Transcriptional activation of the interleukin-2 promoter by hepatitis C virus core protein.

abstract：:We have demonstrated that a liposomal array of well-ordered trimers enhances B cell activation, germinal center formation, and the elicitation of tier-2 autologous neutralizing antibodies. Previously, we coupled well-ordered cleavage-independent NFL trimers via their C-terminal polyhistidine tails to nickel lipids int...

journal_title：Journal of virology

authors： Bale S,Goebrecht G,Stano A,Wilson R,Ota T,Tran K,Ingale J,Zwick MB,Wyatt RT

更新日期：2017-07-27 00:00:00

abstract：:Reverse transcription in hepatitis B viruses is initiated through a unique protein priming mechanism whereby the viral reverse transcriptase (RT) first assembles into a ribonucleoprotein (RNP) complex with its RNA template and then initiates DNA synthesis de novo using the RT itself as a protein primer. RNP formation ...

journal_title：Journal of virology

authors： Hu J,Anselmo D

更新日期：2000-12-01 00:00:00

abstract：:We recently discovered an expanded family of adeno-associated viruses (AAVs) that show promise as improved gene therapy vectors. In this study we evaluated the potential of vectors based on several of these novel AAVs as vaccine carriers for human immunodeficiency virus type 1 Gag. Studies with mice indicated that vec...

journal_title：Journal of virology

authors： Lin J,Zhi Y,Mays L,Wilson JM

更新日期：2007-11-01 00:00:00

abstract：:Infection by viruses depends on a balance between capsid stability and dynamics. This study investigated biologically and biotechnologically relevant aspects of the relationship in foot-and-mouth disease virus (FMDV) between capsid structure and thermostability and between thermostability and infectivity. In the FMDV ...

journal_title：Journal of virology

authors： López-Argüello S,Rincón V,Rodríguez-Huete A,Martínez-Salas E,Belsham GJ,Valbuena A,Mateu MG

更新日期：2019-05-01 00:00:00

abstract：:To investigate the relation between the polyoma tumor-specific transplantation antigen and the virus-coded proteins, mice were immunized by inoculation of a variety of viable polyoma virus mutants and then challenged with polyoma virus-induced tumors. Two classes of early region mutants were used. One class produces a...

journal_title：Journal of virology

authors： Dalianis T,Magnusson G,Ito Y,Klein G

更新日期：1982-09-01 00:00:00

abstract：:Envelope glycoprotein E1 (gp51 to gp54) is the most antigenic protein of hog cholera virus or classical swine fever virus (CSFV). Four antigenic domains, A to D, have been mapped on E1 with a panel of monoclonal antibodies (MAbs) raised against CSFV strain Brescia. The boundaries of these domains have been established...

journal_title：Journal of virology

authors： van Rijn PA,Miedema GK,Wensvoort G,van Gennip HG,Moormann RJ

更新日期：1994-06-01 00:00:00

abstract：:Intrarectal simian immunodeficiency virus (SIV) infection in rhesus macaques is a model for sexual transmission of primate retroviruses. Phylogenetic studies on envelope gene sequences that were present in blood following intrarectal SIV inoculation provided evidence for selective amplification of a subset of viruses ...

journal_title：Journal of virology

authors： Trivedi P,Horejsh D,Hinds SB,Hinds PW II,Wu MS,Salvato MS,Pauza CD

更新日期：1996-10-01 00:00:00

abstract：:Crucial steps in high-risk human papillomavirus (HR-HPV)-related carcinogenesis are the integration of HR-HPV into the host genome and loss of viral episomes. The mechanisms that promote cervical neoplastic progression are, however, not clearly understood. During HR-HPV infection, the HPV E5 protein is expressed in pr...

journal_title：Journal of virology

authors： Muto V,Stellacci E,Lamberti AG,Perrotti E,Carrabba A,Matera G,Sgarbanti M,Battistini A,Liberto MC,Focà A

更新日期：2011-05-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) is a retrovirus which induces a strong immune response and a dramatic increase in the number of infected cells through the expression of a superantigen (SAg). Many cytokines are likely to be involved in the interaction between MMTV and the immune system. In particular, alpha/beta inter...

journal_title：Journal of virology

authors： Maillard I,Launois P,Xenarios I,Louis JA,Acha-Orbea H,Diggelmann H

更新日期：1998-04-01 00:00:00

abstract：:The purpose of this study was to gain insights into the regulation of Epstein-Barr virus (EBV) gene transcription during the establishment of viral latency in B cells. During the early stages of EBV infection in B lymphocytes, transcription of six viral nuclear antigens (EBNAs) is initiated from an early promoter (Wp)...

journal_title：Journal of virology

authors： Schlager S,Speck SH,Woisetschläger M

更新日期：1996-06-01 00:00:00

abstract：:Five regions of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) have been shown to be important in the transcriptional regulation of HIV in HeLa cells. These include the negative regulatory, enhancer, SP1, TATA, and TAR regions. Previous studies in which purified SP1 was used showed that the...

journal_title：Journal of virology

authors： Harrich D,Garcia J,Wu F,Mitsuyasu R,Gonazalez J,Gaynor R

更新日期：1989-06-01 00:00:00

abstract：UNLABELLED:Capsid-associated tegument proteins have been identified in alpha- and betaherpesviruses to play an essential role in viral DNA packaging. Whether and how such tegument proteins exist in gammaherpesviruses have been mysteries. Here, we report a 6-Å-resolution cryo-electron microscopy (cryo-EM) structure of K...

journal_title：Journal of virology

authors： Dai X,Gong D,Wu TT,Sun R,Zhou ZH

更新日期：2014-11-01 00:00:00

abstract：:The S2 gene of bluetongue virus, serotype 17, has been cloned, and the nonstructural protein NS2 has been expressed. Synthetic peptides matching regions within the amino acid sequence of NS2 were used to map three single-stranded RNA (ssRNA)-binding regions within the protein. A prokaryotic expression system was then ...

journal_title：Journal of virology

authors： Fillmore GC,Lin H,Li JK

更新日期：2002-01-01 00:00:00

abstract：:Rhinoviruses (RV) are the major cause of acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Rhinoviruses have been shown to activate macrophages, but rhinovirus replication in macrophages has not been reported. Tumor necrosis factor alpha (TNF-alpha) is implicated in the pathogenesis of ac...

journal_title：Journal of virology

authors： Laza-Stanca V,Stanciu LA,Message SD,Edwards MR,Gern JE,Johnston SL

更新日期：2006-08-01 00:00:00

abstract：:Apoptosis is a type of controlled cell death that is essential for development and tissue homeostasis. It also serves as a robust host response against infection by many viruses. The capacity of neurotropic viruses to induce apoptosis strongly correlates with virulence. However, the precise function of apoptosis in vi...

journal_title：Journal of virology

authors： Pruijssers AJ,Hengel H,Abel TW,Dermody TS

更新日期：2013-12-01 00:00:00

abstract：:Crimean-Congo hemorrhagic fever virus (CCHFV), a member of the genus Nairovirus of the family Bunyaviridae, causes severe disease with high rates of mortality in humans. The CCHFV M RNA segment encodes the virus glycoproteins G(N) and G(C). To understand the processing and intracellular localization of the CCHFV glyco...

journal_title：Journal of virology

authors： Bertolotti-Ciarlet A,Smith J,Strecker K,Paragas J,Altamura LA,McFalls JM,Frias-Stäheli N,García-Sastre A,Schmaljohn CS,Doms RW

更新日期：2005-05-01 00:00:00

abstract：:Maintenance of Kaposi's sarcoma-associated herpesvirus (KSHV) latent infection depends on the viral episomes in the nucleus being distributed to daughter cells following cell division. The latency-associated nuclear antigen (LANA) is constitutively expressed in all KSHV-infected cells. LANA binds sequences in the term...

journal_title：Journal of virology

authors： Krithivas A,Fujimuro M,Weidner M,Young DB,Hayward SD

更新日期：2002-11-01 00:00:00

abstract：:The K15 gene of Kaposi's sarcoma-associated herpesvirus (also known as human herpesvirus 8) consists of eight alternatively spliced exons and has been predicted to encode membrane proteins with a variable number of transmembrane regions and a common C-terminal cytoplasmic domain with putative binding sites for SH2 and...

journal_title：Journal of virology

authors： Brinkmann MM,Glenn M,Rainbow L,Kieser A,Henke-Gendo C,Schulz TF

更新日期：2003-09-01 00:00:00

abstract：:The synthesis of closed circular simian virus 40 (SV40) deoxyribonucleic acid (DNA) containing sequences homologous to host cell DNA depends upon the conditions under which the cells are infected. When BS-C-1 monkey cells were infected with non-plaque-purified virus at low multiplicity of infection [MOI, 0.032 plaque-...

journal_title：Journal of virology

authors： Lavi S,Winocour E

更新日期：1972-02-01 00:00:00

abstract：:Viral infection triggers host innate immune responses through cellular sensor molecules which activate multiple signaling cascades that induce the production of interferons (IFN) and other cytokines. The recent identification of mammalian cytoplasmic viral RNA sensors, such as retinoic acid-inducible gene I (RIG-I)-li...

journal_title：Journal of virology

authors： Biacchesi S,LeBerre M,Lamoureux A,Louise Y,Lauret E,Boudinot P,Brémont M

更新日期：2009-08-01 00:00:00

abstract：UNLABELLED:The encephalitic response to viral infection requires local chemokine production and the ensuing recruitment of immune and inflammatory leukocytes. Accordingly, chemokine receptors present themselves as plausible therapeutic targets for drugs aimed at limiting encephalitic responses. However, it remains uncl...

journal_title：Journal of virology

authors： Michlmayr D,McKimmie CS,Pingen M,Haxton B,Mansfield K,Johnson N,Fooks AR,Graham GJ

更新日期：2014-09-01 00:00:00

abstract：UNLABELLED:Ebola virus (EBOV) causes hemorrhagic fevers with high mortality rates. During cellular entry, the virus is internalized by macropinocytosis and trafficked through endosomes until fusion between the viral and an endosomal membrane is triggered, releasing the RNA genome into the cytoplasm. We found that while...

journal_title：Journal of virology

authors： Mingo RM,Simmons JA,Shoemaker CJ,Nelson EA,Schornberg KL,D'Souza RS,Casanova JE,White JM

更新日期：2015-03-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1)-encoded RNA-binding protein Tat is known to play an essential role in viral gene expression. In the search for novel compounds to inhibit Tat transactivity, one coumarin derivative, BPRHIV001, was identified, with a 50% effective concentration (EC(50)) against HIV-1 at 1...

journal_title：Journal of virology

authors： Lin PH,Ke YY,Su CT,Shiao HY,Hsieh HP,Chao YK,Lee CN,Kao CL,Chao YS,Chang SY

更新日期：2011-09-01 00:00:00

abstract：:Half of the world's population is exposed to the risk of dengue virus infection. Although a vaccine for dengue virus is now available in a few countries, its reported overall efficacy of about 60% is not ideal. Protective immune correlates following natural dengue virus infection remain undefined, which makes it diffi...

journal_title：Journal of virology

authors： Xu M,Züst R,Toh YX,Pfaff JM,Kahle KM,Davidson E,Doranz BJ,Velumani S,Tukijan F,Wang CI,Fink K

更新日期：2016-11-28 00:00:00

abstract：UNLABELLED:The antiviral role of TRIM E3 ligases in vivo is not fully understood. To test the hypothesis that TRIM5α and TRIM22 have differential transcriptional regulation and distinct anti-HIV roles according to infection phase and compartment, we measured TRIM5α, TRIM22, and type I interferon (IFN-I)-inducible myxov...

journal_title：Journal of virology

authors： Singh R,Patel V,Mureithi MW,Naranbhai V,Ramsuran D,Tulsi S,Hiramen K,Werner L,Mlisana K,Altfeld M,Luban J,Kasprowicz V,Dheda K,Abdool Karim SS,Ndung'u T

更新日期：2014-04-01 00:00:00

abstract：:The four temperature-sensitive (ts) loci identified in the PB1 and PB2 gene segments of cold-adapted A/Ann Arbor/6/60 influenza virus, the master donor virus for influenza A virus (MDV-A) FluMist vaccines, were introduced into a divergent A/Puerto Rico/8/34 influenza virus strain. Recombinant A/Puerto Rico/8/34 virus ...

journal_title：Journal of virology

authors： Jin H,Zhou H,Lu B,Kemble G

更新日期：2004-01-01 00:00:00

abstract：:An unusual human retrovirus was isolated from two patients with persistent generalized lymphadenopathy who originate from West-Central Africa and are currently residing in Belgium. Although the virus shared a number of the same biological and morphological properties as human immunodeficiency retrovirus type 1 (HIV-1)...

journal_title：Journal of virology

authors： De Leys R,Vanderborght B,Vanden Haesevelde M,Heyndrickx L,van Geel A,Wauters C,Bernaerts R,Saman E,Nijs P,Willems B

更新日期：1990-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) chronic infection is characterized by low-level or undetectable cellular immune responses against HCV antigens. HCV proteins have been shown to affect various intracellular events and modulate immune responses, although the precise mechanisms used to mediate these effects are not fully understo...

journal_title：Journal of virology

authors： Saito K,Ait-Goughoulte M,Truscott SM,Meyer K,Blazevic A,Abate G,Ray RB,Hoft DF,Ray R

更新日期：2008-04-01 00:00:00

abstract：:The accumulation of an abnormal, protease-resistant form of the protein PrP (PrP-res) in hosts with scrapie and related transmissible spongiform encephalopathies appears to be important in disease pathogenesis. To gain insight into the mechanism of PrP-res accumulation and the in vivo antiscrapie activity of certain p...

journal_title：Journal of virology

authors： Caughey B,Raymond GJ

更新日期：1993-02-01 00:00:00

abstract：:In a previous study (S. Zheng, G. N. Woode, D. R. Melendy, and R. F. Ramig, J. Clin. Microbiol. 27:1939-1945, 1989), it was predicted that the VP7 serotype 6 bovine rotavirus strains NCDV and B641 do not share antigenically similar VP4s. In this study, gene 4 and the VP7 gene of B641 were sequenced, and the amino acid...

journal_title：Journal of virology

authors： Hardy ME,Woode GN,Xu ZC,Gorziglia M

更新日期：1991-10-01 00:00:00