Characterization of the mouse adeno-associated virus AAVS1 ortholog.

Abstract:

:The nonpathogenic human adeno-associated virus (AAV) has developed a mechanism to integrate its genome into human chromosome 19 at 19q13.4 (termed AAVS1), thereby establishing latency. Here, we provide evidence that the chromosomal signals required for site-specific integration are conserved in the mouse genome proximal to the recently identified Mbs85 gene. These sequence motifs can be specifically nicked by the viral Rep protein required for the initiation of site-specific AAV DNA integration. Furthermore, these signals can serve as a minimal origin for Rep-dependent DNA replication. In addition, we isolated the mouse Mbs85 proximal promoter and show transcriptional activity in three mouse cell lines.

journal_name

J Virol

journal_title

Journal of virology

authors

Dutheil N,Yoon-Robarts M,Ward P,Henckaerts E,Skrabanek L,Berns KI,Campagne F,Linden RM

doi

10.1128/JVI.78.16.8917-8921.2004

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

8917-21

issue

16

eissn

0022-538X

issn

1098-5514

pii

78/16/8917

journal_volume

78

pub_type

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