Hepatitis C virus replication is modulated by the interaction of nonstructural protein NS5B and fatty acid synthase.

abstract：:Wild-type Sindbis virus (SINV) strain MRE16 efficiently infects Aedes aegypti midgut epithelial cells (MEC), but laboratory-derived neurovirulent SINV strain TE/5'2J infects MEC poorly. SINV determinants for MEC infection have been localized to the E2 glycoprotein. The E2 amino acid sequences of MRE16 and TE/5'2J diff...

journal_title：Journal of virology

authors： Pierro DJ,Powers EL,Olson KE

更新日期：2008-03-01 00:00:00

abstract：:Murine coronavirus mouse hepatitis virus (MHV) causes persistent infection of the central nervous system (CNS) in rodents, which has been associated with demyelination. However, the precise mechanism of MHV persistence in the CNS remains elusive. Here we show that the progenitor oligodendrocytes (central glial 4 [CG-4...

journal_title：Journal of virology

authors： Liu Y,Zhang X

更新日期：2005-01-01 00:00:00

abstract：:The RNA genome of human immunodeficiency virus type 1 (HIV-1) is converted into DNA after infection in order to integrate into the host cell DNA. However, a large number of these reverse-transcribed genomes remain unintegrated in the nucleus of infected cells. Currently, there are no data available about the intranucl...

journal_title：Journal of virology

authors： Bell P,Montaner LJ,Maul GG

更新日期：2001-08-01 00:00:00

abstract：:A strategy involving polymerase chain reaction amplification of cDNAs was designed to study the expression of the hamster polyomavirus (HaPV) early region in HaPV-transformed rat fibroblasts, productively HaPV-infected cells, and HaPV-induced lymphoma. We identified three mRNAs resulting from alternative splicing of o...

journal_title：Journal of virology

authors： Goutebroze L,Feunteun J

更新日期：1992-04-01 00:00:00

abstract：:Western equine encephalitis virus (WEEV; Togaviridae, Alphavirus) is an enveloped RNA virus that is typically transmitted to vertebrate hosts by infected mosquitoes. WEEV is an important cause of viral encephalitis in humans and horses in the Americas, and infection results in a range of disease, from mild flu-like il...

journal_title：Journal of virology

authors： Sherman MB,Weaver SC

更新日期：2010-10-01 00:00:00

abstract：:The polycistronic P/C mRNA of Sendai virus is translated under cell-free conditions into five proteins (P, C', C, Y1, and Y2) from overlapping reading frames. In this study, we showed that in addition to the P, C', and C proteins, Y1 and Y2 were expressed by six different Sendai virus strains in infected cells. The Y ...

journal_title：Journal of virology

authors： Dillon PJ,Gupta KC

更新日期：1989-02-01 00:00:00

abstract：UNLABELLED:Semen enhances HIV infection in vitro, but how long it retains this activity has not been carefully examined. Immediately postejaculation, semen exists as a semisolid coagulum, which then converts to a more liquid form in a process termed liquefaction. We demonstrate that early during liquefaction, semen exh...

journal_title：Journal of virology

authors： Roan NR,Liu H,Usmani SM,Neidleman J,Müller JA,Avila-Herrera A,Gawanbacht A,Zirafi O,Chu S,Dong M,Kumar ST,Smith JF,Pollard KS,Fändrich M,Kirchhoff F,Münch J,Witkowska HE,Greene WC

更新日期：2014-07-01 00:00:00

abstract：:The human genome encodes over 500 microRNAs (miRNAs), small RNAs (19 to 26 nucleotides [nt]) that regulate the expressions of diverse cellular genes. Many cellular processes are altered through a variety of mechanisms by human cytomegalovirus (HCMV) infection. We asked whether HCMV infection leads to changes in the ex...

journal_title：Journal of virology

authors： Wang FZ,Weber F,Croce C,Liu CG,Liao X,Pellett PE

更新日期：2008-09-01 00:00:00

abstract：:Translation of poliovirus RNA occurs by the binding of ribosomes to an internal segment of RNA sequence within the 5' untranslated region of the viral RNA. This region is predicted to consist of six domains (I to VI) that possess complex secondary and tertiary structures. Domain IV is a large region in which alteratio...

journal_title：Journal of virology

authors： Blyn LB,Chen R,Semler BL,Ehrenfeld E

更新日期：1995-07-01 00:00:00

abstract：:Adenovirus type 2 (Ad2) and Ad5 enter epithelial cells via the coxsackievirus B Ad receptor (CAR) and alpha(v) integrin coreceptors. In the absence of CAR, they can be directed to the Fcgamma receptor 1 of hematopoietic cells by an adaptor comprising the extracellular CAR domain and the Fc portion of a human immunoglo...

journal_title：Journal of virology

authors： Meier O,Gastaldelli M,Boucke K,Hemmi S,Greber UF

更新日期：2005-02-01 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus (SARS-CoV) nsp1 protein has unique biological functions that have not been described in the viral proteins of any RNA viruses; expressed SARS-CoV nsp1 protein has been found to suppress host gene expression by promoting host mRNA degradation and inhibiting translation....

journal_title：Journal of virology

authors： Narayanan K,Huang C,Lokugamage K,Kamitani W,Ikegami T,Tseng CT,Makino S

更新日期：2008-05-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) Tat protein has a critical role in viral transcription, but this study focuses on its additional role as an extracellular effector of lymphocyte cell death. It is well known that Tat induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in peripheral blood mononu...

journal_title：Journal of virology

authors： Yang Y,Tikhonov I,Ruckwardt TJ,Djavani M,Zapata JC,Pauza CD,Salvato MS

更新日期：2003-06-01 00:00:00

abstract：:In the immunocompetent host, primary cytomegalovirus (CMV) infection is resolved by the immune response without causing overt disease. The viral genome, however, is not cleared but is maintained in a latent state that entails a risk of virus recurrence and consequent organ disease. By using murine CMV as a model, we h...

journal_title：Journal of virology

authors： Steffens HP,Kurz S,Holtappels R,Reddehase MJ

更新日期：1998-03-01 00:00:00

abstract：:Viral replication depends on specific interactions with host factors. For example, poliovirus RNA replication requires association with intracellular membranes. Brefeldin A (BFA), which induces a major rearrangement of the cellular secretory apparatus, is a potent inhibitor of poliovirus RNA replication. Most aspects ...

journal_title：Journal of virology

authors： Crotty S,Saleh MC,Gitlin L,Beske O,Andino R

更新日期：2004-04-01 00:00:00

abstract：:The mutational alterations in polyoma virus mutants ts-a and ts-25E which cause their large T-antigens to be thermolabile have been identified. In ts-a, a G leads to A transition at nucleotide 2193 causes the replacement of Ala (GCT) by Thr (ACT). In ts-25E, a G leads to T transversion at nucleotide 2883 causes the re...

journal_title：Journal of virology

authors： Thomas T,Vollmer P,Folk WR

更新日期：1981-03-01 00:00:00

abstract：:Pseudomonas aeruginosa myovirus KZ has a 270-kb genome within a T=27 icosahedral capsid that contains a large, unusual, and structurally well-defined protein cylindrical inner body (IB) spanning its interior. Proteolysis forms a pivotal stage in KZ head and IB morphogenesis, with the protease gp175 cleaving at least 1...

journal_title：Journal of virology

authors： Thomas JA,Black LW

更新日期：2013-08-01 00:00:00

abstract：:In 2010 and 2011, several devastating Newcastle disease (ND) outbreaks occurred in China, affecting broilers, layers, and breeders. The CK-JSX1-201005 virus was isolated from broiler breeder flocks vaccinated with the classical ND virus (NDV) vaccine program, but laying rate decreased from 80% to 30 to 40% in the clin...

journal_title：Journal of virology

authors： Chen F,Liu J,Liu D,Yan Z,Ji J,Qin J,Li H,Ma J,Bi Y,Xie Q

更新日期：2012-11-01 00:00:00

abstract：:The Duplan strain of murine leukemia virus induces murine AIDS in C57BL/6 mice. When spleen cells from C57BL/6 mice infected with the virus were transplanted into nude mice, subcutaneous solid tumors at the transplanted sites were formed and splenomegaly and lymphadenopathy were induced. These transplantable cells wer...

journal_title：Journal of virology

authors： Kubo Y,Nakagawa Y,Kakimi K,Matsui H,Iwashiro M,Kuribayashi K,Masuda T,Hiai H,Hirama T,Yanagawa S

更新日期：1992-09-01 00:00:00

abstract：:The N terminus of the capsid protein (CA) undergoes a considerable conformational change when the human immunodeficiency virus (HIV) protease cleaves it free from the Pr55(Gag) polyprotein. This rearrangement is thought to facilitate the establishment of specific CA-CA interactions that are required for the formation ...

journal_title：Journal of virology

authors： Rue SM,Roos JW,Amzel LM,Clements JE,Barber SA

更新日期：2003-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Vif recruits a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes (APOBEC3C-H) and PP2A phosphatase regulators (PPP2R5A to PPP2R5E). While APOBEC3 antagonism is the canonical function of HIV-1 Vif, this viral accessory protein is also known to trigger G2/...

journal_title：Journal of virology

authors： Salamango DJ,McCann JL,Demir Ö,Becker JT,Wang J,Lingappa JR,Temiz NA,Brown WL,Amaro RE,Harris RS

更新日期：2020-10-14 00:00:00

abstract：:Gammaretroviruses, such as murine leukemia virus (MLV), are functionally distinguished from lentiviruses, such as human immunodeficiency virus, by their inability to infect nondividing cells. Attempts to engineer this property into MLV have been hindered by an incomplete understanding of early events in the viral life...

journal_title：Journal of virology

authors： Yu JH,Schaffer DV

更新日期：2006-09-01 00:00:00

abstract：:Following the initial detection of viral infection, innate immune responses trigger the induction of numerous interferon-stimulated genes (ISGs) to inhibit virus replication and dissemination. One such ISG encodes cholesterol-25-hydroxylase (CH25H), an enzyme that catalyzes the oxidation of cholesterol to form a solub...

journal_title：Journal of virology

authors： Doms A,Sanabria T,Hansen JN,Altan-Bonnet N,Holm GH

更新日期：2018-08-29 00:00:00

abstract：:Antigens derived from host cells are detectable in the envelope of human immunodeficiency virus type 1 (HIV-1) and result in a distinctive viral phenotype reflecting that of the host cell. An immunomagnetic capture assay targeting discriminatory host proteins was developed to differentiate between HIV-1 derived from m...

journal_title：Journal of virology

authors： Lawn SD,Roberts BD,Griffin GE,Folks TM,Butera ST

更新日期：2000-01-01 00:00:00

abstract：:Recombinant adenovirus serotype 5 (rAd5) vector-based vaccines are currently being developed for both human immunodeficiency virus type 1 and other pathogens. The potential limitations associated with rAd5 vectors, however, have led to the construction of novel rAd vectors derived from rare Ad serotypes. Several rare ...

journal_title：Journal of virology

authors： Abbink P,Lemckert AA,Ewald BA,Lynch DM,Denholtz M,Smits S,Holterman L,Damen I,Vogels R,Thorner AR,O'Brien KL,Carville A,Mansfield KG,Goudsmit J,Havenga MJ,Barouch DH

更新日期：2007-05-01 00:00:00

abstract：:The time course and extent of mengovirus production were the same in metaphase-arrested and interphase L-cells, yet the expression of cytopathology was delayed several hours in metaphase cells. ...

journal_title：Journal of virology

authors： Lake RS,Winkler DC,Ludwig EH

更新日期：1970-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) replicates through an error-prone process that may support the evolution of genetic variants resistant to the host cell antiviral response and interferon (IFN)-based therapy. We evaluated HCV-IFN interactions within a long-term culture system of Huh7 cell lines harboring different variants of a...

journal_title：Journal of virology

authors： Sumpter R Jr,Wang C,Foy E,Loo YM,Gale M Jr

更新日期：2004-11-01 00:00:00

abstract：:The Kansas strain of bovine parainfluenza virus type 3 (BPIV3) is 100- to 1,000-fold restricted in replication in the respiratory tracts of nonhuman primates compared to human PIV3 (HPIV3), an important pathogen of infants and young children. BPIV3 is also restricted in replication in human infants and children, yet i...

journal_title：Journal of virology

authors： Skiadopoulos MH,Schmidt AC,Riggs JM,Surman SR,Elkins WR,St Claire M,Collins PL,Murphy BR

更新日期：2003-01-01 00:00:00

abstract：:The v-src coding region was deleted from cloned Rous sarcoma virus DNA, and the deleted clones were tested for infectivity by transfection. All of the coding region, as well as most of the sequences lying between v-src and the unique 3' region (U3), could be deleted without affecting viability. However, at least 9 and...

journal_title：Journal of virology

authors： Sorge J,Hughes SH

更新日期：1982-08-01 00:00:00

abstract：:By using temperature-sensitive (ts) and suppressor-sensitive (sus) mutants, 11 essential genes have been identified in phage phi105. The order of the genes has been established in two- and three-factor crosses. The genes can be arranged in a linear order; this order is identical in the vegetative phage and in the prop...

journal_title：Journal of virology

authors： Armentrout RW,Rutberg L

更新日期：1970-12-01 00:00:00

abstract：:The adenovirus (Ad) E4 ORF3 protein is both necessary and sufficient to reorganize a nuclear subdomain, the PML nuclear body (PML-NB), from punctate structures into elongated nuclear tracks. PML-NB disruption is recapitulated by a variety of DNA viruses that encode proteins responsible for compromising PML-NB integrit...

journal_title：Journal of virology

authors： Ullman AJ,Hearing P

更新日期：2008-08-01 00:00:00