Modulation by gamma interferon of antiviral cell-mediated immune responses in vivo.

abstract：:In vitro transcriptase activity of three group I temperature-sensitive (ts) mutants of vesicular stomatitis virus restricted at 39 C was restored by L-protein fractions derived from wild-type (wt) vesicular stomatitis virion nucleo-capsids. Soluble NS protein from wt nucleocapsids did not reconstitute restricted trans...

journal_title：Journal of virology

authors： Hunt DM,Emerson SU,Wagner RR

更新日期：1976-05-01 00:00:00

abstract：:When Epstein-Barr virus (EBV) negative cells (Raji) were treated with iododeoxyuridine, only the early antigen (EA) component was induced. There was no significant increase in EBV DNA and no virus particles were observed. Somatic-cell hybrids were prepared from the fusion of Raji and D98 cells (D98/Raji). When these c...

journal_title：Journal of virology

authors： Glaser R,Nonoyama M

更新日期：1974-07-01 00:00:00

abstract：:The DNA of lymphomas from 12 AKXD recombinant inbred mouse strains was analyzed to determine the presence of somatically acquired ecotropic and mink cell focus-forming proviruses. Mink cell focus-forming proviruses were associated primarily with T-cell lymphomas, whereas ecotropic proviruses were associated with lymph...

journal_title：Journal of virology

authors： Mucenski ML,Taylor BA,Copeland NG,Jenkins NA

更新日期：1987-09-01 00:00:00

abstract：:The virion host shutoff (vhs) protein encoded by herpes simplex virus type 1 (HSV-1) destabilizes both viral and host mRNAs. An HSV-1 strain with a mutation in vhs is attenuated in virulence and induces immune responses in mice that are protective against corneal infection with virulent HSV-1, but it has the capacity ...

journal_title：Journal of virology

authors： Geiss BJ,Smith TJ,Leib DA,Morrison LA

更新日期：2000-12-01 00:00:00

abstract：:The cellular tropism of the feline immunodeficiency virus (FIV) is affected by changes in variable region 3 (V3) of the surface (SU) envelope glycoprotein (Verschoor, E. J., et al., J. Virol. 69:4752-4757, 1995). By using high-dose DNA transfection, an FIV molecular clone with a non-CRFK-tropic V3 acquired the ability...

journal_title：Journal of virology

authors： Vahlenkamp TW,Verschoor EJ,Schuurman NN,van Vliet AL,Horzinek MC,Egberink HF,de Ronde A

更新日期：1997-09-01 00:00:00

abstract：:Apoptosis is a type of controlled cell death that is essential for development and tissue homeostasis. It also serves as a robust host response against infection by many viruses. The capacity of neurotropic viruses to induce apoptosis strongly correlates with virulence. However, the precise function of apoptosis in vi...

journal_title：Journal of virology

authors： Pruijssers AJ,Hengel H,Abel TW,Dermody TS

更新日期：2013-12-01 00:00:00

abstract：:Although iridoviruses vary widely within and among genera with respect to their host range and virulence, variation within iridovirus species has been less extensively characterized. This study explores the nature and extent of intraspecific variation within an emerging iridovirus of North American warm-water fishes, ...

journal_title：Journal of virology

authors： Goldberg TL,Coleman DA,Grant EC,Inendino KR,Philipp DP

更新日期：2003-08-01 00:00:00

abstract：:The replication of positive-strand RNA viral genomes involves various cis-acting RNA sequences. Generally, regulatory RNA sequences are present at or near genomic termini; however, internal replication elements (IREs) also exist. Here we report the structural and functional characterization of an IRE present in the re...

journal_title：Journal of virology

authors： Monkewich S,Lin HX,Fabian MR,Xu W,Na H,Ray D,Chernysheva OA,Nagy PD,White KA

更新日期：2005-04-01 00:00:00

abstract：:The UL3 protein of equine herpesvirus 1 (EHV-1) KyA strain is a homolog of the ICP27 alpha regulatory protein of herpes simplex virus type 1 (HSV-1) and the ORF 4 protein of varicella-zoster virus. To characterize the regulatory function of the UL3 gene product, a UL3 gene expression vector (pSVUL3) and a vector expre...

journal_title：Journal of virology

authors： Zhao Y,Holden VR,Smith RH,O'Callaghan DJ

更新日期：1995-05-01 00:00:00

abstract：:The retroviral Gag precursor plays an important role in the assembly of virion particles. The capsid (CA) protein of the Gag molecule makes a major contribution to this process. In the crystal structure of the free CA protein of the human immunodeficiency virus type 1 (HIV-1), 11 residues of the C terminus were found ...

journal_title：Journal of virology

authors： Melamed D,Mark-Danieli M,Kenan-Eichler M,Kraus O,Castiel A,Laham N,Pupko T,Glaser F,Ben-Tal N,Bacharach E

更新日期：2004-09-01 00:00:00

abstract：:In-frame stop codons were introduced into the coding region of human immunodeficiency virus type 1 (HIV-1) transmembrane protein (gp41). Truncation of 147 amino acids from the carboxyl terminus of gp41 (TM709) significantly decreased the stability and cell surface expression of the viral Env proteins, while truncation...

journal_title：Journal of virology

authors： Yu X,Yuan X,McLane MF,Lee TH,Essex M

更新日期：1993-01-01 00:00:00

abstract：:Hepatitis delta virus (HDV) is a defective RNA virus which is dependent on hepatitis B virus for essential helper functions. Only a single highly basic phosphoprotein, HDV antigen (HDAg), is expressed by the HDV genome during infection in humans. Antibody directed to HDAg is important in the diagnosis of HDV infection...

journal_title：Journal of virology

authors： Wang JG,Jansen RW,Brown EA,Lemon SM

更新日期：1990-03-01 00:00:00

abstract：:Cottontail rabbit papillomavirus (CRPV)-induced papillomas progress at a high frequency to carcinomas and thus can serve as a model for high-cancer-risk human papillomavirus infection. Previously, we have shown that antibodies to nonstructural and structural proteins are detected in only a fraction of papilloma-bearin...

journal_title：Journal of virology

authors： Selvakumar R,Borenstein LA,Lin YL,Ahmed R,Wettstein FO

更新日期：1994-06-01 00:00:00

abstract：:We have constructed two point mutants of Rous sarcoma virus in which the amino-terminal glycine residue of the transforming protein, p60src, was changed to an alanine or a glutamic acid residue. Both mutant proteins failed to become myristylated and, more importantly, no longer transformed cells. The lack of transform...

journal_title：Journal of virology

authors： Buss JE,Kamps MP,Gould K,Sefton BM

更新日期：1986-05-01 00:00:00

abstract：UNLABELLED:Influenza virus hemagglutinin (HA) mediates virus entry by binding to cell surface receptors and fusing the viral and endosomal membranes following uptake by endocytosis. The acidic environment of endosomes triggers a large-scale conformational change in the transmembrane subunit of HA (HA2) involving a loop...

journal_title：Journal of virology

authors： Wang W,DeFeo CJ,Alvarado-Facundo E,Vassell R,Weiss CD

更新日期：2015-10-01 00:00:00

abstract：:Beyond their role in cellular RNA metabolism, DExD/H-box RNA helicases are hijacked by various RNA viruses in order to assist replication of the viral genome. Here, we identify the DExH-box RNA helicase 9 (DHX9) as a binding partner of chikungunya virus (CHIKV) nsP3 mainly interacting with the C-terminal hypervariable...

journal_title：Journal of virology

authors： Matkovic R,Bernard E,Fontanel S,Eldin P,Chazal N,Hassan Hersi D,Merits A,Péloponèse JM Jr,Briant L

更新日期：2019-02-05 00:00:00

abstract：:Most patients infected with hepatitis C virus (HCV) become chronic carriers. Viruses that efficiently establish persistent infections must have effective ways of evading host defenses. In the case of HCV, little is known about how chronic infections are established or maintained. Besides hepatocytes, several reports s...

journal_title：Journal of virology

authors： Bergqvist A,Rice CM

更新日期：2001-01-01 00:00:00

abstract：UNLABELLED:Type I IFN signaling, which is initiated through activation of the alpha interferon receptor (IFNAR), regulates the expression of proteins that are crucial contributors to immune responses. Paramyxoviruses, including human metapneumovirus (HMPV), have evolved mechanisms to inhibit IFNAR signaling, but the sp...

journal_title：Journal of virology

authors： Hastings AK,Erickson JJ,Schuster JE,Boyd KL,Tollefson SJ,Johnson M,Gilchuk P,Joyce S,Williams JV

更新日期：2015-04-01 00:00:00

abstract：:Swine influenza viruses (SIV) naturally infect pigs and can be transmitted to humans. In the pig, genetic reassortment to create novel influenza subtypes by mixing avian, human, and swine influenza viruses is possible. An SIV vaccine inducing cross-protective immunity between different subtypes and strains circulating...

journal_title：Journal of virology

authors： Richt JA,Lekcharoensuk P,Lager KM,Vincent AL,Loiacono CM,Janke BH,Wu WH,Yoon KJ,Webby RJ,Solórzano A,García-Sastre A

更新日期：2006-11-01 00:00:00

abstract：:Measles virus (MV) fusion requires the participation of both the fusion (F) and hemagglutinin (H) glycoproteins. The canine distemper virus fusion protein (CDVF) cannot substitute for the measles virus fusion protein (MVF) in this process. Introduction of restriction enzyme sites into the cDNAs of CDVF and MVF by site...

journal_title：Journal of virology

authors： Wild TF,Fayolle J,Beauverger P,Buckland R

更新日期：1994-11-01 00:00:00

abstract：:We have established a genetic assay for the multimerization of retroviral gag polyproteins. This assay is based on the GAL4 two-hybrid system for studying protein-protein interactions (S. Fields and O. Song, Nature (London) 340:245-246, 1989). In our initial experiments, we generated Saccharomyces cerevisiae plasmids ...

journal_title：Journal of virology

authors： Luban J,Alin KB,Bossolt KL,Humaran T,Goff SP

更新日期：1992-08-01 00:00:00

abstract：:The DNAs of the five nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid viruses contain overlapping segments of the early region of wild-type SV40 DNA. The complementary DNA strands of these five viruses have been separated with synthetic polyribonucleotides in isopycnic cesium chloride gradients. The relat...

journal_title：Journal of virology

authors： Patch CT,Lewis AM Jr,Levine AS

更新日期：1974-03-01 00:00:00

abstract：:The vaccinia virus Western Reserve A38L protein is a hydrophobic integral membrane glycoprotein with amino acid similarity to mammalian integrin-associated protein. The protein has an N-terminal immunoglobulin superfamily domain, followed by five membrane-spanning domains and a short cytoplasmic tail. Deletion of the ...

journal_title：Journal of virology

authors： Sanderson CM,Parkinson JE,Hollinshead M,Smith GL

更新日期：1996-02-01 00:00:00

abstract：:The structural polypeptides of purified Plodia interpunctella granulosis virus were analyzed by three different two-dimensional gel systems. Isoelectric focusing followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis allowed resolution of 53 acidic polypeptides in the enveloped nucleocapsid of the virus...

journal_title：Journal of virology

authors： Russell DL,Consigli RA

更新日期：1986-10-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) efficiently enters cells of Old World monkeys but encounters a block before reverse transcription. This restriction is mediated by a dominant repressive factor. Recently, a member of the tripartite motif (TRIM) family proteins, TRIM5alpha, was identified as a blocking factor...

journal_title：Journal of virology

authors： Nakayama EE,Miyoshi H,Nagai Y,Shioda T

更新日期：2005-07-01 00:00:00

abstract：:Residual hepatitis B virus (HBV) DNA can be detected in serum and liver after apparent recovery from transient infection. However, it is not known if this residual HBV DNA represents ongoing viral replication and antigen expression. In the current study, ducks inoculated with duck hepatitis B virus (DHBV) were monitor...

journal_title：Journal of virology

authors： Le Mire MF,Miller DS,Foster WK,Burrell CJ,Jilbert AR

更新日期：2005-10-01 00:00:00

abstract：:Suppression of interferon signaling is of paramount importance to a virus. Interferon signaling significantly reduces or halts the ability of a virus to replicate; therefore, viruses have evolved sophisticated mechanisms that suppress activation of the interferon pathway or responsiveness of the infected cell to inter...

journal_title：Journal of virology

authors： Olanubi O,Frost JR,Radko S,Pelka P

更新日期：2017-03-29 00:00:00

abstract：:Replication of the plus-stranded RNA genome of hepatitis C virus (HCV) occurs in a membrane-bound replication complex consisting of viral and cellular proteins and viral RNA. NS5B, the RNA polymerase of HCV, is anchored to the membranes via a C-terminal 20-amino-acid-long hydrophobic domain, which is flanked on each s...

journal_title：Journal of virology

authors： Lee H,Liu Y,Mejia E,Paul AV,Wimmer E

更新日期：2006-11-01 00:00:00

abstract：:Empty capsids of foot-and-mouth disease virus (FMDV) type A22 Iraq 24/64, whose structure has been solved by X-ray crystallography, are unusual for picornaviruses since they contain VP2 and VP4, the cleavage products of the protein precursor VP0. Both the N terminus of VP1 and the C terminus of VP4, which pack togethe...

journal_title：Journal of virology

authors： Curry S,Fry E,Blakemore W,Abu-Ghazaleh R,Jackson T,King A,Lea S,Newman J,Stuart D

更新日期：1997-12-01 00:00:00

abstract：:The Epstein-Barr Virus (EBV) immediate-early protein BRLF1 is one of two transactivators which mediate the switch from latent to lytic replication in EBV-infected cells. DNA viruses often modulate the function of critical cell cycle proteins to maximize the efficiency of virus replication. Here we have examined the ef...

journal_title：Journal of virology

authors： Swenson JJ,Mauser AE,Kaufmann WK,Kenney SC

更新日期：1999-08-01 00:00:00