Structure and expression of murine cytomegalovirus immediate-early gene 2.

abstract：:The cloned murine cytolytic T-lymphocyte line IE1-IL and several sublines detect a murine cytomegalovirus immediate-early (IE) membrane determinant in conjunction with Ld class I major histocompatibility glycoprotein. The lines retained cytolytic activity, strict antigen specificity, and self-restriction even when ada...

journal_title：Journal of virology

authors： Reddehase MJ,Fibi MR,Keil GM,Koszinowski UH

更新日期：1986-12-01 00:00:00

abstract：:Despite successful antiretroviral therapy (ART), low-level viremia (LLV) may be intermittently detected in most HIV-infected patients. Longitudinal blood plasma and resting CD4(+) T cells were obtained from two patients on suppressive ART to investigate the source of LLV. Single-genome sequencing of HIV-1 env from LLV...

journal_title：Journal of virology

authors： Anderson JA,Archin NM,Ince W,Parker D,Wiegand A,Coffin JM,Kuruc J,Eron J,Swanstrom R,Margolis DM

更新日期：2011-05-01 00:00:00

abstract：:We have demonstrated that intracellular forms of NOTCH1 transactivate two major Epstein-Barr virus (EBV) latent promoters, the LMP1 and Cp1 promoters in an EBV-negative B-cell line, BJAB. Truncated intracellular NOTCH1 associated with the nuclear membrane (DeltaE) transactivates the LMP1 promoter fivefold; however, th...

journal_title：Journal of virology

authors： Cotter M,Callahan J,Aster J,Robertson E

更新日期：2000-02-01 00:00:00

abstract：:Toroviruses (family Coronaviridae, order Nidovirales) are enveloped, positive-stranded RNA viruses that have been implicated in enteric disease in cattle and possibly in humans. Despite their potential veterinary and clinical relevance, little is known about torovirus epidemiology and molecular genetics. Here, we pres...

journal_title：Journal of virology

authors： Smits SL,Lavazza A,Matiz K,Horzinek MC,Koopmans MP,de Groot RJ

更新日期：2003-09-01 00:00:00

abstract：UNLABELLED:The positive-sense RNA genome of Sweet potato feathery mottle virus (SPFMV) (genus Potyvirus, family Potyviridae) contains a large open reading frame (ORF) of 3,494 codons translatable as a polyprotein and two embedded shorter ORFs in the -1 frame: PISPO, of 230 codons, and PIPO, of 66 codons, located in the...

journal_title：Journal of virology

authors： Mingot A,Valli A,Rodamilans B,San León D,Baulcombe DC,García JA,López-Moya JJ

更新日期：2016-01-20 00:00:00

abstract：:Apoptosis of neurons and astrocytes is induced by human immunodeficiency type 1 (HIV-1) infection in vitro and has been demonstrated in brain tissue from patients with AIDS. We analyzed a panel of diverse HIV-1 primary isolates for the ability to replicate and induce neuronal and astrocyte apoptosis in primary human b...

journal_title：Journal of virology

authors： Ohagen A,Ghosh S,He J,Huang K,Chen Y,Yuan M,Osathanondh R,Gartner S,Shi B,Shaw G,Gabuzda D

更新日期：1999-02-01 00:00:00

abstract：:Mammalian cells infected with human adenoviruses (Ads) undergo an apoptotic response as a result of expression of the viral E1A proteins, and this process is suppressed by the viral E1B-19K protein. The intermediary steps in the Ad-induced apoptosis pathway are not fully resolved. The apical step in the canonical mamm...

journal_title：Journal of virology

authors： Subramanian T,Vijayalingam S,Lomonosova E,Zhao LJ,Chinnadurai G

更新日期：2007-10-01 00:00:00

abstract：:We present data that retroviral gene expression in early hematopoietic cells is subjected to transcriptional controls similar to those previously described for embryonic stem cells. Transient transfection experiments revealed that both the viral enhancer region in the U3 region of the long terminal repeat as well as a...

journal_title：Journal of virology

authors： Baum C,Hegewisch-Becker S,Eckert HG,Stocking C,Ostertag W

更新日期：1995-12-01 00:00:00

abstract：:The T-helper cell response to the internal proteins of rabies virus was investigated. The rabies virus nucleoprotein was shown to be a major target antigen for T-helper cells that cross-react between rabies and rabies-related viruses. T-helper cells were assayed in vitro by testing virus-induced lymphocytes for lympho...

journal_title：Journal of virology

authors： Ertl HC,Dietzschold B,Gore M,Otvos L Jr,Larson JK,Wunner WH,Koprowski H

更新日期：1989-07-01 00:00:00

abstract：:Integration of viral DNA into the host chromosome is an essential step in the life cycle of retroviruses and is facilitated by the viral integrase enzyme. The first generation of integrase inhibitors recently approved or currently in late-stage clinical trials shows great promise for the treatment of human immunodefic...

journal_title：Journal of virology

authors： Goethals O,Clayton R,Van Ginderen M,Vereycken I,Wagemans E,Geluykens P,Dockx K,Strijbos R,Smits V,Vos A,Meersseman G,Jochmans D,Vermeire K,Schols D,Hallenberger S,Hertogs K

更新日期：2008-11-01 00:00:00

abstract：:An R638A mutation of the polymerase acidic protein (PA) subunit of the RNA polymerase of influenza A/WSN/33 virus results in severe attenuation of viral growth in cell culture by promoting the synthesis of defective interfering RNAs. We propose that R638A is an "elongation" mutant that destabilizes PA-RNA template int...

journal_title：Journal of virology

authors： Fodor E,Mingay LJ,Crow M,Deng T,Brownlee GG

更新日期：2003-04-01 00:00:00

abstract：:To determine mechanisms by which persistent viral infections are established and maintained, we initiated persistent infections of murine erythroleukemia (MEL) cells by using reovirus strains type 3 Abney and type 3 Dearing. Establishment of persistent reovirus infections of MEL cells was not associated with a signifi...

journal_title：Journal of virology

authors： Wetzel JD,Chappell JD,Fogo AB,Dermody TS

更新日期：1997-01-01 00:00:00

abstract：:S-Adenosylhomocysteine was found to have no effect on Epstein-Barr virus-induced transformation of B-lymphocytes and to stimulate viral capsid antigen expression only slightly in the FF41-1 cell line. In contrast, the S-adenosylhomocysteine analogs sinefungin and S-isobutyladenosine inhibited Epstein-Barr virus transf...

journal_title：Journal of virology

authors： Long WK,Fronko GE,Lindemeyer RG,Wu B,Henderson EE

更新日期：1987-01-01 00:00:00

abstract：:Adult T-cell leukemia (ATL) occurs in a small population of human T-cell leukemia virus type 1 (HTLV-1)-infected individuals. Although the critical risk factor for ATL development is not clear, it has been noted that ATL is incidentally associated with mother-to-child infection, elevated proviral loads, and weakness i...

journal_title：Journal of virology

authors： Hasegawa A,Ohashi T,Hanabuchi S,Kato H,Takemura F,Masuda T,Kannagi M

更新日期：2003-03-01 00:00:00

abstract：:Animal influenza viruses pose a clear threat to public health. Transmissibility among humans is a prerequisite for a novel influenza virus to cause a human pandemic. A novel reassortant swine influenza virus acquired sustained human-to-human transmissibility and caused the 2009 influenza pandemic. However, the molecul...

journal_title：Journal of virology

authors： Zhang Y,Zhang Q,Gao Y,He X,Kong H,Jiang Y,Guan Y,Xia X,Shu Y,Kawaoka Y,Bu Z,Chen H

更新日期：2012-09-01 00:00:00

abstract：:Detailed phylogenetic analyses were performed to characterize an HIV-1 outbreak among injection drug users (IDUs) in Stockholm, Sweden, in 2006. This study investigated the source and dynamics of HIV-1 spread during the outbreak as well as associated demographic and clinical factors. Seventy Swedish IDUs diagnosed dur...

journal_title：Journal of virology

authors： Skar H,Axelsson M,Berggren I,Thalme A,Gyllensten K,Liitsola K,Brummer-Korvenkontio H,Kivelä P,Spångberg E,Leitner T,Albert J

更新日期：2011-01-01 00:00:00

abstract：:Respiratory syncytial (RS) virus infects the epithelium of the respiratory tract. We examined the replication and maturation of RS virus in two polarized epithelial cell lines, Vero C1008 and MDCK. Electron microscopy of RS virus-infected Vero C1008 cells revealed the presence of pleomorphic viral particles budding ex...

journal_title：Journal of virology

authors： Roberts SR,Compans RW,Wertz GW

更新日期：1995-04-01 00:00:00

abstract：:Spatial variation in the epidemiological patterns of successive waves of pandemic influenza virus in humans has been documented throughout the 20th century but never understood at a molecular level. However, the unprecedented intensity of sampling and whole-genome sequencing of the H1N1/09 pandemic virus now makes suc...

journal_title：Journal of virology

authors： Nelson MI,Tan Y,Ghedin E,Wentworth DE,St George K,Edelman L,Beck ET,Fan J,Lam TT,Kumar S,Spiro DJ,Simonsen L,Viboud C,Holmes EC,Henrickson KJ,Musser JM

更新日期：2011-01-01 00:00:00

abstract：:Current knowledge of human immunodeficiency virus type 1 envelope (Env) glycoprotein structure and function is based on studies of clade B viruses. We present evidence of sequence and structural differences in viral glycoprotein gp120 between clades B and C. In clade C, the C3 region alpha2-helix exhibits high sequenc...

journal_title：Journal of virology

authors： Gnanakaran S,Lang D,Daniels M,Bhattacharya T,Derdeyn CA,Korber B

更新日期：2007-05-01 00:00:00

abstract：:Treatment of Friend erythroleukemia cells (FLC) with gamma interferon (IFN-gamma) in the presence of anti-IFN-beta antibodies reduces the effectiveness of the antiviral state and the induction of 2'-5'-oligoadenylate synthetase activity, indicating that the antiviral activity of IFN-gamma in FLC is in part mediated by...

journal_title：Journal of virology

authors： Marziali G,Fiorucci G,Coccia EM,Percario Z,Raber J,Battistini A,Rossi GB,Affabris E,Romeo G

更新日期：1991-08-01 00:00:00

abstract：:The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) produces multiple mRNAs through differential splicing and polyadenylation. Reverse transcriptase PCR was used to characterize transcripts from exons 1, 2, 3, and 4 (immediate-early 1 [IE1]). The expected IE72 and IE19 mRNAs were detected, as well as ...

journal_title：Journal of virology

authors： Awasthi S,Isler JA,Alwine JC

更新日期：2004-08-01 00:00:00

abstract：:The adenovirus E1A transforming region, which encodes immortalization, partial cell transformation, and gene activation functions, expresses two early mRNAs, 13S and 12S. Multiple-T antigen species with different electrophoretic mobilities are formed from each mRNA, presumably by unknown posttranslational modification...

journal_title：Journal of virology

authors： Lucher LA,Brackmann KH,Symington JS,Green M

更新日期：1986-05-01 00:00:00

abstract：:Primary HIV-1 infection (PHI) is marked by a flu-like syndrome and high levels of viremia that decrease to a viral set point with the first emergence of virus-specific CD8+ T-cell responses. Here, we investigated in a large cohort of 527 subjects the immunodominance pattern of the first virus-specific cytotoxic T-lymp...

journal_title：Journal of virology

authors： Streeck H,Jolin JS,Qi Y,Yassine-Diab B,Johnson RC,Kwon DS,Addo MM,Brumme C,Routy JP,Little S,Jessen HK,Kelleher AD,Hecht FM,Sekaly RP,Rosenberg ES,Walker BD,Carrington M,Altfeld M

更新日期：2009-08-01 00:00:00

abstract：UNLABELLED:Noroviruses are the leading cause of acute gastroenteritis outbreaks worldwide. The majority of norovirus outbreaks are caused by genogroup II.4 (GII.4). Novel GII.4 strains emerge every 2 to 4 years and replace older variants as the dominant norovirus. Novel variants emerge through a combination of recombin...

journal_title：Journal of virology

authors： Vega E,Donaldson E,Huynh J,Barclay L,Lopman B,Baric R,Chen LF,Vinjé J

更新日期：2014-12-01 00:00:00

abstract：:By pretreating simian virus 40-infected BSC-1 cells with glucosamine, [(3)H]uridine labeling of both cellular and viral RNA can be halted instantaneously by addition of cold uridine. We have studied the fate of pulse-labeled viral RNA from cells at 45 h postinfection under these conditions. During a 5-min period of la...

journal_title：Journal of virology

authors： Chiu NH,Radonovich MF,Thoren MM,Salzman NP

更新日期：1978-11-01 00:00:00

abstract：:Cells of the established MvlLu mink line spontaneously released a reverse transcriptase-containing virus after long-term passage in tissue culture. By molecular hybridization, DNA of normal mink cells was found to possess extensive nucleotide sequence homology with a reverse-transcription product of the viral genome, ...

journal_title：Journal of virology

authors： Barbacid M,Tronick SR,Aaronson SA

更新日期：1978-01-01 00:00:00

abstract：:Radioimmunoassays were developed for the 19,000, 15,000, and 12,000 molecular weight polypeptides of avian myeloblastosis virus and for the 19,000 and 12,000 polypeptides of RAV-0, a subgroup E avian tumor virus. Each polypeptide was shown to possess both group- and type-specific antigenic determinants, in contrast to...

journal_title：Journal of virology

authors： Stephenson JR,Smith EJ,Crittenden LB,Aaronson SA

更新日期：1975-07-01 00:00:00

abstract：:Most poxviruses express multiple proteins containing ankyrin (ANK) repeats accounting for a large superfamily of related but unique determinants of poxviral tropism. Recently, select members of this novel family of poxvirus proteins have drawn considerable attention for their potential roles in modulating intracellula...

journal_title：Journal of virology

authors： Werden SJ,Lanchbury J,Shattuck D,Neff C,Dufford M,McFadden G

更新日期：2009-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) reorganizes intracellular membranes to establish sites of replication. How viral and cellular proteins target, bind, and rearrange specific membranes into the replication factory remains a mystery. We used a lentivirus-based RNA interference (RNAi) screening approach to identify the potential c...

journal_title：Journal of virology

authors： Chao TC,Su WC,Huang JY,Chen YC,Jeng KS,Wang HD,Lai MM

更新日期：2012-02-01 00:00:00

abstract：:The Aichi virus 2A protein is not a protease, unlike many other picornavirus 2A proteins, and it is related to a cellular protein, H-rev107. Here, we examined the replication properties of two 2A mutants in Vero cells and a cell-free translation/replication system. In one mutant, amino acids 36 to 126 were replaced wi...

journal_title：Journal of virology

authors： Sasaki J,Taniguchi K

更新日期：2008-10-01 00:00:00