Abstract:
:Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immunized, immunized animals had a decreased viral burden after challenge with infectious virus, more marked inflammation, and aggravated clinical disease. These data suggest that a more robust immune response in Borna disease can reduce viral load at the expense of increased morbidity.
journal_name
J Viroljournal_title
Journal of virologyauthors
Lewis AJ,Whitton JL,Hatalski CG,Weissenböck H,Lipkin WIdoi
10.1128/JVI.73.3.2541-2546.1999subject
Has Abstractpub_date
1999-03-01 00:00:00pages
2541-6issue
3eissn
0022-538Xissn
1098-5514journal_volume
73pub_type
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