8-kb, polyadenylated mRNA encoding the hepatitis delta antigen (HDAg). It has been proposed that this mRNA species represents the initial product of HDV RNA repli...

journal_title：Journal of virology

authors： Modahl LE,Lai MM

更新日期：1998-07-01 00:00:00

abstract：:Infection of monkey cells with human adenovirus (Ad) is abortive, but the infection can be enhanced by coinfecting with simian virus 40 (SV40). However, in the coinfected monkey cells, Ad interferes strongly with SV40 DNA biosynthesis. This interference was found to be a reproducible, delicately controlled phenomenon ...

journal_title：Journal of virology

authors： van Roy F,Fiers W

更新日期：1978-08-01 00:00:00

abstract：:Thogoto virus (THOV) is a tick-transmitted orthomyxovirus with a genome consisting of six negative-stranded RNA segments. To rescue a recombinant THOV, the viral structural proteins were produced from expression plasmids by means of a vaccinia virus expressing the T7 RNA polymerase. Genomic virus RNAs (vRNAs) were gen...

journal_title：Journal of virology

authors： Wagner E,Engelhardt OG,Gruber S,Haller O,Kochs G

更新日期：2001-10-01 00:00:00

abstract：UNLABELLED:The possibility that vaccination with adenovirus (AdV) vectors increased mucosal T cell activation remains a central hypothesis to explain the potential enhancement of HIV acquisition within the Step trial. Modeling this within rhesus macaques is complicated because human adenoviruses, including human adenov...

journal_title：Journal of virology

authors： Bukh I,Calcedo R,Roy S,Carnathan DG,Grant R,Qin Q,Boyd S,Ratcliffe SJ,Veeder CL,Bellamy SL,Betts MR,Wilson JM

更新日期：2014-08-01 00:00:00

abstract：:Human herpesviruses encode posttranscriptional activators that are believed to up-regulate viral replication by facilitating early and late gene expression. We have reported previously that the Epstein-Barr virus protein EB2 (also called M or SM) promotes nuclear export of RNAs that are poor substrates for spliceosome...

journal_title：Journal of virology

authors： Farjot G,Buisson M,Duc Dodon M,Gazzolo L,Sergeant A,Mikaelian I

更新日期：2000-07-01 00:00:00

abstract：:Hemorrhagic enteritis virus (HEV), a type II avian adenovirus, causes intestinal hemorrhages and immunosuppression in turkeys. In this study, we exposed turkeys to virulent HEV and examined fractionated spleen cells for the presence of viral DNA by in situ hybridization and amplification of DNA extracted from virus-in...

journal_title：Journal of virology

authors： Suresh M,Sharma JM

更新日期：1996-01-01 00:00:00

abstract：UNLABELLED:Venezuelan equine encephalitis virus (VEEV) is an important human and animal pathogen, for which no safe and efficient vaccines or therapeutic means have been developed. Viral particle assembly and budding processes represent potential targets for therapeutic intervention. However, our understanding of the m...

journal_title：Journal of virology

authors： Reynaud JM,Lulla V,Kim DY,Frolova EI,Frolov I

更新日期：2015-12-09 00:00:00

abstract：:The major adenovirus (Ad) capsid proteins hexon, penton, and fiber influence the efficiency and tropism of gene transduction by Ad vectors. Fiber is the high-affinity receptor binding protein that serves to mediate cell attachment in vitro when using coxsackie-adenovirus receptor (CAR)-containing cell lines. This cont...

journal_title：Journal of virology

authors： Schoggins JW,Nociari M,Philpott N,Falck-Pedersen E

更新日期：2005-09-01 00:00:00

abstract：:DNA replication intermediates of three plasmids containing all or part of a modified Epstein-Barr virus cis-acting plasmid maintenance region (oriP) were examined to further investigate oriP function. Replication intermediates were analyzed in vivo and in vitro by neutral-neutral two-dimensional gel electrophoresis. T...

journal_title：Journal of virology

authors： Platt TH,Tcherepanova IY,Schildkraut CL

更新日期：1993-03-01 00:00:00

abstract：:We have established a genetic assay for the multimerization of retroviral gag polyproteins. This assay is based on the GAL4 two-hybrid system for studying protein-protein interactions (S. Fields and O. Song, Nature (London) 340:245-246, 1989). In our initial experiments, we generated Saccharomyces cerevisiae plasmids ...

journal_title：Journal of virology

authors： Luban J,Alin KB,Bossolt KL,Humaran T,Goff SP

更新日期：1992-08-01 00:00:00

abstract：:Human immunodeficiency virus infection in humans and simian immunodeficiency virus (SIV) infection in rhesus macaques (RM) leads to a generalized loss of immune responses involving perturbations in T-cell receptor (TCR) signaling. In contrast, naturally SIV-infected sooty mangabeys (SM) remain asymptomatic and retain ...

journal_title：Journal of virology

authors： Bostik P,Wu P,Dodd GL,Villinger F,Mayne AE,Bostik V,Grimm BD,Robinson D,Kung HJ,Ansari AA

更新日期：2001-12-01 00:00:00

abstract：:Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immuniz...

journal_title：Journal of virology

authors： Lewis AJ,Whitton JL,Hatalski CG,Weissenböck H,Lipkin WI

更新日期：1999-03-01 00:00:00

abstract：:N(pro) is a multifunctional autoprotease unique to pestiviruses. The interacting partners of the N(pro) protein of classical swine fever virus (CSFV), a swine pestivirus, have been insufficiently defined. Using a yeast two-hybrid screen, we identified poly(C)-binding protein 1 (PCBP1) as a novel interacting partner of...

journal_title：Journal of virology

authors： Li D,Li S,Sun Y,Dong H,Li Y,Zhao B,Guo D,Weng C,Qiu HJ

更新日期：2013-02-01 00:00:00

abstract：:A vigorous expansion of antigen-specific CD8(+) T cells lacking apparent effector function was observed in a rhesus macaque acutely infected with the simian immunodeficiency virus (SIV) strain SIVmac239. Antigen-specific CD8(+) T cells were identified using antigenic-peptide class I major histocompatibility complex te...

journal_title：Journal of virology

authors： Xiong Y,Luscher MA,Altman JD,Hulsey M,Robinson HL,Ostrowski M,Barber BH,MacDonald KS

更新日期：2001-03-01 00:00:00

abstract：:Analyses of prototype vesicular stomatitis (VSV, Indiana serotype) mRNA-32P-labeled viral RNA duplexes have established the assignments of 65 of the 72 large oligonucleotides that are recovered by two-dimensional electrophoresis of RNase T1 digests of the viral RNA. Fifty of the oligonucleotides are recovered in the L...

journal_title：Journal of virology

authors： Clewley JP,Bishop DH

更新日期：1979-04-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) is transmitted through a viral synapse and enters target cells via interaction with the glucose transporter GLUT1. Here, we show that Neuropilin-1 (NRP1), the receptor for semaphorin-3A and VEGF-A165 and a member of the immune synapse, is also a physical and functional p...

journal_title：Journal of virology

authors： Ghez D,Lepelletier Y,Lambert S,Fourneau JM,Blot V,Janvier S,Arnulf B,van Endert PM,Heveker N,Pique C,Hermine O

更新日期：2006-07-01 00:00:00

abstract：:Strains of Sindbis virus differ in their virulence for mice of different ages; this variation is related in large part to variations in the amino acid compositions of E1 and E2, the surface glycoproteins. The comparative pathogenesis of Sindbis virus strains which are virulent or avirulent for newborn mice has not bee...

journal_title：Journal of virology

authors： Sherman LA,Griffin DE

更新日期：1990-05-01 00:00:00

abstract：:Two chimpanzees immunized with woodchuck hepatitis virus (WHV) surface antigen (WHsAg) developed antibodies cross-reactive with hepatitis B virus (HBV) surface antigen (HBsAg). After challenge with HBV, one animal was completely protected and the other experienced a subclinical infection, without evidence of liver dis...

journal_title：Journal of virology

authors： Cote PJ,Shapiro M,Engle RE,Popper H,Purcell RH,Gerin JL

更新日期：1986-12-01 00:00:00

abstract：:The immediate-early gene ie2 of murine cytomegalovirus was characterized. The 1.75-kb ie2 transcript is spliced from three exons, of 78, 124, and 1,283 nucleotides, which are separated by introns of 1,245 and 364 nucleotides. An ATG codon located in the third exon leads into an open reading frame of 391 codons. Immedi...

journal_title：Journal of virology

authors： Messerle M,Keil GM,Koszinowski UH

更新日期：1991-03-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV68) infection of mice provides a tractable small-animal system for assessing viral requirements for establishment of and reactivation from latency. The M2 gene product has no homology to any known proteins but has been shown to play a role in both the establishment of MHV68 latency and r...

journal_title：Journal of virology

authors： DeZalia M,Speck SH

更新日期：2008-08-01 00:00:00

abstract：:Passive administration of porcine reproductive and respiratory syndrome virus (PRRSV) neutralizing antibodies (NAbs) can effectively protect pigs against PRRSV infection. However, after PRRSV infection, pigs typically develop a weak and deferred NAb response. One major reason for such a meager NAb response is the phen...

journal_title：Journal of virology

authors： Vu HL,Kwon B,Yoon KJ,Laegreid WW,Pattnaik AK,Osorio FA

更新日期：2011-06-01 00:00:00

abstract：:Multimerization of the Hantaan virus nucleocapsid protein (NP) in Hantaan virus-infected Vero E6 cells was observed in a competitive enzyme-linked immunosorbent assay (ELISA). Recombinant and truncated NPs of Hantaan, Seoul, and Dobrava viruses lacking the N-terminal 49 amino acids were also detected as multimers. Alt...

journal_title：Journal of virology

authors： Yoshimatsu K,Lee BH,Araki K,Morimatsu M,Ogino M,Ebihara H,Arikawa J

更新日期：2003-01-01 00:00:00

abstract：:Mice were infected with lymphocytic choriomeningitis virus and injected once 24 h later with a monoclonal antibody directed against gamma interferon. In comparison with controls, the increase of numbers of CD8+ T cells and the generation of virus-specific cytotoxic T lymphocytes in spleens and virus clearance from org...

journal_title：Journal of virology

authors： Utermöhlen O,Dangel A,Tárnok A,Lehmann-Grube F

更新日期：1996-03-01 00:00:00

abstract：:S-Adenosylhomocysteine was found to have no effect on Epstein-Barr virus-induced transformation of B-lymphocytes and to stimulate viral capsid antigen expression only slightly in the FF41-1 cell line. In contrast, the S-adenosylhomocysteine analogs sinefungin and S-isobutyladenosine inhibited Epstein-Barr virus transf...

journal_title：Journal of virology

authors： Long WK,Fronko GE,Lindemeyer RG,Wu B,Henderson EE

更新日期：1987-01-01 00:00:00

abstract：:Prion diseases are progressive fatal neurodegenerative illnesses caused by the accumulation of transmissible abnormal prion protein (PrP). To find treatments for prion diseases, we searched for substances from natural resources that inhibit abnormal PrP formation in prion-infected cells. We found that high-molecular-w...

journal_title：Journal of virology

authors： Hamanaka T,Nishizawa K,Sakasegawa Y,Oguma A,Teruya K,Kurahashi H,Hara H,Sakaguchi S,Doh-Ura K

更新日期：2017-02-28 00:00:00

abstract：:Repeated passages of vaccinia virus in increasing concentrations of hydroxyurea followed by plaque purification resulted in the isolation of variants capable of growth in 5 mM hydroxyurea, a drug concentration which inhibited the reproduction of wild-type vaccinia virus 1,000-fold. Analyses of viral protein synthesis ...

journal_title：Journal of virology

authors： Slabaugh MB,Mathews CK

更新日期：1986-11-01 00:00:00

abstract：:We have developed a means to identify genes associated with particular aspects of virulence. By beginning with an avirulent deletion mutant of rabbitpox virus and systematically reintroducing overlapping segments of the deleted region, we have identified two regions of the viral genome associated with increased virule...

journal_title：Journal of virology

authors： Bloom DC,Edwards KM,Hager C,Moyer RW

更新日期：1991-03-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) subtype C viruses have been found to almost exclusively use the chemokine receptor CCR5 as a coreceptor for entry, even in patients with advanced AIDS. We have characterized subtype C virus isolates from 28 patients from Harare, Zimbabwe, 20 of whom were receiving antiretrov...

journal_title：Journal of virology

authors： Johnston ER,Zijenah LS,Mutetwa S,Kantor R,Kittinunvorakoon C,Katzenstein DA

更新日期：2003-07-01 00:00:00

abstract：:An in vitro assay was developed to investigate endonuclease activity of Thogoto virus, a tick-borne orthomyxovirus. Endonuclease activity relied on an interaction between the 3' and 5' termini of virion RNA (vRNA) and not those of cRNA. Evidence was obtained that cap structures are cleaved directly from cap donors and...

journal_title：Journal of virology

authors： Leahy MB,Dessens JT,Pritlove DC,Nuttall PA

更新日期：1998-03-01 00:00:00

abstract：:Measles virus (MV) isolated in B95a cells, a marmoset B-cell line, retains full pathogenicity for cynomolgus monkeys, while its derivative obtained by adaptation to the growth in Vero cells, a monkey kidney cell line, loses the pathogenic potential (F. Kobune, H. Sakata, and A. Sugiura, J. Virol. 64:700-705, 1990). He...

journal_title：Journal of virology

authors： Takeda M,Kato A,Kobune F,Sakata H,Li Y,Shioda T,Sakai Y,Asakawa M,Nagai Y

更新日期：1998-11-01 00:00:00