Beyond the consensus: dissecting within-host viral population diversity of foot-and-mouth disease virus by using next-generation genome sequencing.

abstract：:Cowpox virus, in contrast to vaccinia virus, can multiply in Chinese hamster ovary cells. To study the genetic basis for this difference in host range, recombinants between vaccinia and cowpox viruses were isolated and their DNA restriction patterns were examined. The ability to multiply in Chinese hamster ovary cells...

journal_title：Journal of virology

authors： Spehner D,Gillard S,Drillien R,Kirn A

更新日期：1988-04-01 00:00:00

abstract：:Human enterovirus 71 (EV-71) is one of the major etiologic causes of hand, foot, and mouth disease (HFMD) among young children worldwide, with fatal instances of neurological complications becoming increasingly common. Global VP1 capsid sequences (n = 628) sampled over 4 decades were collected and subjected to compreh...

journal_title：Journal of virology

authors： Tee KK,Lam TT,Chan YF,Bible JM,Kamarulzaman A,Tong CY,Takebe Y,Pybus OG

更新日期：2010-04-01 00:00:00

abstract：:Mitochondrial DNA synthesis in adenovirus type 2-infected HeLa cells was measured at various times from 0 to 24 h postinfection. Although viral infection effectively turned off host chromosomal DNA synthesis, mitochondrial DNA synthesis was not inhibited. These findings indicate a dissociation between the regulation o...

journal_title：Journal of virology

authors： Fisher PB,Horwitz MS

更新日期：1977-05-01 00:00:00

abstract：:The V20 cultivar of Nicotiana tabacum was shown previously to exhibit a strain-specific restriction of long-distance movement of tobacco etch potyvirus (TEV). In V20, both TEV-HAT and TEV-Oxnard strains are capable of genome amplification and cell-to-cell movement, but only TEV-Oxnard is capable of systemic infection ...

journal_title：Journal of virology

authors： Schaad MC,Lellis AD,Carrington JC

更新日期：1997-11-01 00:00:00

abstract：:Our previous studies have shown that targeting DNA vaccine-encoded major histocompatibility complex class I epitopes to the proteasome enhanced CD8(+) T-cell induction and protection against lymphocytic choriomeningitis virus (LCMV) challenge. Here, we expand these studies to evaluate CD4(+) T-cell responses induced b...

journal_title：Journal of virology

authors： Rodriguez F,Harkins S,Redwine JM,de Pereda JM,Whitton JL

更新日期：2001-11-01 00:00:00

abstract：:Purified replicative form (RF) and replicative intermediate (RI) prepared from Escherichia coli cells infected with the ribonucleic acid (RNA) bacteriophage R17 were denatured with dimethyl sulfoxide at 37 C or in aqueous solvents of low ionic strength at 97 C. Denaturation was demonstrated for RF and RI by an increas...

journal_title：Journal of virology

authors： Franklin RM

更新日期：1967-06-01 00:00:00

abstract：:Glycoprotein D (gD) interacts with two alternative protein receptors, nectin1 and HveA, to mediate herpes simplex virus (HSV) entry into cells. Fusion of the envelope with the plasma membrane requires, in addition to gD, glycoproteins gB, gH, and gL. Coexpression of the four glycoproteins (gD, gB, gH, and gL) promotes...

journal_title：Journal of virology

authors： Zhou G,Avitabile E,Campadelli-Fiume G,Roizman B

更新日期：2003-03-01 00:00:00

abstract：:Ribonucleic acid extracted from the virions of two human rhinoviruses is infective and is similar in size to poliovirus ribonucleic acid. ...

journal_title：Journal of virology

authors： Nair CN,Lonberg-Holm KK

更新日期：1971-02-01 00:00:00

abstract：:Cycloheximide and 6-azauridine were employed to study the time course of measles virus protein and nucleic acid syntheses in AV3 cells. Synthesis of ribonucleic acid (RNA) essential for infectivity was first detected at 6 hr and increased concurrently with the formation of essential protein. Maximum levels of virus-sp...

journal_title：Journal of virology

authors： Portner A,Bussell RH

更新日期：1973-01-01 00:00:00

abstract：:IgG1 b12 is a broadly neutralizing antibody against human immunodeficiency virus type 1 (HIV-1). The epitope recognized by b12 overlaps the CD4 receptor-binding site (CD4bs) on gp120 and has been a target for vaccine design. Determination of the three-dimensional structure of immunoglobulin G1 (IgG1) b12 allowed model...

journal_title：Journal of virology

authors： Zwick MB,Parren PW,Saphire EO,Church S,Wang M,Scott JK,Dawson PE,Wilson IA,Burton DR

更新日期：2003-05-01 00:00:00

abstract：:Infection of mice with Moloney murine leukemia virus (M-MuLV) as well as with a nonpathogenic variant, Mo+PyF101 M-MuLV, was studied. Mo+PyF101 M-MuLV differs from wild-type M-MuLV by the addition of enhancer sequences from polyomavirus in the long terminal repeat. Previous experiments indicated that Mo+PyF101 establi...

journal_title：Journal of virology

authors： Davis BR,Chandy KG,Brightman BK,Gupta S,Fan H

更新日期：1986-11-01 00:00:00

abstract：:Parvovirus capsids are assembled from multiple forms of a single protein and are quite stable structurally. However, in order to infect cells, conformational plasticity of the capsid is required and this likely involves the exposure of structures that are buried within the structural models. The presence of functional...

journal_title：Journal of virology

authors： Nelson CD,Minkkinen E,Bergkvist M,Hoelzer K,Fisher M,Bothner B,Parrish CR

更新日期：2008-11-01 00:00:00

abstract：UNLABELLED:Enterovirus A71 (EV-A71) is a major cause of hand, foot, and mouth disease (HFMD) and is particularly prevalent in parts of Southeast Asia, affecting thousands of children and infants each year. Revealing the evolutionary and epidemiological dynamics of EV-A71 through time and space is central to understandi...

journal_title：Journal of virology

authors： Geoghegan JL,Tan le V,Kühnert D,Halpin RA,Lin X,Simenauer A,Akopov A,Das SR,Stockwell TB,Shrivastava S,Ngoc NM,Uyen le TT,Tuyen NT,Thanh TT,Hang VT,Qui PT,Hung NT,Khanh TH,Thinh le Q,Nhan le NT,Van HM,Viet do C

更新日期：2015-09-01 00:00:00

abstract：:The S1 gene nucleotide sequences of 10 type 3 (T3) reovirus strains were determined and compared with the T3 prototype Dearing strain in order to study sequence diversity in strains of a single reovirus serotype and to learn more about structure-function relationships of the two S1 translation products, sigma 1 and si...

journal_title：Journal of virology

authors： Dermody TS,Nibert ML,Bassel-Duby R,Fields BN

更新日期：1990-10-01 00:00:00

abstract：:Open reading frame (ORF) E4 is a 353-base-pair ORF of bovine papillomavirus type 1. To determine the biological activities of this ORF in mouse C127 cells, we analyzed the effects of two constructed mutations which are predicted to prevent synthesis of ORF E4 proteins while leaving the amino acid sequence encoded by t...

journal_title：Journal of virology

authors： Neary K,Horwitz BH,DiMaio D

更新日期：1987-04-01 00:00:00

abstract：:A number of cDNA clones complementary to measles virus mRNA and 50S genome RNA have been generated. These clones have been mapped by restriction enzyme analysis and were subsequently sequenced by the method of Maxam and Gilbert (A. M. Maxam and W. Gilbert, Methods Enzymol. 65:499-560, 1980). Computer analysis of these...

journal_title：Journal of virology

authors： Richardson CD,Berkovich A,Rozenblatt S,Bellini WJ

更新日期：1985-04-01 00:00:00

abstract：:We are using site-directed mutagenesis of single viral genes to identify and analyze the genetic determinants of human and simian immunodeficiency virus pathogenicity. In a first approach, we have constructed a series of simian immunodeficiency virus SIVmac nef mutants by partial deletion and insertions in the nef gen...

journal_title：Journal of virology

authors： Binninger D,Ennen J,Bonn D,Norley SG,Kurth R

更新日期：1991-10-01 00:00:00

abstract：:The long terminal repeat U3 sequences were determined for multiple feline leukemia virus proviruses isolated from naturally occurring T-cell tumors. Heterogeneity was evident, even among proviruses cloned from individual tumors. Proviruses with one, two, or three repeats of the long terminal repeat enhancer sequences ...

journal_title：Journal of virology

authors： Fulton R,Plumb M,Shield L,Neil JC

更新日期：1990-04-01 00:00:00

abstract：:The presence of a high number of activated T cells in the bloodstream and spontaneous proliferation of peripheral blood mononuclear cells in vitro are striking characteristics of human T-cell leukemia virus type I (HTLV-I) infection. The HTLV-I regulatory protein Tax and the envelope protein gp46 have been implicated ...

journal_title：Journal of virology

authors： Kimata JT,Palker TJ,Ratner L

更新日期：1993-06-01 00:00:00

abstract：:The biological activity encoded in the putative protease gene (pro) of human T-cell leukemia virus type I was investigated by using a vaccinia virus expression vector. The 53-kilodalton gag precursor polyprotein was processed into the mature p19, p24, and p15 gag proteins when the gag and protease-coding sequence was ...

journal_title：Journal of virology

authors： Nam SH,Kidokoro M,Shida H,Hatanaka M

更新日期：1988-10-01 00:00:00

abstract：:Vaccine-elicited immunoglobulin G (IgG) has been shown to be important for protection against simian-human immunodeficiency virus (SHIV) infection in rhesus monkeys. However, it remains unclear whether vaccine-elicited IgA responses are beneficial or detrimental for protection. In this study, we evaluated the kinetics...

journal_title：Journal of virology

authors： Kang ZH,Bricault CA,Borducchi EN,Stephenson KE,Seaman MS,Pau M,Schuitemaker H,van Manen D,Wegmann F,Barouch DH

更新日期：2018-07-17 00:00:00

abstract：:The phenotypic properties of ICP27 temperature-sensitive and deletion mutants and the results of transient expression assays have demonstrated that ICP27 has a modulatory effect on viral gene expression induced by ICPs 0 and 4. In order to identify the regions of the ICP27 molecule that are responsible for its enhanci...

journal_title：Journal of virology

authors： McMahan L,Schaffer PA

更新日期：1990-07-01 00:00:00

abstract：:Interferon-induced proteins (IFPs) exert multiple functions corresponding to diverse interferon signals. However, the intracellular functions of many IFPs are not fully characterized. Here, we report that IFP35, a member of the IFP family with a molecular mass of 35 kDa, can interact with the bovine Tas (BTas) regulat...

journal_title：Journal of virology

authors： Tan J,Qiao W,Wang J,Xu F,Li Y,Zhou J,Chen Q,Geng Y

更新日期：2008-05-01 00:00:00

abstract：:A panel of monoclonal antibodies that recognize the two major glycoproteins of bovine viral diarrhea virus (BDV) was used to evaluate the antigenic relationship between cytopathic (CP) and noncytopathic (NCP) viruses isolated from cattle dead or dying from fatal BDV infections. Various unrelated BDV isolates were init...

journal_title：Journal of virology

authors： Corapi WV,Donis RO,Dubovi EJ

更新日期：1988-08-01 00:00:00

abstract：:We have developed a system for producing murine leukemia virus (MLV) pseudotyped with human hepatitis B virus (HBV) large (L) and small (S) surface antigens (HBsAg) for targeting primary human hepatocytes. Using the MLV(HBV) pseudotype virus containing a beta-galactosidase reporter gene, we demonstrated that this pseu...

journal_title：Journal of virology

authors： Sung VM,Lai MM

更新日期：2002-01-01 00:00:00

abstract：UNLABELLED:Hepatitis C virus (HCV) requires proteins from the NS3-NS5B polyprotein to create a replicase unit for replication of its genome. The replicase proteins form membranous compartments in cells to facilitate replication, but little is known about their functional organization within these structures. We recentl...

journal_title：Journal of virology

authors： Gomes RG,Isken O,Tautz N,McLauchlan J,McCormick CJ

更新日期：2015-12-30 00:00:00

abstract：:The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) encodes several MIE proteins (MIEPs) produced as a result of alternative splicing and polyadenylation of the primary transcript. Previously we demonstrated that the HCMV MIEPs expressed from the entire MIE gene could rescue the temperature-sensitive ...

journal_title：Journal of virology

authors： Lukac DM,Alwine JC

更新日期：1999-04-01 00:00:00

abstract：:Upon immunization and restimulation with tumors induced by the endogenous AKR/Gross murine leukemia virus (MuLV), C57BL/6 mice generate vigorous H-2K(b)-restricted cytotoxic T-lymphocyte (CTL) responses to a determinant (KSPWFTTL) derived from the p15E transmembrane portion of the viral envelope glycoprotein. By contr...

journal_title：Journal of virology

authors： Kim V,Yewdell JW,Green WR

更新日期：2000-04-01 00:00:00

abstract：:Although hepatitis A virus (HAV) is typically transmitted by the fecal-oral route, little is known of its interactions with cells of the gastrointestinal tract. We studied the replication of HAV in polarized cultures of Caco-2 cells, a human cell line which retains many differentiated functions of small intestinal epi...

journal_title：Journal of virology

authors： Blank CA,Anderson DA,Beard M,Lemon SM

更新日期：2000-07-01 00:00:00

abstract：:The hepatitis C virus (HCV)-specific CD4+ T-cell response against nonstructural proteins is strongly associated with successful viral clearance during acute hepatitis C. To further develop these observations into peptide-based vaccines and clinical immunomonitoring tools like HLA class II tetramers, a detailed charact...

journal_title：Journal of virology

authors： Gerlach JT,Ulsenheimer A,Grüner NH,Jung MC,Schraut W,Schirren CA,Heeg M,Scholz S,Witter K,Zahn R,Vogler A,Zachoval R,Pape GR,Diepolder HM

更新日期：2005-10-01 00:00:00