Aerosol transmission of chronic wasting disease in white-tailed deer.

abstract：:The membrane fusion reaction promoted by the paramyxovirus simian virus 5 (SV5) and human parainfluenza virus type 3 (HPIV-3) fusion (F) proteins and hemagglutinin-neuraminidase (HN) proteins was characterized when the surface densities of F and HN were varied. Using a quantitative content mixing assay, it was found t...

journal_title：Journal of virology

authors： Dutch RE,Joshi SB,Lamb RA

更新日期：1998-10-01 00:00:00

abstract：:Five gibbon ape leukemia virus substrains (two from gibbons with lymphocytic leukemia and three from gibbons with myelogenous leukemia) were examined for unique genomic sequences specific for each form of leukemia. By using sequential adsorption procedures, the genome from each gibbon ape leukemia virus was fractionat...

journal_title：Journal of virology

authors： Sun L,Kawakami TG

更新日期：1980-08-01 00:00:00

abstract：:We isolated revertants of a polyomavirus whose origin of DNA replication contains a point mutation in the palindrome to which large T antigen binds. Four independent second-site revertants contain an Asp-286----Asn-286 substitution in large T antigen. This mutant large T antigen activates replication of DNAs containin...

journal_title：Journal of virology

authors： Tang WJ,Folk WR

更新日期：1989-01-01 00:00:00

abstract：:Since human immunodeficiency virus (HIV)-specific cell-mediated immune (CMI) responses are critical in the early control and resolution of HIV infection and correlate with postchallenge outcomes in rhesus macaque challenge experiments, we sought to identify a plasmid DNA (pDNA) vaccine design capable of eliciting robu...

journal_title：Journal of virology

authors： Luckay A,Sidhu MK,Kjeken R,Megati S,Chong SY,Roopchand V,Garcia-Hand D,Abdullah R,Braun R,Montefiori DC,Rosati M,Felber BK,Pavlakis GN,Mathiesen I,Israel ZR,Eldridge JH,Egan MA

更新日期：2007-05-01 00:00:00

abstract：:Although hepatitis A virus (HAV) is typically transmitted by the fecal-oral route, little is known of its interactions with cells of the gastrointestinal tract. We studied the replication of HAV in polarized cultures of Caco-2 cells, a human cell line which retains many differentiated functions of small intestinal epi...

journal_title：Journal of virology

authors： Blank CA,Anderson DA,Beard M,Lemon SM

更新日期：2000-07-01 00:00:00

abstract：:Spatial variation in the epidemiological patterns of successive waves of pandemic influenza virus in humans has been documented throughout the 20th century but never understood at a molecular level. However, the unprecedented intensity of sampling and whole-genome sequencing of the H1N1/09 pandemic virus now makes suc...

journal_title：Journal of virology

authors： Nelson MI,Tan Y,Ghedin E,Wentworth DE,St George K,Edelman L,Beck ET,Fan J,Lam TT,Kumar S,Spiro DJ,Simonsen L,Viboud C,Holmes EC,Henrickson KJ,Musser JM

更新日期：2011-01-01 00:00:00

abstract：:Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; t...

journal_title：Journal of virology

authors： Luzuriaga K,Wu H,McManus M,Britto P,Borkowsky W,Burchett S,Smith B,Mofenson L,Sullivan JL

更新日期：1999-01-01 00:00:00

abstract：:The human cyclin T1 (hCycT1) protein from the positive transcription elongation factor b (P-TEFb) binds the transactivator Tat and the transactivation response (TAR) RNA stem loop from human immunodeficiency virus type 1 (HIV). This complex activates the elongation of viral transcription. To create effective inhibitor...

journal_title：Journal of virology

authors： Fujinaga K,Irwin D,Geyer M,Peterlin BM

更新日期：2002-11-01 00:00:00

abstract：:We have developed a complementation assay, using transiently transfected COS cells, to facilitate a molecular analysis of the herpes simplex virus type 1 glycoprotein gH. When infected by a gH-null syncytial virus, COS cells expressing wild-type gH generate infectious progeny virions and form a syncytium with neighbor...

journal_title：Journal of virology

authors： Wilson DW,Davis-Poynter N,Minson AC

更新日期：1994-11-01 00:00:00

abstract：:The incorporation of (3)H-thymidine ((3)H-dT) into deoxyribonucleic acid (DNA) has been studied in uninfected confluent monolayer cultures of monkey kidney and mouse kidney cells, simian virus 40 (SV40)-infected cells, and in SV40-transformed mouse kidney cells. Radioautographic measurements revealed that during the p...

journal_title：Journal of virology

authors： Kit S,De Torres RA,Dubbs DR,Salvi ML

更新日期：1967-08-01 00:00:00

abstract：:In vitro transcriptase activity of three group I temperature-sensitive (ts) mutants of vesicular stomatitis virus restricted at 39 C was restored by L-protein fractions derived from wild-type (wt) vesicular stomatitis virion nucleo-capsids. Soluble NS protein from wt nucleocapsids did not reconstitute restricted trans...

journal_title：Journal of virology

authors： Hunt DM,Emerson SU,Wagner RR

更新日期：1976-05-01 00:00:00

abstract：:The human papillomavirus (HPV) E6 oncoproteins recruit the cellular ubiquitin ligase E6AP/UBE3A to target cellular substrates for proteasome-mediated degradation, and one consequence of this activity is the E6 stimulation of E6AP autoubiquitination and degradation. Recent studies identified an autism-linked mutation w...

journal_title：Journal of virology

authors： Thatte J,Banks L

更新日期：2017-10-27 00:00:00

abstract：:Human cytomegalovirus (HCMV) pathogenesis is dependent on the hematogenous spread of the virus to host tissue. While data suggest that infected monocytes are required for viral dissemination from the blood to the host organs, infected endothelial cells are also thought to contribute to this key step in viral pathogene...

journal_title：Journal of virology

authors： Bentz GL,Jarquin-Pardo M,Chan G,Smith MS,Sinzger C,Yurochko AD

更新日期：2006-12-01 00:00:00

abstract：:By using T1 oligonucleotide fingerprinting and mapping techniques, we analyzed the genomic structure of retroviruses produced by thymocytes and splenocytes of reciprocal bone marrow-and thymus-grafted chimeras. We found that the genetic factor(s) derived from NZB mice that suppresses the development of thymic leukemia...

journal_title：Journal of virology

authors： Datta SK,Thomas CY,Nicklas JA,Coffin JM

更新日期：1983-07-01 00:00:00

abstract：:We have examined the pathway of rhinovirus interaction with soluble intercellular adhesion molecule 1 (sICAM-1). Binding of sICAM-1 to rhinovirus serotypes 3 and 14 gives particles with sedimentation coefficients from 145 to 120S, depending on the amount of sICAM-1 bound. The formation of 120S particles is faster and ...

journal_title：Journal of virology

authors： Casasnovas JM,Springer TA

更新日期：1994-09-01 00:00:00

abstract：:We used reovirus reassortant genetics and severe combined immunodeficient (SCID) mice to define viral genes important for organ tropism and virulence in the absence of antigen-specific immunity. Adult SCID mice infected with reovirus serotype 1 strain Lang (T1L) died after 20 +/- 6 days, while infection with serotype ...

journal_title：Journal of virology

authors： Haller BL,Barkon ML,Vogler GP,Virgin HW 4th

更新日期：1995-01-01 00:00:00

abstract：:High-risk human papillomavirus type 16 (HPV16) is the primary causative agent of cervical cancer and therefore is responsible for significant morbidity and mortality worldwide. Cellular transformation is mediated directly by the expression of viral oncogenes, the least characterized of which, E5, subverts cellular pro...

journal_title：Journal of virology

authors： Wetherill LF,Holmes KK,Verow M,Müller M,Howell G,Harris M,Fishwick C,Stonehouse N,Foster R,Blair GE,Griffin S,Macdonald A

更新日期：2012-05-01 00:00:00

abstract：:We have developed a system for producing murine leukemia virus (MLV) pseudotyped with human hepatitis B virus (HBV) large (L) and small (S) surface antigens (HBsAg) for targeting primary human hepatocytes. Using the MLV(HBV) pseudotype virus containing a beta-galactosidase reporter gene, we demonstrated that this pseu...

journal_title：Journal of virology

authors： Sung VM,Lai MM

更新日期：2002-01-01 00:00:00

abstract：:Reverse transcriptases (RTs) are found in a wide variety of mobile genetic elements including viruses, retrotransposons, and infectious organellar introns. An invariant triad of aspartates is thought to be required for the catalytic function of RTs. We generated RT mutants in the yeast retrotransposon Ty1, changing ea...

journal_title：Journal of virology

authors： Uzun O,Gabriel A

更新日期：2001-07-01 00:00:00

abstract：:2'-5'-Oligoadenylate synthetase-like protein (OASL) is an interferon-inducible antiviral protein. Here we describe differential inhibitory activities of human OASL and the two mouse OASL homologs against respiratory syncytial virus (RSV) replication. Interestingly, nonstructural protein 1 (NS1) of RSV promoted proteas...

journal_title：Journal of virology

authors： Dhar J,Cuevas RA,Goswami R,Zhu J,Sarkar SN,Barik S

更新日期：2015-10-01 00:00:00

abstract：:Human herpesvirus 8 (HHV-8) is likely to be involved in the pathogenesis of Kaposi's sarcoma (KS) and body cavity-based lymphomas (BCBLs). The HHV-8 genome is primarily in a latent state in BCBL-derived cell lines like BCBL-1, but lytic replication can be induced by phorbol esters (R. Renne, W. Zhang, B. Herndier, M. ...

journal_title：Journal of virology

authors： Raab MS,Albrecht JC,Birkmann A,Yağuboğlu S,Lang D,Fleckenstein B,Neipel F

更新日期：1998-08-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) alkaline nuclease, encoded by the UL12 gene, plays an important role in HSV-1 replication, as a UL12 null mutant displays a severe growth defect. The HSV-1 alkaline exonuclease UL12 interacts with the viral single-stranded DNA binding protein ICP8 and promotes strand exchange in...

journal_title：Journal of virology

authors： Balasubramanian N,Bai P,Buchek G,Korza G,Weller SK

更新日期：2010-12-01 00:00:00

abstract：:Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction of the innate immune response to influenza virus infection results in hypercytokinemia, which is responsible for mortality and morbidity. However, the mechanism by which influenza induces hypercytokinemia is not fully understood...

journal_title：Journal of virology

authors： Ma N,Li X,Jiang H,Dai Y,Xu G,Zhang Z

更新日期：2021-01-13 00:00:00

abstract：:The adenovirus E1A transforming region, which encodes immortalization, partial cell transformation, and gene activation functions, expresses two early mRNAs, 13S and 12S. Multiple-T antigen species with different electrophoretic mobilities are formed from each mRNA, presumably by unknown posttranslational modification...

journal_title：Journal of virology

authors： Lucher LA,Brackmann KH,Symington JS,Green M

更新日期：1986-05-01 00:00:00

abstract：:Visna lentiviruses have a natural tropism for cells of the macrophage lineage of sheep and goats, but virus replication in these cells in vivo is restricted so that only small quantities of virus are produced. One restricting factor suggested in previous studies is that virus replication is dependent on the maturity o...

journal_title：Journal of virology

authors： Gendelman HE,Narayan O,Kennedy-Stoskopf S,Kennedy PG,Ghotbi Z,Clements JE,Stanley J,Pezeshkpour G

更新日期：1986-04-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) does not replicate in murine cells. We investigated the basis of this block by infecting a murine NIH 3T3 reporter cell line that stably expressed human CD4, CCR5, and cyclin T1 and contained a transactivatable HIV-1 long terminal repeat (LTR)-green fluorescent protein (GFP)...

journal_title：Journal of virology

authors： Mariani R,Rutter G,Harris ME,Hope TJ,Kräusslich HG,Landau NR

更新日期：2000-04-01 00:00:00

abstract：:The structures of canine parvovirus (CPV) and feline parvovirus (FPV) complexed with antibody fragments from eight different neutralizing monoclonal antibodies were determined by cryo-electron microscopy (cryoEM) reconstruction to resolutions varying from 8.5 to 18 A. The crystal structure of one of the Fab molecules ...

journal_title：Journal of virology

authors： Hafenstein S,Bowman VD,Sun T,Nelson CD,Palermo LM,Chipman PR,Battisti AJ,Parrish CR,Rossmann MG

更新日期：2009-06-01 00:00:00

abstract：:Primary RNA transcripts from the human immunodeficiency virus type 1 (HIV-1) are processed into mature mRNA by a complex series of splicing events. Viral structural proteins and reverse transcriptase are translated from unspliced or singly spliced transcripts. Proteins which control virus replication, including tat, r...

journal_title：Journal of virology

authors： Robert-Guroff M,Popovic M,Gartner S,Markham P,Gallo RC,Reitz MS

更新日期：1990-07-01 00:00:00

abstract：:Five human recombinant Fab fragments (Fabs) specific for measles virus (MV) proteins were isolated from three antibody phage display libraries generated from RNAs derived from bone marrow or splenic lymphocytes from three MV-immune individuals. All Fabs reacted in an enzyme-linked immunosorbent assay with MV antigens....

journal_title：Journal of virology

authors： de Carvalho Nicacio C,Williamson RA,Parren PW,Lundkvist A,Burton DR,Björling E

更新日期：2002-01-01 00:00:00

abstract：:Plasmid lambdadv1, which is in a dimeric form, was converted to a linear monomer duplex by the action of EcoRI restriction endonuclease that incises at a unique site in this plasmid genome. The resulting products were then joined by Escherichia coli DNA ligase to produce molecules with various oligomeric forms, and fr...

journal_title：Journal of virology

authors： Matsubara K,Takagi Y,Mukai T

更新日期：1975-09-01 00:00:00