VPg of tobacco etch potyvirus is a host genotype-specific determinant for long-distance movement.

abstract：:Novel molecular approaches to inhibit human immunodeficiency virus type 1 (HIV-1) infection have received increasing attention because of the lack of effective antiviral drug therapies in vivo. We now demonstrate that cells can be intracellularly immunized by cytoplasmic expression of single-chain variable antibody fr...

journal_title：Journal of virology

authors： Shaheen F,Duan L,Zhu M,Bagasra O,Pomerantz RJ

更新日期：1996-06-01 00:00:00

abstract：:Human hepatitis B virus (HBV) HBx protein is a multifunctional protein that activates cellular signaling pathways and is thought to be essential for viral infection. Woodchuck HBV mutants that lack HBx are unable to replicate in vivo or are severely impaired. HBV replication in HepG2 cells, a human hepatoblastoma cell...

journal_title：Journal of virology

authors： Bouchard MJ,Puro RJ,Wang L,Schneider RJ

更新日期：2003-07-01 00:00:00

abstract：:Deletion of the terminal repeats (TR) from herpesvirus saimiri (HVS) renders it unable to produce infectious virus or generate plaques. However, a TR-deleted HVS bacterial artificial chromosome can form replication compartments. Complementation of this mutant shows that one copy of the TR, plus the right junction of t...

journal_title：Journal of virology

authors： White RE,Carline L,Allday MJ

更新日期：2007-06-01 00:00:00

abstract：:RNA transfer (Northern) blot analysis was used to perform the physical characterization of the transcript expressed in murine sensory nerve ganglia latently infected with herpes simplex virus type 1. Most of this latency-associated transcript (LAT) was isolated in the poly(A)- fraction from ganglia. A smaller RNA spec...

journal_title：Journal of virology

authors： Wagner EK,Devi-Rao G,Feldman LT,Dobson AT,Zhang YF,Flanagan WM,Stevens JG

更新日期：1988-04-01 00:00:00

abstract：:A radioimmunoassay (RIA) has been used to measure the quantity of protein P27 (mol wt 27,000; group specific-1 [gs-1]) of avian leukoviruses in different types of chicken embryos and tissues of adult chickens. The RIA used was 200- to 300-fold more sensitive than the complement fixation test and was able to detect as ...

journal_title：Journal of virology

authors： Chen JH,Hanafusa H

更新日期：1974-02-01 00:00:00

abstract：:HeLa cells infected with human rhinovirus type 2 synthesize a mixture of single-and double-stranded ribonucleic acid (RNA). The RNA synthesized by the membrane-bound RNA polymerase complex in vitro is also a mixture of single- and double-stranded RNA, whereas the deoxycholate-treated RNA polymerase complex synthesized...

journal_title：Journal of virology

authors： Yin FH,Knight E Jr

更新日期：1972-07-01 00:00:00

abstract：:The human papillomavirus 1 (HPV-1) virion is composed of two virally encoded proteins: a 57,000-molecular-weight polypeptide (57K polypeptide), which is the product of the L1 open reading frame (ORF), and a 78K polypeptide, which is derived from the L2 ORF. The 57K (L1) product, which represents the major structural c...

journal_title：Journal of virology

authors： Doorbar J,Gallimore PH

更新日期：1987-09-01 00:00:00

abstract：:Adenovirus infection and expression of E1A induces both proliferation and apoptosis, the latter of which is blocked by the adenovirus Bcl-2 homologue E1B 19K. The mechanism of apoptosis induction and the role that it plays in productive infection are not known. Unlike apoptosis mediated by death receptors, infection w...

journal_title：Journal of virology

authors： Cuconati A,Degenhardt K,Sundararajan R,Anschel A,White E

更新日期：2002-05-01 00:00:00

abstract：:Here, we investigated the pre-steady-state deoxynucleoside triphosphate (dNTP) incorporation kinetics of primate foamy virus (PFV) reverse transcriptase (RT) in comparison with those of HIV-1 and MuLV RTs. PFV RT displayed a drastic reduction in primer extension at low dNTP concentrations where HIV-1 RT remains highly...

journal_title：Journal of virology

authors： Santos-Velazquez J,Kim B

更新日期：2008-08-01 00:00:00

abstract：:The chimeric murine oncornavirus FrCas(E) causes a rapidly progressive paralytic disease associated with spongiform neurodegeneration throughout the neuroaxis. Neurovirulence is determined by the sequence of the viral envelope gene and by the capacity of the virus to infect microglia. The neurocytopathic effect of thi...

journal_title：Journal of virology

authors： Askovic S,Favara C,McAtee FJ,Portis JL

更新日期：2001-03-01 00:00:00

abstract：:Previous analyses have demonstrated that adenovirus DNA is packaged into virions in vivo in a polar, left-to-right fashion. The packaging of viral DNA is dependent on cis-acting elements at the left end of the genome. In this report, we describe a genetic analysis of the sequences that are required for efficient packa...

journal_title：Journal of virology

authors： Gräble M,Hearing P

更新日期：1990-05-01 00:00:00

abstract：:Glycoproteins homologous to glycoprotein B (gB) of herpes simplex virus constitute the most highly conserved group of herpesvirus glycoproteins. This strong conservation of amino acid sequences might be indicative of a common functional role. Indeed, gB homologs have been implicated in the processes of viral entry and...

journal_title：Journal of virology

authors： Kopp A,Mettenleiter TC

更新日期：1992-05-01 00:00:00

abstract：:BST-2/CD317/tetherin is a host factor that inhibits the release of HIV-1 and other unrelated viruses. A current model proposes that BST-2 physically tethers virions to the surface of virus-producing cells. The HIV-1-encoded Vpu protein effectively antagonizes the activity of BST-2. How Vpu accomplishes this task remai...

journal_title：Journal of virology

authors： Andrew AJ,Miyagi E,Strebel K

更新日期：2011-03-01 00:00:00

abstract：UNLABELLED:Phenotypic diversity in prion diseases can be specified by prion strains in which biological traits are propagated through an epigenetic mechanism mediated by distinct PrP(Sc) conformations. We investigated the role of host-dependent factors on phenotypic diversity of chronic wasting disease (CWD) in differe...

journal_title：Journal of virology

authors： Crowell J,Hughson A,Caughey B,Bessen RA

更新日期：2015-10-01 00:00:00

abstract：:In response to viral infection, host cells elicit a number of responses, including the expression of alpha/beta interferon (IFN-alpha/beta). In these cells, IFN regulatory factor-3 (IRF-3) undergoes a sequence of posttranslational modifications that allow it to act as a potent transcriptional coactivator of specific I...

journal_title：Journal of virology

authors： Melroe GT,DeLuca NA,Knipe DM

更新日期：2004-08-01 00:00:00

abstract：:Endogenous retroviruses (ERV) are found throughout vertebrate genomes, and failure to silence their activation can have deleterious consequences on the host. Mutation and subsequent disruption of ERV loci is therefore an indispensable component of the cell-intrinsic defenses that maintain the integrity of the host gen...

journal_title：Journal of virology

authors： Treger RS,Tokuyama M,Dong H,Salas-Briceno K,Ross SR,Kong Y,Iwasaki A

更新日期：2019-09-30 00:00:00

abstract：:An adenovirus vector encoding murine Fas ligand (mFasL) under an inducible control was derived. In vivo ectopic expression of mFasL in murine livers induced an inflammatory cellular infiltration. Furthermore, ectopic expression of mFasL by myocytes did not allow prolonged vector-mediated transgene expression. Thus, ec...

journal_title：Journal of virology

authors： Zhang HG,Bilbao G,Zhou T,Contreras JL,Gómez-Navarro J,Feng M,Saito I,Mountz JD,Curiel DT

更新日期：1998-03-01 00:00:00

abstract：:By using temperature-sensitive (ts) and suppressor-sensitive (sus) mutants, 11 essential genes have been identified in phage phi105. The order of the genes has been established in two- and three-factor crosses. The genes can be arranged in a linear order; this order is identical in the vegetative phage and in the prop...

journal_title：Journal of virology

authors： Armentrout RW,Rutberg L

更新日期：1970-12-01 00:00:00

abstract：:Enveloped virus vectors are used in a wide variety of applications. We have discovered that treatment of cultured cells with phosphatidylserine (PS) liposomes can increase virus vector infection by up to 20-fold. This effect does not abrogate virus receptor requirements, is specific to PS compared to other phospholipi...

journal_title：Journal of virology

authors： Coil DA,Miller AD

更新日期：2005-09-01 00:00:00

abstract：UNLABELLED:Replication-deficient rabies virus (RABV)-based vaccines induce rapid and potent antibody responses via T cell-independent and T cell-dependent mechanisms. To further investigate early events in vaccine-induced antibody responses against RABV infections, we studied the role of macrophages as mediators of RAB...

journal_title：Journal of virology

authors： Lytle AG,Shen S,McGettigan JP

更新日期：2015-03-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) produces intense pulmonary inflammation, in part through its ability to induce chemokine synthesis in infected airway epithelial cells. RANTES (regulated upon activation, normally T-cell expressed and presumably secreted) is a CC chemokine which recruits and activates monocytes, lymph...

journal_title：Journal of virology

authors： Casola A,Garofalo RP,Haeberle H,Elliott TF,Lin R,Jamaluddin M,Brasier AR

更新日期：2001-07-01 00:00:00

abstract：:Hantaviruses replicate primarily in the vascular endothelium and cause two human diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). In this report, we demonstrate that the cellular entry of HFRS-associated hantaviruses is facilitated by specific integrins expressed on plate...

journal_title：Journal of virology

authors： Gavrilovskaya IN,Brown EJ,Ginsberg MH,Mackow ER

更新日期：1999-05-01 00:00:00

abstract：:Ten bacteriophages that attack and lyse saprophytic strains of Bdellovibrio bacteriovorus were isolated. Morphological, serological, and host-range studies revealed that there were four different bdellovibrio phages present among the isolates. One of the phages lysed a strain of B. bacteriovorus that requires the pres...

journal_title：Journal of virology

authors： Althauser M,Samsonoff WA,Anderson C,Conti SF

更新日期：1972-09-01 00:00:00

abstract：:Mononuclear phagocytes (MP) and T lymphocytes play a pivotal role in the host immune response to human immunodeficiency virus type 1 (HIV-1) infection. Regulation of such immune responses can be mediated, in part, through the interaction of the T-lymphocyte-expressed molecule CD40 ligand (CD40L) with its receptor on M...

journal_title：Journal of virology

authors： Cotter RL,Zheng J,Che M,Niemann D,Liu Y,He J,Thomas E,Gendelman HE

更新日期：2001-05-01 00:00:00

abstract：:The neuraminidase inhibitors zanamivir and oseltamivir are marketed for the treatment and prophylaxis of influenza and have been stockpiled by many countries for use in a pandemic. Although recent surveillance has identified a striking increase in the frequency of oseltamivir-resistant seasonal influenza A (H1N1) viru...

journal_title：Journal of virology

authors： Hurt AC,Holien JK,Parker M,Kelso A,Barr IG

更新日期：2009-10-01 00:00:00

abstract：:The membrane glycoproteins Gn and Gc of Hantaan virus (HTNV) (family Bunyaviridae) are modified by N-linked glycosylation. The glycoproteins contain six potential sites for the attachment of N-linked oligosaccharides, five sites on Gn and one on Gc. The properties of the N-linked oligosaccharide chains were analyzed b...

journal_title：Journal of virology

authors： Shi X,Elliott RM

更新日期：2004-05-01 00:00:00

abstract：:To combat emerging coronaviruses, developing safe and efficient platforms to evaluate viral protease activities and the efficacy of protease inhibitors is a high priority. Here, we exploit a biosafety level 2 (BSL-2) chimeric Sindbis virus system to evaluate protease activities and the efficacy of inhibitors directed ...

journal_title：Journal of virology

authors： Deng X,Agnihothram S,Mielech AM,Nichols DB,Wilson MW,StJohn SE,Larsen SD,Mesecar AD,Lenschow DJ,Baric RS,Baker SC

更新日期：2014-10-01 00:00:00

abstract：:Although iridoviruses vary widely within and among genera with respect to their host range and virulence, variation within iridovirus species has been less extensively characterized. This study explores the nature and extent of intraspecific variation within an emerging iridovirus of North American warm-water fishes, ...

journal_title：Journal of virology

authors： Goldberg TL,Coleman DA,Grant EC,Inendino KR,Philipp DP

更新日期：2003-08-01 00:00:00

abstract：UNLABELLED:Of the various genetic subtypes of human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV), only in subtype C of HIV-1 is a genetically variant NF-κB binding site found at the core of the viral promoter in association with a subtype-specific Sp1III motif. How the ...

journal_title：Journal of virology

authors： Verma A,Rajagopalan P,Lotke R,Varghese R,Selvam D,Kundu TK,Ranga U

更新日期：2016-07-27 00:00:00

abstract：:When residues 17 and 18 in nef of simian immunodeficiency virus strain SIVmac239 were changed from RQ to YE, the resultant virus was able to replicate in peripheral blood mononuclear cell cultures without prior lymphocyte activation and without the addition of exogenous interleukin-2, caused extensive lymphocyte activ...

journal_title：Journal of virology

authors： Du Z,Ilyinskii PO,Sasseville VG,Newstein M,Lackner AA,Desrosiers RC

更新日期：1996-06-01 00:00:00