Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice.

abstract：:The UL11 tegument protein of herpes simplex virus plays a critical role in the secondary envelopment; however, the mechanistic details remain elusive. Here, we report a new function of UL11 in the budding process in which it directs efficient acquisition of glycoprotein E (gE) via a direct interaction. In vitro bindin...

journal_title：Journal of virology

authors： Han J,Chadha P,Meckes DG Jr,Baird NL,Wills JW

更新日期：2011-09-01 00:00:00

abstract：:It is possible to oxidize in situ the 3'-terminals of the double-stranded ribonucleic acid (RNA) contained in structurally intact cytoplasmic polyhedrosis virus. The number of 3'-terminals subsequently found by reduction with tritiated sodium borohydride was equivalent to the number observed in RNA first isolated from...

journal_title：Journal of virology

authors： Lewandowski LJ,Millward S

更新日期：1971-04-01 00:00:00

abstract：:Activated microglia and astroglia are known to be involved in a variety of neurodegenerative diseases, including prion diseases. In the present experiments, we studied activation of astroglia and microglia after intraocular scrapie infection in transgenic mice expressing prion protein (PrP) in multiple cell types (tg7...

journal_title：Journal of virology

authors： Kercher L,Favara C,Striebel JF,LaCasse R,Chesebro B

更新日期：2007-10-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) lytic infection increases the expression of viral and human interleukin-6 (vIL-6 and hIL-6, respectively), an important factor for cell growth and pathogenesis. Here, we report genome-wide analysis of viral RNA targets of KSHV ORF57 by a novel UV-cross-linking and immunop...

journal_title：Journal of virology

authors： Kang JG,Pripuzova N,Majerciak V,Kruhlak M,Le SY,Zheng ZM

更新日期：2011-03-01 00:00:00

abstract：UNLABELLED:Tetherin (BST2, CD317, or HM1.24) is a host cellular restriction factor that prevents the release of enveloped viruses by mechanically linking virions to the plasma membrane. The precise arrangement of tetherin molecules at the plasma membrane site of HIV-1 assembly, budding, and restriction is not well unde...

journal_title：Journal of virology

authors： Strauss JD,Hammonds JE,Yi H,Ding L,Spearman P,Wright ER

更新日期：2015-11-18 00:00:00

abstract：:The Chinese hamster cell lines E36 and CHOK1 dramatically differ in susceptibility to amphotropic murine leukemia virus (A-MuLV) and gibbon ape leukemia virus (GALV); E36 cells are highly susceptible to both viruses, CHOK1 cells are not. We have previously shown that GALV can infect E36 cells by using both its own rec...

journal_title：Journal of virology

authors： Chaudry GJ,Farrell KB,Ting YT,Schmitz C,Lie SY,Petropoulos CJ,Eiden MV

更新日期：1999-04-01 00:00:00

abstract：:We characterized a number of important features of the structure of the cohesive overlap region of the DNA genome of duck hepatitis B virus. The 5'-terminal nucleotide of minus-strand DNA was localized to nucleotide 2537, a G residue within the 12-base repeat sequence DR1. This G residue was shown to be the site of a ...

journal_title：Journal of virology

authors： Lien JM,Petcu DJ,Aldrich CE,Mason WS

更新日期：1987-12-01 00:00:00

abstract：:The synthesis of minus-strand RNA was studied in cell cultures infected with the heat-resistant strain of Sindbis virus and with temperature-sensitive (ts) belonging to complementation groups A, B, F, and G, all of which exhibited an RNA-negative (RNA-) phenotype when infection was initiated and maintained at 39 degre...

journal_title：Journal of virology

authors： Sawicki DL,Sawicki SG,Keränen S,Kääriäinen L

更新日期：1981-08-01 00:00:00

abstract：:For efficient and versatile use of adenovirus (Ad) as an in vivo gene therapy vector, modulation of the viral tropism is highly desirable. In this study, a novel method to genetically alter the Ad fiber tropism is described. The knob and the last 15 shaft repeats of the fiber gene were deleted and replaced with an ext...

journal_title：Journal of virology

authors： Magnusson MK,Hong SS,Boulanger P,Lindholm L

更新日期：2001-08-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) displays both interstrain and intrastrain genetic variability. Virus populations with extensive microheterogeneity have been defined as swarms or quasispecies. Many of the genomes within HIV-1 swarms appear to be defective in one or more genes required for viral replication....

journal_title：Journal of virology

authors： Lori F,Hall L,Lusso P,Popovic M,Markham P,Franchini G,Reitz MS Jr

更新日期：1992-09-01 00:00:00

abstract：:Recombinant vaccinia viruses expressing C-terminally truncated E's that ranged in length from 9 to 99% of the N-terminal sequence were constructed. The overall antigenicity of the E products was analyzed by radioimmunoprecipitation, using dengue virus hyperimmune mouse ascitic fluid (HMAF) or an anti-E peptide serum. ...

journal_title：Journal of virology

authors： Men RH,Bray M,Lai CJ

更新日期：1991-03-01 00:00:00

abstract：:Gene expression of nonsegmented negative-sense RNA viruses involves sequential synthesis of monocistronic mRNAs and transcriptional attenuation at gene borders resulting in a transcript gradient. To address the role of the heterogeneous rabies virus (RV) intergenic regions (IGRs) in transcription attenuation, we const...

journal_title：Journal of virology

authors： Finke S,Cox JH,Conzelmann KK

更新日期：2000-08-01 00:00:00

abstract：:Latent HIV proviruses are silenced as the result of deacetylation and methylation of histones located at the viral long terminal repeat (LTR). Inhibition of histone deacetylases (HDACs) leads to the reemergence of HIV-1 from latency, but the contribution of histone lysine methyltransferases (HKMTs) to maintaining HIV ...

journal_title：Journal of virology

authors： Friedman J,Cho WK,Chu CK,Keedy KS,Archin NM,Margolis DM,Karn J

更新日期：2011-09-01 00:00:00

abstract：:We have begun to characterize the genomic structure and replication of the baboon papovavirus simian agent 12 (SA12). We have defined a wild-type clone of SA12 (SA12 wt100) by plaque purification from a heterogeneous stock. The functional map of SA12 wt100 can be aligned with those of the other primate papovaviruses b...

journal_title：Journal of virology

authors： Cunningham TP,Pipas JM

更新日期：1985-05-01 00:00:00

abstract：:Cellular inhibitor of apoptosis protein 2 (cIAP2) is a potent suppressor of apoptotic cell death. We have shown previously that cIAP2 is involved in the tumor necrosis factor alpha (TNF-α)-induced anti-hepatitis B virus (HBV) response; however, the mechanism for this antiviral effect remains unclear. In the present st...

journal_title：Journal of virology

authors： Wang Z,Ni J,Li J,Shi B,Xu Y,Yuan Z

更新日期：2011-11-01 00:00:00

abstract：:The small envelope protein of hepatitis B virus is the major component of the viral coat and is also secreted from cells as a 20-nm subviral particle, even in the absence of other viral proteins. Such empty envelope particles are composed of approximately 100 copies of this polypeptide and host-derived lipids and are ...

journal_title：Journal of virology

authors： Mangold CM,Streeck RE

更新日期：1993-08-01 00:00:00

abstract：:Whole-body bioimaging was used to study dissemination of vaccinia virus (VACV) in normal and in immune deficient (nu(-)/nu(-)) mice protected from lethality by postchallenge administration of ST-246. Total fluxes were recorded in the liver, spleen, lungs, and nasal cavities of live mice after intranasal infection with...

journal_title：Journal of virology

authors： Zaitseva M,Shotwell E,Scott J,Cruz S,King LR,Manischewitz J,Diaz CG,Jordan RA,Grosenbach DW,Golding H

更新日期：2013-05-01 00:00:00

abstract：:We have found that the burst size of bacteriophage T7 was decreased in two Escherichia coli temperature-sensitive gyrase mutants incubated at the restrictive temperature. This reduction in burst size indicates that gyrase may be required for T7 growth. ...

journal_title：Journal of virology

authors： Steck TR,Drlica K

更新日期：1985-01-01 00:00:00

abstract：:The roles of the capsid protein (CP) and the CP coding sequence of tobacco etch potyvirus (TEV) in genome amplification were analyzed. A series of frameshift-stop codon mutations that interrupted translation of the CP coding sequence at various positions were introduced into the TEV genome. A series of 3' deletion mut...

journal_title：Journal of virology

authors： Mahajan S,Dolja VV,Carrington JC

更新日期：1996-07-01 00:00:00

abstract：:Axl, a plasma membrane-associated Tyro3/Axl/Mer (TAM) family member, is necessary for optimal Zaire ebolavirus (ZEBOV) glycoprotein (GP)-dependent entry into some permissive cells but not others. To date, the role of Axl in virion entry is unknown. The focus of this study was to characterize entry pathways that are us...

journal_title：Journal of virology

authors： Hunt CL,Kolokoltsov AA,Davey RA,Maury W

更新日期：2011-01-01 00:00:00

abstract：UNLABELLED:The Nairovirus genus of the Bunyaviridae family contains serious human and animal pathogens classified within multiple serogroups and species. Of these serogroups, the Crimean-Congo hemorrhagic fever virus (CCHFV) serogroup comprises sole members CCHFV and Hazara virus (HAZV). CCHFV is an emerging zoonotic v...

journal_title：Journal of virology

authors： Surtees R,Dowall SD,Shaw A,Armstrong S,Hewson R,Carroll MW,Mankouri J,Edwards TA,Hiscox JA,Barr JN

更新日期：2016-09-29 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) accessory protein Nef is heavily targeted by CD8(+) T lymphocytes (CTLs) during acute infection and therefore is included in many candidate vaccines. We investigated whether CTL targeting of Nef during acute infection contributes to immune control by disrupting the funct...

journal_title：Journal of virology

authors： De La Cruz J,Vollbrecht T,Frohnen P,Ng HL,Daar ES,Yang OO,Lewis MJ

更新日期：2014-07-01 00:00:00

abstract：:Host-virus interactions control disease progression in human immunodeficiency virus-infected human beings and in nonhuman primates infected with simian or simian/human immunodeficiency viruses (SHIV). These interactions evolve rapidly during acute infection and are key to the mechanisms of viral persistence and AIDS. ...

journal_title：Journal of virology

authors： Wallace M,Waterman PM,Mitchen JL,Djavani M,Brown C,Trivedi P,Horejsh D,Dykhuizen M,Kitabwalla M,Pauza CD

更新日期：1999-12-01 00:00:00

abstract：:An in vitro assay was developed to investigate endonuclease activity of Thogoto virus, a tick-borne orthomyxovirus. Endonuclease activity relied on an interaction between the 3' and 5' termini of virion RNA (vRNA) and not those of cRNA. Evidence was obtained that cap structures are cleaved directly from cap donors and...

journal_title：Journal of virology

authors： Leahy MB,Dessens JT,Pritlove DC,Nuttall PA

更新日期：1998-03-01 00:00:00

abstract：:Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes resi...

journal_title：Journal of virology

authors： Wu J,Bera AK,Kuhn RJ,Smith JL

更新日期：2005-08-01 00:00:00

abstract：:Among prion infections, two scenarios of prion spread are generally observed: (i) early lymphoid tissue replication or (ii) direct neuroinvasion without substantial antecedent lymphoid amplification. In nature, cervids are infected with chronic wasting disease (CWD) prions by oral and nasal mucosal exposure, and studi...

journal_title：Journal of virology

authors： Hoover CE,Davenport KA,Henderson DM,Denkers ND,Mathiason CK,Soto C,Zabel MD,Hoover EA

更新日期：2017-04-28 00:00:00

abstract：:T cells are central players in the immune response to infectious disease, with the specificity of their responses controlled by the T-cell receptor (TCR)/CD3 complex on the cell surface. Impairment of TCR/CD3-directed CD4(+) T-cell immune responses is frequently observed in individuals infected with human immunodefici...

journal_title：Journal of virology

authors： Segura I,Delmelle-Wibaut C,Janssens M,Cleuter Y,van den Broeke A,Kettmann R,Willard-Gallo KE

更新日期：1999-06-01 00:00:00

abstract：:We have studied protein synthesis in cultured cells infected with the six noncytopathic (nc) mutants of the Australia-Victoria strain (AV-WT) of Newcastle disease virus and their plaque-forming revertants. Virus-specific polypeptides accumulated at 30 to 63% of wild-type levels in nc mutant-infected cells and between ...

journal_title：Journal of virology

authors： Madansky CH,Bratt MA

更新日期：1981-12-01 00:00:00

abstract：:Humoral immune responses to influenza virus vaccines in elderly individuals are poorly adapted toward new antigenically drifted influenza virus strains. Instead, older individuals respond in an original antigenic sin fashion and produce much more cross-reactive but less potent antibodies. Here, we investigated four in...

journal_title：Journal of virology

authors： Kirkpatrick E,Henry C,McMahon M,Jiang K,Strohmeier S,van Bakel H,Wilson PC,Krammer F

更新日期：2020-11-09 00:00:00

abstract：:During viral infection, inflammation and recovery are tightly controlled by competing proinflammatory and regulatory immune pathways. Respiratory syncytial virus (RSV) is the leading global cause of infantile bronchiolitis, which is associated with recurrent wheeze and asthma diagnosis in later life. Th2-driven diseas...

journal_title：Journal of virology

authors： Durant LR,Makris S,Voorburg CM,Loebbermann J,Johansson C,Openshaw PJ

更新日期：2013-10-01 00:00:00