Effect of immune priming on Borna disease.

Abstract:

:Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immunized, immunized animals had a decreased viral burden after challenge with infectious virus, more marked inflammation, and aggravated clinical disease. These data suggest that a more robust immune response in Borna disease can reduce viral load at the expense of increased morbidity.

journal_name

J Virol

journal_title

Journal of virology

authors

Lewis AJ,Whitton JL,Hatalski CG,Weissenböck H,Lipkin WI

doi

10.1128/JVI.73.3.2541-2546.1999

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

2541-6

issue

3

eissn

0022-538X

issn

1098-5514

journal_volume

73

pub_type

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