Polynucleotide ligase activity in cells infected with simian virus 40, polyoma virus, or vaccinia virus.

abstract：:Mouse mammary tumor virus (MTV) was isolated from the milk of RIII mice by density-gradient centrifugation in Ficoll. The homogeneity of the preparation was demonstrated in electron micrographs. The nucleic acid was extracted with phenol in the presence of Pronase. Its viral origin was attested by failure of ribo-nucl...

journal_title：Journal of virology

authors： Sarkar NH,Moore DH

更新日期：1970-02-01 00:00:00

abstract：:"L-cell virion," obtained from chronically infected 929 L-cell lines, was purified on 70% sucrose pads and its ribonucleic acid (RNA) was extracted and analyzed on sucrose gradients. Two RNA components were isolated from the virion, a rapidly sedimenting species (82S) and a more slowly sedimenting species (6S). When t...

journal_title：Journal of virology

authors： Faras AJ,Erikson RL

更新日期：1969-07-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (gammaHV68, or MHV-68) is a genetically tractable, small animal model for the analysis of gammaherpesvirus pathogenesis. The gammaHV68 genome is colinear with the genomes of other sequence gammaherpesviruses, containing large blocks of conserved genes interspersed by a number of putative gen...

journal_title：Journal of virology

authors： Clambey ET,Virgin HW 4th,Speck SH

更新日期：2000-02-01 00:00:00

abstract：:We have previously demonstrated that parainfluenza virus type 3 (PIV3), a significant respiratory pathogen, can markedly inhibit T-cell function in vitro. We now report that the virus potently induces interleukin-10 (IL-10) production by peripheral blood mononuclear cells. The IL-10 produced contributes to viral inhib...

journal_title：Journal of virology

authors： Sieg S,King C,Huang Y,Kaplan D

更新日期：1996-07-01 00:00:00

abstract：:Regulation of immediate-early gene expression in human cytomegalovirus is subject to complex controls. The major immediate-early (mIE) gene is regulated by both positive and negative regulatory signals, including autoregulation mediated by a cis-repressive sequence. A second immediate-early gene, the US3 gene, is tran...

journal_title：Journal of virology

authors： Biegalke BJ

更新日期：1995-09-01 00:00:00

abstract：:An adenovirus vector encoding murine Fas ligand (mFasL) under an inducible control was derived. In vivo ectopic expression of mFasL in murine livers induced an inflammatory cellular infiltration. Furthermore, ectopic expression of mFasL by myocytes did not allow prolonged vector-mediated transgene expression. Thus, ec...

journal_title：Journal of virology

authors： Zhang HG,Bilbao G,Zhou T,Contreras JL,Gómez-Navarro J,Feng M,Saito I,Mountz JD,Curiel DT

更新日期：1998-03-01 00:00:00

abstract：:mRNA's homologous to the herpes simplex virus type 1 DNA restriction endonuclease fragment BamHI p, which contains the thymidine kinase gene, have been identified and mapped by hybrid-arrested translation and mRNA selection. Such mRNA's, when translated in vitro, directed the synthesis of polypeptides of apparent mole...

journal_title：Journal of virology

authors： Preston CM,McGeoch DJ

更新日期：1981-05-01 00:00:00

abstract：:A recombinant adenovirus was constructed by inserting the human immunodeficiency virus type 1 (HIV-1) envelope gene downstream from the early region 3 (E3) promoter of adenovirus type 5 (Ad5), replacing the coding sequences of E3. The recombinant virus replicated as efficiently as the parent virus in all cell lines te...

journal_title：Journal of virology

authors： Dewar RL,Natarajan V,Vasudevachari MB,Salzman NP

更新日期：1989-01-01 00:00:00

abstract：:The genome of all densoviruses (DNVs) so far isolated from mosquitoes or mosquito cell lines consists of a 4-kb single-stranded DNA molecule with a monosense organization (genus Brevidensovirus, subfamily Densovirinae). We previously reported the isolation of a Culex pipiens DNV (CpDNV) that differs significantly from...

journal_title：Journal of virology

authors： Baquerizo-Audiot E,Abd-Alla A,Jousset FX,Cousserans F,Tijssen P,Bergoin M

更新日期：2009-07-01 00:00:00

abstract：:Cytotoxic T-lymphocyte (CTL) responses are crucial for the control of immunodeficiency virus replication. Possible involvement of a dominant single epitope-specific CTL in control of viral replication has recently been indicated in preclinical AIDS vaccine trials, but it has remained unclear if multiple epitope-specif...

journal_title：Journal of virology

authors： Kawada M,Igarashi H,Takeda A,Tsukamoto T,Yamamoto H,Dohki S,Takiguchi M,Matano T

更新日期：2006-02-01 00:00:00

abstract：:The yield of G418-resistant Huh7 cell clones bearing subgenomic dicistronic GB virus B (GBV-B) is significantly affected by the insertion of a portion of the viral core gene between the GBV-B 5' untranslated region and the exogenous neomycin phosphotransferase selector gene (A. De Tomassi, M. Pizzuti, R. Graziani, A. ...

journal_title：Journal of virology

authors： Pizzuti M,De Tomassi A,Traboni C

更新日期：2003-07-01 00:00:00

abstract：:The interaction of the human immunodeficiency virus (HIV) Gag protein with the plasma membrane of a cell is a critical event in the assembly of HIV particles. The matrix protein region (MA) of HIV type 1 (HIV-1) Pr55Gag has previously been demonstrated to confer membrane-binding properties on the precursor polyprotein...

journal_title：Journal of virology

authors： Spearman P,Horton R,Ratner L,Kuli-Zade I

更新日期：1997-09-01 00:00:00

abstract：:Broadly neutralizing antibodies (bNAbs) are being explored for HIV-1 prevention and cure strategies. However, administration of purified bNAbs poses challenges in resource-poor settings, where the HIV-1 disease burden is greatest. In vivo vector-based production of bNAbs represents an alternative strategy. We investig...

journal_title：Journal of virology

authors： Badamchi-Zadeh A,Tartaglia LJ,Abbink P,Bricault CA,Liu PT,Boyd M,Kirilova M,Mercado NB,Nanayakkara OS,Vrbanac VD,Tager AM,Larocca RA,Seaman MS,Barouch DH

更新日期：2018-03-14 00:00:00

abstract：:Prestimulation of the TLR4 pathway with lipopolysaccharide (LPS) protects mice from lethal infection with H5N1 influenza virus. Here, we reveal that the TLR4-TRIF pathway is required for this protective effect by using mice whose TLR4-related molecules were knocked out. Microarray analysis of primary mouse lung cultur...

journal_title：Journal of virology

authors： Shinya K,Ito M,Makino A,Tanaka M,Miyake K,Eisfeld AJ,Kawaoka Y

更新日期：2012-01-01 00:00:00

abstract：:Two foot-and-mouth disease virus (FMDV) genome sequences have been determined for isolates collected from recent field outbreaks in North Africa (Egypt) and the Middle East (Palestinian Autonomous Territories). These data represent the first examples of complete genomic sequences for the FMDV SAT 2 topotype VII, which...

journal_title：Journal of virology

authors： Valdazo-González B,Knowles NJ,Hammond J,King DP

更新日期：2012-08-01 00:00:00

abstract：:Influenza A virus (IAV) remains a global health concern despite the availability of a seasonal vaccine. It is difficult to predict which strains will circulate during influenza season, and therefore, it is extremely challenging to test novel vaccines in the human population. To overcome this obstacle, new vaccines mus...

journal_title：Journal of virology

authors： Fay EJ,Aron SL,Stone IA,Waring BM,Plemper RK,Langlois RA

更新日期：2018-12-10 00:00:00

abstract：:Activation of the interferon-inducible, double-stranded RNA-dependent protein kinase was monitored in monolayer cultures of control and interferon-treated HeLa cells infected with encephalomyocarditis virus. The extent of phosphorylation in the intact cell of the alpha-subunit of eucaryotic protein synthesis initiatio...

journal_title：Journal of virology

authors： Rice AP,Duncan R,Hershey JW,Kerr IM

更新日期：1985-06-01 00:00:00

abstract：:Herpes simplex virus (HSV) has often been suggested for development as a vector, particularly for the nervous system. Considerable evidence has shown that for use of HSV as a vector, immediate-early (IE) gene expression must be minimized or abolished, otherwise such vectors are likely to be highly cytotoxic. Mutations...

journal_title：Journal of virology

authors： Thomas SK,Lilley CE,Latchman DS,Coffin RS

更新日期：1999-09-01 00:00:00

abstract：:Lysyl-tRNA synthetase (LysRS) is packaged into human immunodeficiency virus type 1 (HIV-1) via its interaction with Gag, and this enzyme facilitates the selective packaging of tRNA(3)(Lys), the primer for initiating reverse transcription, into HIV-1. The Gag/LysRS interaction is detected at detergent-resistant membran...

journal_title：Journal of virology

authors： Halwani R,Cen S,Javanbakht H,Saadatmand J,Kim S,Shiba K,Kleiman L

更新日期：2004-07-01 00:00:00

abstract：:The gastric mucosa is an important portal of entry for lymphocytic choriomeningitis virus (LCMV) infections. Within hours after intragastric (i.g.) inoculation, virus appears in the gastric epithelia, then in the mesenteric lymph nodes and spleen, and then in the liver and brain. By 72 h i.g.-inoculated virus is widel...

journal_title：Journal of virology

authors： Yin C,Djavani M,Schenkel AR,Schmidt DS,Pauza CD,Salvato MS

更新日期：1998-11-01 00:00:00

abstract：:In gene therapy, the innate immune system is a significant barrier to the effective application of adenovirus (Ad) vectors. In kidney epithelium-derived (REC) cells, serotype 5 Ad vectors induce the expression of the chemokine CXCL10 (IP-10), a response that is dependent on NFkappaB. Compared to the parental vector Ad...

journal_title：Journal of virology

authors： Liu Q,White LR,Clark SA,Heffner DJ,Winston BW,Tibbles LA,Muruve DA

更新日期：2005-12-01 00:00:00

abstract：:While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of...

journal_title：Journal of virology

authors： Denkers ND,Hayes-Klug J,Anderson KR,Seelig DM,Haley NJ,Dahmes SJ,Osborn DA,Miller KV,Warren RJ,Mathiason CK,Hoover EA

更新日期：2013-02-01 00:00:00

abstract：:There is a high degree of intraisolate sequence heterogeneity in the tax gene of human T-cell leukemia virus type I (HTLV-I), although the sequence variation between patients is small compared with that of human immunodeficiency virus type 1. In the present study, we investigated whether naturally occurring amino acid...

journal_title：Journal of virology

authors： Niewiesk S,Daenke S,Parker CE,Taylor G,Weber J,Nightingale S,Bangham CR

更新日期：1995-04-01 00:00:00

abstract：:Phage P22 can integrate as prophage into a recombination-deficient (Rec(-)) strain of Salmonella typhimurium. At 37 C, the integration efficiency is only 10% that in Rec(+) infection, but at 25 C the efficiencies in Rec(-) and Rec(+) hosts are similar. Rec(-) lysogens cannot be induced by ultraviolet irradiation or by...

journal_title：Journal of virology

authors： Wing JP

更新日期：1968-07-01 00:00:00

abstract：:The initial virus strains from as many as 12% of individuals with primary human immunodeficiency virus (HIV) infection have a 50% inhibitory concentration

journal_title：Journal of virology

authors： Leigh Brown AJ,Frost SD,Good B,Daar ES,Simon V,Markowitz M,Collier AC,Connick E,Conway B,Margolick JB,Routy JP,Corbeil J,Hellmann NS,Richman DD,Little SJ

更新日期：2004-03-01 00:00:00

abstract：:Bats have been identified as the natural reservoir of severe acute respiratory syndrome (SARS)-like and SARS coronaviruses (SLCoV and SCoV). However, previous studies suggested that none of the currently sampled bat SLCoVs is the descendant of the direct ancestor of SCoV, based on their relatively distant phylogenetic...

journal_title：Journal of virology

authors： Hon CC,Lam TY,Shi ZL,Drummond AJ,Yip CW,Zeng F,Lam PY,Leung FC

更新日期：2008-02-01 00:00:00

abstract：:Influenza viruses and rhinoviruses are responsible for a large number of acute respiratory viral infections in human populations and are detected as copathogens within hosts. Clinical and epidemiological studies suggest that coinfection by rhinovirus and influenza virus may reduce disease severity and that they may al...

journal_title：Journal of virology

authors： Gonzalez AJ,Ijezie EC,Balemba OB,Miura TA

更新日期：2018-11-12 00:00:00

abstract：:The mammalian tripartite motif protein, TRIM5α, recognizes retroviral capsids entering the cytoplasm and blocks virus infection. Depending on the particular TRIM5α protein and retrovirus, complete disruption of the TRIM5α RING domain decreases virus-restricting activity to various degrees. TRIM5α exhibits RING domain-...

journal_title：Journal of virology

authors： Kim J,Tipper C,Sodroski J

更新日期：2011-08-01 00:00:00

abstract：:The genome of lymphocytic choriomeningitis virus (LCMV) consists of two negative-sense single-stranded RNA segments, designated L and S. Both segments contain two viral genes in an ambisense coding strategy, with the genes being separated by an intergenic region (IGR). We have developed a reverse genetic system that a...

journal_title：Journal of virology

authors： Lee KJ,Novella IS,Teng MN,Oldstone MB,de La Torre JC

更新日期：2000-04-01 00:00:00

abstract：:Fluorosulfonylbenzoyl 5'-adenosine (FSBA) bound to one site in simian virus 40 large T antigen (T) and covalently modified greater than 95% of the molecules in a complete reaction. This analog for ATP specifically cross-links to the Mg-phosphate pocket in ATP-binding sites. Cyanogen bromide cleavage and tryptic digest...

journal_title：Journal of virology

authors： Bradley MK

更新日期：1990-10-01 00:00:00