A cowpox virus gene required for multiplication in Chinese hamster ovary cells.

abstract：:Varicella-zoster virus (VZV) is distinguished from herpes simplex virus type 1 (HSV-1) by the fact that cell-to-cell fusion and syncytium formation require only gH and gL within a transient-expression system. In the HSV system, four glycoproteins, namely, gH, gL, gB, and gD, are required to induce a similar fusogenic ...

journal_title：Journal of virology

authors： Maresova L,Pasieka TJ,Grose C

更新日期：2001-10-01 00:00:00

abstract：:The dynamics of human immunodeficiency virus type 1 (HIV-1) transcription was analyzed in vitro and in vivo by using a specific molecular approach which allows accurate quantitation of the different classes of viral mRNAs. Unspliced (US) and multiply spliced (MS) HIV-1 transcripts were assayed by competitive reverse t...

journal_title：Journal of virology

authors： Bagnarelli P,Valenza A,Menzo S,Sampaolesi R,Varaldo PE,Butini L,Montroni M,Perno CF,Aquaro S,Mathez D,Leibowitch J,Balotta C,Clementi M

更新日期：1996-11-01 00:00:00

abstract：:A fresh inoculum of human adenovirus type 12 (Ad12) was obtained from the American Type Culture Collection and passaged once on human embryonic kidney cells, and Ad12 DNA was prepared from the first-passage yield to avoid higher passages which might have generated host-virus DNA recombinants. The 18 PstI fragments of ...

journal_title：Journal of virology

authors： Sprengel J,Schmitz B,Heuss-Neitzel D,Zock C,Doerfler W

更新日期：1994-01-01 00:00:00

abstract：:Lipoxins are host anti-inflammatory molecules that play a vital role in restoring tissue homeostasis. The efficacy of lipoxins and their analog epilipoxins in treating inflammation and its associated diseases has been well documented. Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL) are two well-known inflamm...

journal_title：Journal of virology

authors： Chandrasekharan JA,Huang XM,Hwang AC,Sharma-Walia N

更新日期：2016-11-28 00:00:00

abstract：UNLABELLED:SSV-type integrases, encoded by fuselloviruses which infect the hyperthermophilic archaea of the Sulfolobales, are archaeal members of the tyrosine recombinase family. These integrases catalyze viral integration into and excision from a specific site on the host genome. In the present study, we have establis...

journal_title：Journal of virology

authors： Zhan Z,Zhou J,Huang L

更新日期：2015-11-01 00:00:00

abstract：:The viral membrane proteins M and E are the minimal requirements for the budding of coronavirus particles. Since the E protein occurs in particles only in trace amounts, the lateral interactions between the M proteins apparently generate the major driving force for envelope formation. By using coimmunoprecipitation an...

journal_title：Journal of virology

authors： de Haan CA,Vennema H,Rottier PJ

更新日期：2000-06-01 00:00:00

abstract：:Cell cycle progression during cytomegalovirus infection was investigated by fluorescence-activated cell sorter (FACS) analysis of the DNA content in growth-arrested as well as serum-stimulated human fibroblasts. Virus-infected cells maintained in either low (0.2%) or high (10%) serum failed to progress into S phase an...

journal_title：Journal of virology

authors： Dittmer D,Mocarski ES

更新日期：1997-02-01 00:00:00

abstract：:Interspecies transmission of the transmissible spongiform encephalopathies (TSEs), or prion diseases, can result in the adaptation and selection of TSE strains with an expanded host range and increased virulence such as in the case of bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease. To investiga...

journal_title：Journal of virology

authors： Bartz JC,Bessen RA,McKenzie D,Marsh RF,Aiken JM

更新日期：2000-06-01 00:00:00

abstract：:Infection with the murine coronavirus strain JHM decreases cell surface expression of major histocompatibility complex class I antigens. Northern blots showed that JHM virus infection rapidly reduced the level of actin mRNA, whereas the levels of major histocompatibility complex class I and tubulin mRNAs were reduced ...

journal_title：Journal of virology

authors： Kyuwa S,Cohen M,Nelson G,Tahara SM,Stohlman SA

更新日期：1994-10-01 00:00:00

abstract：:Our previous studies with influenza A viruses indicated that the association of M1 with viral RNA and nucleoprotein (NP) is required for the efficient formation of helical ribonucleoprotein (RNP) and for the nuclear export of RNPs. RNA-binding domains of M1 map to the following two independent regions: a zinc finger m...

journal_title：Journal of virology

authors： Liu T,Ye Z

更新日期：2004-09-01 00:00:00

abstract：:The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a formidable battle horse for the study of viral immunology, as well as viral persistence and associated diseases. Investigations with LCMV have uncovered basic mechanisms by which viruses avoid elimination by the host adaptive immune response. In ...

journal_title：Journal of virology

authors： Martínez-Sobrido L,Zúñiga EI,Rosario D,García-Sastre A,de la Torre JC

更新日期：2006-09-01 00:00:00

abstract：:Vaccine-induced memory T cells localized at mucosal sites can provide rapid protection from viral infection. All-trans-retinoic acid (ATRA) has been shown to act physiologically to induce the expression of gut-homing receptors on lymphocytes. We tested whether the administration of exogenous ATRA during a systemic vac...

journal_title：Journal of virology

authors： Tan X,Sande JL,Pufnock JS,Blattman JN,Greenberg PD

更新日期：2011-08-01 00:00:00

abstract：:Norovirus (NV) gastroenteritis is a major contributor to global morbidity and mortality, yet little is known about immune mechanisms leading to NV control. Previous studies using the murine norovirus (MNV) model have established a key role for T cells in MNV clearance. Despite these advances, important questions remai...

journal_title：Journal of virology

authors： Tomov VT,Osborne LC,Dolfi DV,Sonnenberg GF,Monticelli LA,Mansfield K,Virgin HW,Artis D,Wherry EJ

更新日期：2013-06-01 00:00:00

abstract：:The hepatitis A virus (HAV) internal ribosome entry segment (IRES) is unique among the picornavirus IRESs in that it is inactive in the presence of either the entero- and rhinovirus 2A or aphthovirus Lb proteinases. Since these proteinases both cleave eukaryotic initiation factor 4G (eIF4G) and HAV IRES activity could...

journal_title：Journal of virology

authors： Borman AM,Michel YM,Kean KM

更新日期：2001-09-01 00:00:00

abstract：:A adenovirus type 5 host range mutant (hr440) has been isolated which is defective in a splicing event required to generate the middle-sized mRNA from early region 1A. This defect has been ascribed to two adjacent nucleotide changes which lie five and six nucleotides from the 5' splice site for this mRNA (Solnick, Nat...

journal_title：Journal of virology

authors： Solnick D,Anderson MA

更新日期：1982-04-01 00:00:00

abstract：:We investigated the synergism between influenza virus and Streptococcus pneumoniae, particularly the role of deletions in the stalk region of the neuraminidase (NA) of H2N2 and H9N2 avian influenza viruses. Deletions in the NA stalk (ΔNA) had no effect on NA activity or on the adherence of S. pneumoniae to virus-infec...

journal_title：Journal of virology

authors： Chockalingam AK,Hickman D,Pena L,Ye J,Ferrero A,Echenique JR,Chen H,Sutton T,Perez DR

更新日期：2012-04-01 00:00:00

abstract：:CCR5 serves as a requisite fusion coreceptor for clinically relevant strains of human immunodeficiency virus type 1 (HIV-1) and provides a promising target for antiviral therapy. However, no study to date has examined whether monoclonal antibodies, small molecules, or other nonchemokine agents possess broad-spectrum a...

journal_title：Journal of virology

authors： Trkola A,Ketas TJ,Nagashima KA,Zhao L,Cilliers T,Morris L,Moore JP,Maddon PJ,Olson WC

更新日期：2001-01-01 00:00:00

abstract：:A series of contiguous 30-bp deletions were introduced into the regions upstream of the p19 and p40 promoters of adeno-associated virus (AAV), and the effects of these deletions on induction of AAV transcription by the rep gene products was evaluated. A novel complementation system was devised for supplying wild-type ...

journal_title：Journal of virology

authors： McCarty DM,Christensen M,Muzyczka N

更新日期：1991-06-01 00:00:00

abstract：:Cell-free translation of separated Sendai virus mRNA species identified the message for polypeptide M and suggested the identity of the message for polypeptide NP. ...

journal_title：Journal of virology

authors： Jones K,Pridgen C,Kingsbury DW

更新日期：1978-10-01 00:00:00

abstract：:Influenza virus hemagglutinin consists of a highly variable and immunodominant head domain and a more conserved but immunosubdominant stalk domain. We introduced seven N-linked glycosylation sites in the hemagglutinin head domain to shield the immunodominant antigenic sites. The hyperglycosylated hemagglutinin enhance...

journal_title：Journal of virology

authors： Eggink D,Goff PH,Palese P

更新日期：2014-01-01 00:00:00

abstract：:Expression of the selectable drug resistance gene in retroviral vectors used for gene therapy can lead to a decreased expression of the gene of interest and may induce a host immune response, resulting in a decreased efficiency of gene therapy. In this study, we demonstrate that high-frequency deletion of direct repea...

journal_title：Journal of virology

authors： Delviks KA,Pathak VK

更新日期：1999-10-01 00:00:00

abstract：:The 5'-untranslated regions (5' UTRs) of picornavirus genomes contain an internal ribosomal entry site (IRES) that promotes the end-independent initiation of translation. Picornavirus IRESs are classified into four structurally distinct groups, each with different initiation factor requirements. Here, we identify a fi...

journal_title：Journal of virology

authors： Sweeney TR,Dhote V,Yu Y,Hellen CU

更新日期：2012-02-01 00:00:00

abstract：:Adeno-associated virus (AAV) codes for four related nonstructural Rep proteins. AAV both replicates and assembles in the nucleus and requires coinfection with a helper virus, either adenovirus (Ad) or herpesvirus, for a productive infection. Like other more complex DNA viruses, it is believed that AAV interacts or mod...

journal_title：Journal of virology

authors： Nash K,Chen W,Salganik M,Muzyczka N

更新日期：2009-01-01 00:00:00

abstract：:The UL11 tegument protein of herpes simplex virus plays a critical role in the secondary envelopment; however, the mechanistic details remain elusive. Here, we report a new function of UL11 in the budding process in which it directs efficient acquisition of glycoprotein E (gE) via a direct interaction. In vitro bindin...

journal_title：Journal of virology

authors： Han J,Chadha P,Meckes DG Jr,Baird NL,Wills JW

更新日期：2011-09-01 00:00:00

abstract：:Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) infect and establish latency in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is associated with the exacerbation of clinical symptoms and the induction of recurrences in humans and animal models. T...

journal_title：Journal of virology

authors： Ives AM,Bertke AS

更新日期：2017-06-09 00:00:00

abstract：:Retroviruses, as a result of the presence of two identical genomic RNA molecules in their virions, recombine at a high rate. When nonhomologous RNA is present in the dimer RNA molecules, nonhomologous recombination can occur, although the rate is very low, only 0.1% of the rate of essentially homologous recombination ...

journal_title：Journal of virology

authors： Zhang J,Temin HM

更新日期：1994-04-01 00:00:00

abstract：:Rotavirus replication and virulence are strongly influenced by virus strain and host species. The rotavirus proteins VP3, VP4, VP7, NSP1, and NSP4 have all been implicated in strain and species restriction of replication; however, the mechanisms have not been fully determined. Simian (RRV) and bovine (UK) rotaviruses ...

journal_title：Journal of virology

authors： Feng N,Sen A,Wolf M,Vo P,Hoshino Y,Greenberg HB

更新日期：2011-03-01 00:00:00

abstract：:We isolated revertants of a polyomavirus whose origin of DNA replication contains a point mutation in the palindrome to which large T antigen binds. Four independent second-site revertants contain an Asp-286----Asn-286 substitution in large T antigen. This mutant large T antigen activates replication of DNAs containin...

journal_title：Journal of virology

authors： Tang WJ,Folk WR

更新日期：1989-01-01 00:00:00

abstract：:Ascoviruses (family Ascoviridae) are double-stranded DNA viruses with circular genomes that attack lepidopterans, where they produce large, enveloped virions, 150 by 400 nm, and cause a chronic, fatal disease with a cytopathology resembling that of apoptosis. After infection, host cell DNA is degraded, the nucleus fra...

journal_title：Journal of virology

authors： Bideshi DK,Demattei MV,Rouleux-Bonnin F,Stasiak K,Tan Y,Bigot S,Bigot Y,Federici BA

更新日期：2006-12-01 00:00:00

abstract：:The coronavirus nucleocapsid (N) protein plays a multifunctional role in the virus life cycle, from regulation of replication and transcription and genome packaging to modulation of host cell processes. These functions are likely to be facilitated by interactions with host cell proteins. The potential interactome of t...

journal_title：Journal of virology

authors： Emmott E,Munday D,Bickerton E,Britton P,Rodgers MA,Whitehouse A,Zhou EM,Hiscox JA

更新日期：2013-09-01 00:00:00