Characterization of the mouse adeno-associated virus AAVS1 ortholog.


:The nonpathogenic human adeno-associated virus (AAV) has developed a mechanism to integrate its genome into human chromosome 19 at 19q13.4 (termed AAVS1), thereby establishing latency. Here, we provide evidence that the chromosomal signals required for site-specific integration are conserved in the mouse genome proximal to the recently identified Mbs85 gene. These sequence motifs can be specifically nicked by the viral Rep protein required for the initiation of site-specific AAV DNA integration. Furthermore, these signals can serve as a minimal origin for Rep-dependent DNA replication. In addition, we isolated the mouse Mbs85 proximal promoter and show transcriptional activity in three mouse cell lines.


J Virol


Journal of virology


Dutheil N,Yoon-Robarts M,Ward P,Henckaerts E,Skrabanek L,Berns KI,Campagne F,Linden RM




Has Abstract


2004-08-01 00:00:00














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    authors: Lu A,Miller LK

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  • Importance of both the coding and the segment-specific noncoding regions of the influenza A virus NS segment for its efficient incorporation into virions.

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    pub_type: 杂志文章


    authors: Fujii K,Fujii Y,Noda T,Muramoto Y,Watanabe T,Takada A,Goto H,Horimoto T,Kawaoka Y

    更新日期:2005-03-01 00:00:00

  • Herpes simplex virus 1 recombinants with noninverting genomes frozen in different isomeric arrangements are capable of independent replication.

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    pub_type: 杂志文章


    authors: Jenkins FJ,Roizman B

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    authors: Steffens HP,Kurz S,Holtappels R,Reddehase MJ

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  • Rescue of recombinant Thogoto virus from cloned cDNA.

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    pub_type: 杂志文章


    authors: Wagner E,Engelhardt OG,Gruber S,Haller O,Kochs G

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  • A patch of positively charged amino acids surrounding the human immunodeficiency virus type 1 Vif SLVx4Yx9Y motif influences its interaction with APOBEC3G.

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  • Site-Specific Recombination by SSV2 Integrase: Substrate Requirement and Domain Functions.

    abstract:UNLABELLED:SSV-type integrases, encoded by fuselloviruses which infect the hyperthermophilic archaea of the Sulfolobales, are archaeal members of the tyrosine recombinase family. These integrases catalyze viral integration into and excision from a specific site on the host genome. In the present study, we have establis...

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  • The carboxy terminus of human immunodeficiency virus type 1 gp160 limits its proteolytic processing and transport in transfected cell lines.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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  • Molecular cloning and characterization of human papilloma virus DNA derived from a laryngeal papilloma.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Taddie JA,Traktman P

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    journal_title:Journal of virology

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Trkola A,Ketas TJ,Nagashima KA,Zhao L,Cilliers T,Morris L,Moore JP,Maddon PJ,Olson WC

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    pub_type: 杂志文章


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