Abstract:
:We have found that the burst size of bacteriophage T7 was decreased in two Escherichia coli temperature-sensitive gyrase mutants incubated at the restrictive temperature. This reduction in burst size indicates that gyrase may be required for T7 growth.
journal_name
J Viroljournal_title
Journal of virologyauthors
Steck TR,Drlica Kdoi
10.1128/JVI.53.1.296-298.1985subject
Has Abstractpub_date
1985-01-01 00:00:00pages
296-8issue
1eissn
0022-538Xissn
1098-5514journal_volume
53pub_type
杂志文章abstract::Recent studies of varicella-zoster virus (VZV) DNA sequence variation, involving large numbers of globally distributed clinical isolates, suggest that this virus has diverged into at least three distinct genotypes designated European (E), Japanese (J), and mosaic (M). In the present study, we determined and analyzed t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00835-06
更新日期:2006-10-01 00:00:00
abstract::The pandemic H1N1 virus of 2009 (2009 H1N1) continues to cause illness worldwide, primarily in younger age groups. To better understand the pathogenesis of these viruses in mammals, we used a mouse model to evaluate the relative virulence of selected 2009 H1N1 viruses and compared them to a representative human triple...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02742-09
更新日期:2010-05-01 00:00:00
abstract::Vif(IIIB), which has been a standard model for the viral infectivity factor of human immunodeficiency virus type 1 (HIV-1), binds the cytidine deaminase APOBEC3G (A3G) and induces its degradation, thereby precluding its lethal incorporation into assembling virions. Additionally, Vif(IIIB) less efficiently degrades A3F...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01078-07
更新日期:2008-01-01 00:00:00
abstract::The membrane glycoproteins G1 and G2 of Uukuniemi virus, a member of the Bunyaviridae family, are cotranslationally cleaved from a common precursor in the endoplasmic reticulum (ER). Here, we show that newly made G1 and G2 associate transiently with calnexin and calreticulin, two lectins involved in glycoprotein foldi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.7.6123-6127.1999
更新日期:1999-07-01 00:00:00
abstract::Signal peptidase cleavage at the C-prM junction in the flavivirus structural polyprotein is inefficient in the absence of the cytoplasmic viral protease, which catalyzes cleavage at the COOH terminus of the C protein. The signal peptidase cleavage occurs efficiently in circumstances where the C protein is deleted or i...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.3.2141-2149.1998
更新日期:1998-03-01 00:00:00
abstract::The late 19S RNAs of simian virus 40 (SV40) are functionally polycistronic, i.e., all encode both VP2 and VP3. The VP3-coding sequences are situated in the same reading frame as the VP2-coding sequences, within the carboxy-terminal two-thirds of the VP2-coding sequences. To test whether VP3 is produced by proteolytic ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.3.954-961.1988
更新日期:1988-03-01 00:00:00
abstract::Venezuelan equine encephalitis (VEE) virus antigenic subtypes and varieties are considered either epidemic/epizootic or enzootic. In addition to epidemiological differences between the epidemic and enzootic viruses, several in vitro and in vivo laboratory markers distinguishing the viruses have been identified, includ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.9.4258-4263.2000
更新日期:2000-05-01 00:00:00
abstract::Interferon (IFN) is an important immune system molecule capable of inducing an antiviral state within cells. Herpes simplex virus type 1 (HSV-1) replication is somewhat reduced in tissue culture in the presence of IFN, presumably due to decreased viral transcription. Here, we show mutations that inactivate immediate-e...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.4.2052-2056.2000
更新日期:2000-02-01 00:00:00
abstract::To study the expression of the Autographa californica nuclear polyhedrosis virus (AcNPV) genome, intracellular virus-specific proteins and mRNAs were pulsed-labeled, extracted, and analyzed at 6-h intervals during the replicative cycle. Most RNAs were detected between 12 and 24 h postinfection (p.i.), but many continu...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.50.3.739-747.1984
更新日期:1984-06-01 00:00:00
abstract::A protein-protein interaction within the helicase domain of the Tobacco mosaic virus (TMV) 126- and 183-kDa replicase proteins was previously implicated in virus replication (S. Goregaoker, D. Lewandowski, and J. Culver, Virology 282:320-328, 2001). To further characterize the interaction, polypeptides covering the in...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.6.3549-3556.2003
更新日期:2003-03-01 00:00:00
abstract::Immunological comparisons were made of baculovirus structural proteins by using a modification of the radioimmunological techniques described by Renart et al. (Proc. Natl. Acad. Sci. U.S.A. 76: 3116-3120, 1979) and Towbin et al. (Proc. Natl. Acad. Sci. U.S.A. 76: 4350-4354, 1979). Viral proteins were electrophoresed i...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.39.1.125-137.1981
更新日期:1981-07-01 00:00:00
abstract:UNLABELLED:Marburg virus (MARV) infection is a lethal hemorrhagic fever for which no licensed vaccines or therapeutics are available. Development of appropriate medical countermeasures requires a thorough understanding of the interaction between the host and the pathogen and the resulting disease course. In this study,...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01147-15
更新日期:2015-10-01 00:00:00
abstract::Myeloblastosis-associated virus type 1 (MAV1) derived from a molecular clone of infectious proviral DNA (B. Perbal, J. S. Lipsick, J. Svoboda, R. F. Silva, and M. A. Baluda, J. Virol. 56:240-244, 1985) was shown to specifically induce nephroblastoma in chickens and therefore belongs to the MAV-N class. We show that ne...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.4.1803-1807.1989
更新日期:1989-04-01 00:00:00
abstract::Poliovirus proteinase 2A (2Apro) is autocatalytically released from the viral polyprotein by cleavage in cis of a Tyr-Gly dipeptide at its own amino terminus, resulting in separation of the P1 structural and P2-P3 nonstructural protein precursors. A second Ty-Gly dipeptide within 3D polymerase is cleaved by 2Apro in t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.6.3330-3338.1992
更新日期:1992-06-01 00:00:00
abstract::The activation of the human polyomavirus BK causes polyomavirus-associated nephropathy in immunocompromised humans. Studies of the virus have been restricted since the virus DNA replication is species specific. Cell-based and cell-free DNA replication systems, including the BK virus (BKV) monopolymerase DNA replicatio...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00527-10
更新日期:2010-07-01 00:00:00
abstract::We constructed vaccine vectors based on live recombinant vesicular stomatitis virus (VSV) and a Semliki Forest virus (SFV) replicon (SFVG) that propagates through expression of the VSV glycoprotein (G). These vectors expressing simian immunodeficiency virus (SIV) Gag and Env proteins were used to vaccinate rhesus maca...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00342-11
更新日期:2011-06-01 00:00:00
abstract::Nonenveloped viral capsids are metastable structures that undergo conformational changes during virus entry that lead to interactions of the capsid or capsid fragments with the cell membrane. For members of the Caliciviridae, neither the nature of these structural changes in the capsid nor the factor(s) responsible fo...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02371-09
更新日期:2010-06-01 00:00:00
abstract::Human immunodeficiency virus (HIV) infection is associated with immune activation, CD4⁺-T-cell loss, and a progressive decline of immune functions. Antiretroviral therapy (ART) only partially reverses HIV-associated immune dysfunction, suggesting that approaches that target immune activation and improve virus-specific...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.05609-11
更新日期:2012-01-01 00:00:00
abstract::Synthetic peptides of increasing length and corresponding in sequence to the C-terminal end of the HA1 molecule of influenza virus were constructed and examined for their immunogenic and antigenic properties. Peptides containing at least the four C-terminal amino acids, when coupled to keyhole limpet hemocyanin, were ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.12.4745-4751.1988
更新日期:1988-12-01 00:00:00
abstract::Retroviruses and retrotransposons insert into the host genome with no obvious sequence specificity. We examined the target sites of the retroelement ZAM by sequencing each host-ZAM junction in the genome of Drosophila melanogaster. Our overall data provide compelling evidence that ZAM integration machinery recognizes ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.8.7061-7064.1999
更新日期:1999-08-01 00:00:00
abstract::The conversion of simian virus 40 (SV40) component II deoxyribonucleic acid to component I has been used to assay polynucleotide ligase in extracts of tissue culture cells. All cell types examined, including chicken, hamster, mouse, monkey, and human cells, contained adenosine triphosphate-dependent ligase. After infe...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.4.5.719-726.1969
更新日期:1969-11-01 00:00:00
abstract::It was recently shown that the 7a protein of severe acute respiratory syndrome coronavirus induces biochemical changes associated with apoptosis. In this study, the mechanism by which the 7a protein induces apoptosis was examined. The 7a protein was tested for the ability to inhibit cellular gene expression because se...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.80.2.785-793.2006
更新日期:2006-01-01 00:00:00
abstract::Simian immunodeficiency virus (SIV) of macaques isolate SIVmac239 is highly resistant to neutralization by polyclonal antisera or monoclonal antibodies, a property that it shares with most primary isolates of human immunodeficiency virus type 1 (HIV-1). This resistance is important for the ability of the virus to pers...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.18.9993-10003.2003
更新日期:2003-09-01 00:00:00
abstract::The hepatitis C virus (HCV) encodes a large polyprotein; therefore, all viral proteins are produced in equimolar amounts regardless of their function. The aim of our study was to determine the ratio of nonstructural proteins to RNA that is required for HCV RNA replication. We analyzed Huh-7 cells harboring full-length...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.21.13594-13605.2005
更新日期:2005-11-01 00:00:00
abstract::Synthesis of polynucleotide 5'-triphosphatase, which is presumably involved in the initial modification in the series of reactions by which 5'-termini of vaccinia mRNA become capped and methylated, has been demonstrated in vaccinia virus infected HeLa cells. Synthesis of the enzyme is prevented by actinomycin D and cy...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.25.1.37-41.1978
更新日期:1978-01-01 00:00:00
abstract::Human cytomegalovirus (HCMV) virions are composed of a DNA-containing nucleocapsid surrounded by a tegument layer and host-derived lipid envelope studded with virally encoded glycoproteins. These complex virions are estimated to be composed of more than 50 viral proteins. Assembly of HCMV virions is poorly understood,...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01551-10
更新日期:2011-01-01 00:00:00
abstract::Arenaviruses are negative-strand RNA viruses that cause human diseases such as lymphocytic choriomeningitis, Bolivian hemorrhagic fever, and Lassa hemorrhagic fever. No licensed vaccines exist, and current treatment is limited to ribavirin. The prototypic arenavirus, lymphocytic choriomeningitis virus (LCMV), is a mod...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02081-10
更新日期:2011-04-01 00:00:00
abstract::Covalently closed circular molecules of viral DNA synthesized in virus-infected cells are composed mainly of monomers sedimenting at 22 to 27S in neutral sucrose gradients. These monomers are detected by annealing with complementary DNA or transfection assay. However, 11% of the infectious circles sediment faster than...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.29.2.799-804.1979
更新日期:1979-02-01 00:00:00
abstract::Receptors (FcgammaRs) for the constant region of immunoglobulin G (IgG) are an important link between humoral immunity and cellular immunity. To help define the role of FcgammaRs in determining the fate of human immunodeficiency virus type 1 (HIV-1) immune complexes, cDNAs for the four major human Fcgamma receptors (F...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00656-09
更新日期:2009-08-01 00:00:00
abstract::Epstein-Barr virus (EBV) infection leads to lifelong viral persistence through its latency in B cells. EBV-specific T cells control reactivations and prevent the development of EBV-associated malignancies in most healthy carriers, but infection can sometimes cause chronic disease and malignant transformation. Epstein-...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00852-13
更新日期:2013-08-01 00:00:00