Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax.

abstract：:Diseases of the nasopharyngeal epithelium due to Epstein-Barr virus (EBV) infection typically occur in chronic virus carriers with preexisting virus-specific antibodies. In vitro studies have shown that EBV-specific immunoglobulin A (IgA) promotes infection of human epithelial cells, otherwise refractory to EBV, via t...

journal_title：Journal of virology

authors： Gan YJ,Chodosh J,Morgan A,Sixbey JW

更新日期：1997-01-01 00:00:00

abstract：:It has been previously shown that rotavirus maturation and stability of the outer capsid are calcium-dependent processes. More recently, it has been hypothesized that penetration of the cell membrane is also affected by conformational changes of the capsid induced by Ca2+. In this study, we determined quantitatively t...

journal_title：Journal of virology

authors： Ruiz MC,Charpilienne A,Liprandi F,Gajardo R,Michelangeli F,Cohen J

更新日期：1996-08-01 00:00:00

abstract：:While a large number of mosquito-transmitted alphaviruses are known to cause serious human diseases, there are no licensed vaccines that protect against alphavirus infections. The alphavirus chikungunya virus (CHIKV) has caused multiple recent outbreaks of chikungunya fever. This virus has the potential to cause a wor...

journal_title：Journal of virology

authors： Chattopadhyay A,Wang E,Seymour R,Weaver SC,Rose JK

更新日期：2013-01-01 00:00:00

abstract：:Protein kinase activity in general is stimulated at least 5- to 10-fold in ribosomal salt wash preparations from poliovirus-infected HeLa cells compared with those from mock-infected cells. The stimulation of kinase activity is manifested by increased phosphorylation of ribosome-associated polypeptides having approxim...

journal_title：Journal of virology

authors： Ransone LJ,Dasgupta A

更新日期：1987-06-01 00:00:00

abstract：:A new method was developed for isolation of intracellular forms of simian virus 40 (SV40) nucleoprotein complexes from SV40-infected CV-1 cells late in the infectious cycle. In contrast to the Triton extraction method, which yields only a 60-70S complex, this new procedure yielded three forms of SV40 nucleoprotein com...

journal_title：Journal of virology

authors： Fernandez-Munoz R,Coca-Prados M,Hsu MT

更新日期：1979-02-01 00:00:00

abstract：:In July 1991, an influenza A virus, designated A/Maryland/12/91 (A/MD), was isolated from the bronchial secretions of a 27-year-old animal caretaker. He had been admitted to the hospital with bilateral pneumonia and died of acute respiratory distress syndrome 13 days later. Antigenic analyses with postinfection ferret...

journal_title：Journal of virology

authors： Wentworth DE,Thompson BL,Xu X,Regnery HL,Cooley AJ,McGregor MW,Cox NJ,Hinshaw VS

更新日期：1994-04-01 00:00:00

abstract：UNLABELLED:The noncovalent interactions that mediate trimerization of the influenza hemagglutinin (HA) are important determinants of its biological activities. Recent studies have demonstrated that mutations in the HA trimer interface affect the thermal and pH sensitivities of HA, suggesting a possible impact on vaccin...

journal_title：Journal of virology

authors： Yang H,Chang JC,Guo Z,Carney PJ,Shore DA,Donis RO,Cox NJ,Villanueva JM,Klimov AI,Stevens J

更新日期：2014-05-01 00:00:00

abstract：:Approximately 20 to 22 copies of adenovirus type 12 (Ad12) DNA per cell were integrated into the genome of the cell line T637. Only a few of these copies seemed to remain intact and colinear with virion DNA. All other persisting viral genomes exhibited deletions or inversions or both in the right-hand part of Ad12 DNA...

journal_title：Journal of virology

authors： Eick D,Doerfler W

更新日期：1982-04-01 00:00:00

abstract：UNLABELLED:Flaviviruses pose a significant threat to both animals and humans. Recently, a novel flavivirus, duck Tembusu virus (DTMUV), was identified to be the causative agent of a serious duck viral disease in Asia. Its rapid spread, expanding host range, and uncertain transmission routes have raised substantial conc...

journal_title：Journal of virology

authors： Wang HJ,Li XF,Liu L,Xu YP,Ye Q,Deng YQ,Huang XY,Zhao H,Qin ED,Shi PY,Gao GF,Qin CF

更新日期：2016-06-24 00:00:00

abstract：:Integrase of human immunodeficiency virus type 1 (HIVIN) consists of 288 amino acids, and its minimum DNA-binding domain (MDBD) (amino acids [aa] 220 to 270) is required for the integration reaction. We produced and characterized four murine monoclonal antibodies (MAbs) to the MDBD of HIVIN (strain LAI). Immunoblot an...

journal_title：Journal of virology

authors： Ishikawa T,Okui N,Kobayashi N,Sakuma R,Kitamura T,Kitamura Y

更新日期：1999-05-01 00:00:00

abstract：:DNA was extracted from [(3)H]thymidine-labeled Marek's disease virus (MDV) and purified by two cycles of CsCl gradient centrifugation in a fixed-angle rotor. The DNA was transcribed in vitro into (32)P-labeled complementary RNA (cRNA). MDV cRNA did not hybridize with DNA from chicken embryo fibroblast cultures or from...

journal_title：Journal of virology

authors： Nazerian K,Lindahl T,Klein G,Lee LF

更新日期：1973-10-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1)-infected macrophages damage mature neurons in the brain, although their effect on neuronal development has not been clarified. In this study, we show that HIV-1-infected macrophages produce factors that impair the development of neuronal precursor cells and that soluble vira...

journal_title：Journal of virology

authors： Kitayama H,Miura Y,Ando Y,Hoshino S,Ishizaka Y,Koyanagi Y

更新日期：2008-03-01 00:00:00

abstract：:The nonpathogenic human adeno-associated virus (AAV) has developed a mechanism to integrate its genome into human chromosome 19 at 19q13.4 (termed AAVS1), thereby establishing latency. Here, we provide evidence that the chromosomal signals required for site-specific integration are conserved in the mouse genome proxim...

journal_title：Journal of virology

authors： Dutheil N,Yoon-Robarts M,Ward P,Henckaerts E,Skrabanek L,Berns KI,Campagne F,Linden RM

更新日期：2004-08-01 00:00:00

abstract：:Bovine herpesvirus 1 (BHV-1) specifies and unspliced early 2.6-kb RNA (ER2.6) which is 3' coterminal with exon 2 of the 2.9-kb immediate-early (IE) RNA. The two transcripts have a common open reading frame (676 codons). The predicted protein, designated BHV-1 infected cell protein 0 (BICP0), contains a zinc finger dom...

journal_title：Journal of virology

authors： Fraefel C,Zeng J,Choffat Y,Engels M,Schwyzer M,Ackermann M

更新日期：1994-05-01 00:00:00

abstract：:Human papillomavirus type 16 (HPV16) is the primary etiologic agent for cervical cancer. The infectious entry of HPV16 into cells occurs via a so-far poorly characterized clathrin- and caveolin-independent endocytic pathway, which involves tetraspanin proteins and actin. In this study, we investigated the specific rol...

journal_title：Journal of virology

authors： Scheffer KD,Gawlitza A,Spoden GA,Zhang XA,Lambert C,Berditchevski F,Florin L

更新日期：2013-03-01 00:00:00

abstract：:Clink, a 20-kDa protein of faba bean necrotic yellows virus, a single-stranded DNA plant virus, interacts with pRB family members and a SKP1 homologue from Medicago sativa. An LxCxE motif and an F-box of Clink mediate the interactions with the respective proteins. The capacity of Clink to bind pRB correlates with its ...

journal_title：Journal of virology

authors： Aronson MN,Meyer AD,Györgyey J,Katul L,Vetten HJ,Gronenborn B,Timchenko T

更新日期：2000-04-01 00:00:00

abstract：:The protease (PR) from human immunodeficiency virus (HIV) is essential for viral replication: this aspartyl protease, active only as a dimer, is responsible for cleavage of the viral polyprotein precursors (Gag and Gag-Pol), to release the functional mature proteins. In this work, we have studied the structure-functio...

journal_title：Journal of virology

authors： Dautin N,Karimova G,Ladant D

更新日期：2003-08-01 00:00:00

abstract：:Adeno-associated virus (AAV) is a human parvovirus currently being developed as a vector for gene therapy applications. Because the gene transfer vector commonly retains only the AAV terminal repeats, propagation of recombinant AAV (rAAV) requires that the viral replication (Rep) and capsid (Cap) proteins be supplied ...

journal_title：Journal of virology

authors： Vincent KA,Piraino ST,Wadsworth SC

更新日期：1997-03-01 00:00:00

abstract：:The integrase protein of human immunodeficiency virus type 1 removes two nucleotides from the 3' ends of reverse-transcribed human immunodeficiency virus type 1 DNA (3' processing) and covalently inserts the processed ends into a target DNA (DNA strand transfer). Mutant integrase proteins that lack the amino-and/or ca...

journal_title：Journal of virology

authors： Engelman A,Hickman AB,Craigie R

更新日期：1994-09-01 00:00:00

abstract：:There is an open reading frame in the E3 transcription unit of adenovirus type 3 (Ad3) and Ad7 that could encode a protein of 16 kDa (16K protein). Ad3 and Ad7 are members of subgroup B of human adenoviruses. Using a rabbit antipeptide antiserum, we show that the 16K protein is expressed in Ad3- and Ad7-infected cells...

journal_title：Journal of virology

authors： Hawkins LK,Wilson-Rawls J,Wold WS

更新日期：1995-07-01 00:00:00

abstract：:Some strains of the protozoan parasite genus Leishmania are persistently infected with single-segmented double-stranded RNA viruses, which are termed LRV. The function of these cytoplasmic viruses is unknown. In order to address the question of whether LRV affects the parasite's phenotype, pairs of isogenic LRV(+)-LRV...

journal_title：Journal of virology

authors： Widmer G

更新日期：1995-07-01 00:00:00

abstract：:Glycoprotein B (gB) is a conserved herpesvirus virion component implicated in membrane fusion. As with many-but not all-herpesviruses, the gB of murid herpesvirus 4 (MuHV-4) is cleaved into disulfide-linked subunits, apparently by furin. Preventing gB cleavage for some herpesviruses causes minor infection deficits in ...

journal_title：Journal of virology

authors： Glauser DL,Milho R,Frederico B,May JS,Kratz AS,Gillet L,Stevenson PG

更新日期：2013-10-01 00:00:00

abstract：:The mechanisms involved in the emergence of virulent mammalian viruses were investigated in the adult immunodeficient SCID mouse infected by the attenuated prototype strain of the parvovirus Minute Virus of Mice (MVMp). Cloned MVMp intravenously inoculated in mice consistently evolved during weeks of subclinical infec...

journal_title：Journal of virology

authors： Rubio MP,López-Bueno A,Almendral JM

更新日期：2005-09-01 00:00:00

abstract：:We have used Northern blot hybridization to study the accumulation of specific cellular mRNAs in Vero cells infected with herpes simplex virus (HSV) type 1 or type 2. HSV-1 infection decreased the cytoplasmic levels of beta- and gamma-actin, beta-tubulin, and histone H3 and H4 mRNAs, though not all at the same rate. H...

journal_title：Journal of virology

authors： Schek N,Bachenheimer SL

更新日期：1985-09-01 00:00:00

abstract：:The regulation of murine cytomegalovirus early (E) gene expression was studied in the cell line B25, which is stably transfected with the immediate-early ie1/ie3 gene complex. Infection of B25 cells in the presence of the protein synthesis inhibitor cycloheximide resulted in the expression of some E genes, whereas for...

journal_title：Journal of virology

authors： Bühler B,Keil GM,Weiland F,Koszinowski UH

更新日期：1990-05-01 00:00:00

abstract：:Coronaviruses that infect humans belong to the Alpha-coronavirus (including HCoV-229E) and Beta-coronavirus (including SARS-CoV and SARS-CoV-2) genera. In particular, SARS-CoV-2 is currently a major threat to public health worldwide. The spike (S) homotrimers bind to their receptors via the receptor-binding domain (RB...

journal_title：Journal of virology

authors： Shi Y,Shi J,Sun L,Tan Y,Wang G,Guo F,Hu G,Fu Y,Fu ZF,Xiao S,Peng G

更新日期：2021-01-07 00:00:00

abstract：:Cas-Br-M is an ecotropic murine leukemia virus (MuLV) of wild-mouse origin that causes neurogenic hind-limb paralysis. By virtue of its N-tropism, the virus replicates well in tissues of mice bearing the n but not the b allele at the Fv-1 locus. To determine if different Fv-1n strains of mice were equally susceptible ...

journal_title：Journal of virology

authors： Hoffman PM,Morse HC 3rd

更新日期：1985-01-01 00:00:00

abstract：:The family Bunyaviridae is the most diversified family of RNA viruses. We describe a novel prototypic bunyavirus, tentatively named Gouléako virus, isolated from various mosquito species trapped in Côte d'Ivoire. The S segment comprised 1,087 nucleotides (nt), the M segment 3,188 nt, and the L segment 6,358 nt, consti...

journal_title：Journal of virology

authors： Marklewitz M,Handrick S,Grasse W,Kurth A,Lukashev A,Drosten C,Ellerbrok H,Leendertz FH,Pauli G,Junglen S

更新日期：2011-09-01 00:00:00

abstract：:The complete genomic sequence of kelp fly virus (KFV), originally isolated from the kelp fly, Chaetocoelopa sydneyensis, has been determined. Analyses of its genomic and structural organization and phylogeny show that it belongs to a hitherto undescribed group within the picorna-like virus superfamily. The single-stra...

journal_title：Journal of virology

authors： Hartley CJ,Greenwood DR,Gilbert RJ,Masoumi A,Gordon KH,Hanzlik TN,Fry EE,Stuart DI,Scotti PD

更新日期：2005-11-01 00:00:00

abstract：:Expression of the human T-cell leukemia virus type 1 (HTLV-1) oncoprotein Tax is correlated with cellular transformation contributing to the development of adult T-cell leukemia. Tax has been shown to modulate the activities of several cellular promoters. Existing evidence suggests that Tax need not directly bind to D...

journal_title：Journal of virology

authors： Kibler KV,Jeang KT

更新日期：2001-03-01 00:00:00