The Epstein-Barr virus protein BRLF1 activates S phase entry through E2F1 induction.

abstract：:Upon cell entry, the genomes of herpes simplex virus type 1 (HSV-1) and adenovirus (Ad) associate with distinct nuclear structures termed ND10 or promyelocytic leukemia (PML) nuclear bodies (NBs). PML NB morphology is altered or disrupted by specific viral proteins as replication proceeds. We examined whether adeno-as...

journal_title：Journal of virology

authors： Fraefel C,Bittermann AG,Büeler H,Heid I,Bächi T,Ackermann M

更新日期：2004-01-01 00:00:00

abstract：:Serial serum specimens from 22 herpes simplex virus (HSV)-seronegative recipients of an HSV type 2 (HSV-2) glycoprotein subunit vaccine were analyzed by radioimmunoprecipitation and polyacrylamide gel electrophoresis for the development of antibodies to HSV-2 gB, gD, and g80, a complex of gC and gE. Volunteers receive...

journal_title：Journal of virology

authors： Ashley R,Mertz G,Clark H,Schick M,Salter D,Corey L

更新日期：1985-11-01 00:00:00

abstract：:The virion host shutoff protein (vhs) of herpes simplex virus (HSV) triggers global shutoff of host protein synthesis and accelerated mRNA turnover during virus infection and induces endoribonucleolytic cleavage of exogenous RNA substrates when it is produced in a rabbit reticulocyte (RRL) in vitro translation system....

journal_title：Journal of virology

authors： Lu P,Jones FE,Saffran HA,Smiley JR

更新日期：2001-02-01 00:00:00

abstract：:Previous studies have indicated that B cells make a significant contribution to the resolution of influenza virus infection. To determine how B cells participate in the control of the infection, we transferred intact, major histocompatibility complex class II (MHC-II)-negative or B-cell receptor (BCR)-transgenic splee...

journal_title：Journal of virology

authors： Mozdzanowska K,Furchner M,Zharikova D,Feng J,Gerhard W

更新日期：2005-05-01 00:00:00

abstract：:Plasmid lambdadv1, which is in a dimeric form, was converted to a linear monomer duplex by the action of EcoRI restriction endonuclease that incises at a unique site in this plasmid genome. The resulting products were then joined by Escherichia coli DNA ligase to produce molecules with various oligomeric forms, and fr...

journal_title：Journal of virology

authors： Matsubara K,Takagi Y,Mukai T

更新日期：1975-09-01 00:00:00

abstract：:The chimeric murine oncornavirus FrCas(E) causes a rapidly progressive paralytic disease associated with spongiform neurodegeneration throughout the neuroaxis. Neurovirulence is determined by the sequence of the viral envelope gene and by the capacity of the virus to infect microglia. The neurocytopathic effect of thi...

journal_title：Journal of virology

authors： Askovic S,Favara C,McAtee FJ,Portis JL

更新日期：2001-03-01 00:00:00

abstract：:ISG15, a 15-kDa interferon-induced protein that participates in antiviral defenses of mammals, is highly conserved among vertebrates. In fish, as in mammals, viral infection and interferon treatment induce isg15 expression. The two ubiquitin-like domains of ISG15 and the presence of a consensus LRLRGG sequence in the ...

journal_title：Journal of virology

authors： Langevin C,van der Aa LM,Houel A,Torhy C,Briolat V,Lunazzi A,Harmache A,Bremont M,Levraud JP,Boudinot P

更新日期：2013-09-01 00:00:00

abstract：:Pancreatic islets from DBA/2 mice infected with the D variant of encephalomyocarditis (EMC-D) virus revealed lymphocytic infiltration with moderate to severe destruction of pancreatic beta cells. Our previous studies showed that the major population of infiltrating cells at the early stages of infection is macrophages...

journal_title：Journal of virology

authors： Hirasawa K,Jun HS,Maeda K,Kawaguchi Y,Itagaki S,Mikami T,Baek HS,Doi K,Yoon JW

更新日期：1997-05-01 00:00:00

abstract：:Viral recombination has been postulated to play two roles in the development of human immunodeficiency virus (HIV) resistance to antiretroviral drugs. First, recombination has the capacity to associate resistance mutations expressed by distinct viruses, thereby contributing to the development of viruses with improved ...

journal_title：Journal of virology

authors： Nora T,Charpentier C,Tenaillon O,Hoede C,Clavel F,Hance AJ

更新日期：2007-07-01 00:00:00

abstract：:Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for ...

journal_title：Journal of virology

authors： Rinaldo C,Huang XL,Fan ZF,Ding M,Beltz L,Logar A,Panicali D,Mazzara G,Liebmann J,Cottrill M

更新日期：1995-09-01 00:00:00

abstract：:This paper is concerned with the physiological role(s) of T4 phage-coded dihydrofolate reductase, which functions both in DNA precursor metabolism and as a virion protein. (i) We have detected enzyme activity in noninfectious particles produced under restrictive conditions by gene 11 mutants. This supports the conclus...

journal_title：Journal of virology

authors： Mosher RA,DiRenzo AB,Mathews CK

更新日期：1977-09-01 00:00:00

abstract：:The active site serine of the acetylesterase of influenza C virus was localized to amino acid 71 of the hemagglutinin-esterase protein by affinity labeling with 3H-labeled diisopropylfluorophosphate. This serine and the adjacent amino acids (Phe-Gly-Asp-Ser) are part of a consensus sequence motif found in serine hydro...

journal_title：Journal of virology

authors： Vlasak R,Muster T,Lauro AM,Powers JC,Palese P

更新日期：1989-05-01 00:00:00

abstract：:Vaccinia virus assembles two distinct lipoprotein membranes. The primary membrane contains nonglycosylated proteins, appears as crescents in the cytoplasm, and delimits immature and mature intracellular virions. The secondary or wrapping membrane contains glycoproteins, is derived from virus-modified trans-Golgi or en...

journal_title：Journal of virology

authors： Husain M,Moss B

更新日期：2003-11-01 00:00:00

abstract：:The phosphoprotein, P, of vesicular stomatitis virus (VSV) is a key subunit of the viral RNA-dependent RNA polymerase complex. The protein is phosphorylated at multiple sites in two different domains. We recently showed that specific serine and threonine residues within the amino-terminal acidic domain I of P protein ...

journal_title：Journal of virology

authors： Hwang LN,Englund N,Das T,Banerjee AK,Pattnaik AK

更新日期：1999-07-01 00:00:00

abstract：:Viruses actively interact with host metabolism because viral replication relies on host cells to provide nutrients and energy. Vaccinia virus (VACV; the prototype poxvirus) prefers glutamine to glucose for efficient replication to the extent that VACV replication is hindered in glutamine-free medium. Remarkably, our d...

journal_title：Journal of virology

authors： Pant A,Cao S,Yang Z

更新日期：2019-06-14 00:00:00

abstract：:All plus-strand RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that functions as the catalytic subunit of the viral replication/transcription complex, directing viral RNA synthesis in concert with other viral proteins and, sometimes, host proteins. RNA synthesis essentially can be initiated by two different...

journal_title：Journal of virology

authors： Beerens N,Selisko B,Ricagno S,Imbert I,van der Zanden L,Snijder EJ,Canard B

更新日期：2007-08-01 00:00:00

abstract：:Adult T-cell leukemia (ATL) occurs in a small population of human T-cell leukemia virus type 1 (HTLV-1)-infected individuals. Although the critical risk factor for ATL development is not clear, it has been noted that ATL is incidentally associated with mother-to-child infection, elevated proviral loads, and weakness i...

journal_title：Journal of virology

authors： Hasegawa A,Ohashi T,Hanabuchi S,Kato H,Takemura F,Masuda T,Kannagi M

更新日期：2003-03-01 00:00:00

abstract：:Although in vitro replication of the hepatitis C virus (HCV) JFH1 clone of genotype 2a (HCVcc) has been developed, a robust cell culture system for the 1a and 1b genotypes, which are the most prevalent viruses in the world and resistant to interferon therapy, has not yet been established. As a surrogate virus system, ...

journal_title：Journal of virology

authors： Tani H,Komoda Y,Matsuo E,Suzuki K,Hamamoto I,Yamashita T,Moriishi K,Fujiyama K,Kanto T,Hayashi N,Owsianka A,Patel AH,Whitt MA,Matsuura Y

更新日期：2007-08-01 00:00:00

abstract：:We used the Escherichia coli chloramphenicol acetyltransferase gene (cat) to study sequences that influence expression of the equine infectious anemia virus (EIAV) genome. The EIAV long terminal repeat (LTR) directed CAT activity in a canine cell line, but at levels much lower than those achieved with other eucaryotic...

journal_title：Journal of virology

authors： Sherman L,Gazit A,Yaniv A,Kawakami T,Dahlberg JE,Tronick SR

更新日期：1988-01-01 00:00:00

abstract：:The poliovirus (PV) genome was manipulated by replacing its 2A-encoding sequence with the corresponding sequence of coxsackie B4 virus (CBV4) or human rhinovirus type 2 (HRV2). In vitro translation of the resulting chimeric PV genomes revealed a normal cis-cleavage activity for both heterologous 2A(pro) proteinases in...

journal_title：Journal of virology

authors： Lu HH,Li X,Cuconati A,Wimmer E

更新日期：1995-12-01 00:00:00

abstract：:Expression of the immediate-early (IE) genes of herpes simplex virus (HSV) is specifically stimulated by a 65-kilodalton virion transcription factor (VF65 or VP16) that is introduced as a component of infecting virions. In both the IE175(ICP4) and IE110(ICP0) promoters, this activation requires an upstream cis-acting ...

journal_title：Journal of virology

authors： apRhys CM,Ciufo DM,O'Neill EA,Kelly TJ,Hayward GS

更新日期：1989-06-01 00:00:00

abstract：:The largest tegument protein of herpes simplex virus 1 (HSV-1), UL36, contains a novel deubiquitinating activity embedded in it. All members of the Herpesviridae contain a homologue of HSV-1 UL36, the N-terminal segments of which show perfect conservation of those residues implicated in catalysis. For murine cytomegal...

journal_title：Journal of virology

authors： Schlieker C,Korbel GA,Kattenhorn LM,Ploegh HL

更新日期：2005-12-01 00:00:00

abstract：:Adeno-associated virus (AAV) is a human parvovirus currently being developed as a vector for gene therapy applications. Because the gene transfer vector commonly retains only the AAV terminal repeats, propagation of recombinant AAV (rAAV) requires that the viral replication (Rep) and capsid (Cap) proteins be supplied ...

journal_title：Journal of virology

authors： Vincent KA,Piraino ST,Wadsworth SC

更新日期：1997-03-01 00:00:00

abstract：:Novel molecular approaches to inhibit human immunodeficiency virus type 1 (HIV-1) infection have received increasing attention because of the lack of effective antiviral drug therapies in vivo. We now demonstrate that cells can be intracellularly immunized by cytoplasmic expression of single-chain variable antibody fr...

journal_title：Journal of virology

authors： Shaheen F,Duan L,Zhu M,Bagasra O,Pomerantz RJ

更新日期：1996-06-01 00:00:00

abstract：:The members of Flaviviridae utilize several endocytic pathways to enter a variety of host cells. Our previous work showed that classical swine fever virus (CSFV) enters porcine kidney (PK-15) cells through a clathrin-dependent pathway that requires Rab5 and Rab7. The entry mechanism for CSFV into other cell lines rema...

journal_title：Journal of virology

authors： Zhang YN,Liu YY,Xiao FC,Liu CC,Liang XD,Chen J,Zhou J,Baloch AS,Kan L,Zhou B,Qiu HJ

更新日期：2018-07-17 00:00:00

abstract：:We used the mammalian reoviruses to determine the molecular basis of the clearance of a virus from the bloodstream by specific organs. Reovirus serotypes 1 (T1) and 3 (T3) were radiolabeled with [35S]methionine or 125I, and the viruses were injected intravenously into weanling rats. The distribution of radioactivity w...

journal_title：Journal of virology

authors： Verdin EM,Lynn SP,Fields BN,Maratos-Flier E

更新日期：1988-02-01 00:00:00

abstract：:Human influenza viruses are more efficiently isolated by inoculating patient samples into the amniotic rather than the allantoic cavity of embryonated chicken eggs. This type of cultivation selects virus variants with mutations around the hemagglutinin (HA) receptor binding site. To understand the molecular basis of t...

journal_title：Journal of virology

authors： Ito T,Suzuki Y,Takada A,Kawamoto A,Otsuki K,Masuda H,Yamada M,Suzuki T,Kida H,Kawaoka Y

更新日期：1997-04-01 00:00:00

abstract：:In order to clarify the effect of an accumulation of amino acid substitutions on the hemadsorption character of the influenza AH3 virus hemagglutinin (HA) protein, we introduced single-point amino acid changes into the HA1 domain of the HA proteins of influenza viruses isolated in 1968 (A/Aichi/2/68) and 1997 (A/Sydne...

journal_title：Journal of virology

authors： Nakajima K,Nobusawa E,Nagy A,Nakajima S

更新日期：2005-05-01 00:00:00

abstract：:Expression of human papillomavirus late genes encoding L1 and L2 capsid proteins is restricted to terminally differentiated epithelial cells. We have previously identified and characterized an AU-rich, cis-acting negative regulatory element in the 3' untranslated region of human papillomavirus type 1 late mRNAs. This ...

journal_title：Journal of virology

authors： Zhao C,Tan W,Sokolowski M,Schwartz S

更新日期：1996-06-01 00:00:00

abstract：:Toscana virus (TOSV) is a phlebovirus, of the Bunyaviridae family, that is responsible for central nervous system (CNS) injury in humans. Previous data have shown that the TOSV NSs protein is a gamma interferon (IFN-β) antagonist when transiently overexpressed in mammalian cells, inhibiting IRF-3 induction (G. Gori Sa...

journal_title：Journal of virology

authors： Gori-Savellini G,Valentini M,Cusi MG

更新日期：2013-06-01 00:00:00