Emergence and dissemination of a swine H3N2 reassortant influenza virus with 2009 pandemic H1N1 genes in pigs in China.

abstract：:Hepatitis C virus core protein forms the viral nucleocapsid and plays a critical role in the formation of infectious particles. In this study, we demonstrate that the highly conserved residue G33, located within domain 1 of the core protein, is important for the production of cell culture-infectious virus (HCVcc). Ala...

journal_title：Journal of virology

authors： Angus AG,Loquet A,Stack SJ,Dalrymple D,Gatherer D,Penin F,Patel AH

更新日期：2012-01-01 00:00:00

abstract：:The bacteriophage PRD1 is a lipid-bearing phage that infects a wide variety of gram-negative bacteria, including Escherichia coli and Salmonella typhimurium when they contain the appropriate plasmid. It contains a linear duplex DNA molecule that is covalently bound by its 5' ends to a terminal protein. We report here ...

journal_title：Journal of virology

authors： Gerendasy DD,Ito J

更新日期：1987-02-01 00:00:00

abstract：:Rhinoviruses (RV) are the major cause of acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Rhinoviruses have been shown to activate macrophages, but rhinovirus replication in macrophages has not been reported. Tumor necrosis factor alpha (TNF-alpha) is implicated in the pathogenesis of ac...

journal_title：Journal of virology

authors： Laza-Stanca V,Stanciu LA,Message SD,Edwards MR,Gern JE,Johnston SL

更新日期：2006-08-01 00:00:00

abstract：:Hypoviruses Cryphonectria hypovirus 1 (CHV-1)/EP713, CHV-1/Euro7, and CHV-1/EP721, which infect the chestnut blight fungus Cryphonectria parasitica, differ in their degrees of virulence attenuation (hypovirulence), symptom expression, and viral RNA accumulation, even though they share between 90% and 99% amino acid se...

journal_title：Journal of virology

authors： Zhang X,Shi D,Nuss DL

更新日期：2012-12-01 00:00:00

abstract：:The degree of genetic heterogeneity of DNA virus populations in nature and its consequences for disease control are virtually unknown. The parvovirus minute virus of mice (MVMi) was used here to investigate (i) the frequency of antibody-escape mutants in populations of a DNA virus and (ii) the ability of a DNA virus t...

journal_title：Journal of virology

authors： López-Bueno A,Mateu MG,Almendral JM

更新日期：2003-02-01 00:00:00

abstract：:Epstein-Barr virus (EBV) transforms B lymphocytes through the expression of the latent viral proteins EBNA and latent membrane protein (LMP). Recently, it has become apparent that microRNAs (miRNAs) also contribute to EBV's oncogenic properties; recombinant EBVs that lack the BHRF1 miRNA cluster display a reduced abil...

journal_title：Journal of virology

authors： Feederle R,Haar J,Bernhardt K,Linnstaedt SD,Bannert H,Lips H,Cullen BR,Delecluse HJ

更新日期：2011-10-01 00:00:00

abstract：:Newcastle disease virus (NDV) belongs to serotype 1 of the avian paramyxoviruses (APMV-1) and causes severe disease in chickens. Current live attenuated NDV vaccines are not fully satisfactory. An alternative is to use a viral vector vaccine that infects chickens but does not cause disease. APMV serotype 3 infects a w...

journal_title：Journal of virology

authors： Kumar S,Nayak B,Collins PL,Samal SK

更新日期：2011-07-01 00:00:00

abstract：:Bats are the second largest group of mammals on earth and act as reservoirs of many emerging viruses. In this study, a novel bat adenovirus (AdV) (BtAdV-TJM) was isolated from bat fecal samples by using a bat primary kidney cell line. Infection studies indicated that most animal and human cell lines are susceptible to...

journal_title：Journal of virology

authors： Li Y,Ge X,Zhang H,Zhou P,Zhu Y,Zhang Y,Yuan J,Wang LF,Shi Z

更新日期：2010-04-01 00:00:00

abstract：:Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immuniz...

journal_title：Journal of virology

authors： Lewis AJ,Whitton JL,Hatalski CG,Weissenböck H,Lipkin WI

更新日期：1999-03-01 00:00:00

abstract：:Most retroviral packaging cell lines were established by a helper virus plasmid cotransfected with a separate plasmid encoding a selection marker. Since this selection marker coexisted in trans with the helper virus sequence, helper virus gene expression could be inactivated by host DNA methylation despite selection f...

journal_title：Journal of virology

authors： Young WB,Link CJ Jr

更新日期：2000-06-01 00:00:00

abstract：:Effectively recognizing invading viruses and subsequently inducing innate antiviral immunity are essential for host antiviral defense. Although these processes are closely regulated by the host to maintain immune balance, viruses have evolved the ability to downregulate or upregulate these processes for their survival...

journal_title：Journal of virology

authors： Xu T,Chu Q,Cui J,Bi D

更新日期：2018-01-02 00:00:00

abstract：:The buoyant density of hepatitis C virus (HCV), with high in vivo infectivity (strain H) or low in vivo infectivity (strain F), was determined by sucrose gradient equilibrium centrifugation. Viral RNA of strain H was detected in fractions with densities of < or = 1.09 g/ml (principally approximately 1.06 g/ml), while ...

journal_title：Journal of virology

authors： Hijikata M,Shimizu YK,Kato H,Iwamoto A,Shih JW,Alter HJ,Purcell RH,Yoshikura H

更新日期：1993-04-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular carcinoma. An important player in subverting the host response to HCV in...

journal_title：Journal of virology

authors： Çevik RE,Cesarec M,Da Silva Filipe A,Licastro D,McLauchlan J,Marcello A

更新日期：2017-08-24 00:00:00

abstract：:The investigation of papillomavirus chromatin has been hampered by the unavailability of a tissue culture system for vegetative growth of these viruses. We have used, therefore, bovine papillomavirus type 1-transformed hamster embryo fibroblasts containing 200 to 250 episomal genome equivalents per cell as a source of...

journal_title：Journal of virology

authors： Rösl F,Waldeck W,Sauer G

更新日期：1983-05-01 00:00:00

abstract：:The hepatitis B virus X protein acts as a transcriptional transactivator in vitro. To elucidate possible biological effects of X protein on liver cells in vivo, we generated four lines of transgenic mice carrying the X gene open reading frame under the control of the human alpha-1-antitrypsin regulatory region. The pl...

journal_title：Journal of virology

authors： Lee TH,Finegold MJ,Shen RF,DeMayo JL,Woo SL,Butel JS

更新日期：1990-12-01 00:00:00

abstract：:Two defective RNAs (designated D RNA 3 alpha and D RNA 3 beta) were found to be associated with the Fny strain of cucumber mosaic cucumovirus but not with the Sny strain after serial passages in a tobacco host. The D RNAs were derived from RNA 3 by single, in-frame deletions within the 3a open reading frame. A full-le...

journal_title：Journal of virology

authors： Graves MV,Roossinck MJ

更新日期：1995-08-01 00:00:00

abstract：:Kinetic curves for neutralization of adenovirus type 2 with anti-hexon serum revealed no lag periods even when the serum was highly diluted or when the temperature was lowered to 4 degrees C, thus indicating a single-hit mechanism. Multiplicity curves determined with anti-hexon serum displayed a linear correlation bet...

journal_title：Journal of virology

authors： Wohlfart C

更新日期：1988-07-01 00:00:00

abstract：:The genomic RNA of human T-cell leukemia virus type 1 encodes three polyproteins, Gag, Gag-Pro, and Gag-Pro-Pol, which are translated as a result of no, one, and two frameshifts, respectively. In this report we demonstrate that the 77 residues encoded at the C terminus of the Gag-Pro precursor can be collectively dete...

journal_title：Journal of virology

authors： Heidecker G,Hill S,Lloyd PA,Derse D

更新日期：2002-12-01 00:00:00

abstract：:N(pro) is a multifunctional autoprotease unique to pestiviruses. The interacting partners of the N(pro) protein of classical swine fever virus (CSFV), a swine pestivirus, have been insufficiently defined. Using a yeast two-hybrid screen, we identified poly(C)-binding protein 1 (PCBP1) as a novel interacting partner of...

journal_title：Journal of virology

authors： Li D,Li S,Sun Y,Dong H,Li Y,Zhao B,Guo D,Weng C,Qiu HJ

更新日期：2013-02-01 00:00:00

abstract：:The U(S)3 open reading frame of herpes simplex virus 1 (HSV-1) was reported to encode two mRNAs each directing the synthesis of the same protein. We report that the U(S)3 gene encodes two proteins. The predominant U(S)3 protein is made in wild-type HSV-1-infected cells. The truncated mRNA and a truncated protein desig...

journal_title：Journal of virology

authors： Poon AP,Roizman B

更新日期：2005-07-01 00:00:00

abstract：:Senecavirus A (SVA) is a picornavirus that causes acute vesicular disease (VD), that is clinically indistinguishable from foot-and-mouth disease (FMD), in pigs. Notably, SVA RNA has been detected in lymphoid tissues of infected animals several weeks following resolution of the clinical disease, suggesting that the vir...

journal_title：Journal of virology

authors： Maggioli MF,Fernandes MHV,Joshi LR,Sharma B,Tweet MM,Noll JCG,Bauermann FV,Diel DG

更新日期：2019-10-15 00:00:00

abstract：:The protection of individuals from human immunodeficiency virus type 1 (HIV-1) infection with an envelope subunit derived from a single isolate will require the presentation of conserved epitopes in gp120. The objective of the studies presented here was to test whether a native recombinant gp120 (rgp120) immunogen wou...

journal_title：Journal of virology

authors： Haigwood NL,Nara PL,Brooks E,Van Nest GA,Ott G,Higgins KW,Dunlop N,Scandella CJ,Eichberg JW,Steimer KS

更新日期：1992-01-01 00:00:00

abstract：:The large (L) protein of Ebola virus is a key protein for virus replication. Its N-terminal region harbors the RNA-dependent RNA polymerase activity, and its C terminus contains a cap assembling line composed of a capping domain and a methyltransferase domain (MTase) followed by a C-terminal domain (CTD) of unknown fu...

journal_title：Journal of virology

authors： Valle C,Martin B,Debart F,Vasseur JJ,Imbert I,Canard B,Coutard B,Decroly E

更新日期：2020-06-01 00:00:00

abstract：:Norovirus (NoV) infections are a leading cause of gastroenteritis. The humoral immune response plays an important role in the control of NoV, and recent studies have identified neutralizing antibodies that bind the capsid protein VP1 to block viral infection. Here, we utilize a NoV GI.1 Jun-Fos-assisted phage display ...

journal_title：Journal of virology

authors： Huang W,Soeung V,Boragine DM,Hu L,Prasad BVV,Estes MK,Atmar RL,Palzkill T

更新日期：2020-12-09 00:00:00

abstract：:Bacterial lipopolysaccharide (LPS) induces interferon (IFN) secretion and an antiviral state in murine peritoneal macrophages (PM). These cells secrete predominantly IFN-beta, as shown by neutralization assays with monoclonal antibodies. Secretion of IFN-beta is also induced in PM by IFN-gamma. LPS and IFN-gamma syner...

journal_title：Journal of virology

authors： Gessani S,Belardelli F,Pecorelli A,Puddu P,Baglioni C

更新日期：1989-06-01 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV) is a human gammaherpesvirus with latent and lytic reactivation cycles. The mechanism by which KSHV evades the innate immune system to establish latency has not yet been precisely elucidated. Toll-like receptors (TLRs) are the first line of defense against viral ...

journal_title：Journal of virology

authors： Zhao Q,Liang D,Sun R,Jia B,Xia T,Xiao H,Lan K

更新日期：2015-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRp) that acts as a key player in the HCV replication complex. Understanding the interplay between the viral and cellular components of the HCV replication complex could provide new insight for prevention of the progression of...

journal_title：Journal of virology

authors： Huang JT,Tseng CP,Liao MH,Lu SC,Yeh WZ,Sakamoto N,Chen CM,Cheng JC

更新日期：2013-05-01 00:00:00

abstract：:The enzymatic activity of recombinant influenza virus RNA polymerase is strictly dependent on the addition of a template RNA containing 5' and 3' viral sequences. Here we report the analysis of the binding specificity and physical characterization of the complex by using gel shift, modification interference, and densi...

journal_title：Journal of virology

authors： Tiley LS,Hagen M,Matthews JT,Krystal M

更新日期：1994-08-01 00:00:00

abstract：UNLABELLED:Although the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) epidemic was controlled by nonvaccine measures, coronaviruses remain a major threat to human health. The design of optimal coronavirus vaccines therefore remains a priority. Such vaccines present major challenges: coronavirus im...

journal_title：Journal of virology

authors： Honda-Okubo Y,Barnard D,Ong CH,Peng BH,Tseng CT,Petrovsky N

更新日期：2015-03-01 00:00:00

abstract：:Current human immunodeficiency virus type 1 (HIV-1) envelope vaccine candidates elicit high antibody binding titers with neutralizing activity against T-cell line-adapted but not primary HIV-1 isolates. Serum antibodies from these human vaccine recipients were also found to be preferentially directed to linear epitope...

journal_title：Journal of virology

authors： VanCott TC,Mascola JR,Kaminski RW,Kalyanaraman V,Hallberg PL,Burnett PR,Ulrich JT,Rechtman DJ,Birx DL

更新日期：1997-06-01 00:00:00