Intracellular forms of simian virus 40 nucleoprotein complexes. I. Methods of isolation and characterization in CV-1 cells.

abstract：:T-cell epitopes on the E2 protein of rubella virus were studied by using 15 overlapping synthetic peptides covering the E2 protein sequence. The most frequently recognized epitopes on E2 were E2-4 (residues 54 to 74), with 5 of 10 tested T-cell lines responding to it. Two CD4+ cytotoxic T-cell cloned isolated from one...

journal_title：Journal of virology

authors： Ou D,Chong P,Choi Y,McVeigh P,Jefferies WA,Koloitis G,Tingle AJ,Gillam S

更新日期：1992-11-01 00:00:00

abstract：:The poliovirus (PV) genome was manipulated by replacing its 2A-encoding sequence with the corresponding sequence of coxsackie B4 virus (CBV4) or human rhinovirus type 2 (HRV2). In vitro translation of the resulting chimeric PV genomes revealed a normal cis-cleavage activity for both heterologous 2A(pro) proteinases in...

journal_title：Journal of virology

authors： Lu HH,Li X,Cuconati A,Wimmer E

更新日期：1995-12-01 00:00:00

abstract：:The tsB5 mutant of herpes simplex virus type 1 (HSV-1) strain HFEM was shown previously to be temperature sensitive for accumulation of the mature form of glycoprotein gB, for production or activity of a factor required in virus-induced cell fusion, and for production of virions with normal levels of infectivity. In a...

journal_title：Journal of virology

authors： Haffey ML,Spear PG

更新日期：1980-07-01 00:00:00

abstract：:The mRNAs of Bunyamwera virus (BUNV), the prototype of the Bunyaviridae family, possess a 5' cap structure but lack a 3' poly(A) tail, a common feature of eukaryotic mRNAs that greatly enhances translation efficiency. Viral mRNAs also contain untranslated regions (UTRs) that flank the coding sequence. Using model viru...

journal_title：Journal of virology

authors： Blakqori G,van Knippenberg I,Elliott RM

更新日期：2009-04-01 00:00:00

abstract：:Ebola virus (EBOV) infections result in aggressive hemorrhagic fever in humans, with fatality rates reaching 90% and with no licensed specific therapeutics to treat ill patients. Advances over the past 5 years have firmly established monoclonal antibody (MAb)-based products as the most promising therapeutics for treat...

journal_title：Journal of virology

authors： Wang H,Wong G,Zhu W,He S,Zhao Y,Yan F,Rahim MN,Bi Y,Zhang Z,Cheng K,Jin H,Cao Z,Zheng X,Gai W,Bai J,Chen W,Zou Y,Gao Y,Gao GF,Yang S,Xia X,Qiu X

更新日期：2019-02-19 00:00:00

abstract：:It is well established that chronic viral infections can cause immune suppression, resulting in increased susceptibility to other infectious diseases. However, the effects of chronic viral infection on T-cell responses and vaccination against highly pathogenic viruses are not well understood. We have recently shown th...

journal_title：Journal of virology

authors： Alves-Peixoto P,Férez M,Knudson CJ,Melo-Silva CR,Stotesbury C,Wong EB,Correia-Neves M,Sigal LJ

更新日期：2020-02-14 00:00:00

abstract：:In addition to encoding the structural and regulatory proteins, many viruses encode auxiliary proteins, some of which have been shown to play important roles in lytic and latent states of the viruses. The human neurotropic JC virus (JCV) genome encodes an auxiliary protein called Agno whose function remains unknown. H...

journal_title：Journal of virology

authors： Safak M,Barrucco R,Darbinyan A,Okada Y,Nagashima K,Khalili K

更新日期：2001-02-01 00:00:00

abstract：UNLABELLED:Plasma microRNAs (miRNAs) change in abundance in response to disease and have been associated with liver fibrosis severity in chronic hepatitis C virus (HCV) infection. However, the early dynamics of miRNA release during acute HCV infection are poorly understood. In addition, circulating miRNA signatures hav...

journal_title：Journal of virology

authors： El-Diwany R,Wasilewski LN,Witwer KW,Bailey JR,Page K,Ray SC,Cox AL,Thomas DL,Balagopal A

更新日期：2015-09-01 00:00:00

abstract：:Measles virus (MV) can infect the central nervous system and, in rare cases, causes subacute sclerosing panencephalitis, characterized by a progressive degeneration of neurons. The route of MV transmission in neurons was investigated in cultured rat hippocampal slices by using MV expressing green fluorescent protein. ...

journal_title：Journal of virology

authors： Ehrengruber MU,Ehler E,Billeter MA,Naim HY

更新日期：2002-06-01 00:00:00

abstract：:The 2009 pandemic influenza virus (pdm/09) has been frequently introduced to pigs and has reassorted with other swine viruses. Recently, H3N2 reassortants with pdm/09-like internal genes were isolated in Guangxi and Hong Kong, China. Genetic and epidemiological analyses suggest that these viruses have circulated in sw...

journal_title：Journal of virology

authors： Fan X,Zhu H,Zhou B,Smith DK,Chen X,Lam TT,Poon LL,Peiris M,Guan Y

更新日期：2012-02-01 00:00:00

abstract：:The release of Bluetongue virus (BTV) and other members of the Orbivirus genus from infected host cells occurs predominantly by cell lysis, and in some cases, by budding from the plasma membrane. Two nonstructural proteins, NS3 and NS3A, have been implicated in this process. Here we show that both proteins bind to hum...

journal_title：Journal of virology

authors： Wirblich C,Bhattacharya B,Roy P

更新日期：2006-01-01 00:00:00

abstract：:Hepatitis delta virus (HDV), a single-stranded RNA virus, bears a single coding region whose product, the hepatitis delta antigen (HDAg), is expressed in two isoforms, small (S-HDAg) and large (L-HDAg). S-HDAg is required for replication of HDV, while L-HDAg inhibits viral replication and is required for the envelopme...

journal_title：Journal of virology

authors： Bell P,Brazas R,Ganem D,Maul GG

更新日期：2000-06-01 00:00:00

abstract：:Foamy viruses (FVs) are the least known retroviruses commonly found in primates, cats, horses, and cattle. Although FVs are considered apathogenic, simian and feline FVs have been shown to be associated with some transient health abnormalities in animal models. Currently, data regarding the course of infection with bo...

journal_title：Journal of virology

authors： Materniak M,Hechler T,Löchelt M,Kuzmak J

更新日期：2013-03-01 00:00:00

abstract：:We followed the dynamics of capsid amino acid replacement among 403 Nigerian outbreak isolates of type 2 circulating vaccine-derived poliovirus (cVDPV2) from 2005 through 2011. Four different functional domains were analyzed: (i) neutralizing antigenic (NAg) sites, (ii) residues binding the poliovirus receptor (PVR), ...

journal_title：Journal of virology

authors： Shaw J,Jorba J,Zhao K,Iber J,Chen Q,Adu F,Adeniji A,Bukbuk D,Baba M,Henderson E,Dybdahl-Sissoko N,McDonald S,Weldon WC,Gumede N,Oberste MS,Kew OM,Burns CC

更新日期：2018-04-13 00:00:00

abstract：:Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for chikungunya fever. Nonstructural protein 2 (nsP2), a multifunctional protein essential for viral replication, has an N-terminal helicase region (nsP2h), which as both nucleotide triphosphatase and RNA triphosphatase activities, as well as a C-ter...

journal_title：Journal of virology

authors： Law YS,Wang S,Tan YB,Shih O,Utt A,Goh WY,Lian BJ,Chen MW,Jeng US,Merits A,Luo D

更新日期：2020-12-16 00:00:00

abstract：UNLABELLED:The antiviral role of TRIM E3 ligases in vivo is not fully understood. To test the hypothesis that TRIM5α and TRIM22 have differential transcriptional regulation and distinct anti-HIV roles according to infection phase and compartment, we measured TRIM5α, TRIM22, and type I interferon (IFN-I)-inducible myxov...

journal_title：Journal of virology

authors： Singh R,Patel V,Mureithi MW,Naranbhai V,Ramsuran D,Tulsi S,Hiramen K,Werner L,Mlisana K,Altfeld M,Luban J,Kasprowicz V,Dheda K,Abdool Karim SS,Ndung'u T

更新日期：2014-04-01 00:00:00

abstract：:We established a novel experimental model for human T-cell leukemia virus type 1 (HTLV-1)-induced tumor using NOD-SCID/gammac(null) (NOG) mice. This model is very useful for investigating the mechanism of tumorigenesis and malignant cell growth of adult T-cell leukemia (ATL)/lymphoma, which still remains unclear. Nine...

journal_title：Journal of virology

authors： Dewan MZ,Terashima K,Taruishi M,Hasegawa H,Ito M,Tanaka Y,Mori N,Sata T,Koyanagi Y,Maeda M,Kubuki Y,Okayama A,Fujii M,Yamamoto N

更新日期：2003-05-01 00:00:00

abstract：:Many viral fusion proteins are primed by proteolytic cleavage near their fusion peptides. While the coronavirus (CoV) spike (S) protein is known to be cleaved at the S1/S2 boundary, this cleavage site is not closely linked to a fusion peptide. However, a second cleavage site has been identified in the severe acute res...

journal_title：Journal of virology

authors： Madu IG,Roth SL,Belouzard S,Whittaker GR

更新日期：2009-08-01 00:00:00

abstract：:The Cas-Br-E murine leukemia virus is a nondefective retrovirus that induces non-T-, non-B-cell lymphomas in susceptible NIH/Swiss mice. By using a DNA probe derived from Cas-Br-E provirus-flanking sequences, we identified a DNA region, originally called Sic-1, rearranged in 16 of 24 tumors analyzed (67%). All proviru...

journal_title：Journal of virology

authors： Bergeron D,Poliquin L,Kozak CA,Rassart E

更新日期：1991-01-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) UL138 protein downregulates the cell surface expression of the multidrug resistance-associated protein 1 (MRP1) transporter. We examined the genetic requirements within UL138 for MRP1 downregulation. We determined that the acidic cluster dileucine motif is essential for UL138-mediated ...

journal_title：Journal of virology

authors： Gelbmann CB,Kalejta RF

更新日期：2019-05-15 00:00:00

abstract：:RNA silencing is a conserved eukaryotic gene regulatory system in which sequence specificity is determined by small RNAs. Plant RNA silencing also acts as an antiviral mechanism; therefore, viral infection requires expression of a silencing suppressor. The mechanism and the evolution of silencing suppression are still...

journal_title：Journal of virology

authors： Mérai Z,Kerényi Z,Molnár A,Barta E,Válóczi A,Bisztray G,Havelda Z,Burgyán J,Silhavy D

更新日期：2005-06-01 00:00:00

abstract：:Homozygous human immunodeficiency virus type 1 (HIV-1)-transgenic mice (Tg26) appear normal at birth but die within 3 to 4 weeks. The skin of these animals shows diffuse scaling and high-level expression of both HIV-1 mRNA and gp120. Previous experiments showed that treatment with human chorionic gonadatropin (hCG) pr...

journal_title：Journal of virology

authors： De SK,Devadas K,Notkins AL

更新日期：2002-11-01 00:00:00

abstract：:The U(S)3 open reading frame of herpes simplex virus 1 (HSV-1) was reported to encode two mRNAs each directing the synthesis of the same protein. We report that the U(S)3 gene encodes two proteins. The predominant U(S)3 protein is made in wild-type HSV-1-infected cells. The truncated mRNA and a truncated protein desig...

journal_title：Journal of virology

authors： Poon AP,Roizman B

更新日期：2005-07-01 00:00:00

abstract：:RNA transfer (Northern) blot analysis was used to perform the physical characterization of the transcript expressed in murine sensory nerve ganglia latently infected with herpes simplex virus type 1. Most of this latency-associated transcript (LAT) was isolated in the poly(A)- fraction from ganglia. A smaller RNA spec...

journal_title：Journal of virology

authors： Wagner EK,Devi-Rao G,Feldman LT,Dobson AT,Zhang YF,Flanagan WM,Stevens JG

更新日期：1988-04-01 00:00:00

abstract：UNLABELLED:The latent HIV reservoir is a major impediment to curing HIV infection. The contribution of CD4(+) T cell activation status to the establishment and maintenance of the latent reservoir was investigated by enumerating viral DNA components in a cohort of 12 individuals commencing antiretroviral therapy (ART) c...

journal_title：Journal of virology

authors： Murray JM,Zaunders JJ,McBride KL,Xu Y,Bailey M,Suzuki K,Cooper DA,Emery S,Kelleher AD,Koelsch KK,PINT Study Team.

更新日期：2014-03-01 00:00:00

abstract：:Primate lentiviruses use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection. Simian immunodeficiency virus (SIV) productively infects human cells expressing CD4 and the human allele of the chemokine coreceptor CCR-5 as efficiently as it infects macaque cells expressing human CD4, suggest...

journal_title：Journal of virology

authors： Chackerian B,Long EM,Luciw PA,Overbaugh J

更新日期：1997-05-01 00:00:00

abstract：UNLABELLED:The increasing prevalence of ranavirus (RV; Iridoviridae) infections of wild and commercially maintained aquatic species is raising considerable concerns. While Xenopus laevis is the leading model for studies of immunity to RV, amphibian antiviral interferon (IFN) responses remain largely uncharacterized. Ac...

journal_title：Journal of virology

authors： Grayfer L,De Jesús Andino F,Robert J

更新日期：2014-05-01 00:00:00

abstract：:The Duplan strain of murine leukemia virus induces murine AIDS in C57BL/6 mice. When spleen cells from C57BL/6 mice infected with the virus were transplanted into nude mice, subcutaneous solid tumors at the transplanted sites were formed and splenomegaly and lymphadenopathy were induced. These transplantable cells wer...

journal_title：Journal of virology

authors： Kubo Y,Nakagawa Y,Kakimi K,Matsui H,Iwashiro M,Kuribayashi K,Masuda T,Hiai H,Hirama T,Yanagawa S

更新日期：1992-09-01 00:00:00

abstract：:The structural instability of inactivated foot-and-mouth disease virus (FMDV) hinders the development of vaccine industry. Here we found that some transition metal ions like Cu2+ and Ni2+ could specifically bind to FMDV capsids at capacities about 7089 and 3448 metal ions per capsid, respectively. These values are abo...

journal_title：Journal of virology

authors： Lin X,Yang Y,Song Y,Li S,Zhang X,Su Z,Zhang S

更新日期：2021-01-13 00:00:00

abstract：:Complement, part of the innate immune system, acts to remove pathogens and unwanted host material. Complement is known to function in all tissues, including the central nervous system (CNS). In this study, we demonstrated the importance of the complement system within the CNS in the development of behavioral seizures ...

journal_title：Journal of virology

authors： Libbey JE,Kirkman NJ,Wilcox KS,White HS,Fujinami RS

更新日期：2010-07-01 00:00:00