Abstract:
:Influenza virus hemagglutinin consists of a highly variable and immunodominant head domain and a more conserved but immunosubdominant stalk domain. We introduced seven N-linked glycosylation sites in the hemagglutinin head domain to shield the immunodominant antigenic sites. The hyperglycosylated hemagglutinin enhanced stalk-directed seroreactivity while dampening the head response in immunized mice. Upon influenza virus challenge, mice vaccinated with the hyperglycosylated hemagglutinin were better protected against morbidity and mortality than mice receiving the wild-type hemagglutinin.
journal_name
J Viroljournal_title
Journal of virologyauthors
Eggink D,Goff PH,Palese Pdoi
10.1128/JVI.02608-13subject
Has Abstractpub_date
2014-01-01 00:00:00pages
699-704issue
1eissn
0022-538Xissn
1098-5514pii
JVI.02608-13journal_volume
88pub_type
杂志文章abstract::Equine infectious anemia virus (EIAV) is an equine lentivirus similar to HIV-1, targets host immune cells, and causes a life-long infection in horses. The Chinese live EIAV vaccine is attenuated from long-term passaging of a highly virulent strain in vitro The parent pathogenic strain (EIAVDLV34) induces a host inflam...
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abstract::Entry of the budded virus form of baculoviruses into insect and mammalian cells is generally thought to occur through a low-pH-dependent endocytosis pathway, possibly through clathrin-coated pits. This insight is primarily based on (immuno)electron microscopy studies but requires biochemical support to exclude the use...
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pub_type: 杂志文章
doi:10.1128/JVI.00880-06
更新日期:2006-09-01 00:00:00
abstract::Natural killer (NK) cells are an important component in the control of influenza virus infection, acting to both clear virus-infected cells and release antiviral cytokines. Engagement of CD16 on NK cells by antibody-coated influenza virus-infected cells results in antibody-dependent cellular cytotoxicity (ADCC). Incre...
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.8.5689-5694.1996
更新日期:1996-08-01 00:00:00
abstract:UNLABELLED:The APOBEC3 family of DNA cytosine deaminases has important roles in innate immunity and cancer. It is unclear how DNA tumor viruses regulate these enzymes and how these interactions, in turn, impact the integrity of both the viral and cellular genomes. Polyomavirus (PyVs) are small DNA pathogens that contai...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00771-16
更新日期:2016-06-24 00:00:00
abstract::Broadly neutralizing antibodies (bnAbs) can prevent lentiviral infection in nonhuman primates and may slow the spread of human immunodeficiency virus type 1 (HIV-1). Although protection by passive transfer of human bnAbs has been demonstrated in monkeys, durable expression is essential for its broader use in humans. G...
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pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.46.3.709-717.1983
更新日期:1983-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.8.4746-4751.1995
更新日期:1995-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03001-14
更新日期:2015-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.12.4691-4696.1988
更新日期:1988-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.62.12.4499-4509.1988
更新日期:1988-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00293-12
更新日期:2012-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00559-15
更新日期:2015-09-01 00:00:00
abstract:UNLABELLED:The discovery that measles virus (MV) uses the adherens junction protein nectin-4 as its epithelial receptor provides a new vantage point from which to characterize its rapid spread in the airway epithelium. We show here that in well-differentiated primary cultures of airway epithelial cells from human donor...
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pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
abstract::Respiratory syncytial virus (RSV) is the most important cause of severe, lower respiratory tract infections in infants, and RSV infections have been associated with chronic wheezing and asthma during childhood. However, the mechanism of RSV-induced airway inflammation and airway hyperresponsiveness (AHR) is poorly und...
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更新日期:2011-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章,随机对照试验
doi:10.1128/JVI.00073-11
更新日期:2011-07-01 00:00:00
abstract::Virus-specific cytotoxic T lymphocytes (CTL) exert intense selection pressure on replicating simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) in infected individuals. The immunodominant Mamu-A(*)01-restricted Gag p11C, C-M epitope is highly conserved among all sequenced isolates of S...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.23.12572-12578.2003
更新日期:2003-12-01 00:00:00
abstract::Recent studies have explored the chromatin structures associated with the herpes simplex virus type 1 (HSV-1) genome during latency, particularly with regard to specific histone tail modifications such as acetylation and dimethylation. The objective of our present study was to develop a rapid systemic method of in viv...
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更新日期:2007-06-01 00:00:00
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更新日期:2019-11-13 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00555-06
更新日期:2006-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1979-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
abstract:UNLABELLED:HIV-1-specific CD8 T cells can influence HIV-1 disease progression during untreated HIV-1 infection, but the functional and phenotypic properties of HIV-1-specific CD8 T cells in individuals treated with suppressive antiretroviral therapy remain less well understood. Here we show that a subgroup of HIV-1-spe...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00789-15
更新日期:2015-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.7.4495-4499.1995
更新日期:1995-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.4.2508-2515.1996
更新日期:1996-04-01 00:00:00